JAX changed science 90 years ago with the advent of inbred laboratory mouse models and a genetic theory of cancer. It’s about to do so again. @ A growing place with big ideas – The Jackson Laboratory Website – The JAX Blog &# The Nobel Prize Website

Do the downloads!! Share!! The diffusion of very important information and knowledge is essential for the world progress always!! Thanks!!

  • – > Mestrado – Dissertation – Tabelas, Figuras e Gráficos – Tables, Figures and Graphics – ´´My´´ Dissertation @ #Innovation #energy #life #health #Countries #Time #Researches #Reference #Graphics #Ages #Age #Mice #People #Person #Mouse #Genetics #PersonalizedMedicine #Diagnosis #Prognosis #Treatment #Disease #UnknownDiseases #Future #VeryEfficientDrugs #VeryEfficientVaccines #VeryEfficientTherapeuticalSubstances #Tests #Laboratories #Investments #Details #HumanLongevity #DNA #Cell #Memory #Physiology #Nanomedicine #Nanotechnology #Biochemistry #NewMedicalDevices #GeneticEngineering #Internet #History #Science #World

Pathol Res Pract. 2012 Jul 15;208(7):377-81. doi: 10.1016/j.prp.2012.04.006. Epub 2012 Jun 8.

The influence of physical activity in the progression of experimental lung cancer in mice

Renato Batista Paceli 1Rodrigo Nunes CalCarlos Henrique Ferreira dos SantosJosé Antonio CordeiroCassiano Merussi NeivaKazuo Kawano NagaminePatrícia Maluf Cury


Impact_Fator-wise_Top100Science_Journals

GRUPO_AF1 – GROUP AFA1 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 1 – GROUP AFAN1 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO_AF2 – GROUP AFA2 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 2 – GROUP AFAN 2 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

Slides – mestrado – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

CARCINÓGENO DMBA EM MODELOS EXPERIMENTAIS

DMBA CARCINOGEN IN EXPERIMENTAL MODELS

Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

https://pubmed.ncbi.nlm.nih.gov/22683274/

Abstract

Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.

https://www.nobelprize.org/

https://www.jax.org/jax90/a-growing-place-with-big-ideas

https://www.facebook.com/JacksonLaboratory/

https://www.instagram.com/jaxlab/?hl=pt

https://www.jax.org/

https://www.linkedin.com/company/the-jackson-laboratory

https://www.jax.org/jax-mice-and-services

https://en.wikipedia.org/wiki/Jackson_Laboratory

https://www.jax.org/about-us

https://www.jax.org/research-and-faculty

https://www.jax.org/clinical-genomics

https://www.jax.org/jax-mice-and-services/in-vivo-pharmacology/humanized-mice

Featured Article A growing place with big ideas By Joyce Dall’Acqua Peterson JAX changed science 90 years ago with the advent of inbred laboratory mouse models and a genetic theory of cancer. It’s about to do so again. The scientific world originally embraced C.C. Little’s inbred mouse because it was a way to reduce the daunting complexity of biology and focus on a single genetic trait, such as coat color or cancer susceptibility. But this reductionism comes at a cost: That complexity we’re eliminating is what defines a unique individual, mouse or human. Enter mouse populations with stupendous quantities of genetic variation. In 2004 JAX Professor Gary Churchill, together with JAX Professor Elissa Chesler when she was at Oak Ridge National Laboratory and dozens of other leading laboratory mouse experts around the world (known collectively as the Complex Traits Consortium), devised the Collaborative Cross: a mouse population established with eight different founder strains, including standard inbred strains but also some wild-type mice. Crossing these animals shuffles the genetic deck to yield populations of mice with greater genetic diversity than is present in the entire human race. And that variety is visible to the naked eye. “Some are as big as capybaras,” Churchill jokes. “Some are small, some are yellow, some are fat, and some live a very long time.” Sequencing the DNA of each animal allows the researchers to peg physiological and behavioral characteristics (phenotypes, in the vernacular) to specific genetic variants. Today the Collaborative Cross concept (as well as a further refinement, Diversity Outbred mouse populations) is a big idea in the research community, with more than 1,400 citations in the scientific literature.  Rethinking the mouse model in drug developmentAustralian researcher Sarah Stephenson wanted to fast-track her research of Parkinson’s disease, so she shuffled the genetic deck using a new experimental platform at The Jackson Laboratory. JAX is now applying the powerful idea of modeling genetic diversity (GeDi for short, and yes, it’s pronounced “Jedi”) to tackle the biggest challenge of medical research: prediction based on digital genomic data.

Share

Research newsletters

Learn about the latest research breakthroughs in the fight against Alzheimer’s, cancer and other devastating diseases.

