Internal brain timers linked with motivation and behavior @ ´´Neuroscience (or neurobiology) is the scientific study of the nervous system.[1] It is a multidisciplinary branch of biology[2] that combines physiology, anatomy, molecular biology, developmental biology, cytology, mathematical modeling, and psychology to understand the fundamental and emergent properties of neurons and neural circuits.[3][4][5][6][7] The understanding of the biological basis of learning, memory, behavior, perception, and consciousness has been described by Eric Kandel as the “ultimate challenge” of the biological sciences.[8]´´ & Very Important Websites, Links and Images




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DECEMBER 6, 2019

Internal brain timers linked with motivation and behavior

by Alice McCarthy, Children’s Hospital Boston

Internal brain timers linked with motivation and behavior
Motivation and behavior are under the control of neurons that track time. Credit: Adobe Stock

Time can be measured in many ways: a watch, a sundial, or the body’s natural circadian rhythms. But what about the sexual behavior of a fruit fly?

“If you ask a bunch of scientists whether animals can keep time, many would say they cannot, that things happen over time—but time itself is not measured,” says Michael Crickmore, Ph.D., a researcher in Boston Children’s Hospital’s F.M. Kirby Neurobiology Center whose laboratory studies motivation. But in new research published in the journal Neuron in collaboration with the lab of Dragana Rogulja, Ph.D. at Harvard Medical School, he shows that the mating behavior of fruit flies is not haphazard. Instead, motivation and behavior are under the control of neurons that track time.

Crickmore uses the mating drive in male flies to study how motivations are produced by the brain.

A six-minute internal timer

Fruit fly matings certainly appear to be timed. In earlier research, Crickmore discovered that if left undisturbed, a male will mate with a female for an average of 23 minutes from start to finish—almost never more than 27 minutes or less than 19.

“But if you challenge the flies with extreme heat during mating, the male has to make a decision,” he says.

The male could decide to stop mating and fly away, but before six minutes he will never do that. Instead, he is willing to sacrifice his and his partner’s life because the sperm isn’t transferred until six minutes into mating. If he persists he’s likely to sire over fifty progeny, providing a strong evolutionary prerogative to brave the danger.Male fruit flies initiate and maintain mating behavior for 23 minutes on average. Credit: Michael Crickmore

“At six minutes, he will have a change in his psychological state, his motivation,” Crickmore says. “After transferring sperm he will keep sending other useful proteins over to the female, but clearly he doesn’t think they’re very important because if something bad happens, he’s out of there.”

Crickmore’s team wanted to know more about what goes on in the male’s head and how he knows when his six minutes—or 23 minutes—are up.

Memory enzyme sets the clock

Crickmore’s lab discovered that an enzyme famous for its role in memory, CaMKII, is the six-minute timer. “CaMKII might be the most well-studied enzyme in neuroscience,” Crickmore says. “It is mostly thought of as a memory molecule, but we think what it really does is hold information over long timescales, either for memory or for timing other brain processes.”

What his team learned is that CaMKII, also found in the neurons of humans and other mammals, gets activated in four specific neurons when mating begins and remains active for six minutes.

“The sustained activity of CaMKII in these four neurons delays sperm transfer and the change in motivation for six minutes,” he says. “It has a defined starting point and ticks down in a reproducible manner—just like a timer.”

Also like a clock, the CaMKII enzyme is made up of 12 subunits that form a circle. Once activated, each subunit activates its neighbors to maintain activity even after the triggering signal has faded away. While this research centers solely on those first six minutes of mating, Crickmore plans on digging deeper into the remaining 17 minutes of mating. He suspects that this other timing system may also use CaMKII, in different neurons and with different settings, like plugging in a different number into the timer on your phone.

Internal brain timers linked with motivation and behavior
CAMKII enzyme activates brain neurons starting an internal timer. Credit: Lenov: Wikimedia Commons

Behavior is organized by time

Most behaviors take millions of times longer than the time it takes for neurons to fire. “But this is the first clear example that a behavior is organized using time itself, as opposed to just one thing happening after another,” Crickmore says.

Since the structure of CaMKII is almost identical in humans, flies, and even the most simple animals, Crickmore believes it might be helpful for understanding lots of human behaviors.

“Our lives are organized in reproducible ways over long time scales,” he says. “We may just be doing one thing after another, but it also may be that our motivations have timers built in to them to help us realize when we should switch behaviors.”

The clock on the wall does not make us do anything, but it helps us organize our lives. A glance at a clock can motivate us to make a change; whether to get out of bed, make dinner, or feed the dog.

“I think that is what these clocks within neurons are doing,” Crickmore says. “Maybe not telling us exactly what to do, but urging us toward or away from behaviors that we’ve been doing for a while, or that we haven’t done in a while.”

