GenScript Biotech Corporation @ ´´Biological engineering, or bioengineering/bio-engineering, is the application of principles of biology and the tools of engineering to create usable, tangible, economically viable products.[1] Biological engineering employs knowledge and expertise from a number of pure and applied sciences,[2] such as mass and heat transfer, kinetics, biocatalysts, biomechanics, bioinformatics, separation and purification processes, bioreactor design, surface science, fluid mechanics, thermodynamics, and polymer science.´´ @ ´´In general, biological engineers (or biomedical engineers) attempt to either mimic biological systems to create products or modify and control biological systems so that they can replace, augment, sustain, or predict chemical and mechanical processes.[6] ´´Biological engineering is a science-based discipline founded upon the biological sciences in the same way that chemical engineering, electrical engineering, and mechanical engineering[8] can be based upon chemistry, electricity and magnetism, and classical mechanics, respectively.[9]´´

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  • – > Mestrado – Dissertation – Tabelas, Figuras e Gráficos – Tables, Figures and Graphics´´My´´ Dissertation @ #Innovation #energy #life #health #Countries #Time #Researches #Reference #Graphics #Ages #Age #Mice #People #Person #Mouse #Genetics #PersonalizedMedicine #Diagnosis #Prognosis #Treatment #Disease #UnknownDiseases #Future #VeryEfficientDrugs #VeryEfficientVaccines #VeryEfficientTherapeuticalSubstances #Tests #Laboratories #Investments #Details #HumanLongevity #DNA #Cell #Memory #Physiology #Nanomedicine #Nanotechnology #Biochemistry #NewMedicalDevices #GeneticEngineering #Internet #History #Science #World

Pathol Res Pract. 2012 Jul 15;208(7):377-81. doi: 10.1016/j.prp.2012.04.006. Epub 2012 Jun 8.

The influence of physical activity in the progression of experimental lung cancer in mice

Renato Batista Paceli 1Rodrigo Nunes CalCarlos Henrique Ferreira dos SantosJosé Antonio CordeiroCassiano Merussi NeivaKazuo Kawano NagaminePatrícia Maluf Cury


Impact_Fator-wise_Top100Science_Journals

GRUPO_AF1GROUP AFA1 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 1GROUP AFAN1 – Anaerobic Physical ActivityAtividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO_AF2GROUP AFA2 – Aerobic Physical ActivityAtividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 2GROUP AFAN 2 – Anaerobic Physical ActivityAtividade Física Anaeróbia´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

Slides – mestrado´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

CARCINÓGENO DMBA EM MODELOS EXPERIMENTAIS

DMBA CARCINOGEN IN EXPERIMENTAL MODELS

Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo´´My´´ Dissertation Faculty of Medicine of Sao Jose do Rio Preto

https://pubmed.ncbi.nlm.nih.gov/22683274/

Abstract

Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.

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GenScript Biotech Corporation(Stock Code: 1548.HK) is a global biotechnology group. GenScript’s businesses encompass four major categories based on its leading gene synthesis technology, including operation as a Life Science CRO, enzyme and synthetic biology products, biologics development and manufacturing, as well as cell therapy.

Founded in 2002 and listed on the Hong Kong Stock Exchange in 2015, GenScript has an established global presence across Greater China, North America, the EU, and Asia Pacific. Today, over 300,000 customers from over 160 countries and regions around the world have used GenScript’s premier, convenient, and reliable products and services.

GenScript currently has more than 3000 employees globally, 33% of whom hold master’s and/or Ph.D. degrees. In addition, GenScript has a number of leading commercial technologies developed in the fields of synthetic biology, immunotherapy, antibody design, chemical synthesis and bioinformatics, including more than 70 patents and over 200 patent applications. As of January 2019, GenScript’s products and services have been cited by 36,500 scientific papers worldwide.

GenScript is committed to striving towards its vision of being the most reliable biotech company in the world to make humans and nature healthier through biotechnology.

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  Jon StonehouseJon Stonehouse, a pharmaceutical executive for more than 20 years, has strong commercialization, financial transaction, business development and management expertise. He joined BioCryst as President and CEO in January 2007. The transformation that has taken place since then has advanced BioCryst to a company with its first product revenue and approvals, pivotal clinical programs and a diverse clinical pipeline, as well as the financial flexibility to build an enduring, successful biopharmaceutical company. Before joining BioCryst, he served as Senior Vice President of Corporate Development at Merck KGaA with responsibility for global licensing and business development, corporate mergers and acquisitions, corporate strategic planning and alliance management. Among his accomplishments, he was responsible for leading the effort to develop a strategy for Merck that significantly changed the company, which culminated with the acquisition of Serono, S.A., the largest biotechnology company in Europe.
  George ChurchDr. George Church, Professor of Genetics at Harvard Medical School and Professor of Health Sciences and Technology at Harvard and the Massachusetts Institute of Technology (MIT), co-author of 515 papers, 143 patent publications & the book “Regenesis”. Dr. Church has developed methods used for the first genome sequence (1994) & million-fold cost reductions since (via fluor-NGS & nanopores), plus barcoding, DNA assembly from chips, genome editing, writing & recoding. He also co-initiated BRAIN Initiative (2011) & Genome Projects (GP-Read-1984, GP-Write-2016, PGP-2005: world’s open-access personal precision medicine datasets); machine learning for protein engineering, tissue reprogramming, organoids, xeno-transplanation, in situ 3D DNA, RNA, protein imaging.

