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The influence of physical activity in the progression of experimental lung cancer in mice
- PMID: 22683274
- DOI: 10.1016/j.prp.2012.04.006
GRUPO_AF1 – GROUP AFA1 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO AFAN 1 – GROUP AFAN1 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO_AF2 – GROUP AFA2 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO AFAN 2 – GROUP AFAN 2 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
Slides – mestrado – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
DMBA CARCINOGEN IN EXPERIMENTAL MODELS
Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.
Copyright © 2012 Elsevier GmbH. All rights reserved.Mestrado – ´´My´´ Dissertation – Tabelas, Figuras e Gráficos – Tables, Figures and Graphics – Faculty of Medicine of Sao Jose do Rio Preto BaixarRedefine Statistical SignificanceBaixar
´´We propose to change the default P-value threshold for statistical significance from 0.05 to 0.005 for claims of new discoveries.´´ https://www.nature.com/articles/s41562-017-0189-z Published: Daniel J. Benjamin, James O. Berger, […]Valen E. Johnson Nature Human Behaviour volume 2, pages6–10 (2018)
´´My´´ Monografia – Monograph – Induction of benznidazole resistance in human Trypanosoma cruzi isolates – Indução de resistência ao benzonidazol em isolados humanos de Trypanosoma cruzi – UFTM – Federal University of Triangulo Mineiro – Uberaba
LISTA DE NOMES DE PESSOAS QUE ME DERAM FEEDBACK POSITIVO SOBRE A LISTA DE EMAILS QUE FIZ EM 2015 (PROJETO) – PEOPLE´S NAMES (POSITIVE FEEDBACK ABOUT THE EMAIL LIST I DID IN 2015) – E-MAIL LIST – LISTA DE E-MAILS – PROJECT – PESQUISA -RESEARCH
Adial Pharmaceuticals is a clinical-stage biopharmaceutical company focused on the development of a therapeutic agent for the treatment of alcohol use disorder “AUD” using our lead investigational new drug product, AD04. A Phase 2b University of Virginia investigator sponsored clinical trial of AD04 for the treatment of AUD showed promising results and no overt safety concerns (there were no statistically significant serious adverse events reported). The Company plans to commence a Phase 3 clinical trial using AD04 for the potential treatment of AUD in subjects with certain target genotypes.
´´Professor Dr. Johnson is currently the founder and Chairman of the Board of the Global Institutes on Addictions (GIA). He is also the Chief Medical Officer of Adial Pharmaceuticals, Inc. Professor Dr. Johnson (2013 – 2019) served as The Dr. Irving J. Taylor Professor and Chair in the Department of Psychiatry, Professor of Anatomy & Neurobiology, Medicine, Neurology, and Pharmacology at the University of Maryland School of Medicine. Professor Dr. Johnson’s primary area of research expertise is on ion channels, neuropsychopharmacology, molecular genetics, mathematics, neuroimaging, and medications for treating addictions. He is the world foremost authority on research and treatment of alcoholism and alcohol use disorders, with several USA patents and over 70 equivalent foreign patents. ´´
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What Happens in an Internet Minute in 2019?
Published10 months ago
onMarch 13, 2019
During an average workday, a single minute might seem negligible.
If you’re lucky, a minute might buy you enough time to write a quick email, grab a coffee from the break room, or make small talk with a coworker.
But in other situations, a minute can also be quite extraordinary. Imagine being a quarterback in the Superbowl in overtime, or finding yourself in a life-and-death situation in which every second counts towards the outcome.
Visualizing an Internet Minute
When it comes to gauging the epic scale of the internet, it would seem that each minute leans closer to the extraordinary side of the spectrum.
How is it possible that 188 millions of emails are sent every minute? How does Google process 3.8 million search queries in such a short span of time?
Simply put, the number of actions packed into just 60 seconds is extraordinary.
A Side-by-Side Comparison
The internet is incredibly dynamic, which means there are always new and interesting segments that are emerging out of the internet’s ether.
To get a sense of this, take a look at the comparison of last year’s version of this graphic with the more recent entry:
Platforms such as Instagram and Netflix continue to grow at a blistering pace, while new categories such as smart speakers are quickly building a strong foundation for the future.
