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Pathol Res Pract. 2012 Jul 15;208(7):377-81. doi: 10.1016/j.prp.2012.04.006. Epub 2012 Jun 8.

The influence of physical activity in the progression of experimental lung cancer in mice

Renato Batista Paceli 1Rodrigo Nunes CalCarlos Henrique Ferreira dos SantosJosé Antonio CordeiroCassiano Merussi NeivaKazuo Kawano NagaminePatrícia Maluf Cury


GRUPO_AF1GROUP AFA1 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 1GROUP AFAN1 – Anaerobic Physical ActivityAtividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO_AF2GROUP AFA2 – Aerobic Physical ActivityAtividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 2GROUP AFAN 2 – Anaerobic Physical ActivityAtividade Física Anaeróbia´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

Slides – mestrado´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto



Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo´´My´´ Dissertation Faculty of Medicine of Sao Jose do Rio Preto


Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.


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Identification of Natural Regulatory T Cell Epitopes Reveals Convergence on a Dominant Autoantigen.IMMUNITY 47:107 (2017) IF=22.845

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“I’ve been very happy with Cyagen’s service so I’ve been referring a lot of colleagues… thanks for the great service.”Washington University in St. Louis

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Knockout Mice

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crispr cas9 knockout mice
Engineered nuclease-mediated genome editing (especially CRISPR/Cas9) is an emerging technology which can serve as an alternative to the conventional, ES cell homologous recombination-based knockout (KO) animal generation. When gRNA(s) designed to target specific site(s) in the mouse genome and Cas9 are co-injected into fertilized mouse eggs, cleavage at the target site(s) followed by imperfect repair can result in indels (insertion or deletion). If the cut site is in the coding region of a gene, this may result in a frameshift mutation downstream of the site, generating a constitutive knockout. If deletion of exon(s) encoding critical domains is desirable, two gRNAs targeting sites upstream and downstream of the exon(s) can be co-injected with Cas9 and knockout pups with critical region deletion can be generated. Genome editing using CRISPR/Cas9 system can generate constitutive knockout founder animals in as little as 3 months, far faster than the typical 8~12 months required for conventional knockout mice generation with ES cell homologous recombination. We guarantee delivery of a minimum of 2 founders or 3 F1 animals for knockout.

Discount of the Decade Event: Save up to 25% on all custom animal models

 ◆ Workflow of CRISPR/Cas9-mediated Knockout (KO) Mouse Services

workflow of CRISPR/Cas9 knockout mouse services - Cyagen US Inc.

◆ Description of Services

Knockout (KO) strategy design

Tell us the name of gene you wish to knockout and we will design a nuclease-mediated strategy for you. This includes the selection of target sites in the gene based on our optimized algorithm that maximizes on-target nuclease activity and minimizes off-target activity, and the design of nuclease expression vector(s). For each gene to be knocked out, we will design vectors against at least two target sites in the gene to ensure success. Genotyping assays based on PCR and sequencing will also be designed for the screening of knockout founder mice.

Nucleases expression vector construction

DNA vectors that express the desired nucleases will be constructed. Where needed, the efficacy of these vectors will be tested in cell culture.

Nuclease injection into mouse eggs

– mRNA preparation: Nuclease expression vectors will be transcribed in vitro. The resulting mRNA will be artificially capped and polyadenylated to facilitate its proper translation into protein in mammalian cells.

– Nuclease injection to obtain founders: The in vitro transcribed nuclease mRNA(s) will be injected into fertilized mouse eggs, followed by implantation of the eggs into surrogate mothers to obtain offspring. In cases where the nuclease expression vectors are designed and constructed by Cyagen, we will inject as many eggs and/or target as many sites as needed to fulfill the guarantee. In cases where the nuclease expression vectors (or their mRNA products) are provided by the customer, we will inject a minimum of 200/300 eggs (based on strain) and screen pups for founders carrying desired mutation. If no founders are identified, more injections can be performed at an additional charge.

Founder screening

Pups will be screened by PCR and sequencing to identify knockout founder mice. Specifically, the site targeted by the nucleases will be PCR-amplified, followed by sequencing of the PCR product to reveal any mutations that might have occurred. Mice carrying frameshift deletions/insertions or critical exon(s) deletion on at least one allele are considered knockout founders. Occasionally, an animal may be found to have both alleles of the target site mutated.

Breeding founders to obtain F1

For some projects, the generation of founder mice is the end point. However, some customers wish to have us breed the founders further to obtain F1 mice. We will breed up to 3 founders to wildtype mice of matching strain background, and genotype their offspring to obtain F1 mice bearing the knockout allele.

◆ Donor Strain Information

We typically produce CRISPR-mediated knockout mice in the C57BL/6 and FVB background, but we may be able to use other strains per your request.