Celebrating 90 years at The Jackson Laboratory

Leading the search fortomorrow’s cures

©2019 The Jackson Laboratory

Jackson Laboratory

Open Access MiniCourses

CRISPR, Diversity Outbred Mice and more!Enroll today About Us The Jackson Laboratory is an independent, nonprofit biomedical research institution dedicated to the discovery of precise genomic solutions for human disease. Research Highlight Revealing cellular traits, one cell at a time Research Highlight Exercise staves off diet-related brain damage in mice Celebrating 90 years It’s our 90th birthday! Here are some moments in time that best represent who and what JAX is.

Investigating the details of type 2 diabetes onset

A new study published in Nature sets a new precedent for understanding the development of type 2 diabetes, and it provides a trove of data for ongoing research. Learn More

Perspectives on ME/CFS

Chronic fatigue syndrome is frustrating on all fronts. It’s difficult to diagnose, difficult to treat and a pain to live with. Learn More

Making a difference for rural cancer patients

Dr. Jens Rueter and the Maine Cancer Genomics Initiative are providing advanced genomic tools to oncology practices throughout Maine. Learn More

JAX® MICE & SERVICES

Breeding and Rederivation Services

Learn More

In Vivo Pharmacology

Learn More

Mouse Cryopreservation, Recovery and Strain Submission

Learn More

Surgical and Preconditioning Services

Learn More

JAX mice phone number is 1-800-422-6423
JAX mice phone number is 1-800-422-6423

Find or Order Jax Mice

Advanced Mice Search

Search for Mice

Leading the search fortomorrow’s cures

©2019 The Jackson Laboratory

Jackson Laboratory

JAX® Mice & Services

jmcrs landing page header

JAX® Mice are the highest quality and most-published mouse models in the world. Take advantage of our large inventories of common inbred strains and the convenience of having your breeding and drug efficacy needs met by the leading experts in mouse modeling.Advanced Mice Search

Search for Mice

  • Technical Support Our technical information scientists are standing by to answer in-depth mouse-related questions, field comments, suggestions, and technical problems.
  • Guide: Generating Mouse Models with CRISPR/Cas9 Genome editing with CRISPR/Cas9 enables the generation of new mouse models with unprecedented speed and simplicity. The Jackson Laboratory was an early adopter of CRISPR/Cas9 technology for mouse model development, and in this brief guide we describe the technology and lessons learned to generate knockouts and knockins in more than a dozen different genetic backgrounds.
  • Customer Service Our customer service representatives are here to help you find and order the best mice and services for your research.
  • Guide: Humanized Mice for Immuno-Oncology NSG™ mice are a proven host for engraftment of human tumors or establishment of human immunity following hematopoietic stem cell transplantation. This guide explains why the interactions between human immune cells and tumors are paramount when devising treatment strategies that prevent tumor evasion of immune cells and improve cytotoxic responses.

Now Available Worldwide Your research shouldn’t wait, 
JAX is here when you need us
Learn More Humanized Mice NSG™ and NSG™-SGM3 Mice engrafted with human hematopoetic stem cells represent powerful tools for studying oncology, infectious disease, and hematopoiesis and are helping accelerate the development of novel therapies. learn more

Upcoming Education

Aug 15 – 24 Short Course

28th Annual Short Course on Experimental Models of Human Cancer

Oct 23 – 24 Programs

JAX Healthcare Forum

Online Courses and On-Demand Webinars

Webinar: Using Cre-lox Technology to Model Cancer, Neurodegenerative Diseases and More

Cre-lox system,Cancer/Tumors,Amyotrophic Lateral Sclerosis ALS,Neurodegenerative Disease,Resource Development and Dissemination Video

Webinar: Tips and Tricks for Care of NSG™ Mice

Immunodeficiency,Cancer/Tumors,Infectious Disease Video

PDX for Cancer Therapeutics Development and Predictive Modeling

Cancer/Tumors,Model Development,Computational Biology

Webinar: Innovative Preclinical Research Using Humanized NSG™ Mice

Immunodeficiency,Immunology,Infectious Disease,Cancer/Tumors,Graft vs Host Disease,Infectious Disease Research,Cancer

Genetic Testing Technology

Cancer/Tumors,Cancer,Genetics and Genomics

Webinar: Cell Press Nucleus: Humanized Mouse Models in Disease

Model Development,Cancer/Tumors,Infectious Disease,Infectious Disease Research,Cancer

Related

Immuno-oncology

Humanized NSG™ (hu-NSG™) mice represent an innovative and cost-effective immuno-oncology platform to simulate trials, evaluate multiple…

Cancer Cell Line Efficacy Studies

JAX In Vivo Pharmacology Services has experience with a range of common tumor cell lines and the capability to use customer provided cancer…

Humanized Mice

Humanized NSG™ and NSG™-SGM3 mouse models are powerful tools for studying cancer, inflammatory and infectious disease, and hematopoiesis….