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Over the past five years, GenScript has developed a highly efficient service philosophy: One stop for gene, peptide, protein, and antibody services. These four areas, are each essential to modern molecular biological research, the driving impetus of modern drug discovery. GenScript’s one-stop service package eliminates the need to search for and coordinate multiple vendors, maximizes innovation and insight, and reduces waste. GenScript’s efficiency and dedication to quality have helped establish strong partnerships with customers in over 60 countries. Many top pharmaceutical companies are our customers. In order to better serve its customers, GenScript has recently established a strategic partnership with VWR, a world-leading distributor and supplier of custom solutions. GenScript has been included on VWR BioSciences’s list of partners in both proteomics and genomics. GenScript is the only company so honored by VWR Biosciences to provide the full gamut of early discovery biology services.

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Biological engineering

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ribosome is a biological machine that utilizes protein dynamicsSome biological machines

Biological engineering, or bioengineering/bio-engineering, is the application of principles of biology and the tools of engineering to create usable, tangible, economically viable products.[1] Biological engineering employs knowledge and expertise from a number of pure and applied sciences,[2] such as mass and heat transfer, kinetics, biocatalysts, biomechanics, bioinformatics, separation and purification processes, bioreactor design, surface science, fluid mechanics, thermodynamics, and polymer science. It is used in the design of medical devices, diagnostic equipment, biocompatible materials, renewable bioenergy, ecological engineering, agricultural engineering, and other areas that improve the living standards of societies. Examples of bioengineering research include bacteria engineered to produce chemicals, new medical imaging technology, portable and rapid disease diagnostic devices, prostheticsbiopharmaceuticals, and tissue-engineered organs.[3][4] Bioengineering overlaps substantially with biotechnology and the biomedical sciences[5] in a way analogous to how various other forms of engineering and technology relate to various other sciences (for example, aerospace engineering and other space technology to kinetics and astrophysics).

In general, biological engineers (or biomedical engineers) attempt to either mimic biological systems to create products or modify and control biological systems so that they can replace, augment, sustain, or predict chemical and mechanical processes.[6] Bioengineers can apply their expertise to other applications of engineering and biotechnology, including genetic modification of plants and microorganisms, bioprocess engineering, and biocatalysis. Working with doctors, clinicians and researchers, bioengineers use traditional engineering principles and techniques and apply them to real-world biological and medical problems.[7]

Contents

History[edit]

Biological engineering is a science-based discipline founded upon the biological sciences in the same way that chemical engineeringelectrical engineering, and mechanical engineering[8] can be based upon chemistry, electricity and magnetism, and classical mechanics, respectively.[9]

Before WWII, biological engineering had just begun being recognized as a branch of engineering, and was a very new concept to people. Post-WWII, it started to grow more rapidly, partially due to the term “bioengineering” being coined by British scientist and broadcaster Heinz Wolff in 1954 at the National Institute for Medical Research. Wolff graduated that same year and became the director of the Division of Biological Engineering at the university. This was the first time Bioengineering was recognized as its own branch at a university. Electrical engineering is considered to pioneer this engineering sector due to its work with medical devices and machinery during this time.[10] When engineers and life scientists started working together, they recognized the problem that the engineers didn’t know enough about the actual biology behind their work. To resolve this problem, engineers who wanted to get into biological engineering devoted more of their time and studies to the details and processes that go into fields such as biology, psychology, and medicine.[11] The term biological engineering may also be applied to environmental modifications such as surface soil protection, slope stabilization, watercourse and shoreline protection, windbreaks, vegetation barriers including noise barriers and visual screens, and the ecological enhancement of an area. Because other engineering disciplines also address living organisms, the term biological engineering can be applied more broadly to include agricultural engineering.

The first biological engineering program was created at University of California, San Diego in 1966, making it the first biological engineering curriculum in the United States.[12] More recent programs have been launched at MIT[13] and Utah State University.[14] Many old agricultural engineering departments in universities over the world have re-branded themselves as agricultural and biological engineering or agricultural and biosystems engineering, due to biological engineering as a whole being a rapidly developing field with fluid categorization. According to Professor Doug Lauffenburger of MIT,[13][15] biological engineering has a broad base which applies engineering principles to an enormous range of size and complexities of systems. These systems range from the molecular level (molecular biologybiochemistrymicrobiologypharmacologyprotein chemistry, cytologyimmunologyneurobiology and neuroscience) to cellular and tissue-based systems (including devices and sensors), to whole macroscopic organisms (plants, animals), and can even range up to entire ecosystems.