>> Rat models are also available. Learn more about CRISPR Knockout Rat Services.

◆ Pricing and Turnaround Time

For projects where nuclease expression vectors are constructed by Cyagen

StagesServicePriceTurnaround time
1Knockout strategy designFree1-4 days
2Nuclease expression vector construction for knockout$1,9503-5 weeks
3mRNA preparation$9501-2 weeks
4CRISPR/Cas9 injection to obtain knockout foundersFVB$5,9506-8 weeks
C57BL/6$9,9506-10 weeks
5Genotyping pups to identify knockout founders$9501-2 weeks
6Off-target analysis$5951-2 weeks
7Breeding founders to obtain F1$2,45012-16 weeks

 Note: For nuclease-mediated knockout mouse services not listed above, please inquire about availability and pricing. The turnaround time above does not include the time for obtaining host institution’s approval for mouse importation, nor transit time during shipping.

◆ Guarantee

Cyagen offers the best guarantee in the industry – we guarantee generation of constitutive knockout mice. We will fully refund the client’s service fee if animals with the specified genotype are not generated (except for genetic modifications severely affecting viability, morbidity, or fertility). Given the complexity of biological systems, a particular genetic modification may not result in the desired phenotype. As such, Cyagen’s guarantee covers the creation of animals with the specified genotype, not a particular phenotypic outcome in terms of transcription, protein/RNA function, or organismal biology.

◆ Inquiries and Quote Requests

Request a quote now. Alternatively, you can always email or call 877-598-8122 to inquire about our services or obtain a quote for your project.

◆ Price Matching

If you find another commercial service provider that offers better pricing than ours, we will match the price plus an additional 5% off.

◆ Payments

Standard payment terms include a 50% upfront payment before the project begins, and the remaining 50% plus shipping charge paid after completion of the project. If you need us to design your knockout strategy, we will provide this service for free irrespective of whether you end up choosing us for your project. 

◆ Bulk Discount

We offer up to a 10% bulk discount for large orders. Large orders are defined as 5 or more projects from the same institution. If you bundle your orders with those of your colleagues, you can all qualify for the bulk discount.

◆ Shipping

Products are shipped from our facility in China to our Santa Clara, California facility, then are relayed to end users. For mouse shipments, the shipping charge includes courier cost plus a $100/crate handling fee. DNA constructs in E. coli are shipped at room temperature, and the charge includes courier cost plus a $10 handling fee. We typically use World Courier to ship live mice and FedEx for other shipments.

◆ Animal Programs

All animal work is conducted in our specific pathogen free (SPF) facilities that have been AAALAC accredited and OLAW assured. For details information, please visit our support section for Description of our FacilityAnimal Health and Animal Welfare Program.

◆ Customer References

Please click here to view a map of customer who have used Cyagen before worldwide. 

◆ Citations

Please click here for a list of publications that have cited Cyagen.

◆ Case studies on our Knockout Mice

Case 1

Identification of Natural Regulatory T Cell Epitopes Reveals Convergence on a Dominant Autoantigen.
Cell Death and Disease 47: 107–117 (2017)
Leonard JD, Gilmore DC, Dileepan T, Nawrocka WI, Chao JL, Schoenbach MH, Jenkins MK, Adams EJ, Savage PA


Regulatory T (Treg) cells expressing the transcription factor Foxp3 are critical for the prevention of autoimmunity and the suppression of anti-tumor immunity. The major self-antigens recognized by Treg cells remain undefined, representing a substantial barrier to the understanding of immune regulation. Here, we have identified natural Treg cell ligands in mice. We found that two recurrent Treg cell clones, one prevalent in prostate tumors and the other associated with prostatic autoimmune lesions, recognized distinct non-overlapping MHC-class-II-restricted peptides derived from the same prostate-specific protein. Notably, this protein is frequently targeted by autoantibodies in experimental models of prostatic autoimmunity. On the basis of these findings, we propose a model in which Treg cell responses at peripheral sites converge on those self-proteins that are most susceptible to autoimmune attack, and we suggest that this link could be exploited as a generalizable strategy for identifying the Treg cell antigens relevant to human autoimmunity.

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A Brief History of Animal Modeling

Animal models are essential to biological research: issues and perspectives

animal model listen (A-nih-mul MAH-dul)An animal with a disease either the same as or like a disease in humans. Animal models are used to study the development and progression of diseases and to test new treatments before they are given to humans. Animals with transplanted human cancers or other tissues are called xenograft models.

What is an animal model?

Learn more about Animal Models

An animal model is a non-human species used in medical research because it can mimic aspects of a disease found in humans. Animal models are used to obtain information about a disease and its prevention, diagnosis, and treatment. By using animals, researchers can carry out experiments that would be impractical or ethically prohibited with humans.