Explore furtherFruit fly sex drive hints at how animals choose behaviors

More information: Stephen C. Thornquist et al. CaMKII Measures the Passage of Time to Coordinate Behavior and Motivational State, Neuron (2019). DOI: 10.1016/j.neuron.2019.10.018Journal information:NeuronProvided by Children’s Hospital Boston706 shares

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From Wikipedia, the free encyclopediaJump to navigationJump to searchFor the journal, see Neuroscience (journal).”Brain science” redirects here. For other aspects of brain science, see cognitive sciencecognitive psychologyneurology, and neuropsychology.Drawing by Santiago Ramón y Cajal (1899) of neurons in the pigeon cerebellum

Neuroscience (or neurobiology) is the scientific study of the nervous system.[1] It is a multidisciplinary branch of biology[2] that combines physiologyanatomymolecular biologydevelopmental biologycytologymathematical modeling, and psychology to understand the fundamental and emergent properties of neurons and neural circuits.[3][4][5][6][7] The understanding of the biological basis of learning, memory, behavior, perception, and consciousness has been described by Eric Kandel as the “ultimate challenge” of the biological sciences.[8]

The scope of neuroscience has broadened over time to include different approaches used to study the nervous system at different scales and the techniques used by neuroscientists have expanded enormously, from molecular and cellular studies of individual neurons to imaging of sensory, motor and cognitive tasks in the brain.



Main article: History of neuroscienceIllustration from Gray’s Anatomy (1918) of a lateral view of the human brain, featuring the hippocampus among other neuroanatomical features

The earliest study of the nervous system dates to ancient EgyptTrepanation, the surgical practice of either drilling or scraping a hole into the skull for the purpose of curing head injuries or mental disorders, or relieving cranial pressure, was first recorded during the Neolithic period. Manuscripts dating to 1700 BC indicate that the Egyptians had some knowledge about symptoms of brain damage.[9]

Early views on the function of the brain regarded it to be a “cranial stuffing” of sorts. In Egypt, from the late Middle Kingdom onwards, the brain was regularly removed in preparation for mummification. It was believed at the time that the heart was the seat of intelligence. According to Herodotus, the first step of mummification was to “take a crooked piece of iron, and with it draw out the brain through the nostrils, thus getting rid of a portion, while the skull is cleared of the rest by rinsing with drugs.”[10]

The view that the heart was the source of consciousness was not challenged until the time of the Greek physician Hippocrates. He believed that the brain was not only involved with sensation—since most specialized organs (e.g., eyes, ears, tongue) are located in the head near the brain—but was also the seat of intelligence. Plato also speculated that the brain was the seat of the rational part of the soul.[11] Aristotle, however, believed the heart was the center of intelligence and that the brain regulated the amount of heat from the heart.[12] This view was generally accepted until the Roman physician Galen, a follower of Hippocrates and physician to Roman gladiators, observed that his patients lost their mental faculties when they had sustained damage to their brains.

AbulcasisAverroesAvicennaAvenzoar, and Maimonides, active in the Medieval Muslim world, described a number of medical problems related to the brain. In Renaissance EuropeVesalius (1514–1564), René Descartes (1596–1650), Thomas Willis (1621–1675) and Jan Swammerdam (1637–1680) also made several contributions to neuroscience.The Golgi stain first allowed for the visualization of individual neurons.

Luigi Galvani‘s pioneering work in the late 1700s set the stage for studying the electrical excitability of muscles and neurons. In the first half of the 19th century, Jean Pierre Flourens pioneered the experimental method of carrying out localized lesions of the brain in living animals describing their effects on motricity, sensibility and behavior. In 1843 Emil du Bois-Reymond demonstrated the electrical nature of the nerve signal,[13] whose speed Hermann von Helmholtz proceeded to measure,[14] and in 1875 Richard Caton found electrical phenomena in the cerebral hemispheres of rabbits and monkeys.[15] Adolf Beck published in 1890 similar observations of spontaneous electrical activity of the brain of rabbits and dogs.[16] Studies of the brain became more sophisticated after the invention of the microscope and the development of a staining procedure by Camillo Golgi during the late 1890s. The procedure used a silver chromate salt to reveal the intricate structures of individual neurons. His technique was used by Santiago Ramón y Cajal and led to the formation of the neuron doctrine, the hypothesis that the functional unit of the brain is the neuron.[17] Golgi and Ramón y Cajal shared the Nobel Prize in Physiology or Medicine in 1906 for their extensive observations, descriptions, and categorizations of neurons throughout the brain.

In parallel with this research, work with brain-damaged patients by Paul Broca suggested that certain regions of the brain were responsible for certain functions. At the time, Broca’s findings were seen as a confirmation of Franz Joseph Gall‘s theory that language was localized and that certain psychological functions were localized in specific areas of the cerebral cortex.[18][19] The localization of function hypothesis was supported by observations of epileptic patients conducted by John Hughlings Jackson, who correctly inferred the organization of the motor cortex by watching the progression of seizures through the body. Carl Wernicke further developed the theory of the specialization of specific brain structures in language comprehension and production. Modern research through neuroimaging techniques, still uses the Brodmann cerebral cytoarchitectonic map (referring to study of cell structure) anatomical definitions from this era in continuing to show that distinct areas of the cortex are activated in the execution of specific tasks.[20]

During the 20th century, neuroscience began to be recognized as a distinct academic discipline in its own right, rather than as studies of the nervous system within other disciplines. Eric Kandel and collaborators have cited David RiochFrancis O. Schmitt, and Stephen Kuffler as having played critical roles in establishing the field.[21] Rioch originated the integration of basic anatomical and physiological research with clinical psychiatry at the Walter Reed Army Institute of Research, starting in the 1950s. During the same period, Schmitt established a neuroscience research program within the Biology Department at the Massachusetts Institute of Technology, bringing together biology, chemistry, physics, and mathematics. The first freestanding neuroscience department (then called Psychobiology) was founded in 1964 at the University of California, Irvine by James L. McGaugh.[22] This was followed by the Department of Neurobiology at Harvard Medical School, which was founded in 1966 by Stephen Kuffler.[23]