PDX Efficacy Services

Simplify compound efficacy studies by partnering with our experienced study directors. Our preclinical testing facility uses the…

Sponsored Strain Distribution

Our experts in animal husbandry and reproductive sciences can maintain your valuable research strains and provide them to…

Popular Strains

Over 30,000 peer-reviewed publications cite use of JAX® Mice strains. Hundreds of new papers referencing JAX® Mice strains are published…

Breeding Services

Our Breeding Services makes managing your mouse colonies easy and affordable. We’ll make sure you get the mice you need when…

Biospecimens

The Jackson Laboratory can save you time spent processing, money spent on reagents, and space used for housing mice by providing you with…

JAX Healthcare Forum

28th Annual Short Course on Experimental Models of Human Cancer

The Cancer Short Course provides a broad survey of the cancer research and experimental modeling from systems and computational genetics,…

Leading the search fortomorrow’s cures

©2019 The Jackson Laboratory

Jackson Laboratory

Humanized Mice Services

Humanized NSG™ represents an innovative and cost-effective platform to simulate trials, evaluate multiple drugs alone or in combination, and produce predictive data.

REQUEST A QUOTE

micetech@jax.org | 1.800.422.6423 (US) | 1.207.288.5845 (International)

Contact Technical Support

Our collection of humanized mice support the development of multiple cellular components of the human immune system, many of which are functional and used in modeling key portions of human immunity. Mouse models with human immune cell engraftment represent ground-breaking platforms to evaluate compounds to treat a variety of human diseases, from cancer and infectious diseases to allergies, inflammation, and Graft versus Host Disease (GvHD).

JAX humanized mice include several host strains, each designed to improve specific aspects of human immune function. All are based on the NOD scid gamma (NSG™) mouse, developed by JAX Professor Lenny Shultz, a strain shown to support highly efficient engraftment of human hematopoietic stem cells (hu-CD34+) and human peripheral blood mononuclear cells (hu-PBMC). The NSG™-SGM3 strain supports improved myeloid and regulatory T cell development and the newly available NSG™-IL15 strain develops mature human natural killer (NK) cells at human physiological levels.

An additional model, the NSG™-A2, is currently undergoing characterization studies and is available on a limited basis. Please inquire for more information.

CD34+ humanized mice

Humanized CD34+ mice (hu-CD34) are a robust in vivo platform for analyzing the safety and effectiveness of potential new drugs to modulate the immune system. Hu-CD34+ mice are advantageous in vivo models for long-term studies in the fields of human immune cell biology, immuno-oncology, and infectious disease.

Models engrafted with cord blood-derived hematopoietic stem cells (HSC) develop multi-lineage engraftment and display robust T-cell maturation and T-cell dependent inflammatory responses. Large cohorts of humanized CD34+ NSG™ and NSG™-SGM3 mice are available for immediate delivery or to enroll in JAX drug efficacy testing services.

The latest model, the humanized NSG™-IL15 is now also available in limited quantities.

PBMC humanized mice

Humanized PBMC (hu-PBMC) mice feature quick engraftment of adult peripheral blood mononuclear cells and enable short-term studies requiring mature human T cells. Hu-PBMC mice are used as in vivo models to study and evaluate compounds for T cell immune modulation, infectious diseases and graft rejection research. Onco-Hu® Models Onco-Hu® Models are a robust immuno-oncology platform for efficacy testing of novel immunotherapies targeting T cells and myeloid cells to help destroy cancers in vivo.   learn more PDX Live™ Tumor Models Get experimental data up to 80% faster with PDX Live™ tumors. This valuable off-the-shelf resource can save your project more than 6-12 weeks time. LEARN MORE NSG™ Variants Portfolio
Our study-ready NSG™ and NSG™-SGM3 mice are the most versatile immunodeficient strains. Start your research today with our readily-available models.
LEARN MORE

Leading the search fortomorrow’s cures

©2019 The Jackson Laboratory

Jackson Laboratory

The JAX Blog

Learn about new technologies and discoveries focused on precise and personalized treatments for patients.

Considerations For The Development Of A Liquid Biopsy Assay For Cancer

Blog Post: Honey Reddi, Ph.D., FACMG

Considerations for the development of a liquid biopsy assay for cancer

Non-invasive evaluation of molecular markers has shifted from the realm of prenatal diagnosis to tracking the effect of cancer treatment and management.

Read the Article Get science in your inbox Sign up to receive updates from JAX and gain insights into bioscience, technology, and the quest to improve human health. Subscribe

