It is very important to consider the significance of variants like weight, age and genetics in relation to cancer. It is not easy to understand cancer in all aspects. So, more researches about it are very necessary in the world. This issue is very important for human health, of course.
Note about my dissertartion: during anaerobic exercise it was necessary to briefly hold the tail of the mice for better physical performance and better adaptation to the submitted environment. In this same type of exercise, there were times when the mice could not exercise and sank, causing manual manipulation again. The physical wear of the animals was intense.
It´s very important professors, students, scientists, researchers and other people worldwide know about my dissertation made at Faculty of Medicine of Sao Jose do Rio Preto because it was a very innovative and important research as well as my monograph (Chagas Disease research in laboratory at Federal University of Triangulo Mineiro -> Induction of benzonidazole resistance in human isolates of Trypanosoma cruzi). The data like graphics I made about variations of weights in all mice of different ages (Control Group -> treated with urethane and without physical activity and Study Group – Aerobic Group -> treated with urethane and subjected to aerobic swimming free exercise – Anaerobic Group –> treated with urethane and subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight) during all experimental time [My dissertation -> Lung cancer research in mice – Article: The influence of physical activity in the progression of experimental lung cancer in mice – Pathol Res Pract. 2012 Jul 15;208(7):377-81] are essential for the world scientific community. These graphics I did related to my dissertation aren´t in the article nor in my dissertation as well as details about time of exercise and rest of the animals. They can be an excellent reference for many types of researches like in the field of genetic engineering.
Very important observations:
- Cancer is very related to the weight loss of the patient. Weight loss of the patient is very associated with cancer – The syndrome of Anorexia-Cachexia (SAC) is a frequent complication in patients with advanced malignant neoplasia.
- Age, weight and genetics of the person are very important factors that influence cancer in a determined ways.
- The genetics of the mouse is very similar to that of the human.
- Maintaining proper body weight is one of the main ways to prevent cancer of a person.
- Animal testing has a very high importance to world society.
- The mouse is the main animal model used as the basis for research on diseases that affect humans.
- Weight lifting (bodybuilder) is a great example of anaerobic physical activity in humans.
The age of the mouse and the human being with the genetics influence in certain ways in pathophysiology in the humans and mice. So, mice researches are very important for the society as well as researches with humans.
In ´´my´´ dissertation the progression of lung cancer was lower in the group of mice that practiced anaerobic physical activity. Weight lifting is an anaerobic physical activity in humans. It would be very important, innovative and interesting to do researches in mice and humans testing a substance or substances, analyzing biochemical, pathological, pharmacological and physiological factors like weights in all experimental time (weight loss of the patient is very associated with cancer), the influence of age and genetics within the group itself and in the other groups in the inhibition and progression of cancer, for example. In this context, it is very important to seek new methodologies for the treatment, prevention and early detection of cancer and other diseases, such as vaccines and other very modern and efficient technologies. More informations about it are in this link (my dissertation): https://science1984.wordpress.com/2018/07/15/i-did-very-important-detailed-and-innovative-graphics-about-variations-of-all-mice-weigths-during-all-exerimental-time-my-dissertation-they-can-be-an-excelent-reference-for-future-researches-like-2/
The society needs to have more excellent ideas and scientific discoveries for human live longer faster.
It is very important to consider the significance of variants like weight, age and genetics in relation to cancer.It is not easy to understand cancer in all aspects. So, more researches about it are very necessary in the world. This issue is very important for human health.
– Link about my monograph: Chagas Disease research in laboratory at Federal University of Triangulo Mineiro -> Induction of benzonidazole resistance in human isolates of Trypanosoma cruzi: https://science1984.wordpress.com/2018/07/15/my-monography-chagas-disease-research-in-laboratory-2/
Science events and researches are essential for world progress in all aspects. Unfortunately there are very dangerous and fatal diseases without cure or total prevention methods like vacination. The human expectancy of life needs to increase so much faster. Therefore, new scientific discoveries are very necessary for human life urgently.
Facebook Page about this Blog: https://www.facebook.com/scientificblog/
YouTube Channel: https://www.youtube.com/channel/UC9gsWVbGYWO04iYO2TMrP8Q
Instagram: @rodrigoncal84 @calrodrigonunes
E-mails: rodrigonunescal@yahoo.com rodrigoncal1984@gmail.com
Curriculum Lattes: http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4240145A2
LinkedIn: https://www.linkedin.com/in/rodrigo-nunes-cal-81433b168/
Twitter: @CalZole
https://www.researchgate.net/scientific-contributions/76406552_Rodrigo_Nunes_Cal
Article of ´´my´´ dissertation: The influence of physical activity in the progression of experimental lung cancer in mice – Pathol Res Pract. 2012 Jul 15;208(7):377-81. The research was made at Faculty of Medicine of Sao Jose do Rio Preto.