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The Animal Model

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Animal Models

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While extrapolation from animals to humans should always be made with caution, it is turning out to be possible to study behaviour in animals and to make connections between behaviour, brains, cell biology and genetics.

Different strains of mice, for example, vary in certain behavioural traits. Some are particularly neurotic, for example, and possible genetic contributions to this trait have been identified. This does not reveal a ‘gene for neuroticism’, but does suggest a possible biological mechanism influencing neuroticism in mice and, by extension, humans.



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Have Scientists Discovered a Collective Consciousness?

(Listen below) For over three decades the psychologist Roger Nelson Ph.D. and his colleagues at Princeton have explored an extended property of the mind that is unexplained by current science.

Results of these experiments seem to suggest that our thoughts and intentions are not encapsulated within our brains or bodies, but extend mysteriously into the world around us, and in repeatable, scientifically measurable ways.

While controversial, a careful but open-minded look at this research strongly suggests the effects are real. In my conversation with Roger (listen below), we explore this research, including his later experiments, with the Global Consciousness Project, that hint to the existence of a larger collective consciousness, in which our individual minds participate.

Today we discuss the findings of these experiments, and what could be their profound implications.

I hope you enjoy this conversation. If you’d like to support this podcast, please visit my patreon page:

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Postdoctoral Fellow, Cell Metabolism & Autophagy in Cancer, CRUK Beatson Institute, Glasgow, UK

Postdoctoral position

Team: Tumour Cell Death Laboratory (TCDL) headed by Professor Kevin Ryan
Salary: £31,604 – £41,929
Term: Initial 3 year fixed term contract (with possibility of up to 2 years extension)
Where to apply?

A postdoctoral position is offered in the Tumour Cell Death Laboratory (TCDL) headed by Professor Kevin Ryan. The TCDL is a vibrant team which aims to understand how cell viability is controlled during tumour development and in response to cancer therapy. We focus on cell metabolism, autophagy and apoptosis – pathways that control cell viability, tumour development and the response to cancer therapy. The successful applicant will use cell biology and genetics to investigate the mechanisms controlling cell viability with the aim of enhancing the effectiveness of chemotherapy.

Key recent publications from the group include: Sierra Gonzalez et al. Nature 563(7733): 719-723; Sakamaki et al. Molecular Cell 66(4): 517-543; Rosenfeldt et al. Nature 504(7479): 296-30; Long et al. Molecular Cell 50(3): 394-406;

Applicants must have a PhD in a relevant field, be ambitious and be driven by scientific curiosity. Existing skills with regard to mammalian cell culture and molecular biology are desired and experience or interest in in vivo cancer models would be an advantage.

To find out more about this unique opportunity to establish advanced skills and expertise in this exciting field please contact: Professor Kevin Ryan,

The Cancer Research UK Beatson Institute is committed to increase the number of female scientists at this level and encourages female applicants to apply. We have recently introduced a highly attractive maternity policy which provides 12-18 months support and funding for postdocs wishing to take time off to spend with their children.

Application deadline: 29 Nov 2019


Managing a Multiparty Negotiation

Expert advice on handling multiparty negotiation and the complications created by multiple parties.


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Product Notices

Prices and specifications are subject to change without notice. Kent Scientific may substitute products of equal or superior specifications upon customer notification.

Product Return Policy

Please contact the Customer Service Department to report the product issue and obtain a Return Merchandise Authorization (RMA) number. All returns, including product repairs under warranty, must have an RMA number to be accepted by the Receiving Department. Return authorization procedures include a completed RMA form, proper RMA identification on the outside of the return package and return shipment within 14 days of RMA number issuance. A full credit will be issued for stock products returned within 15 days. Special ordered products cannot be returned and will be repaired or replaced if faulty. Customer pays shipping and handling charges. Products returned for credit must be unused, all accessories included and in new condition. Sterile products can only be returned if unopened. All product returned for repair or replacement must be sanitary and cleaned appropriately. All charged repairs require written authorization by the customer.

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All product descriptions in this catalog and in other Kent Scientific Corporation literature, such as the company website and product manuals, are only suggestions for product use. The user is solely responsible in determining the suitability of any Kent Scientific product for their particular use. Kent Scientific Corporation and our employees or distributors are not responsible for the use, misuse, or any verbal or written claims or guarantees on the suitability of any item for a particular use.

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Innovative Research Solutions for Mice & Rats

Kent Scientific provides integrated, modular solutions for small animal pre-clinical research and drug discovery advancement.
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An innovative low-flow anesthesia system that is safe for you and safer for your animalsView the SomnoSuite


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A non-invasive, high throughput system for measuring blood pressureView CODA HT

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