Last year, for example, only 67 voice-first devices were being shipped per minute – and in 2019, there are now 180 smart speakers being shipped in the same window of time.
What will this look like in 2020?
Going Sideways or Backwards
Interestingly, even as more and more people gain access to the internet around the world each year, there are still parts of the web that are plateauing or even shrinking in size.
You’ll see that Facebook logins and Google searches both increased only incrementally from last year. Further, the amount of emails getting sent is also quite stagnant, likely thanks to to the rise of workplace collaboration tools such as Slack.
Snap is another story altogether. In the last year, the app saw a decrease in millions of users due to the infamous redesign that helped torpedo the app’s rising popularity.
Regardless, we’re certain that by this time next year, an internet minute will have changed significantly yet again!
Get your mind blown on a daily basis:Related Topics:internetscalesocial mediatechUp Next Which Countries Are Set to Attract the Highest Skilled Workers from Abroad?Don’t Miss Decentralized Finance: An Emerging Alternative to the Global Financial System
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Cents and Sounds: How Music Streaming Makes Money
This infographic explores how the music streaming industry generates almost half of the global music market’s $19.1 billion in revenue.
Published5 days ago
onDecember 20, 2019
How Music Streaming Makes Money
The global music market experienced its fourth consecutive year of growth in 2018, generating over $19 billion in revenue. Music streaming now accounts for almost half of that revenue, with 255 million paid users worldwide.
Today’s infographic from Global Web Index compares the popularity of streaming services, exploring how streaming behavior differs by age group and region.
While listeners can now gain access to an abundance of streaming options—is the success of the industry good news for everyone?
The Age of Streaming
Streaming platforms are web-based services that allow users to listen to high-definition music without having to download and store large files.
The foundations of music streaming were laid by peer-to-peer file sharing system Napster when it was created in 2001, followed by Apple’s iTunes a couple of years later. Spotify, in an attempt to combat music piracy, was founded in 2006 by Swedish duo Daniel Ek and Martin Lorentzon.
Today, 68% of adults use a music streaming service of some kind. According to Global Web Index, Gen Z leads the way with the highest average streaming times, accessing their favorite tracks across multiple platforms.
How Streaming Platforms Make Money
There are currently 33 active streaming platforms available, with a range of different features and characteristics available. Spotify and Apple Music, the largest of the streaming giants, rely on almost identical models to generate revenue:
- Paid Subscriptions: Advertising drives free users towards monthly subscription packages, which include a premium offering for $10 a month and a family offering for $15 a month.
- Advertising: Advertisers pay for exposure, with ads played every 15 minutes for 30 seconds, and can also include sponsored playlists, and homepage takeovers.
With 217 million active users, and revenues of almost $6 billion in 2018, Spotify is the global leader in music streaming.
For Spotify, 91% of the company’s revenue comes from its 100 million paid subscriptions—double that of Apple Music—while the other 9% comes from advertising.
Apple’s streaming service commands a larger user-base than Spotify in the Asia Pacific and the Middle East and Africa regions.
While Apple Music has not been a profitable move for the company, the streaming platform bolsters Apple’s ecosystem of services—encouraging a more loyal consumer base.
How Artists Make Money
For both Spotify and Apple Music, 70% of the revenue generated from paid subscriptions and advertising goes towards paying music labels and artists.
Both platforms use the pro-rata model, which pays based on the total share of streams each artist has. For example, if $100 million is generated in revenue, and an artist accounts for 1% of all streams, then they would receive $1 million in royalties.
However, artists advocate for a fairer, more user-centric model that would pay artists based on who each user listens to the most, using their subscription fee. Smaller platforms like Deezer are moving towards a user-centric model and pressuring more established platforms to do the same.
The Future of Streaming
Over the next decade, the music streaming industry will continue to transform, with new innovations presenting significant opportunities and challenges for both streaming platforms and consumers alike.
- Personalization: Streaming platforms are using technology to fully understand a user’s listening habits and to tailor music recommendations directly to them.
- Original Content: Spurred on by the growth of streaming services like Netflix and YouTube, Spotify’s purchase of Gimlet Media for over $200 million signals the beginning of streaming platforms investing in original content.