Filter By

Blog

  • Linda Steinmark, MS, LCGC – Clinical Education at JAXJune 05, 2019Multigene panels for hereditary breast cancer riskGenetic testing is becoming increasingly accessible for patients as the list of clinical indications and number of genes are growing, and the cost of testing is decreasing.
  • Maya Dubey, Ph.D.May 06, 2019CKB, powered by JAX, oncology spotlight: Revealing complex clinical genomic associationsHarnessing the complex and continued accumulation of data associated with tumors has been traditionally difficult. The majority of cancer efficacy data has been represented as one drug associated with a single alteration. The Clinical Knowledgebase (CKB), powered by JAX, is designed to capture previously reported efficacy data, as well as new data, as it relates to mutations arising from therapeutic resistance or multiple alterations responding to a cocktail of therapies. This tool can aid in the interpretation of complex scenarios and facilitate accurate drug treatment decisions.
  • Adriano Flora, Ph.D.March 27, 2019Revealing antibody half-life and stability using FcRn mouse models from JAXPicture this: You’ve been developing a therapeutic antibody for a while, and you have identified a handful of promising variants. What’s the next step? How do you go about conducting antibody optimization studies? The collection of humanized FcRn mouse models exclusively from The Jackson Laboratory is designed for therapeutic antibody and variant stability assessment.
  • Maya Dubey, Ph.D.March 13, 2019Welcome MSNASH/PcoJ: the latest mouse model from JAXUtilizing the most translationally-relevant in vivo model is crucial to generating meaningful data and getting a potential therapeutic closer to Investigational New Drug Application (IND) filing. With the availability of the MSNASH/PcoJ mouse from JAX, which can be used to study obesity, diabetes, and metabolic syndrome—including NASH, researchers worldwide can access and include this in vivo model that offers several benefits over the previously published models.

Load More

Leading the search fortomorrow’s cures

©2019 The Jackson Laboratory

Jackson Laboratory

About The Jackson Laboratory

Imagine a world free of devastating disease.  A world where cancer, diabetes, Alzheimer’s – many of the conditions that undermine human health – are understood and can be stopped.

Imagine a world free from devastating disease

Jackson Laboratory Overview Brochure

A world where where cancer, diabetes, Alzheimer’s — many of the conditions that undermine human health — are understood and can be stopped.

At The Jackson Laboratory (JAX), we apply passion, innovation and ever-increasing precision to make this vision a reality. We are accelerating disruptive scientific breakthroughs tailored to the needs of individual patients and closing in on the genetic and molecular courses of disease. We also educate current and future scientists and empower the global biomedical community by providing critical resources, data, tools and services. 

JAX has its mammalian genetics headquarters in Bar Harbor, Maine; a Genomic Medicine institute in Farmington, Conn.; and facilities in Sacramento, Calif. and Ellsworth, Maine.

Learn how the use of mice in biomedical research has contributed dramatically to medical progress.

Research Partnerships

For inquiries about collaborating with JAX research, please contact BJ Bormann, Vice President for Translational Science and Network Alliances Learn Facts and Financials Connect Social Media Directory Visit Tour Schedule

  • Our Mission To discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.
  • Leadership Our leadership team drives the strategic direction of the organization. As a nonprofit organization, The Jackson Laboratory is governed by its Board of Trustees.
  • Careers Join The Jackson Laboratory and help lead the search for cures through genetics, genomics and precision medicine.  We invite all interested scientists to submit applications for faculty positions.
  • Accelerating Discovery The Jackson Laboratory is leading the search for cures through the science of genetics, genomics and precision medicine. Learn more about how the Laboratory’s scientists are accelerating discovery.
  • Our mice, our hope For more than a century, scientists have used the mouse as a genetic model of the human being to understand our fundamental biology and to identify and test better treatments and cures for the most devastating diseases.
  • Contractor Information Contractor and bid information for all campuses of The Jackson Laboratory

By The Numbers

90

Years

2,200+

Employees

75+

Principal Investigators

1

Mission

Give to JAX

Research and Faculty

Support the education of tomorrow’s scientists

Support cutting-edge technology and resources

Your gift to The Jackson Laboratory supports our mission to discover precise genomic solutions for disease and empower the global biomedical community in our shared quest to improve human health.

Make a Gift

Related

Systems Genetics of Metabolic Disease: A Team Science Approach

This course prepares participants for team science aimed specifically toward interrogation of the systems genetics of…

Bar Harbor, Maine

Our 43-acre Bar Harbor campus is nestled between the Gulf of Maine and the mountains of Acadia National Park. Scientists here research the…

Farmington, Connecticut

JAX Genomic Medicine sits on a 17-acre site on the campus of the University of Connecticut Health Center. Scientists here investigate how…

Our Research

Research overview of The Jackson Laboratory

The Whole Scientist – Bigelow Laboratory

Join us to expand your professional skills as you embark on a fulfilling science career.

The Whole Scientist

Join us to expand your professional skills as you embark on a fulfilling science career.

Career Fair October 2019

Principles and Techniques in Mouse Behavioral Phenotyping and Pharmacology

This new intensive hands-on JAX course will provide scientists with the skills and knowledge required for rigorous design, execution,…

The Whole Scientist

Join us to expand your professional skills as you embark on a fulfilling science career.

The Whole Scientist

PAST EVENT: Join us to expand your professional skills as you embark on a fulfilling science career.

JAX Postdoctoral Scholars

The JAX Scholar award offers exceptional early-career scientists the opportunity to develop their independent research program at The…

PostBacc at JAX

A one- to two-year research and education program for students intending on pursuing an advanced degree in science or…

PostBacc at JAX

A one- to two-year research and education program for students intending on pursuing an advanced degree in science or…

Mouse Genome Informatics

International database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data.