The understanding of neurons and of nervous system function became increasingly precise and molecular during the 20th century. For example, in 1952, Alan Lloyd Hodgkin and Andrew Huxley presented a mathematical model for transmission of electrical signals in neurons of the giant axon of a squid, which they called “action potentials“, and how they are initiated and propagated, known as the Hodgkin–Huxley model. In 1961–1962, Richard FitzHugh and J. Nagumo simplified Hodgkin–Huxley, in what is called the FitzHugh–Nagumo model. In 1962, Bernard Katz modeled neurotransmission across the space between neurons known as synapses. Beginning in 1966, Eric Kandel and collaborators examined biochemical changes in neurons associated with learning and memory storage in Aplysia. In 1981 Catherine Morris and Harold Lecar combined these models in the Morris–Lecar model. Such increasingly quantitative work gave rise to numerous biological neuron models and models of neural computation.

As a result of the increasing interest about the nervous system, several prominent neuroscience organizations have been formed to provide a forum to all neuroscientist during the 20th century. For example, the International Brain Research Organization was founded in 1961,[24] the International Society for Neurochemistry in 1963,[25] the European Brain and Behaviour Society in 1968,[26] and the Society for Neuroscience in 1969.[27] Recently, the application of neuroscience research results has also given rise to applied disciplines as neuroeconomics,[28] neuroeducation,[29] neuroethics,[30] and neurolaw.[31]

Over time, brain research has gone through philosophical, experimental, and theoretical phases, with work on brain simulation predicted to be important in the future.[32]

Modern neuroscience[edit]

Main article: Outline of neuroscienceHuman nervous system

The scientific study of the nervous system increased significantly during the second half of the twentieth century, principally due to advances in molecular biologyelectrophysiology, and computational neuroscience. This has allowed neuroscientists to study the nervous system in all its aspects: how it is structured, how it works, how it develops, how it malfunctions, and how it can be changed.

For example, it has become possible to understand, in much detail, the complex processes occurring within a single neuron. Neurons are cells specialized for communication. They are able to communicate with neurons and other cell types through specialized junctions called synapses, at which electrical or electrochemical signals can be transmitted from one cell to another. Many neurons extrude a long thin filament of axoplasm called an axon, which may extend to distant parts of the body and are capable of rapidly carrying electrical signals, influencing the activity of other neurons, muscles, or glands at their termination points. A nervous system emerges from the assemblage of neurons that are connected to each other.

The vertebrate nervous system can be split into two parts: the central nervous system (defined as the brain and spinal cord), and the peripheral nervous system. In many species — including all vertebrates — the nervous system is the most complex organ system in the body, with most of the complexity residing in the brain. The human brain alone contains around one hundred billion neurons and one hundred trillion synapses; it consists of thousands of distinguishable substructures, connected to each other in synaptic networks whose intricacies have only begun to be unraveled. At least one out of three of the approximately 20,000 genes belonging to the human genome is expressed mainly in the brain.[33]

Due to the high degree of plasticity of the human brain, the structure of its synapses and their resulting functions change throughout life.[34]

Making sense of the nervous system’s dynamic complexity is a formidable research challenge. Ultimately, neuroscientists would like to understand every aspect of the nervous system, including how it works, how it develops, how it malfunctions, and how it can be altered or repaired. Analysis of the nervous system is therefore performed at multiple levels, ranging from the molecular and cellular levels to the systems and cognitive levels. The specific topics that form the main foci of research change over time, driven by an ever-expanding base of knowledge and the availability of increasingly sophisticated technical methods. Improvements in technology have been the primary drivers of progress. Developments in electron microscopycomputer scienceelectronicsfunctional neuroimaging, and genetics and genomics have all been major drivers of progress.

Molecular and cellular neuroscience[edit]

Main articles: Molecular neuroscience and Cellular neurosciencePhotograph of a stained neuron in a chicken embryo

Basic questions addressed in molecular neuroscience include the mechanisms by which neurons express and respond to molecular signals and how axons form complex connectivity patterns. At this level, tools from molecular biology and genetics are used to understand how neurons develop and how genetic changes affect biological functions. The morphology, molecular identity, and physiological characteristics of neurons and how they relate to different types of behavior are also of considerable interest.

Questions addressed in cellular neuroscience include the mechanisms of how neurons process signals physiologically and electrochemically. These questions include how signals are processed by neurites and somas and how neurotransmitters and electrical signals are used to process information in a neuron. Neurites are thin extensions from a neuronal cell body, consisting of dendrites (specialized to receive synaptic inputs from other neurons) and axons (specialized to conduct nerve impulses called action potentials). Somas are the cell bodies of the neurons and contain the nucleus.

Another major area of cellular neuroscience is the investigation of the development of the nervous system. Questions include the patterning and regionalization of the nervous system, neural stem cellsdifferentiation of neurons and glia (neurogenesis and gliogenesis), neuronal migration, axonal and dendritic development, trophic interactions, and synapse formation.

Computational neurogenetic modeling is concerned with the development of dynamic neuronal models for modeling brain functions with respect to genes and dynamic interactions between genes.