- Premium Prices: Artists and music labels are demanding more for music, forcing streaming platforms to hike their subscription rates in an attempt to make up for lost revenue.
- Live Streaming: With live streaming rising in popularity, artists can offer audiences an intimate connection and more authentic version of their music.
Currently, artists can increase their chances of being featured on more playlists and ultimately earn more money by altering their music based on streaming platform algorithms. For example, artists only get paid if their song is listened to for 30 seconds, which results in much shorter songs that open with the chorus to keep the listener’s attention.
While streaming platforms continue to provide more avenues for artists to get in front of the right ears, many industry critics argue that music is no longer about creating something for pure enjoyment, but rather about using a formulaic approach to make more money.
Is the future of music safe in the hands of tech giants?
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An Investing Megatrend: How Technological Breakthroughs are Shaping the Future
New technological breakthroughs can create massive opportunities while subsequently closing doors to old ones. Here’s what drives such innovations.
Published6 days ago
onDecember 20, 2019
Since Apple released the first iPhone in 2007, few industries have been left unaffected.
This transformational device is a prototypical example of a technological breakthrough. It was a tipping point in turning entire business models upside-down, while also impacting our everyday lives at a more fundamental level.
New growth opportunities emerged from the ensuing disruption, while many status quo solutions were rendered obsolete.
Today’s infographic from BlackRock highlights the pervasive and positive impact that technological breakthroughs can have on the global economy.
Fueling the Flames of Innovation
According to recent data from Accenture, it’s estimated that 71% of businesses are on the brink of being disrupted.
In fact, disruptive innovation most often emerges in two scenarios:
- New solutions to existing problems or challenges that have proven difficult to solve
- New competitors in highly profitable sectors with historically high returns
The occurrence of technological breakthroughs can also be accelerated through several factors, including significant demographic shifts, sustained economic growth, innovative political environments, and urgent societal needs.
Technological Adoption is Speeding Up
Breakthrough inventions have always sent ripple effects throughout society, but today those ripples are travelling faster than ever.
Moore’s Law – the assertion that number of components in a dense integrated circuit (i.e., transistors, resistors, diodes, or capacitors) will double every year, while still getting cheaper – is one factor. Similar examples of staggering increases in utility for less cost can be found in a number of other instances, from DNA sequencing to data storage.
The rate of technological adoption is also speeding up. For example, consider the mobile phone─due to the price point and ease of use, the number of U.S. adults with a cell phone jumped from 10% in 1994 to over 96% in 2019. This is also evident in new technologies such as smart speakers, where the adoption rate in the U.S. is expected to double to 55% in less than 3 years.
Breakthrough Investment Opportunities
Where innovation leads, investment usually follows. However, predicting which technological innovations will have a lasting impact on society has often proved difficult.
Instead, investors can track the wider trends that often spark technological disruption, in order to unlock potential opportunities:
- Research and Development Funding:
The number of investments in emerging technologies is growing. Tech company acquisitions also totalled US$278 billion by Q2 2018—a 50% increase from the year before.
- The Future Workforce:
Historically, productivity gains have increased the demand for more skilled labour. Technical and soft skills are top priorities for employers for their future teams, and it it’s projected that the amount of hours that workers spend using technological skills will increase by 55% from 2016 to 2030.
- Shifts in Consumer Demand:
Companies aware of these factors should seek to incorporate innovations into their platforms for a more customer-centric experience.
- Societal Needs:
Persistent global social issues such as access to better healthcare are drivers of innovative solutions that offer a better quality of life. Symphony Post-Acute Network harnessed artificial intelligence (AI) and machine learning (ML) to be able to offer personalised healthcare for over 80,000 patients─cutting costs by more than US$13,000 per patient.
Future Impact of Technological Innovation
Technological change will likely continue to accelerate, and investors should tailor their portfolios accordingly.
At the same time, traditional barriers to entry for new competitors are consistently being eroded by these breakthroughs, sending industries into flux and creating potential new opportunities.
Humanity’s co-evolution with technology will continue to profoundly impact the economy, while improving life on Earth in unimaginable ways.
