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The influence of physical activity in the progression of experimental lung cancer in mice
- PMID: 22683274
- DOI: 10.1016/j.prp.2012.04.006
GRUPO_AF1 – GROUP AFA1 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO AFAN 1 – GROUP AFAN1 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO_AF2 – GROUP AFA2 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO AFAN 2 – GROUP AFAN 2 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
Slides – mestrado – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
DMBA CARCINOGEN IN EXPERIMENTAL MODELS
Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.
Copyright © 2012 Elsevier GmbH. All rights reserved.
´´Dr. Kocher is a Professor of Orthpaedic Surgery at Harvard Medical School and the Associate Director of the Division of Sports Medicine at Boston Children’s Hospital.´´
´´He is a world renown expert in Orthopaedic Surgery, Pediatric & Adolescent Sports Medicine, and Orthopaedic Clinical Epidemiology Research.´´
´´He has been named a top orthopedic surgeon by US News & World Report, Top Doctors, Castle Connelly, and Boston Magazine. He has been featured in the New York Times, Wall Street Journal, USA Today, Boston Globe, New England Journal of Medicine, Chicago Tribune, San Francisco Chronicle, ABC World News, Scientific American, and Sports Illustrated.´´
´´He has presented over 300 talks at major national and international scientific conferences, published over 150 scientific peer-reviewed medical journal articles, written over 100 book chapters, and authored 4 textbooks.´´
´´He has been a visiting Professor at institutions in over 20 countries. He is actively involved in the teaching of medical students, residents, fellows, and visiting national and international orthopaedic surgeons.´´
´´He has received numerous research awards including the Von Meyer Award, Richard Kilfoyle Award, Angela Kuo Award, Arthur Heune Award, and the Kappa Delta Award (orthopedic surgery’s “Nobel Prize”).´´
´´He has served on the Board of Directors of the American Academy of Orthopaedic Surgeons, the American Orthopaedic Society for Sports Medicine, and the Pediatric Orthopaedic Society of North America. He has been elected to the Herodicus Society and the International Pediatric Orthopaedic Think Tank.´´
´´He has served on the editorial board of numerous medical journals and has consulted with medical companies including Smith+Nephew, OrthoPediatrics, Pivot Medical, Biomet, ConMed Linvatec, and Ossur.´´