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The influence of physical activity in the progression of experimental lung cancer in mice
- PMID: 22683274
- DOI: 10.1016/j.prp.2012.04.006
GRUPO_AF1 – GROUP AFA1 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO AFAN 1 – GROUP AFAN1 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO_AF2 – GROUP AFA2 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO AFAN 2 – GROUP AFAN 2 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
Slides – mestrado – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
DMBA CARCINOGEN IN EXPERIMENTAL MODELS
Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.
Copyright © 2012 Elsevier GmbH. All rights reserved.
I´m graduated in biomedicine at Federal University of Triangulo Mineiro, I have a Master´degree in cancer research in mice at Faculty of Medicine of Sao Jose do Rio Preto and nowadays I work as inspector of students in Sao Jose do Rio Preto since 2012. Maybe I do a doctorate to work as professor.
– Link of my dissertation: https://science1984.wordpress.com/2018/07/15/masters-degree-my-dissertation-lung-cancer-research-in-mice-scientific-article-was-published-in-a-great-journal-text-i-typed-about-nanomedicine/ Avaliação da influência da atividade física na progressão do câncer de pulmão experimental em camundongos – The influence of physical activity in the progression of experimental lung cancer in mice – Pathol Res Pract. 2012 Jul 15;208(7):377-81. It was a very innovative and important research! The graphics I did about the variations of all mice weights during all experimental time (cancer research in mice) aren´t in the scientific article related to my dissertation and neither in my dissertation as well as details of exercise time and rest of the animals. These data can be an excellent reference for researches in animal testing (in the area of genetic engineering for example) and in other types of researches.
-Link about my monograph: Chagas Disease research in laboratory -> Induction of benzonidazole resistance in human isolates of Trypanosoma cruzi – Indução de resistência ao benzonidazol em isolados humanos de Trypanosoma cruzi – https://science1984.wordpress.com/2018/07/15/my-monography-chagas-disease-research-in-laboratory-2/
It´s very important promote the researches I participated. The world needs more efficient researches, of course. There are many laboratories that used mice to study pathologies and received financial investments of many types. The human expectancy of life worldwide needs to increase with better researches for example.
I was invited by Twitter to participate in Science Advisory Board – an online community of scientific and medical professionals from all around the world.
Minha página do Facebook – My Facebook Page –>>> https://www.facebook.com/scientificblog/
Currículo Lattes – My Curriculum – –>> http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4240145A2
Meu Canal do YouTube – My YouTube channel –>> https://www.youtube.com/channel/UC9gsWVbGYWO04iYO2TMrP8Q
My Emails accounts: firstname.lastname@example.org email@example.com firstname.lastname@example.org
My Twitter accounts: @RodrigoNCal1 @rodrigonunescal @scienceblog100
My LinkedIn Profile: https://www.linkedin.com/in/rodrigo-nunes-cal-81433b168/
My Instagram accounts: @calrodrigonunes @rodrigoncal84
Sou formado em Biomedicina pela Universidade Federal do Triângulo Mineiro (2003-2007), Mestre em Ciências da Saúde (Fisiopatologia do câncer de pulmão em camundongos – 2008-2012) pela Faculdade de Medicina de São José do Rio Preto e Inspetor de Alunos desde 2012 em São José do Rio Preto após ser aprovado em concurso público.
Live the present time in the best way! Viva o tempo presente da melhor forma!
My opinion article (Nanomedicine: An Evolving Research) was published in Journal of Nanomedicine & Biotherapeutic Discovery that is listed among the top 10 Journals on Nanomedicine in the world.
Fui convidado por meio da Internet para participar de 52 eventos científicos de grande importância mundial em 24 cidades em menos de 1 ano porque participei de ótimas pesquisas. Minha dissertação e monografia foram pesquisas muito importantes e inovadoras.