Education[edit]

The average length of study is three to five years, and the completed degree is signified as a bachelor of engineering (B.S. in engineering). Fundamental courses include thermodynamics, bio-mechanics, biology, genetic engineering, fluid and mechanical dynamics, kinetics, electronics, and materials properties.[16][17]

Sub-disciplines[edit]

Modeling of the spread of disease using Cellular Automata and Nearest Neighbor Interactions

Depending on the institution and particular definitional boundaries employed, some major branches of bioengineering may be categorized as (note these may overlap):

Organizations[edit]

  • Accreditation Board for Engineering and Technology (ABET),[22] the U.S.-based accreditation board for engineering B.S. programs, makes a distinction between biomedical engineering and biological engineering, though there is much overlap (see above).
  • American Institute for Medical and Biological Engineering (AIMBE) is made up of 1,500 members. Their main goal is to educate the public about the value biological engineering has in our world, as well as invest in research and other programs to advance the field. They give out awards to those dedicated to innovation in the field, and awards of achievement in the field. (They do not have a direct contribution to biological engineering, they more recognize those who do and encourage the public to continue that forward movement).[23]
  • Institute of Biological Engineering (IBE) is a non-profit organization, they run on donations alone. They aim to encourage the public to learn and to continue advancements in biological engineering. (Like AIMBE, they do not perform research directly; however, they offer scholarships to students who show promise in the field).[24]
  • Society for Biological Engineering (SBE) is a technological community associated with the American Institute of Chemical Engineers (AIChE). SBE hosts international conferences, and is a global organization of leading engineers and scientists dedicated to advancing the integration of biology with engineering.[25]

References[edit]

  1. ^ Abramovitz, Melissa (2015). Biological engineering. Gale Virtual Reference Library. p. 10. ISBN 978-1-62968-526-7.
  2. ^ Herold, Keith; Bentley, William E.; Vossoughi, Jafar (2010). The Basics of Bioengineering Education. 26Th Southern Biomedical Engineering Conference, College Park, Maryland. p. 65. ISBN 9783642149979.
  3. ^ “What is Bioengineering?”bioeng.berkeley.edu. Retrieved 2018-07-21.
  4. ^ “MSB: About the Munich School of BioEngineering”http://www.bioengineering.tum.de. Retrieved 2020-02-03.
  5. ^ “Biotechnology vs Biomedical Science vs Biomedical Engineering (Bioengineering)”Tanmoy Ray. 2018-07-19. Retrieved 2018-07-21.
  6. ^ Pasotti, Lorenzo; Zucca, Susanna (2014-08-03). “Advances and Computational Tools towards Predictable Design in Biological Engineering”Computational and Mathematical Methods in Medicine2014: 369681. doi:10.1155/2014/369681PMC 4137594PMID 25161694.
  7. ^ Sheffield, University of. “What is bioengineering? – Bioengineering – The University of Sheffield”http://www.sheffield.ac.uk. Retrieved 2018-07-21.
  8. Jump up to:a b Abramovitz, Melissa (2015). Biological Engineering. Gale Virtual Reference Library. p. 18. ISBN 978-1-62968-526-7.
  9. ^ Cuello JC, Engineering to biology and biology to engineering, The bi-directional connection between engineering and biology in biological engineering design, Int J Engng Ed 2005, 21, 1-7
  10. ^ Medical & biological engineering. Oxford ; New York: Pergamon Press. 1966–1976.
  11. ^ Naik, edited by Ganesh R. (2012). Applied biological engineering : principles and practice. Rijeka: InTech. ISBN 9789535104124.
  12. ^ “Founder of UCSD Bioengineering Program”. jacobsschool.ucsd.edu. 1 Mar 2004. Retrieved 22 May 2018.
  13. Jump up to:a b “MIT, Department of Biological Engineering”. Retrieved 16 April 2015.
  14. ^ “Utah State University, Department of Biological Engineering”. be.usu.edu. Retrieved 2011-11-13.
  15. ^ “MIT Directory, Doug Lauffenburger”. Retrieved 15 April 2015.
  16. ^ Linsenmeier RA, Defining the Undergraduate Biomedical Engineering Curriculum
  17. ^ Johnson AT, Phillips WM. “Philosophical foundations of biological engineering”. Journal of Engineering Education1995 (84): 311–318.
  18. Jump up to:a b c d e f g “Bioengineering”Encyclopedia Britannica.
  19. ^ “Convention on Biological Diversity”. Retrieved 27 April 2018.
  20. ^ “Biomimetics: its practice and theory”Royal Society Publishing.
  21. ^ “Bioprinting”. Retrieved 1 May 2018.
  22. ^ ABET Accreditation, accessed 9/8/2010.
  23. ^ “AIMBE About Page”.
  24. ^ “Institute of Biological Engineering”. Retrieved 20 April 2018.
  25. ^ “The Society for Biological Engineering”. Retrieved 21 August2019.

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