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The influence of physical activity in the progression of experimental lung cancer in mice
- PMID: 22683274
- DOI: 10.1016/j.prp.2012.04.006
GRUPO_AF1 – GROUP AFA1 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO AFAN 1 – GROUP AFAN1 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO_AF2 – GROUP AFA2 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO AFAN 2 – GROUP AFAN 2 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
Slides – mestrado – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
DMBA CARCINOGEN IN EXPERIMENTAL MODELS
Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.
Copyright © 2012 Elsevier GmbH. All rights reserved.
‘The creation of AGI will be the most important technological development in human history,’ says OpenAI boss
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The Independent Tech
OpenAI said the investment would go towards its efforts of building artificial general intelligence (AGI) that can rival and surpass the cognitive capabilities of humans.
“The creation of AGI will be the most important technological development in human history, with the potential to shape the trajectory of humanity,” said OpenAI CEO Sam Altman.
“Our mission is to ensure that AGI technology benefits all of humanity, and we’re working with Microsoft to build the supercomputing foundation on which we’ll build AGI.”
The two firms will jointly build AI supercomputing technologies, which OpenAI plans to commercialise through Microsoft and its Azure cloud computing business.
OpenAI was founded in 2015 with the goal of developing AGI that can learn and master several disciplines, rather than the narrow abilities of most modern artificial intelligence systems.
The startup has already achieved a number of AI milestones, most notably beating the world’s best human players at the video game Dota 2, but hopes its technology can one day help address climate change and other major challenges facing the planet.
“An AGI working on a problem would be able to see connections across disciplines that no human could,” OpenAI CTO Greg Brockman wrote in a blog post announcing the investment.
“We want AGI to work with people to solve currently intractable multi-disciplinary problems, including global challenges such as climate change, affordable and high-quality healthcare, and personalised education.”
OpenAI also claims its technology will ultimately provide everyone with the economic freedom to pursue whatever they find most fulfilling, while creating “new opportunities for all our lives that are unimaginable today”.
Since co-founding OpenAI three years ago, Mr Musk has since stepped back from the AI startup but remains vocal about the risks artificial intelligence poses to humanity, claiming its development poses a greater risk than nuclear weapons.
In 2017, the SpaceX and Tesla CEO joined Microsoft researchers in signing an open letter outlining principles that will ensure the development of AI that is beneficial to humanity.
“We cannot predict what we might achieve when this intelligence is magnified by the tools AI may provide, but the eradication of disease and poverty are not unfathomable,” the letter stated.