Neural circuits and systems[edit]

Main articles: Neural circuit and Systems neuroscienceProposed organization of motor-semantic neural circuits for action language comprehension. Adapted from Shebani et al. (2013)

Questions in systems neuroscience include how neural circuits are formed and used anatomically and physiologically to produce functions such as reflexesmultisensory integrationmotor coordinationcircadian rhythmsemotional responseslearning, and memory. In other words, they address how these neural circuits function in large-scale brain networks, and the mechanisms through which behaviors are generated. For example, systems level analysis addresses questions concerning specific sensory and motor modalities: how does vision work? How do songbirds learn new songs and bats localize with ultrasound? How does the somatosensory system process tactile information? The related fields of neuroethology and neuropsychology address the question of how neural substrates underlie specific animal and human behaviors. Neuroendocrinology and psychoneuroimmunology examine interactions between the nervous system and the endocrine and immune systems, respectively. Despite many advancements, the way that networks of neurons perform complex cognitive processes and behaviors is still poorly understood.

Cognitive and behavioral neuroscience[edit]

Main articles: Behavioral neuroscience and Cognitive neuroscience

Cognitive neuroscience addresses the questions of how psychological functions are produced by neural circuitry. The emergence of powerful new measurement techniques such as neuroimaging (e.g., fMRIPETSPECT), EEGMEGelectrophysiologyoptogenetics and human genetic analysis combined with sophisticated experimental techniques from cognitive psychology allows neuroscientists and psychologists to address abstract questions such as how cognition and emotion are mapped to specific neural substrates. Although many studies still hold a reductionist stance looking for the neurobiological basis of cognitive phenomena, recent research shows that there is an interesting interplay between neuroscientific findings and conceptual research, soliciting and integrating both perspectives. For example, the neuroscience research on empathy solicited an interesting interdisciplinary debate involving philosophy, psychology and psychopathology.[35] Moreover, the neuroscientific identification of multiple memory systems related to different brain areas has challenged the idea of memory as a literal reproduction of the past, supporting a view of memory as a generative, constructive and dynamic process.[36]

Neuroscience is also allied with the social and behavioral sciences as well as nascent interdisciplinary fields such as neuroeconomicsdecision theorysocial neuroscience, and neuromarketing to address complex questions about interactions of the brain with its environment. A study into consumer responses for example uses EEG to investigate neural correlates associated with narrative transportation into stories about energy efficiency.[37]

Computational neuroscience[edit]

Main article: Computational neuroscience

Questions in computational neuroscience can span a wide range of levels of traditional analysis, such as developmentstructure, and cognitive functions of the brain. Research in this field utilizes mathematical models, theoretical analysis, and computer simulation to describe and verify biologically plausible neurons and nervous systems. For example, biological neuron models are mathematical descriptions of spiking neurons which can be used to describe both the behavior of single neurons as well as the dynamics of neural networks. Computational neuroscience is often referred to as theoretical neuroscience.

Translational research and medicine[edit]

Further information: Translational research and Translational neuroscienceParasagittal MRI of the head of a patient with benign familial macrocephaly

Neurologypsychiatryneurosurgerypsychosurgeryanesthesiology and pain medicineneuropathologyneuroradiologyophthalmologyotolaryngologyclinical neurophysiologyaddiction medicine, and sleep medicine are some medical specialties that specifically address the diseases of the nervous system. These terms also refer to clinical disciplines involving diagnosis and treatment of these diseases.

Neurology works with diseases of the central and peripheral nervous systems, such as amyotrophic lateral sclerosis (ALS) and stroke, and their medical treatment. Psychiatry focuses on affective, behavioral, cognitive, and perceptual disorders. Anesthesiology focuses on perception of pain, and pharmacologic alteration of consciousness. Neuropathology focuses upon the classification and underlying pathogenic mechanisms of central and peripheral nervous system and muscle diseases, with an emphasis on morphologic, microscopic, and chemically observable alterations. Neurosurgery and psychosurgery work primarily with surgical treatment of diseases of the central and peripheral nervous systems.

Recently, the boundaries between various specialties have blurred, as they are all influenced by basic research in neuroscience. For example, brain imaging enables objective biological insight into mental illnesses, which can lead to faster diagnosis, more accurate prognosis, and improved monitoring of patient progress over time.[38]

Integrative neuroscience describes the effort to combine models and information from multiple levels of research to develop a coherent model of the nervous system. For example, brain imaging coupled with physiological numerical models and theories of fundamental mechanisms may shed light on psychiatric disorders.[39]

Major branches[edit]

Modern neuroscience education and research activities can be very roughly categorized into the following major branches, based on the subject and scale of the system in examination as well as distinct experimental or curricular approaches. Individual neuroscientists, however, often work on questions that span several distinct subfields.

