Master´s degree – My Dissertation: The influence of physical activity in the progression of experimental lung cancer in mice – The scientific article was published in a great journal -> Pathology – Research and Practice – Elsevier & Unfortunately, crime in Brazil and in other countries is high @ Links about my dissertation – Scientific Article & My Twitter follower (Ophthalmology @opthalmicres) sent a message for me a a time ago #@¨%&* The graphics I made about variations of all mice weights in the experimental time are not in the article nor in my dissertation as well as details about time of exercise and rest of the animals. These data can be an excellent reference for researches in laboratory animal tests (in the field of genetic engineering, for example) and in other types of researches. Details on this subject are in the informed link.

15Jul 201819 Jan 2019

-Nanomedicine – Text I typed about Nanomedicine

-https://science1984.files.wordpress.com/2018/07/nanomedicine.pdf

-My Twitter follower-> Ophthalmology @opthalmicres (Opthalmology Case Reports is a scientific Open access Journal that deals and describes the developmental activities conducted in the field of Eye research Joined December 2016) sent a message for me about the message I sent a time ago by Twitter. ´´Hello Rodrigo N Cal.. Thankyou for connecting with us.. Sounds great that you are working on various important topics.. If you have any article related to our Journal you can Submit to us by email at opthamology@alliedjournals.org´´ Ok. Thank you. Rodrigo Nunes Cal @ Links of my dissertation

-Evaluation of aerobic and anaerobic physical activity in the progression of experimental lung cancer

The influence of physical activity in the progression of experimental lung cancer in mice

Paceli RB¹, Cal RN, dos Santos CH, Cordeiro JA, Neiva CM, Nagamine KK, Cury PM.

-Pathol Res Pract. 2012 Jul 15;208(7):377-81. doi: 10.1016/j.prp.2012.04.006. Epub 2012 Jun 8.

-https://www.journals.elsevier.com/pathology-research-and-practice

1. Links of my Dissertation:

https://www.sciencedirect.com/science/article/pii/S0344033812001082

-https://www.ncbi.nlm.nih.gov/pubmed/22683274

-http://bdtd.famerp.br/handle/tede/164

-https://www.researchgate.net/publication/225286318_The_influence_of_physical_activity_in_the_progression_of_experimental_lung_cancer_in_mice

-http://bdtd.famerp.br/bitstream/tede/164/1/rodrigonunescal_dissert.pdf

ABSTRACT

Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.

RESUMO

Introdução: O câncer de pulmão é uma das neoplasias mais incidentes no mundo, sendo a principal causa de mortalidade por câncer. Muitos estudos epidemiológicos têm sugerido que a atividade física pode reduzir o risco do câncer de pulmão, outros trabalhos avaliaram a eficácia da utilização da atividade física na supressão, remissão e redução da recorrência de tumores. Objetivo: Avaliar os efeitos da atividade física aeróbia e anaeróbia no desenvolvimento e na progressão do câncer de pulmão experimental. Material e Métodos: Os tumores de pulmão foram induzidos com uma dose de 3mg de uretana/kg, em 67 camundongos Balb-C, divididos em três grupos: Grupo 1 – 24 camundongos tratados com uretana e sem atividade física; Grupo 2 – 25 camundongos tratados com uretana e submetidos ao exercício aeróbio em natação; Grupo 3 – 18 camundongos tratados com uretana, submetidos ao exercício anaeróbio em natação com carga gradual de 5 a 20% do peso corporal. Todos os animais foram sacrificados após 20 semanas, e as lesões pulmonares foram analisadas. Resultados: A mediana do número de lesões (nódulos e hiperplasias) foi de 3,0 para o grupo 1, 2,0 para o grupo 2 e 1,5 para o grupo 3 (p = 0,052). Quando comparado apenas a presença ou ausência de lesão, houve uma diminuição no número de lesões no grupo 3 em comparação com o grupo 1 (p = 0,03), mas não em relação ao grupo 2. Não houve metástases ou outras alterações em outros órgãos. Conclusão: A atividade física anaeróbia, mas não a aeróbia, diminuiu a incidência dos tumores de pulmão experimental.