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The influence of physical activity in the progression of experimental lung cancer in mice
- PMID: 22683274
- DOI: 10.1016/j.prp.2012.04.006
GRUPO_AF1 – GROUP AFA1 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO AFAN 1 – GROUP AFAN1 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO_AF2 – GROUP AFA2 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO AFAN 2 – GROUP AFAN 2 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
Slides – mestrado – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
DMBA CARCINOGEN IN EXPERIMENTAL MODELS
Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.
Copyright © 2012 Elsevier GmbH. All rights reserved.
Thank you for being my Twitter Follower! I´m graduated in Biomedicine at Federal University of Triangulo Mineiro (Uberaba – 2003-2007), I have a Master´s degree in lung cancer research in mice at Faculty of Medicine of Sao Jose do Rio Preto (2008-2012). Nowadays I work as inspector of students since 2012 in Sao Jose do Rio Preto. Maybe I can do a doctorate to work as professor and researcher abroad or in Brazil. I hope in some way with my blog http://www.science1984.wordpress.com to help significantly in the socio-economic and technical-scientific development of the countries. The human quality of life needs to improve to people live longer. My blog goal is help any one in anyway who visited it. The blog content is very good with high quality. There are many important, interesting and updated informations. I elaborated it in 2018. There are 58 followers of my blog, 175 likes, 6 thousand 300 comments approved and 695 posts made by me. The blog is very well informative. Many people of different countries have visited it. – > Videos: Acknowledgment for the recognition of the researches (dissertation and monograph) I participated at Medical School of Sao Jose do Rio Preto and Federal University of the Triangulo Mineiro – Uberaba – Brazil. I was invited directly by Internet to participate in 61 very important science events worldwide in 27 cities of different countries in a little time(Madrid, Suzhou, Stanbul, Miami, Singapore, Kuala Lumpur, Abu Dhabi, San Diego, Bangkok, Dublin, Sao Paulo, Dubai, Boston, Berlin, Stockholm, Prague, Valencia, Osaka, Amsterdam, Helsinki, Paris, Tokyo, Vienna, Rome, Zurich, London and Frankfurt) because I participated of very innovative researches in Brazil. Informations about it are in my blog: http://www.science1984.wordpress.com – > Video 1: https://www.youtube.com/watch?v=eGbu5GKzjMk … … – > Video 2: https://www.youtube.com/watch?v=dB5zxg8bjoY … … -> Video 3 – Gratitude: I was invited to participate in 55 very important science events in 25 cities of different countries in less than 1 year. https://www.youtube.com/watch?v=mWWDMV2W7QM … … – Link related with my dissertation: https://science1984.wordpress.com/2018/07/15/i-did-very-important-detailed-and-innovative-graphics-about-variations-of-all-mice-weigths-during-all-exerimental-time-my-dissertation-they-can-be-an-excelent-reference-for-future-researches-like-2/ … … – Article of my dissertation: The influence of physical activity in the progression of experimental lung cancer in mice – Pathol Res Pract. 2012 Jul 15;208(7):377-81. The research was made at Faculty of Medicine of Sao Jose do Rio Preto. – Link about my monograph: Chagas Disease research in laboratory at Federal University of Triangulo Mineiro -> Induction of benzonidazole resistance in human isolates of Trypanosoma cruzi https://science1984.wordpress.com/2018/07/15/my-monography-chagas-disease-research-in-laboratory-2/ … … It´s fundamental inform you the researches I participated. They can be a very good references for future researches. The world needs more efficient researches with high quality and precision. There are many laboratories that used mice to study pathologies and received very important financial investments. Many people won very important prizes because used mice in their researches. Sharing interesting and important informations is a very important act because it helps in the diffusion of the same in the world. Facebook Page about my Blog: https://www.facebook.com/scientificblog/ YouTube Channel: https://www.youtube.com/channel/UC9gsWVbGYWO04iYO2TMrP8Q … … Curriculum Lattes: http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4240145A2 … … LinkedIn Profile: https://www.linkedin.com/in/rodrigo-nunes-cal-81433b168/ … … E-mails Acoounts: email@example.com firstname.lastname@example.org email@example.com Twitter Account:
@CalZole My Instagram accounts: @calrodrigonunes @rodrigoncal84 https://www.researchgate.net/scientific-contributions/76406552_Rodrigo_Nunes_Cal?_sg=ZIpVjGGv7eVzEc9yJ9aPkTMGB6pMQsrWx29bFgaQAZqbcOeBtkDU9nJbgRH4EGlpmSGNWbF7nSuHpA … … https://www.researchgate.net/publication/225286318_The_influence_of_physical_activity_in_the_progression_of_experimental_lung_cancer_in_mice … … https://www.researchgate.net/scientific-contributions/76406552_Rodrigo_Nunes_Cal … …
youtube.com/watch?v=mWWDMV2W7QM … … Gratitude: I was invited directly to participate in 55 very important science events in 25 cities of different countries in less than 1 year because I participated of very innovative researches in Brazil. My goal was always to make a high quality blog for anyone who access it. Science events and researches are essential for world progress in all aspects. Unfortunately there are very dangerous and fatal diseases without cure or total prevention methods like vacination. The human expectancy of life needs to increase so much faster. Therefore, new scientific discoveries are very necessary for human life urgently. Visit, watch and share ! Thank you in advance.
It´s fundamental professors, students, scientists, researchers and other people worldwide know about my dissertation made at Faculty of Medicine of Sao Jose do Rio Preto because it was a very innovative and important research as well as my monograph (Chagas Disease research in laboratory at Federal University of Triangulo Mineiro -> Induction of benzonidazole resistance in human isolates of Trypanosoma cruzi). The data like graphics I made about variations of weights in all mice of different ages (Control Group -> treated with urethane and without physical activity and Study Group – Aerobic Group -> treated with urethane and subjected to aerobic swimming free exercise – Anaerobic Group –> treated with urethane and subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight) during all experimental time [My dissertation -> Lung cancer research in mice – Article: The influence of physical activity in the progression of experimental lung cancer in mice – Pathol Res Pract. 2012 Jul 15;208(7):377-81] are very important for the scientific community. These graphics I did related to my dissertation aren´t in the article nor in my dissertation as well as details about time of exercise and rest of the animals. They can be an excellent reference for many types of researches like in the field of genetic engineering! The age of the human, of the animal and the genetics influence in certain ways in the physiology and in other aspects. Very Important Observations: 1. Cancer is very related to the weight loss of the patient. 2. Age and genetics of the person are very important factors that influence cancer. ´´The mouse is the main animal model used as the basis for research on diseases that affect humans.´´ The genetics of the mouse is very similar to that of the human. Animal testing has a very high importance to world society. In my dissertation the progression of lung cancer was lower in the group of mice that practiced anaerobic physical activity. Weight lifting is an anaerobic physical activity in humans. It would be very important, innovative and interesting to do researches in mice and humans testing a substance or substances, analyzing biochemical, pathological, pharmacological and physiological factors like weights in all experimental time [Weight loss of the patient is very associated with cancer – The syndrome of anorexia-cachexia (SAC) is a frequent complication in patients with advanced malignant neoplasia], the influence of age and genetics within the group itself and in the other groups in the inhibition and progression of cancer, for example. In this context, it is essential to seek new methodologies for the treatment, prevention and early detection of cancer and other diseases, such as vaccines and other very modern and efficient technologies. More informations about it are in this link (my dissertation): https://science1984.wordpress.com/2018/07/15/i-did-very-important-detailed-and-innovative-graphics-about-variations-of-all-mice-weigths-during-all-exerimental-time-my-dissertation-they-can-be-an-excelent-reference-for-future-researches-like-2/ … … Visit and share this link! Thanks! The society needs to have more excellent ideas and scientific discoveries for human live longer faster. It is very important to consider the significance of variants like weight, age and genetics in relation to cancer. It is not easy to understand cancer in all aspects. So, more researches about it are very necessary in the world. Have a very good day! Best wishes.
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