Affective neuroscienceAffective neuroscience is the study of the neural mechanisms involved in emotion, typically through experimentation on animal models.[40]
Behavioral neuroscienceBehavioral neuroscience (also known as biological psychology, physiological psychology, biopsychology, or psychobiology) is the application of the principles of biology to the study of genetic, physiological, and developmental mechanisms of behavior in humans and non-human animals.
Cellular neuroscienceCellular neuroscience is the study of neurons at a cellular level including morphology and physiological properties.
Clinical neuroscienceThe scientific study of the biological mechanisms that underlie the disorders and diseases of the nervous system.
Cognitive neuroscienceCognitive neuroscience is the study of the biological mechanisms underlying cognition.
Computational neuroscienceComputational neuroscience is the theoretical study of the nervous system.
Cultural neuroscienceCultural neuroscience is the study of how cultural values, practices and beliefs shape and are shaped by the mind, brain and genes across multiple timescales.[41]
Developmental neuroscienceDevelopmental neuroscience studies the processes that generate, shape, and reshape the nervous system and seeks to describe the cellular basis of neural development to address underlying mechanisms.
Evolutionary neuroscienceEvolutionary neuroscience studies the evolution of nervous systems.
Molecular neuroscienceMolecular neuroscience studies the nervous system with molecular biology, molecular genetics, protein chemistry, and related methodologies.
Neural engineeringNeural engineering uses engineering techniques to interact with, understand, repair, replace, or enhance neural systems.
NeuroanatomyNeuroanatomy is the study of the anatomy of nervous systems.
NeurochemistryNeurochemistry is the study of how neurochemicals interact and influence the function of neurons.
NeuroethologyNeuroethology is the study of the neural basis of non-human animals behavior.
NeurogastronomyNeurogastronomy is the study of flavor and how it affects sensation, cognition, and memory.[42]
NeurogeneticsNeurogenetics is the study of the genetical basis of the development and function of the nervous system.
NeuroimagingNeuroimaging includes the use of various techniques to either directly or indirectly image the structure and function of the brain.
NeuroimmunologyNeuroimmunology is concerned with the interactions between the nervous and the immune system.
NeuroinformaticsNeuroinformatics is a discipline within bioinformatics that conducts the organization of neuroscience data and application of computational models and analytical tools.
NeurolinguisticsNeurolinguistics is the study of the neural mechanisms in the human brain that control the comprehension, production, and acquisition of language.
NeurophysicsNeurophysics deals with the development of physical experimental tools to gain information about the brain.
NeurophysiologyNeurophysiology is the study of the functioning of the nervous system, generally using physiological techniques that include measurement and stimulation with electrodes or optically with ion- or voltage-sensitive dyes or light-sensitive channels.
NeuropsychologyNeuropsychology is a discipline that resides under the umbrellas of both psychology and neuroscience, and is involved in activities in the arenas of both basic science and applied science. In psychology, it is most closely associated with biopsychologyclinical psychologycognitive psychology, and developmental psychology. In neuroscience, it is most closely associated with the cognitive, behavioral, social, and affective neuroscience areas. In the applied and medical domain, it is related to neurology and psychiatry.
PaleoneurobiologyPaleoneurobiology is a field which combines techniques used in paleontology and archeology to study brain evolution, especially that of the human brain.
Social neuroscienceSocial neuroscience is an interdisciplinary field devoted to understanding how biological systems implement social processes and behavior, and to using biological concepts and methods to inform and refine theories of social processes and behavior.
Systems neuroscienceSystems neuroscience is the study of the function of neural circuits and systems.

Neuroscience organizations[edit]

The largest professional neuroscience organization is the Society for Neuroscience (SFN), which is based in the United States but includes many members from other countries. Since its founding in 1969 the SFN has grown steadily: as of 2010 it recorded 40,290 members from 83 different countries.[43] Annual meetings, held each year in a different American city, draw attendance from researchers, postdoctoral fellows, graduate students, and undergraduates, as well as educational institutions, funding agencies, publishers, and hundreds of businesses that supply products used in research.

Other major organizations devoted to neuroscience include the International Brain Research Organization (IBRO), which holds its meetings in a country from a different part of the world each year, and the Federation of European Neuroscience Societies (FENS), which holds a meeting in a different European city every two years. FENS comprises a set of 32 national-level organizations, including the British Neuroscience Association, the German Neuroscience Society (Neurowissenschaftliche Gesellschaft), and the French Société des Neurosciences. The first National Honor Society in Neuroscience, Nu Rho Psi, was founded in 2006.

In 2013, the BRAIN Initiative was announced in the US. An International Brain Initiative was created in 2017,[44] currently integrated by more than seven national-level brain research initiatives (US, EuropeAllen InstituteJapanChinaAustraliaCanadaKoreaIsrael)[45] spanning four continents.

Public education and outreach[edit]

In addition to conducting traditional research in laboratory settings, neuroscientists have also been involved in the promotion of awareness and knowledge about the nervous system among the general public and government officials. Such promotions have been done by both individual neuroscientists and large organizations. For example, individual neuroscientists have promoted neuroscience education among young students by organizing the International Brain Bee, which is an academic competition for high school or secondary school students worldwide.[46] In the United States, large organizations such as the Society for Neuroscience have promoted neuroscience education by developing a primer called Brain Facts,[47] collaborating with public school teachers to develop Neuroscience Core Concepts for K-12 teachers and students,[48] and cosponsoring a campaign with the Dana Foundation called Brain Awareness Week to increase public awareness about the progress and benefits of brain research.[49] In Canada, the CIHR Canadian National Brain Bee is held annually at McMaster University.[50]

Neuroscience educators formed Faculty for Undergraduate Neuroscience (FUN) in 1992 to share best practices and provide travel awards for undergraduates presenting at Society for Neuroscience meetings.[51]

Finally, neuroscientists have also collaborated with other education experts to study and refine educational techniques to optimize learning among students, an emerging field called educational neuroscience.[52] Federal agencies in the United States, such as the National Institute of Health (NIH)[53] and National Science Foundation (NSF),[54] have also funded research that pertains to best practices in teaching and learning of neuroscience concepts.