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Bankole A. Johnson, DSc, MD, MPhil, FRCPsych (born 5 November 1959) is a licensed physician and board-certified psychiatrist throughout Europe and the United States who served as Alumni Professor and Chairman of the Department of Psychiatry and Neurobehavioral Sciences at the University of Virginia. Johnson’s primary area of research expertise is the psychopharmacology of medications for treating addictions, and he is well known in the field for his discovery that topiramate, a gamma-aminobutyric acid (GABA) facilitator and glutamate antagonist, is an effective treatment for alcoholism. Professor Johnson also received national media attention for his appearance in the Home Box Office (HBO) original documentary feature, “Addiction”, which won the prestigious Governors Award, a special Emmy Award, from the Academy of Television Arts and Sciences. Professor Johnson recently accepted an appointment to join the University of Maryland as the Chairman of Psychiatry and to lead a Brain Science Research Consortium in the neurosciences.
Johnson was born on 5 November 1959 in Nigeria. Johnson attended King’s College in Lagos, Nigeria and received his diploma in 1975. He then went on to Davies’ College in Sussex, England followed by the Institute Catholique de Paris in Paris, France. Johnson graduated from the University of Glasgow in Scotland in 1982 with a Medicinae Baccalaureum et Chirurgie Baccalaureum degree. He went on to train in psychiatry at the Royal London and Maudsley and Bethlem Royal Hospitals, and to train in research at the Institute of Psychiatry (University of London). In 1991, Johnson graduated from the University of London with a Master of Philosophy degree in neuropsychiatry. Johnson conducted his doctoral research at Oxford University and obtained a doctorate degree in medicine, Medicinae Doctorem, from the University of Glasgow in 1993. Most recently, in 2004, Johnson earned his Doctor of Science degree in medicine from the University of Glasgow – the highest degree that can be granted in science by a British university.
Johnson joined the faculty at the University of Texas Health Science Center in Houston in 1993 and later became the Deputy chairman for Research and Chief of the Division of Alcohol and Drug Addiction in the Department of Psychiatry at the University of Texas Health Science Center in San Antonio in 1998. In 2001, Johnson received the Dan Anderson Research Award from the Hazelden Foundation for his “distinguished contribution as a researcher who has advanced the scientific knowledge of addiction recovery.” In 2002, Johnson received the Distinguished Senior Scholar of Distinction Award from the National Medical Association. Johnson was inducted into the Texas Hall of Fame in 2003 for his contributions to science, mathematics, and technology. On 1 September 2004, Johnson accepted an appointment to serve as Alumni Professor and Chairman of the Department of Psychiatric Medicine at the University of Virginia. Johnson became a fellow of the Royal College of Psychiatrists in 2007. In 2009 Johnson was named Associate Editor of the Editorial Board of The American Journal of Psychiatry, and from 2010 to 2011 he served as Field Editor-in-Chief of Frontiers in Psychiatry.
Johnson’s research focus is on the neuropsychopharmacology of addiction. His work integrates the neuroscience and behavioural aspects of addiction medicine with the goal of formulating a more thorough understanding of the basis of drug-seeking behaviour and developing effective treatments. Central to his research is the role of and interaction between midbrain monoamine systems with a focus on serotonin, gamma-aminobutyric acid (GABA)/glutamate and dopamine.
Johnson’s Journal of the American Medical Association (JAMA) paper, titled “Topiramate for treating alcohol dependence: a randomized controlled trial” and published in 2007, gained national and international media attention. The 14-week US multi-site clinical trial involved 371 male and female alcoholics. Those patients taking topiramate had reduced heavy drinking and showed better results with lowering cholesterol, body mass index, liver enzymes, and blood pressure than those taking the placebo. The study results were featured on Reuters, MSNBC, CBS, ABC, CNN, Fox News, USA Today, the Associated Press, and many other media outlets.
Johnson’s current research involves clinical trials and human laboratory studies, and includes neuroimaging and molecular genetics. He now incorporates neuroimaging evaluations into his drug interaction studies to identify the site-specific effects of abused drugs and to evaluate the effectiveness of potential medications for the treatment of addiction. Current studies include a clinical trial aimed at determining the effectiveness of ondansetron, a serotonin-3 antagonist, for the treatment of subtypes of alcoholics, as well as a human laboratory project trying to elucidate the effects of naltrexone and acamprosate on hepatic and renal function in alcohol-dependent individuals.
