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The influence of physical activity in the progression of experimental lung cancer in mice
- PMID: 22683274
- DOI: 10.1016/j.prp.2012.04.006
GRUPO_AF1 – GROUP AFA1 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO AFAN 1 – GROUP AFAN1 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO_AF2 – GROUP AFA2 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO AFAN 2 – GROUP AFAN 2 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
Slides – mestrado – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
DMBA CARCINOGEN IN EXPERIMENTAL MODELS
Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.
Copyright © 2012 Elsevier GmbH. All rights reserved.
Dr. Timothy Kassis completed his postdoctoral training under Profs. Linda Griffith (BE) and David Trumper (MechE) at MIT. Prior to that, Dr. Kassis obtained a Ph.D. in Bioengineering and an M.S. in Mechanical Engineering from the Georgia Institute of Technology in Atlanta, GA, and a B.Eng. in Electronic and Communications Engineering from the University of Nottingham, UK. Dr. Kassis has lived for extended amounts of time in the Philippines, Canada, UK, Lebanon, Syria, and since 2008, the United States.
Teaching and Mentorship
Dr. Kassis is currently the lead instructor for the School of Engineering’s New Engineering Education Transformation (NEET) Living Machines (LM) thread and is also the instructor for 20.051, 20.052 and 20.053 which are the three classes entitled ‘Living Machines’ required by all students participating in the LM thread.
Dr. Kassis’ research interests lie at the convergence of engineering, biology, and computation. He is particularly interested in creating engineering tools to answer difficult biological questions. Dr. Kassis has worked on a variety of interdisciplinary research projects from elucidating the role of lymphatics in lipid transport to designing organ-on-chip microfluidic models to developing deep convolutional networks for biomedical image processing.