Nobel prizes related to neuroscience[edit]

YearPrize fieldImageLaureateLifetimeCountryRationaleRef
1904Physiology Ivan Petrovich Pavlov1849–1936Russian Empire“in recognition of his work on the physiology of digestion, through which knowledge on vital aspects of the subject has been transformed and enlarged”[55]
1906Physiology Camillo Golgi1843–1926Kingdom of Italy“in recognition of their work on the structure of the nervous system”[56]
 Santiago Ramón y Cajal1852–1934Restoration (Spain)
1914Physiology Robert Bárány1876–1936Austria-Hungary“for his work on the physiology and pathology of the vestibular apparatus”[57]
1932Physiology Charles Scott Sherrington1857–1952United Kingdom“for their discoveries regarding the functions of neurons”[58]
 Edgar Douglas Adrian1889–1977United Kingdom
1936Physiology Henry Hallett Dale1875–1968United Kingdom“for their discoveries relating to chemical transmission of nerve impulses”[59]
 Otto Loewi1873–1961Austria
1938Physiology Corneille Jean François Heymans1892–1968Belgium“for the discovery of the role played by the sinus and aortic mechanisms in the regulation of respiration[60]
1944Physiology Joseph Erlanger1874–1965United States“for their discoveries relating to the highly differentiated functions of single nerve fibres”[61]
 Herbert Spencer Gasser1888–1963United States
1949Physiology Walter Rudolf Hess1881–1973Switzerland“for his discovery of the functional organization of the interbrain as a coordinator of the activities of the internal organs”[62]
 António Caetano Egas Moniz1874–1955Portugal“for his discovery of the therapeutic value of leucotomy in certain psychoses”[62]
1957Physiology Daniel Bovet1907–1992Italy“for his discoveries relating to synthetic compounds that inhibit the action of certain body substances, and especially their action on the vascular system and the skeletal muscles”[63]
1961Physiology Georg von Békésy1899–1972United States“for his discoveries of the physical mechanism of stimulation within the cochlea”[64]
1963Physiology John Carew Eccles1903–1997Australia“for their discoveries concerning the ionic mechanisms involved in excitation and inhibition in the peripheral and central portions of the nerve cell membrane”[65]
 Alan Lloyd Hodgkin1914–1998United Kingdom
 Andrew Fielding Huxley1917–2012United Kingdom
1967Physiology Ragnar Granit1900–1991Finland
“for their discoveries concerning the primary physiological and chemical visual processes in the eye”[66]
 Haldan Keffer Hartline1903–1983United States
 George Wald1906–1997United States
1970Physiology Julius Axelrod1912–2004United States“for their discoveries concerning the humoral transmittors in the nerve terminals and the mechanism for their storage, release and inactivation”[65]
 Ulf von Euler1905–1983Sweden
 Bernard Katz1911–2003United Kingdom
1981Physiology Roger W. Sperry1913–1994United States“for his discoveries concerning the functional specialization of the cerebral hemispheres[66]
 David H. Hubel1926–2013Canada“for their discoveries concerning information processing in the visual system[66]
 Torsten N. Wiesel1924–Sweden
1986Physiology Stanley Cohen1922–United States“for their discoveries of growth factors[67]
 Rita Levi-Montalcini1909–2012Italy
1997Chemistry Jens C. Skou1918–2018Denmark“for the first discovery of an ion-transporting enzyme, Na+, K+ -ATPase”[68]
2000Physiology Arvid Carlsson1923–2018Sweden“for their discoveries concerning signal transduction in the nervous system[69]
 Paul Greengard1925–2019United States
 Eric R. Kandel1929–United States
2003Chemistry Roderick MacKinnon1956–United States“for discoveries concerning channels in cell membranes […] for structural and mechanistic studies of ion channels”[70]
2014Physiology John O’Keefe1939–United States
United Kingdom
“for their discoveries of cells that constitute a positioning system in the brain”[71]
 May-Britt Moser1963–Norway
 Edvard I. Moser1962–Norway
2017Physiology Jeffrey C. Hall1939–United States“for their discoveries of molecular mechanisms controlling the circadian rhythm[72]
 Michael Rosbash1944–United States
 Michael W. Young1949–United States

See also[edit]