Honors and awards
- Inductee, Texas Hall of Fame for Science, Mathematics and Technology, 2003
- Appointed to the National Advisory Council for NIH/NIDA, 2004 – 2007
- Member, Medications Development Subcommittee of NIDA’s Advisory Council on Drug Abuse, 2004 – 2007
- Member, Extramural Advisory Board for NIH/NIAAA, 2004 – present
- Member, Medications Development Scientific Advisory Board for NIH/NIDA, 2005 – 2009
- American Psychiatric Association Distinguished Psychiatrist Lecturer Award, 2006 (for outstanding achievement in the field of psychiatry as an educator, researcher, and clinician)
- NIH Roadmap Consultant, 2006 – present
- Listed in “Best Doctors in America”, 2007, 2009–2010
- Fellow, Royal College of Psychiatrists, 2007 – present
- Distinguished Fellow, American Psychiatric Association, 2008 – present
- American Psychiatric Association, Solomon Carter Fuller Award, 2009
- Fellow, American College of Neuropsychopharmacology, 2010 – present
- Jack Mendelson Award, NIAAA – 2013
- ^ Johnson BA, Ait-Daoud N, Bowden CL, et al. 2003. Oral topiramate for treatment of alcohol dependence: A randomised controlled trial. Lancet 361, 1677–1685
- ^ “NIH received two emmy awards for the addiction project” 16 September 2007. http://www.medicalnewstoday.com/articles/82613.php
- ^ “Drs. Bankole Johnson, Wen-Hwa Lee join luminaries in Texas Hall of Fame”. February 2003. http://www.uthscsa.edu/mission/article.asp?id=123
- ^ “Dr. Bankole Johnson, new chairman of Psychiatric Medicine”. 2004. “Archived copy”. Archived from the original on 24 July 2008. Retrieved 2008-11-10.
- ^ Johnson BA, Rosenthal N, Capece JA, et al. 2008. Improvement of physical health and quality of life of alcohol-dependent individuals with topiramate treatment: US multisite randomized controlled trial. Archives of Internal Medicine. 168: 1188–1199.
- ^ “A pill to cure alcoholism? A new treatment may offer hope to millions of people battling alcohol addiction” 13 June 2008. http://health.usnews.com/articles/health/2008/06/13/a-pill-to-cure-alcoholism.html
- ^ “Topiramate may help treat alcohol dependence” 10 October 2007. http://www.medicalnewstoday.com/printerfriendlynews.php?newsid=85202
- ^ “Study: Migraine pill helps some alcoholics taper off” 9 October 2007. “Archived copy”. Archived from the original on 19 December 2008. Retrieved 2008-11-10.
- ^ “Pill helps alcoholics taper off drinking” 9 October 2007. http://www.foxnews.com/printer_friendly_wires/2007Oct09/0,4675,AlcoholismPill,00.html
- ^ “Migraine drug may treat alcoholism, too” 9 October 2007. http://abcnews.go.com/Health/Drugs/story?id=3708419&page=1
- ^ “Migraine pill helps curb drinking without detox: New approach called promising, but side effects still a problem, study finds” 9 October 2007. http://www.nbcnews.com/id/21209314
- University of Virginia: http://www.healthsystem.virginia.edu/internet/psychiatric/staffandfaculty/research.cfm?uva_id=bj4x&hideintro=1
- The Excelsior Program: http://www.medicine.virginia.edu/clinical/departments/psychiatry/patients/excelsior
- HBO Addiction Film Series: “Addiction”: http://www.hbo.com/addiction/thefilm/centerpiece/618_segment_7.html
- Frontiers in Psychiatry: https://web.archive.org/web/20100211141806/http://frontiersin.org/psychiatry/psychiatry/missionstatement/
- University of Maryland: http://somvweb.som.umaryland.edu/absolutenm/templates/?a=2446&z=41
- 1959 births
- Bipolar disorder researchers
- Nigerian psychiatrists
- Alumni of the University of Glasgow
- Alumni of the University of London
- Alumni of the University of Oxford
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- University of Virginia School of Medicine faculty
- Science writers
- Living people
- Yoruba physicians
- Fellows of the Royal College of Psychiatrists
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