Susan Sheehan

Researches the genetics that effect declining kidney function with age with a focus on quantifying histological changes with…

The Palucka Lab

Studying the mechanisms of human immunity and developing cancer immunotherapies.

Leading the search fortomorrow’s cures

©2019 The Jackson Laboratory

Jackson Laboratory

News and Insights

Gain insights into bioscience, technology and the quest to improve human health.

Get science in your inbox.

Sign up for weekly JAX updates.

Kaczorowski Neuron paper 2018 cover art

Press Release

New Alzheimer’s mouse models show how human diversity affects disease onset

A new genetically diverse mouse population is opening possibilities for translational research into Alzheimer’s disease that accurately recreates human disease symptoms and progression.

Learn More

Filter By

Topic JAX Research Area Content Type

  • Maggie MooreJune 19, 2019The Microbiome RevolutionMiguel Ilzarbe, Director of Operations and Administration, and Professor George Weinstock, Ph.D., discuss how to harness the health benefits of the microbiome. Photo by Charles Camarda.
  • Maggie MooreJune 18, 2019Connected through ScienceWhen Isabelle Chen, a senior at The Ethel Walker School in Simsbury, Conn., met Ann Bresnahan ‘69 during a science alumnae panel discussion at Bresnahan’s 50-year high school reunion, the two knew that they shared a passion for science.
  • Joyce Dall’Acqua PetersonJune 17, 2019The McKusick Short Course at 60: Bringing genetics to medicineGenetics is changing medicine from a “one size fits all” approach to treatments and preventive measures targeted at each individual’s unique genetic makeup. Today genetics makes up an increasing part of a medical student’s curriculum, and an annual course in coastal Maine has had an outsized role in that evolution.
  • Mark WannerJune 04, 2019The advantages of diversity mouse strains and populationsInbred mice are somewhat like identical twins, except that instead of just two, there can be many, many of them. Outbred mice are somewhat like the human population, with profound genetic differences between individuals. Knowing the differences between them, and how scientists are using them, is important as biomedical research enters a new era of incorporating genetic diversity.

Load More Revolutionize Medicine Together, we can use the power of genomics to fundamentally change human health. Learn how jax blog Learn about new technologies and therapies from people on the front lines of discovery. Learn More explore by topic Navigate through an A-to-Z listing of the latest topical content in your area of interest. Learn more

JAX in the News

Leading the search fortomorrow’s cures

©2019 The Jackson Laboratory

Jackson Laboratory

Clinical Genomics

JAX Clinical Genomics integrates the latest sequencing technologies with the insights of an experienced multidisciplinary team of scientists to help clinicians and translational researchers select the best options for personalized care.

At JAX Genomic Medicine we are delivering precise genomic solutions to disease. As part of the Clinical Genomics lab’s contribution to this commitment, our scientists and staff provide tools, curate critical data, and deliver diagnostic services that help the achievement of goals held by research and clinical communities around the world.

Bringing the power of genomics to treatment decisions

Sequencing data, combined with skilled bioanalytical approaches and an expert team of gene curators, enables clinicians to access the benefits of the latest genomic advances without having to become technology experts themselves.

The Jackson Laboratory: a significant force in genetic discovery for over 80 years

At JAX, our specialty is putting genetics and genomics in context, enabling researchers and physicians to put these insights to work. From our earliest research that established cancer as a genetic disease to today’s work in precision medicine, our unswerving focus on genetics and genomics continues to generate advances that improve human health. ActionSeq™ ActionSeq™ is a targeted panel of 212 cancer related genes analyzed using next-generation sequencing. The panel assesses all identified functional variants for clinical relevance, based on associations in the biomedical literature with response or resistance to FDA-approved targeted therapies.  Learn More FusionSeq™ The FusionSeq™ assay is designed to detect fusions involving one or more of 53 genes known to be associated with various carcinomas, sarcomas and hematologic malignancies.   LEARN MORE Cancer Treatment Profile™ This test provides analysis of 358 cancer-associated genes through next-generation sequencing. The panel assesses all identified functional variants for clinical relevance, based on associations in the biomedical literature with response or resistance to FDA-approved targeted therapies or new drugs in development. Learn More Clinical Knowledgebase JAX-Clinical Knowledgebase (CKB) is a powerful tool for interpreting complex genomic profiles, and represents a valuable resource for clinicians and translational and clinical researchers around the world. learn more Clinical Team Browse profiles of our Clinical Genomics leadership team.   Learn More Order now Download requisition forms to get your tests started today.  Learn More

Related

Making a difference for rural cancer patients

Dr. Jens Rueter and the Maine Cancer Genomics Initiative are providing advanced genomic tools to oncology practices…

Career Fair October 2019

From tragedy, hope and closure

Doctors who treat rare pediatric cancers face an awful truth: many of their patients will die far too young.