  1. ^ “Neuroscience”Merriam-Webster Medical Dictionary.
  2. ^ “Neurobiology” Retrieved 2017-01-22.
  3. ^ Kandel, Eric R. (2012). Principles of Neural Science, Fifth Edition. McGraw-Hill Education. pp. I. Overall perspective. ISBN 978-0071390118.
  4. ^ Ayd, Frank J., Jr. (2000). Lexicon of Psychiatry, Neurology and the Neurosciences. Lippincott, Williams & Wilkins. p. 688. ISBN 978-0781724685.
  5. ^ Shulman, Robert G. (2013). “Neuroscience: A Multidisciplinary, Multilevel Field”Brain Imaging: What it Can (and Cannot) Tell Us About Consciousness. Oxford University Press. p. 59. ISBN 9780199838721.
  6. ^ Ogawa, Hiroto; Oka, Kotaro (2013). Methods in Neuroethological Research. Springer. p. v. ISBN 9784431543305.
  7. ^ Tanner, Kimberly D. (2006-01-01). “Issues in Neuroscience Education: Making Connections”CBE: Life Sciences Education5 (2): 85. doi:10.1187/cbe.06-04-0156ISSN 1931-7913PMC 1618510.
  8. ^ Kandel, Eric R. (2012). Principles of Neural Science, Fifth Edition. McGraw-Hill Education. p. 5. ISBN 978-0071390118The last frontier of the biological sciences – their ultimate challenge – is to understand the biological basis of consciousness and the mental processes by which we perceive, act, learn, and remember.
  9. ^ Mohamed W (2008). “The Edwin Smith Surgical Papyrus: Neuroscience in Ancient Egypt”IBRO History of Neuroscience. Retrieved 2014-07-06.
  10. ^ Herodotus (2009) [440 BCE]. The Histories: Book II (Euterpe). Translated by George Rawlinson.
  11. ^ Plato (2009) [360 BCE]. Timaeus. Translated by George Rawlinson.
  12. ^ Finger, Stanley (2001). Origins of Neuroscience: A History of Explorations into Brain Function (3rd ed.). New York: Oxford University Press, USA. pp. 3–17. ISBN 978-0-19-514694-3.
  13. ^ Finkelstein, Gabriel (2013). Emil du Bois-Reymond: Neuroscience, Self, and Society in Nineteenth-Century Germany. Cambridge; London: The MIT Press. pp. 72–74, 89–95. ISBN 9780262019507.
  14. ^ Harrison, David W. (2015). Brain Asymmetry and Neural Systems Foundations in Clinical Neuroscience and Neuropsychology. Springer International Publishing. pp. 15–16. ISBN 978-3-319-13068-2.
  15. ^ “Caton, Richard – The electric currents of the brain” Retrieved 2018-12-21.
  16. ^ Coenen, Anton; Edward Fine; Oksana Zayachkivska (2014). “Adolf Beck: A Forgotten Pioneer In Electroencephalography”. Journal of the History of the Neurosciences23 (3): 276–286. doi:10.1080/0964704x.2013.867600PMID 24735457.
  17. ^ Guillery, R (Jun 2005). “Observations of synaptic structures: origins of the neuron doctrine and its current status”Philos Trans R Soc Lond B Biol Sci360 (1458): 1281–307. doi:10.1098/rstb.2003.1459PMC 1569502PMID 16147523.
  18. ^ Greenblatt SH (1995). “Phrenology in the science and culture of the 19th century”. Neurosurgery37 (4): 790–805. doi:10.1227/00006123-199510000-00025PMID 8559310.
  19. ^ Bear MF; Connors BW; Paradiso MA (2001). Neuroscience: Exploring the Brain (2nd ed.). Philadelphia: Lippincott Williams & Wilkins. ISBN 978-0-7817-3944-3.
  20. ^ Kandel ER; Schwartz JH; Jessel TM (2000). Principles of Neural Science (4th ed.). New York: McGraw-Hill. ISBN 978-0-8385-7701-1.
  21. ^ Cowan, W.M.; Harter, D.H.; Kandel, E.R. (2000). “The emergence of modern neuroscience: Some implications for neurology and psychiatry”. Annual Review of Neuroscience23: 345–346. doi:10.1146/annurev.neuro.23.1.343PMID 10845068.
  22. ^ “James McGaugh”The history of neuroscience in autobiographyVolume4. Squire, Larry R., Society for Neuroscience. Washington DC: Society for Neuroscience. 1996. p. 410. ISBN 0916110516OCLC 36433905.
  23. ^ “History – Department of Neurobiology”.
  24. ^ “History of IBRO”International Brain Research Organization. 2010.
  25. ^ The Beginning Archived April 21, 2012, at the Wayback Machine, International Society for Neurochemistry
  26. ^ “About EBBS”European Brain and Behaviour Society. 2009. Archived from the original on 2016-03-03.
  27. ^ “About SfN”Society for Neuroscience.
  28. ^ “How can neuroscience inform economics?” (PDF). Current Opinion in Behavioral Sciences.
  29. ^ Zull, J. (2002). The art of changing the brain: Enriching the practice of teaching by exploring the biology of learning. Sterling, Virginia: Stylus Publishing, LLC
  30. ^ “What is Neuroethics?” Retrieved 2019-02-22.
  31. ^ Petoft, Arian (2015-01-05). “Neurolaw: A brief introduction”Iranian Journal of Neurology14 (1): 53–58. ISSN 2008-384XPMC 4395810PMID 25874060.
  32. ^ Fan, Xue; Markram, Henry (2019-05-07). “A Brief History of Simulation Neuroscience”Frontiers in Neuroinformatics13: 32. doi:10.3389/fninf.2019.00032ISSN 1662-5196PMC 6513977PMID 31133838.
  33. ^ U.S. National Institute of Neurological Disorders and Stroke. Brain basics: genes at work in the brain. Date last modified: 2018-12-27. [1] Retrieved Feb. 4, 2019.
  34. ^ The United States Department of Health and Human Services. Mental Health: A Report of the Surgeon General. “Chapter 2: The Fundamentals of Mental Health and Mental Illness” pp 38 [2]Retrieved May 21, 2012
