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The influence of physical activity in the progression of experimental lung cancer in mice
- PMID: 22683274
- DOI: 10.1016/j.prp.2012.04.006
GRUPO_AF1 – GROUP AFA1 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO AFAN 1 – GROUP AFAN1 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO_AF2 – GROUP AFA2 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO AFAN 2 – GROUP AFAN 2 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
Slides – mestrado – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
DMBA CARCINOGEN IN EXPERIMENTAL MODELS
Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.
Copyright © 2012 Elsevier GmbH. All rights reserved.
The Role of Irisin in Alzheimer’s Disease (Important issue – Assunto importante) https://www.mdpi.com/2077-0383/7/11/407/html
http://g1.globo.com/jornal-nacional/noticia/2017/07/cientistas-da-ufrj-conseguem-parar-o-avanco-do-alzheimer-em-animais.html (Related research – Pesquisa relacionada)
Pesquisa liderada pelo governo brasileiro sugere que o hormônio pode reverter a perda de memória causada por Alzheimer | Ciência e Saúde
Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer’s models
- Mychael V. Lourenco,
- Rudimar L. Frozza,
- Guilherme B. de Freitas,
- Hong Zhang,
- Grasielle C. Kincheski,
- Felipe C. Ribeiro,
- Rafaella A. Gonçalves,
- Julia R. Clarke,
- Danielle Beckman,
- Agnieszka Staniszewski,
- Hanna Berman,
- Lorena A. Guerra,
- Letícia Forny-Germano,
- Shelby Meier,
- Donna M. Wilcock,
- Jorge M. de Souza,
- Soniza Alves-Leon,
- Vania F. Prado,
- Marco A. M. Prado,
- Jose F. Abisambra,
- Fernanda Tovar-Moll,
- Paulo Mattos,
- Ottavio Arancio,
- Sergio T. Ferreira &
- Fernanda G. De Felice
Uma nova esperança
´´Cientistas brasileiros revelaram que há relação entre um hormônio chamado irisina, produzido pelo corpo durante a prática de exercícios físicos, e o tratamento da perda da memória provocada pelo Alzheimer. O estudo, publicado na revista “Nature Medicine”, foi feito com camundongos que têm a doença. Eles foram estimulados a produzir o hormônio e também receberam doses. Os autores dizem que 3 novidades foram descobertas:´´
- há baixos níveis de irisina no cérebro de pacientes afetados pelo Alzheimer. Essa mesma deficiência foi vista nos camundongos;
- a reposição dos níveis de irisina no cérebro, inclusive por meio de exercícios físicos, foi capaz de reverter a perda de memória;
- a irisina é o que regula os efeitos positivos do exercício físico na memória dos camundongos.
´´Os pesquisadores Mychael Lourenço e Fernanda De Felice, da UFRJ, explicam que o fato de a irisina ser produzida pelo próprio organismo diminui as chances de efeitos colaterais, o que dá esperança para novos tratamentos. Leia mais sobre a pesquisa.´´
LOURENCO, MYCHAEL V. ; FROZZA, RUDIMAR L. ; FREITAS, G. B. ; ZHANG, H. ; KINCHESKI, GRASIELLE C. ; CLARKE, J. R. ; RIBEIRO, FELIPE C. ; BECKMAN, DANIELLE ; STANISZEVSKI, A. ; BERMAN, H. ; GUERRA, L. A. ; FORNY-GERMANO, LETICIA ; MEIER, S. ; ABISAMBRA, J. F. ; WILCOCK, D. M. ; PRADO, M. A. M. ; DE SOUZA, JORGE M. ; ALVES-LEON, S. ; TOVAR-MOLL, F. ; MATTOS, P. ; ARANCIO, O. ; Ferreira ST. ; DE FELICE, FERNANDA G. . Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer´s models. NATURE MEDICINE , 2018.
Defective brain hormonal signaling has been associated with Alzheimer’s disease (AD), a disorder characterized by synapse and memory failure. Irisin is an exercise-induced myokine released on cleavage of the membrane-bound precursor protein fibronectin type III domain-containing protein 5 (FNDC5), also expressed in the hippocampus. Here we show that FNDC5/irisin levels are reduced in AD hippocampi and cerebrospinal fluid, and in experimental AD models. Knockdown of brain FNDC5/irisin impairs long-term potentiation and novel object recognition memory in mice. Conversely, boosting brain levels of FNDC5/irisin rescues synaptic plasticity and memory in AD mouse models. Peripheral overexpression of FNDC5/irisin rescues memory impairment, whereas blockade of either peripheral or brain FNDC5/irisin attenuates the neuroprotective actions of physical exercise on synaptic plasticity and memory in AD mice. By showing that FNDC5/irisin is an important mediator of the beneficial effects of exercise in AD models, our findings place FNDC5/irisin as a novel agent capable of opposing synapse failure and memory impairment in AD.
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