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Pathol Res Pract. 2012 Jul 15;208(7):377-81. doi: 10.1016/j.prp.2012.04.006. Epub 2012 Jun 8.

The influence of physical activity in the progression of experimental lung cancer in mice

Renato Batista Paceli 1Rodrigo Nunes CalCarlos Henrique Ferreira dos SantosJosé Antonio CordeiroCassiano Merussi NeivaKazuo Kawano NagaminePatrícia Maluf Cury


GRUPO_AF1 – GROUP AFA1 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 1 – GROUP AFAN1 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO_AF2 – GROUP AFA2 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 2 – GROUP AFAN 2 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

Slides – mestrado – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto



Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto



Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.


Citation: Cal RN (2018) Nanomedicine: An Evolving Research. J Nanomedine Biotherapeutic Discov 8: 160. DOI: 10.4172/2155-983X.1000160

Nanomedicine: An Evolving Research






I´m graduated in Biomedicine at Federal University of Triangulo Mineiro (Uberaba – 2003-2007), I have a Master´s degree in cancer research in mice (lung cancer) at Faculty of Medicine of Sao Jose do Rio Preto (2008-2012). Nowadays I work as Inspector of Students since 2012 in Sao Jose do Rio Preto (Brazil). Maybe I can do a doctorate to work as professor and researcher.

I hope in some way with this blog www.science1984.wordpress.com to help significantly in the socio-economic and technical-scientific development of the countries. Note: I do not earn money with my blog. I never earned money with blogs I did.

This blog goal is help any one in anyway who visited it. The blog content is very good with high quality. There are many important informations in it! I elaborated it in 2018. There are 41 followers of my blog, 161 likes, 1,1mil comments approved and 625 posts typed by me.

 – > Videos: Acknowledgment for the recognition of the researches (dissertation and monograph) I participated at Medical School of Sao Jose do Rio Preto and Federal University of the Triangulo Mineiro – Uberaba – Brazil. I was invited by Internet to participate in 57 very important science events worldwide in 26 cities of different countries in less than 1 year (Suzhou, Stanbul, Miami, Singapore, Kuala Lumpur, Abu Dhabi, San Diego, Bangkok, Dublin, Sao Paulo, Dubai, Boston, Berlin, Stockholm, Prague, Valencia, Osaka, Amsterdam, Helsinki, Paris, Tokyo, Vienna, Rome, Zurich, London and Frankfurt). Informations about it are in this blog.

– > Video 1: https://www.youtube.com/watch?v=eGbu5GKzjMk

– > Video 2: https://www.youtube.com/watch?v=dB5zxg8bjoY

The human quality of life needs to improve to people live longer.

Link related with my dissertation: https://science1984.wordpress.com/2018/07/15/i-did-very-important-detailed-and-innovative-graphics-about-variations-of-all-mice-weigths-during-all-exerimental-time-my-dissertation-they-can-be-an-excelent-reference-for-future-researches-like-2/

Article: The influence of physical activity in the progression of experimental lung cancer in mice – Pathol Res Pract. 2012 Jul 15;208(7):377-81. The graphics I did about the variations of all mice weights during all experimental time (lung cancer research in mice) aren´t in the scientific article related to my dissertation nor in my dissertation as well as details about time of exercise and rest of the animals. These data can be an excellent reference for future researches in animal testing (in the area of genetic engineering for example) and in other types of researches, of course. Informations about it are in the link informed above.

Link about my monograph: Chagas Disease research in laboratory at Federal University of Triangulo Mineiro -> Induction of benzonidazole resistance in human isolates of Trypanosoma cruzi https://science1984.wordpress.com/2018/07/15/my-monography-chagas-disease-research-in-laboratory-2/

Facebook Page about my blog: https://www.facebook.com/scientificblog/ There are 84 followers and 77 likes in it.

My YouTube Channel: https://www.youtube.com/channel/UC9gsWVbGYWO04iYO2TMrP8Q Subscribe!

My Curriculum Lattes: http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4240145A2

It´s very important inform you  the researches I participated. The world needs more efficient researches with high quality. There are many laboratories that use mice to study pathologies and receive very important financial investments. The human expectancy of life needs to increase so much with more efficient researches, of course. Unfortunately there are fatal diseases.

It is fundamental professors, students, researchers and other people worldwide know about my monograph and dissertation because the researches were very innovative and important in the world. The data like detailed graphics I made about variations of weights in all mice (Control Group and Study Group – Dissertation) during all experimental time (Lung cancer research in mice – The influence of physical activity in the progression of experimental lung cancer in mice – Pathol Res Pract. 2012 Jul 15;208(7):377-81) are essential for the scientific community. Therefore, this issue is very important for people, of course! They can be a very good reference for many types of researches in the future! These data are available in this link: https://science1984.wordpress.com/2018/07/15/i-did-very-important-detailed-and-innovative-graphics-about-variations-of-all-mice-weigths-during-all-exerimental-time-my-dissertation-they-can-be-an-excelent-reference-for-future-researches-like-2/ The human expectancy of life needs to increase faster. Visit! Share! Thank you in advance! Best wishes!



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