Booklet: Oncology

This booklet explains how JAX® Mice, Clinical and Research Services for oncology are essential tools for the <em>in vivo</em> study of…

Booklet: Oncology

This booklet explains how JAX® Mice, Clinical and Research Services for oncology are essential tools for the in vivo study of hematological…

Accelerating Discovery

The Jackson Laboratory is leading the search for cures through the science of genetics, genomics and precision medicine. Learn more about…

Al’s story: Turning science into cures

Al Raymond beat cancer, but at a cost: the treatments he received for chronic lymphocytic leukemia (CLL) damaged his immune…

Can polyps detected by early screening help to identify individuals at risk of hereditary colorectal cancer syndromes?

Because March is Colorectal Cancer Awareness Month, we wanted to circle back around to the screening guideline released by…

Communicating with patients about somatic tumor testing

Communicating about the goals of genomic tumor testing and the associated benefits and limitations with patients like Carole will guide…

Multigene panels for hereditary breast cancer risk

Genetic testing is becoming increasingly accessible for patients as the list of clinical indications and number of genes are growing, and…

Systems Genetics of Metabolic Disease: A Team Science Approach

This course prepares participants for team science aimed specifically toward interrogation of the systems genetics of…

Portfolio: PDX Models and Services

This portfolio discusses why PDX models provide a relevant and translatable animal model to study human cancer biology compared to…

Portfolio: PDX Models and Services

This portfolio discusses why PDX models provide a relevant and translatable animal model to study human cancer biology compared to…

Precision Medicine- Personalized Treatments for Cancer

The role of Patient-Derived Xenografts models in predicting patient response fits well into the Precision Medicine Initiative, focused on …

Jennifer Trowbridge, Ph.D.

Researches regulation of stem cells in the blood in normal development, aging and leukemia transformation.

Exploring the higher risk of heart failure in aging

A recent paper from a team including JAX Professor Se-Jin Lee shows that a signaling pathway once thought to protect heart…

Leading the search fortomorrow’s cures

Jackson Laboratory

From Wikipedia, the free encyclopedia Jump to navigationJump to search

This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed.
Find sources: “Jackson Laboratory” – news · newspapers · books · scholar · JSTOR (March 2014) (Learn how and when to remove this template message)
Established1929
TypeNonprofit Organization Research Institute
HeadquartersBar Harbor, Maine, US
LeaderEdison Liu
Staff 2100
Websitejax.org

Located near scenic Frenchman Bay on Mount Desert Island, Maine, The Jackson Laboratory is a nonprofit biomedical research institution.

The Jackson Laboratory (often abbreviated as JAX) is an independent, nonprofit biomedical research institution dedicated to contributing to a future of better health care based on the unique genetic makeup of each individual. With more than 2,100 employees in Bar Harbor, Maine; Sacramento, California; and at a new genomic medicine institute in Farmington, Connecticut; the Laboratory’s mission is to discover precise genomic solutions for disease and empower the global biomedical community in the shared quest to improve human health.[1] The institution is a National Cancer Institute-designated Cancer Center and has NIH centers of excellence in aging and systems genetics.

The laboratory is also the world’s source for more than 8,000 strains of genetically defined mice, is home of the Mouse Genome Informatics database and is an international hub for scientific courses, conferences, training and education.[2]

Contents

Major research areas

Jackson Laboratory research, represented by the activities of more than 60 laboratories, performs research in six areas:

  • Cancer: The Jackson Laboratory Cancer Center (JAXCC) has a National Cancer Institute designated Cancer Center. Cancer areas of focus include: brain, leukemia, lung, lymphoma, prostate, breast; cancer initiation and progression; cancer prevention and therapies
  • Development/Reproductive Biology: birth defects, Down syndrome, osteoporosis, fertility
  • Immunology: HIV-AIDS, anemia, autoimmunity, cancer immunology, immune system disorders, lupus, tissue transplant rejection, vaccines
  • Metabolic diseases: atherosclerosis, cardiovascular disease, diabetes, high blood pressure, obesity
  • Neurobiology: blindness, Alzheimer’s, deafness, epilepsy, glaucoma, macular degeneration, neurodegenerative diseases
  • Neurobehavioral disorders: autism, addiction, depression

History

Contemporary research highlights

  • A grant from the National Institute of General Medical Sciences funds the development of new computational tools to understand how multiple genes interact in complex diseases.
  • The National Institute on Aging provides $25 million to develop new treatments, future therapies based on precision modeling.
  • The National Institutes of Health (NIH) funds phase 2 of the Knockout Mouse Production and Phenotyping Project (KOMP2).[3]
  • A charitable contribution of $8,410,000 from the Harold Alfond Foundation will support The Jackson Laboratory’s efforts to enhance cancer diagnostics and treatment in Maine.
  • Researchers link mutations to butterfly-shaped pigment dystrophy, an inherited macular disease [4]
  • Jackson Laboratory researchers discover mutation involved in neurodegeneration
  • The Jackson Laboratory for Genomic Medicine opens in Farmington, CT.[5]

