CRISPR: kick-starting the revolution in drug discovery @ Cancer Research : Accelerated Tumor Progression in Mice Lacking the ATP Receptor P2X7 # 12 – Limitations of Mouse Models in Human Cancer Research – Interview with Dr. Allan Balmain @ Mouse models of lung cancer & The Life Of A Lab Rat | VICE on HBO (Bonus) & Introducing Therapy Mouse – from Mobility Research

CRISPR: kick-starting the revolution in drug discovery

Free email sign-up

About us | Advertise with us | Contact us

Login | Subscribe Free | Email Sign-up


CRISPR: kick-starting the revolution in drug discovery

Gene editing using the CRISPR system has been established as the most powerful tool in the search for new drugs and is now being exploited for therapeutic purposes. Here, Pushpanathan Muthuirulan discusses the promises and wider opportunities of using CRISPR technology to open up the possibility of large-scale screening of drug targets. He also highlights the importance of implementing CRISPR technology into clinical practice for development of next-generation therapeutics and patient-tailored medicine.

THE DRUG discovery process, in which new drug candidates are discovered and evaluated for therapeutic use, has resulted in both promising and life-saving therapies for numerous diseases including inherited genetic disorders and pathogenic infections.1 However, the discovery and testing of a new drug candidate typically takes more than a decade and the total cost associated with drug discovery processes can exceed $1 billion.2 In the United States, the drug discovery process takes an average of 12 years and in excess of $1 billion to develop a new drug.3 Furthermore, only a few drug candidates actually make it to market; the chance of a new drug actually reaching market is only one in 5,000. The high cost and lengthy effort of getting new drugs to market make the drug development process a risky endeavour for pharmaceutical companies, which consequently hinders discovery and development of new therapies. The recent emergence of genome editing technologies and advances in our understanding of human genome sequences have raised hope that direct manipulation of the genome could potentially revolutionise the process of drug discovery and therapeutics.4 In particular, new technologies like CRISPR-Cas9 are key to unlocking potential drug targets and could have a profound impact on modern drug discovery and development.1,5

To read this article in full, please complete the form below. By clicking submit you confirm that you accept our terms and conditions and privacy policy.FIRST NAME *SURNAME *JOB TITLE *ORGANISATION *TOWN/CITY *COUNTRY *EMAIL *TELEPHONE *

This content is provided to you for free thanks to the kind support of our sponsor: BMG Labtech, ForteBioI am happy for my details to be shared with the sponsors

By Dr Pushpanathan Muthuirulan (Harvard University)

13 December 2019

No comments yet




Issue #4 2019


CRISPRDisease researchDrug TargetsGenome editingGenomicsResearch & DevelopmentScreening


ancerCystic fibrosisHaemophiliaHeart diseasehereditary tyrosinemiaHIVOsteoarthritissickle cell disease

Subscription banner

Most popular…

DTR42019 Cover

Read the latest issue

All subscriptions include online membership, giving you access to the journal and exclusive content.SUBSCRIBE TODAYRELATED CONTENT


Previously unknown role of dendritic cells in inflammation revealed

By Victoria Rees (Drug Target Review)


Antibody characterisation – an essential researchers’ resource

By Nikki Withers (Drug Target Review)


Open innovation – a collaboration between academia and the pharmaceutical industry to further leverage drug discovery expertise and assets

By Dr David Murray (AstraZeneca)Dr Mark Wigglesworth (AstraZeneca)Marian Preston (AstraZeneca)


New insights into major disease pathways made with protein discovery

By Rachael Harper (Drug Target Review)

Leave a Reply

Your email address will not be published. Required fields are marked *





This site uses Akismet to reduce spam. Learn how your comment data is processed.





T: +44 (0)1959 563311
F: +44 (0)1959 563123


Drug Target Review is published by:
Russell Publishing Ltd.
Court Lodge
Hogtrough Hill
Brasted, Kent, TN16 1NU
United Kingdom

© Russell Publishing Limited, 2010-2019. All rights reserved.

Website development by e-Motive Media Limited.

Privacy Overview

This website uses cookies to improve your experience while you navigate through the website. Out of these cookies, the cookies that are categorized as necessary are stored on your browser as they are as essential for the working of basic…NecessaryAlways Enabled



  1. I precisely needed to thank you so much all over again. I am not sure the things I would’ve undertaken without those points discussed by you over such area. It truly was a very scary dilemma in my view, however , observing the very skilled mode you handled that forced me to jump with happiness. Now i am happy for this guidance and even trust you really know what a great job your are getting into training the mediocre ones using a site. I’m certain you’ve never come across all of us.


Leave a Reply

Fill in your details below or click an icon to log in: Logo

You are commenting using your account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s