  35. ^ Aragona M, Kotzalidis GD, Puzella A. (2013) The many faces of empathy, between phenomenology and neuroscience. Archives of Psychiatry and Psychotherapy, 4:5-12
  36. ^ Ofengenden, Tzofit (2014). “Memory formation and belief”(PDF). Dialogues in Philosophy, Mental and Neuro Sciences7 (2): 34–44.
  37. ^ Gordon, Ross; Ciorciari, Joseph; Van Laer, Tom (2018). “Using EEG to examine the role of attention, working memory, emotion, and imagination in narrative transportation”. European Journal of Marketing52: 92–117. doi:10.1108/EJM-12-2016-0881SSRN 2892967.
  38. ^ Lepage M (2010). “Research at the Brain Imaging Centre”Douglas Mental Health University Institute. Archived from the original on March 5, 2012.
  39. ^ Gordon E (2003). “Integrative neuroscience”. Neuropsychopharmacology. 28 Suppl 1: S2-8. doi:10.1038/sj.npp.1300136PMID 12827137.
  40. ^ Panksepp J (1990). “A role for “affective neuroscience” in understanding stress: the case of separation distress circuitry”. In Puglisi-Allegra S; Oliverio A (eds.). Psychobiology of Stress. Dordrecht, Netherlands: Kluwer Academic. pp. 41–58. ISBN 978-0-7923-0682-5.
  41. ^ Chiao, J.Y. & Ambady, N. (2007). Cultural neuroscience: Parsing universality and diversity across levels of analysis. In Kitayama, S. and Cohen, D. (Eds.) Handbook of Cultural Psychology, Guilford Press, New York, pp. 237-254.
  42. ^ 1933-, Shepherd, Gordon M. (2013-07-16). Neurogastronomy : how the brain creates flavor and why it mattersISBN 9780231159111OCLC 882238865.
  43. ^ “Financial and organizational highlights” (PDF). Society for Neuroscience. Archived from the original (PDF) on September 15, 2012.
  44. ^ “International Brain Initiative | The Kavli Foundation” Retrieved 2019-05-29.
  45. ^ Rommelfanger, Karen S.; Jeong, Sung-Jin; Ema, Arisa; Fukushi, Tamami; Kasai, Kiyoto; Ramos, Khara M.; Salles, Arleen; Singh, Ilina; Amadio, Jordan (2018). “Neuroethics Questions to Guide Ethical Research in the International Brain Initiatives”. Neuron100(1): 19–36. doi:10.1016/j.neuron.2018.09.021PMID 30308169.
  46. ^ “About the International Brain Bee”The International Brain Bee.
  47. ^ “Brain Facts: A Primer on the Brain and Nervous System”Society for Neuroscience.
  48. ^ “Neuroscience Core Concepts: The Essential Principles of Neuroscience”Society for Neuroscience. Archived from the original on April 15, 2012.
  49. ^ “Brain Awareness Week Campaign”The Dana Foundation.
  50. ^ “Official CIHR Canadian National Brain Bee Website”. Archived from the original on May 30, 2014. Retrieved 24 September 2014.
  51. ^
  52. ^ Goswami U (2004). “Neuroscience, education and special education”. Br J Spec Educ31 (4): 175–183. doi:10.1111/j.0952-3383.2004.00352.x.
  53. ^ “The SEPA Program”NIH. Archived from the original on September 20, 2011. Retrieved September 23, 2011.
  54. ^ “About Education and Human Resources”NSF. Retrieved September 23, 2011.
  55. ^ “The Nobel Prize in Physiology or Medicine 1904”. Nobel Foundation. Retrieved 28 July 2007.
  56. ^ “The Nobel Prize in Physiology or Medicine 1906”. Nobel Foundation. Retrieved 28 July 2007.
  57. ^ “The Nobel Prize in Physiology or Medicine 1914”. Nobel Foundation. Retrieved 28 July 2007.
  58. ^ “The Nobel Prize in Physiology or Medicine 1932”. Nobel Foundation. Retrieved 28 July 2007.
  59. ^ “The Nobel Prize in Physiology or Medicine 1936”. Nobel Foundation. Retrieved 28 July 2007.
  60. ^ “The Nobel Prize in Physiology or Medicine 1938”. Nobel Foundation. Archived from the original on 30 September 2007. Retrieved 28 July 2007.
  61. ^ “The Nobel Prize in Physiology or Medicine 1944”. Nobel Foundation. Retrieved 28 July 2007.
  62. Jump up to:a b “The Nobel Prize in Physiology or Medicine 1949”. Nobel Foundation. Retrieved 28 July 2007.
  63. ^ “The Nobel Prize in Physiology or Medicine 1957”. Nobel Foundation. Retrieved 28 July 2007.
  64. ^ “The Nobel Prize in Physiology or Medicine 1961”. Nobel Foundation. Retrieved 28 July 2007.
  65. Jump up to:a b “The Nobel Prize in Physiology or Medicine 1970”. Nobel Foundation.
  66. Jump up to:a b c “The Nobel Prize in Physiology or Medicine 1981”. Nobel Foundation.
  67. ^ “The Nobel Prize in Physiology or Medicine 1986”. Nobel Foundation. Archived from the original on 3 February 2014. Retrieved 28 July 2007.
  68. ^ “The Nobel Prize in Chemistry 1997”. Nobel Foundation. Retrieved 1 July 2019.
  69. ^ “The Nobel Prize in Physiology or Medicine 2000”. Nobel Foundation. Retrieved 28 July 2007.
  70. ^ “The Nobel Prize in Chemistry 2003”. Nobel Foundation. Retrieved 4 April 2019.
  71. ^ “The Nobel Prize in Physiology or Medicine 2014”. Nobel Foundation. Retrieved 7 October 2013.
  72. ^ “The Nobel Prize in Physiology or Medicine 2017”. Nobel Foundation. Retrieved 2 October 2017.

Further reading[edit]

External links[edit]

Wikiversity has learning resources about Topic: Neuroscience
Wikibooks has a book on the topic of: Neuroscience
Look up neuroscience in Wiktionary, the free dictionary.
Wikimedia Commons has media related to neuroscience.
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