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Pathol Res Pract. 2012 Jul 15;208(7):377-81. doi: 10.1016/j.prp.2012.04.006. Epub 2012 Jun 8.

The influence of physical activity in the progression of experimental lung cancer in mice

Renato Batista Paceli 1Rodrigo Nunes CalCarlos Henrique Ferreira dos SantosJosé Antonio CordeiroCassiano Merussi NeivaKazuo Kawano NagaminePatrícia Maluf Cury


Impact_Fator-wise_Top100Science_Journals

GRUPO_AF1 – GROUP AFA1 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 1 – GROUP AFAN1 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO_AF2 – GROUP AFA2 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 2 – GROUP AFAN 2 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

Slides – mestrado – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

CARCINÓGENO DMBA EM MODELOS EXPERIMENTAIS

DMBA CARCINOGEN IN EXPERIMENTAL MODELS

Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

https://pubmed.ncbi.nlm.nih.gov/22683274/

Abstract

Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.

https://www.jax.org/education-and-learning/education-calendar/webinars/on-demand/on-demand-mouse-models-of-cardiovascular-disease

https://www.ncbi.nlm.nih.gov/pubmed/23545574

https://gcn.com/Articles/2019/08/16/facial-recognition-cities-concern.aspx

https://gcn.com/articles/2019/02/08/ibm-quantum.aspx

https://www.freethink.com/articles/lab-grown-mini-brain?fbclid=IwAR1UDwDd_ZzBQvyPMRyCN3LTOMW02zbPSsZ7kr-emLRiQm3lGHXRKcVR0_A

http://www.google.com

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WEBINAR: MOUSE MODELS OF CARDIOVASCULAR DISEASE

Cardiovascular disease is the leading cause of morbidity and mortality worldwide. Our mouse model repository maintains hundreds of mouse models to accelerate research in coronary heart disease (including,  atherosclerosis, ischemic/reperfusion injury and myocardial infarction),  hypertension, hypertrophy and heart failure, and  other heart abnormalities. Join us to learn more about:

  • Published data characterizing key mouse models of cardiovascular disease
  • Strain-specific details about disease onset, phenotypes, and severity
  • Online resources to assist with mouse model selection, including the “Cardiovascular Research Resource” and the “Mouse Phenome Database”

Meet the Presenter

Peter_Kelmenson

Peter Kelmenson

Technical Information Scientist
The Jackson Laboratory

Peter Kelmenson has worked at The Jackson Laboratory for over 16 years. He began in the Laboratory of Dr. Beverly Paigen, where he studied cardiovascular disease.  Peter’s areas of expertise within Technical Information Services include JAX® Services, genotyping, complex breeding schemes, diversity outbred mice, and models of cardiovascular disease. Peter earned a Bachelor of Arts from Carleton College, Northfield, MN, in 1993 and completed graduate courses at the University of Georgia in 1995.
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