Historic research highlights

The Jackson Laboratory was founded in 1929 in Bar Harbor, Maine, by former University of Maine and University of Michigan president C. C. Little under the name Roscoe B. Jackson Memorial Laboratory.[6] (Roscoe B. Jackson was a one-time head of the Hudson Motor Company who helped provide the funds for the first laboratory building at the property and the first five years of operation.)[7]

  • Established that cancer is a genetic disorder, a novel concept before the Laboratory’s founding in 1929.
  • Dr. Leroy Stevens first described cells that can develop into different tissues – today known as stem cells.
  • Dr. Elizabeth Russell performed the first bone marrow transplants in a mammal, leading to new treatments for blood and immunological diseases.
  • Dr. George Snell won the Nobel Prize in 1980 for providing an in-depth understanding of the immune system’s major histocompatibility complex, making organ transplants possible.
  • Dr. Douglas L. Coleman discovered the hormone leptin, central to obesity and diabetes research, earning him the Shaw Prize, the Albert Lasker Award, the Gairdner International Award, Frontiers of Knowledge Award in Biomedicine, and the King Faisal International Prize in Medicine.
  • Is pioneering the use of cancer avatars – mice with implanted human tumors – to test targeted therapies for cancer patients.

Recent research has provided insight into cancer stem cells and treatments for leukemia; progress with type 1 diabetes and lupus; and a breakthrough in extending mammalian life span.

The Jackson Laboratory Cancer Center

The Jackson Laboratory Cancer Center (JAXCC) first received its National Cancer Institute designation in 1983 in recognition of the foundational cancer research conducted there. The JAXCC is one of seven NCI-designated Cancer Centers with a focus on basic research.

The Jackson Laboratory Cancer Center has a single program, “Genetic Models for Precision Cancer Medicine,” composed of three biological themes: cancer cell robustness, genomic and genetic complexity, and progenitor cell biology. The themes emphasize the systems genetics of cancer and translational cancer genomics, and all are supported by the JAX Cancer Center’s technological initiatives in mouse modeling, genome analytics and quantitative cell biology.

The Morrell Park fire

On May 10, 1989, a flash fire destroyed the Morrell Park mouse production facility.[8] The fire raged for five hours, requiring over 100 firefighters from 15 companies and a total of 16 trucks for the fire to be contained. Four workers of the Colwell Construction Company who were installing fiberglass wallboard in the room where the fire broke out were injured, one with burns over 15 percent of his body. While none of the foundation strains were lost, 300,000 production mice (about 50% of their stock) died, resulting in a national shortage of laboratory mice and the layoff of 60 employees.[9]

This was the second fire to severely affect the laboratory; the 1947 fire that burned most of the island destroyed most of the laboratory, and its mice. Worldwide donations of funds and mice allowed the lab to resume operations in 1948.[10]

Research resources

  • Hosts the Mouse Genome Informatics database, by far the world’s most significant source for information on mouse genetics and biology.
  • Distributes more than 3 million JAX® mice annually to more than 20,000 investigators in at least 50 countries for research and drug discovery.
  • Offers more than 11,000 genetically defined strains of JAX® mice to the international research community.
  • Provides animal husbandry, reproductive science and in vivo drug efficacy services in a wide range of therapeutic areas for biomedical researchers.
  • Conducts over 100 educational seminars and webinars yearly to educate and enable external biomedical researchers.

Educational programs

  • Summer Student Program has brought thousands of talented high school and college students to campus over 89 years for mentoring, including three who later won Nobel Prizes: David Baltimore, Howard Temin and Jack Szostak.
  • Nearly 700 students, researchers and physicians attend Laboratory courses, conferences and workshops annually.
  • Participates in three collaborative degree programs: the Tufts University Ph.D. program in Genetics, the Ph.D. program in Biomedical Sciences of the University of Maine, and the Master’s of Science in Teaching program of the University of Maine.
  • Offers predoctoral and postdoctoral training programs and a visiting scientists program.
  • Coordinates and hosts the Maine State Science Fair for high school students.

Business model

The Jackson Laboratory is recognized by the IRS as a public charity.[11] According to organization literature, revenue comes primarily from the sale of materials and services (~70%) and from government support (~25%).[12] Less than 5% of 2012 revenue came from charitable donations.[12]

Notable researchers

Controversy

In 2013, a jury in Maine found that Jackson Laboratory did not violate that state’s whistleblower protection law when they fired an employee who claimed to have been terminated after reporting her concerns about the treatment of animals to the National Institutes of Health Office for Laboratory Animal Welfare. The worker accused the laboratory of “allowing mice to suffer and then die in their cages instead of euthanizing them” and of cutting off the toes of mice to identify them. Jackson laboratory denied the allegations and said the worker was fired for her confrontational demeanor.[13]

In 2009, Jackson Laboratory was fined $161,680 by the EPA for improperly handling and storing hazardous materials.[14]

