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Pathol Res Pract. 2012 Jul 15;208(7):377-81. doi: 10.1016/j.prp.2012.04.006. Epub 2012 Jun 8.

The influence of physical activity in the progression of experimental lung cancer in mice

Renato Batista Paceli 1Rodrigo Nunes CalCarlos Henrique Ferreira dos SantosJosé Antonio CordeiroCassiano Merussi NeivaKazuo Kawano NagaminePatrícia Maluf Cury


GRUPO_AF1 – GROUP AFA1 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 1 – GROUP AFAN1 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO_AF2 – GROUP AFA2 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 2 – GROUP AFAN 2 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

Slides – mestrado – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto



Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto



Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.


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IBM’s new 53-qubit quantum computer is its biggest yet

The system will go online in October.

SEPTEMBER 18, 2019 5:00 AM PDT

IBM Q quantum computer close-up
A close-up view of the IBM Q quantum computer. The processor is in the silver-colored cylinder.Stephen Shankland/CNET

IBM’s 14th quantum computer is its most powerful so far, a model with 53 of the qubits that form the fundamental data-processing element at the heart of the system. The system, available online to quantum computing customers in October, is a big step up from the last IBM Q machine with 20 qubits and should help advance the marriage of classical computers with the crazy realm of quantum physics.

Quantum computing remains a highly experimental field, limited by the difficult physics of the ultra-small and by the need to keep the machines refrigerated to within a hair’s breadth of absolute zero to keep outside disturbances from ruining any calculations.

But if engineers and scientists can continue the progress, quantum computers could help solve computing problems that are, in practice, impossible on today’s classical computers. That includes things like simulating the complexities of real-world molecules used in medical drugs and materials science, optimizing financial investment performance, and delivering packages with a minimum of time and fuel.

Quantum computers rely on qubits to store and process data. Unlike regular computer bits, which can store either a zero or a one, qubits can store a combination of both through a concept called superposition. Another factor is entanglement, which links the states of two qubits even if they’re separated.

Watch this: Quantum computers will blow your mind 2:45

“The new quantum system is important because it offers a larger lattice and gives users the ability to run even more complex entanglement and connectivity experiments,” said Dario Gil, director of IBM Research.

IBM is competing with companies like GoogleMicrosoftHoneywellRigetti ComputingIonQIntel and NTT in the race to make useful quantum computers. Another company, D-Wave, uses a different approach called annealing that’s already got some customers, while AT&T and others are pursuing the even more distant realm of quantum networking.

If you’re used to classical computers, you’ll be familiar with powers of 2 that crop up all over the place: 1, 2, 4, 8, 16, 32, 64, 128, 256, 512, etc. So what’s up with a quantum computer with 53 qubits? It stems from the hexagonally derived lattice of qubits that’s advantageous when it comes to minimizing unwanted interactions, IBM said.

IBM is pushing a concept called quantum volume to measure quantum computer performance. It’s designed to capture more aspects of quantum computing than just qubits, which can be misleading since other factors can degrade qubit performance. IBM’s 20-qubit quantum computers, of which there are now five, have a quantum volume of 16, but IBM hasn’t yet tested the 53-qubit model.BY TABOOLASPONSORED LINKSYOU MAY ALSO LIKEUm dos melhores smartphones do mundo é vendido 10 vezes mais barato no BrasilXONE PHONE45 Amazing World MapsFAR & WIDEConheça o alarme que assusta qualquer bandido.ALARME VERISUREInside the $160 Million ‘Manor’WORK + MONEY




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