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The influence of physical activity in the progression of experimental lung cancer in mice
- PMID: 22683274
- DOI: 10.1016/j.prp.2012.04.006
GRUPO_AF1 – GROUP AFA1 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO AFAN 1 – GROUP AFAN1 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO_AF2 – GROUP AFA2 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO AFAN 2 – GROUP AFAN 2 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
Slides – mestrado – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
DMBA CARCINOGEN IN EXPERIMENTAL MODELS
Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.
Copyright © 2012 Elsevier GmbH. All rights reserved.
I was invited by Internet to participate in 39 very important science events in less than 9 months in 18 cities of different countries because of the relevant research I did (my dissertation was an excellent research and it is available on my blog) as well as my monograph (Chagas disease research in laboratory). I did very important, detailed and useful graphics about variations of all mice weights during all experimental time of my dissertation – The influence of physical activity in the progression of experimental lung cancer in mice – Pathol Res Pract. 2012 Jul 15;208(7):377-81. It was a very innovative and important research! These graphics can be an excellent reference for researches in animal testing (in the area of genetic engineering for example) or in other types of researches. They are not in the scientific article related to my dissertation. So, I´d like so much you visit and share this blog. It is of high importance for society. The human expectancy of life needs to increase so much with better researches. There are very updated, interesting and important topics on my blog. Very Important Note: I never earned money with my Blog and other Blogs I did, my YouTube Channel, e-mails accounts and my Social Networkings for example.
I have a degree in biomedicine (2003-2007 – during my monograph I had a government financial aid), I have a master’s degree in physiology of experimental lung cancer in mice without government financial aid (2008-2012), and I work as a student inspector after being approved in a public contest in 2012 in Sao Jose do Rio Preto – Sao Paulo State. Maybe I can do a doctorate to work as researcher and professor in Brazil or abroad like USA.
*Link of my dissertation: https://science1984.wordpress.com/2018/07/15/i-did-very-important-detailed-and-innovative-graphics-about-variations-of-all-mice-weigths-during-all-exerimental-time-my-dissertation-they-can-be-an-excelent-reference-for-future-researches-like-2/ Visit! Share !!
Video –>> I was invited to participate in 35 very important scientific events worldwide in 16 cities of different countries in less than 7 months because of the great research I did. https://www.youtube.com/watch?v=XKxxrgfJKUA Watch! Share! Thanks! Best wishes!