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The influence of physical activity in the progression of experimental lung cancer in mice
- PMID: 22683274
- DOI: 10.1016/j.prp.2012.04.006
GRUPO_AF1 – GROUP AFA1 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO AFAN 1 – GROUP AFAN1 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO_AF2 – GROUP AFA2 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO AFAN 2 – GROUP AFAN 2 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
Slides – mestrado – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
DMBA CARCINOGEN IN EXPERIMENTAL MODELS
Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.
Copyright © 2012 Elsevier GmbH. All rights reserved.
MIT reshapes itself to shape the future
Gift of $350 million establishes the MIT Stephen A. Schwarzman College of Computing, an unprecedented, $1 billion commitment to world-changing breakthroughs and their ethical application.
´´Ever since the beginning of the AI boom in the early 2010s, there’s been a corresponding drought in talented AI developers and researchers. The way to fix this is to educate more of them, and today, MIT announced a $1 billion initiative to do exactly that: it will establish a new college of computing to train the next generation of machine learning mavens.´´
´´Importantly, the college isn’t just about training AI skills. Instead, it will focus on what MIT president L. Rafael Reif calls “the bilinguals of the future.” By that, he means students in fields like biology, chemistry, physics, politics, history, and linguistics who also know how to apply machine learning to these disciplines. (Presumably, Reif feels safe borrowing the term “bilingual” because, in the future, AI will be doing all the translation anyway.)´´
´´Two-thirds of the planned $1 billion commitment has been raised so far, with $350 million coming from Stephen A. Schwarzman, CEO of the private equity firm Blackstone. The new college will be named after Schwarzman, and it will include 50 new faculty positions, half of which will focus solely on computer science, while the rest are jointly appointed by the college and other MIT departments. The college is scheduled to open in September 2019, and its new building is planned to be completed in 2022.´´
´´MIT is also angling the college as an ethically minded enterprise; one of its stated aims is to research “ethical considerations relevant to computing and AI.” It’s a frequent criticism of contemporary AI efforts that researchers sometimes ignore the history and lessons of the fields they are trying to “disrupt.” More collaboration should help.´´
“As computing reshapes our world, MIT intends to help make sure it does so for the good of all,” said Reif in a press statement. “The MIT Schwarzman College of Computing will constitute both a global center for computing research and education, and an intellectual foundry for powerful new AI tools. Just as important, the College will equip students and researchers in any discipline to use computing and AI to advance their disciplines and vice-versa, as well as to think critically about the human impact of their work.”