See also

References

“About The Jackson Laboratory”. Jackson Laboratory. Retrieved 2 April 2013. “JAX Mice and Research Services Provided Through Charles River”. Retrieved 2016-01-10. “Knockout Mouse Project (KOMP)”. The Jackson Laboratory. Retrieved 2017-07-16. http://www.nature.com/ng/journal/v48/n2/full/ng.3474.htmlhttp://www.courant.com/health/hc-jackson-laboratory-20141002-story.html“The Jackson Laboratory Milestones: 1900 – 1929”. The Jackson Laboratory Timeline. Jackson Laboratory. Archived from the original on 2006-09-25. Retrieved 2006-12-13. “85 Years of Discovery”. Jackson Laboratory. Retrieved 2019-03-24. Harbour, Kathy (August 21, 1989). “Probable causes given for Jackson Lab fire”. Bangor Daily News (Hancock County ed.). p. 8. Retrieved 2013-02-28. Mathewson, Judy (June 26, 1989). “Debris Cleared, Jackson Begins Recovery From Fire”. The Scientist. Retrieved 2013-02-28. “The Jackson Laboratory Milestones: 1940 – 1949”. The Jackson Laboratory Timeline. Jackson Laboratory. Archived from the original on 2006-09-25. Retrieved 2006-12-13. “Exempt Organizations Select Check” (search results). IRS. EIN 01-0211513. Retrieved December 14, 2014. “2012 Annual Report” (PDF). Retrieved December 14, 2014. Trotter, Bill (3 June 2013). “Former worker who accused Jackson Lab of mistreating mice loses whistleblower lawsuit”. BDN Maine. Retrieved 6 August 2015.

  1. Trotter, Bill (2 April 2009). “Jackson Laboratory to pay $161,680 EPA fine”. Bangor Daily News. Retrieved 6 August 2015.
vteUniversity of Maine
UMaine Notable people Orono Collins Center for the Arts Fay Hyland Botanical Plantation Fogler Library Hudson Museum Maynard F. Jordan Observatory Page Farm & Home Museum Museum of Art University of Maine system
Media The Maine Campus Ubris WMEB-FM The Maine Stein Song
Sports Maine Black Bears Black Bear Sports Network Baseball Football Men’s basketball Women’s basketball Men’s ice hockey Women’s ice hockey Alfond Arena Alfond Stadium Mahaney Diamond Memorial Gymnasium
Organizations and Greek Francis Crowe Society The Senior Skull Honor Society Phi Eta Kappa
Affiliates Jackson Laboratory Maine Public Broadcasting Network

Coordinates: 44.3655°N 68.1965°W Categories:

Navigation menu

Search

Interaction

Tools

Print/export

Languages

Edit links

19 Comments

  1. I like the valuable information you provide in your
    articles. I will bookmark your weblog and check again here regularly.
    I’m quite sure I will learn a lot of new stuff right here!
    Best of luck for the next!

    Like

  2. An outstanding share! I have just forwarded this onto a coworker who had been conducting a little research on this. And he actually ordered me dinner because I stumbled upon it for him… lol. So let me reword this…. Thanks for the meal!! But yeah, thanks for spending time to discuss this matter here on your web page.

    Like

  3. I was very happy to discover this website. I wanted to thank you for ones time due to this wonderful read!! I definitely really liked every part of it and I have you book marked to check out new stuff in your web site.

    Like

  4. Woah! I’m really enjoying the template/theme of this site. It’s simple, yet effective. A lot of times it’s hard to get that “perfect balance” between superb usability and visual appearance. I must say that you’ve done a fantastic job with this. In addition, the blog loads very quick for me on Opera. Excellent Blog!

    Like

  5. Sweet blog! I found it while surfing around on Yahoo News. Do you have any tips on how to get listed in Yahoo News? I’ve been trying for a while but I never seem to get there! Appreciate it

    Like

  6. Excellent blog you have here but I was wanting to know if you knew of any discussion boards that cover the same topics talked about in this article? I’d really like to be a part of community where I can get opinions from other knowledgeable people that share the same interest. If you have any suggestions, please let me know. Thanks!

    Like

  7. I’m truly enjoying the design and layout of your site. It’s a very easy on the eyes which makes it much more pleasant for me to come here and visit more often. Did you hire out a developer to create your theme? Exceptional work!

    Like

  8. Thank you for sharing superb informations. Your web-site is so cool. I’m impressed by the details that you’ve on this blog. It reveals how nicely you understand this subject. Bookmarked this website page, will come back for more articles. You, my friend, ROCK! I found simply the information I already searched all over the place and just couldn’t come across. What an ideal site.

    Like

  9. Discount Levaquin Express Delivery Medication Amex [url=https://cheapcialisir.com/]brand name cialis online[/url] Propecia Generico Finasteride 1mg Cialis Dutasteride Avolve Bangor

    Like

  10. buy cialis where [url=https://bbuycialisss.com/]Buy Cialis[/url] Find isotretinoin online discount with overnight delivery cheap Buy Cialis Can I Drink Alcohol With Zithromax

    Like

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s