I did very innovative, detailed and important graphics about variations of all mice (control and study groups – lung cancer research in mice) during all experimental time related to ´´my´´ dissertation. They can be an excellent reference for future researches of many types. So, it is fundamental share this blog! https://science1984.wordpress.com/2019/03/08/it-is-fundamental-professors-students-researchers-and-other-people-worldwide-know-about-my-dissertation-because-the-research-was-very-innovative-and-important-in-the-world-these-data-like-graphics/
-Nanomedicine – Text I typed about Nanomedicine
-https://science1984.files.wordpress.com/2018/07/nanomedicine.pdf
I did very important, detailed and innovative graphics about variations of all mice weigths during all experimental time (my dissertation). They aren´t in the scientific article related to my dissertation nor in my dissertation. They can be an excelent reference for future researches like animal testing in the field of genetic engineering, for example. It was a very innovative and important research! So, many researchers, scientists, professors, students and other people of the world need to know about it to visit and share this blog as soon as possible because unfortunately there are very dangerous and fatal diseases without cure or total prevention methods like vacination.
My Dissertation –>> The influence of physical activity in the progression of experimental lung cancer in mice
-https://www.researchgate.net/publication/225286318_The_influence_of_physical_activity_in_the_progression_of_experimental_lung_cancer_in_mice
ABSTRACT
Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.
RESUMO
Introdução: O câncer de pulmão é uma das neoplasias mais incidentes no mundo, sendo a principal causa de mortalidade por câncer. Muitos estudos epidemiológicos têm sugerido que a atividade física pode reduzir o risco do câncer de pulmão, outros trabalhos avaliaram a eficácia da utilização da atividade física na supressão, remissão e redução da recorrência de tumores. Objetivo: Avaliar os efeitos da atividade física aeróbia e anaeróbia no desenvolvimento e na progressão do câncer de pulmão experimental. Material e Métodos: Os tumores de pulmão foram induzidos com uma dose de 3mg de uretana/kg, em 67 camundongos Balb-C, divididos em três grupos: Grupo 1 – 24 camundongos tratados com uretana e sem atividade física; Grupo 2 – 25 camundongos tratados com uretana e submetidos ao exercício aeróbio em natação; Grupo 3 – 18 camundongos tratados com uretana, submetidos ao exercício anaeróbio em natação com carga gradual de 5 a 20% do peso corporal. Todos os animais foram sacrificados após 20 semanas, e as lesões pulmonares foram analisadas. Resultados: A mediana do número de lesões (nódulos e hiperplasias) foi de 3,0 para o grupo 1, 2,0 para o grupo 2 e 1,5 para o grupo 3 (p = 0,052). Quando comparado apenas a presença ou ausência de lesão, houve uma diminuição no número de lesões no grupo 3 em comparação com o grupo 1 (p = 0,03), mas não em relação ao grupo 2. Não houve metástases ou outras alterações em outros órgãos. Conclusão: A atividade física anaeróbia, mas não a aeróbia, diminuiu a incidência dos tumores de pulmão experimental.
-CARCINÓGENO DMBA EM MODELOS EXPERIMENTAIS -DMBA CARCINOGEN IN EXPERIMENTAL MODELS
-SLIDES – MESTRADO – DISSERTATION – RESEARCH -PESQUISA – DISSERTAÇÃO
Note: during anaerobic exercise it was necessary to briefly hold the tail of the mice for better physical performance and better adaptation to the submitted environment. In this same type of exercise, there were times when the mice could not exercise and sank, causing manual manipulation again. The physical wear of the animals was intense.
Observação: durante o exercício anaeróbio foi preciso segurar por pouco tempo a cauda dos camundongos para a aquisição de um melhor rendimento físico e uma melhor adaptação ao meio submetido. Neste mesmo tipo de exercício, houve momentos em que os camundongos não conseguiram ficar se exercitando e afundaram, fazendo com que houvesse a manipulação manual novamente. O desgaste físico dos animais foi intenso.
->> Details about time of exercise and rest of the animals.
Other link about my dissertation: The influence of physical activity in the progression of experimental lung cancer in mice. Pathol Res Pract. 2012 Jul 15;208(7):377-81) – https://science1984.wordpress.com/2018/03/31/mestrado/
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