Microsoft paid $26 billion for LinkedIn, then mostly left it alone—and CEO Jeff Weiner is good with that – Microsoft closed its $26.2 billion LinkedIn acquisition three years ago this month @ Best Global Brands 2019 Rankings @ Amazon beats Apple and Google to become the world’s most valuable brand at $315.5 billion & LinkedIn message for me from my LinkedIn contact Dr. Sheraz Khan, Instructor at Massachusetts General Hospital (MGH) and Harvard Medical School @ Some videos, links, websites and images @ Top 10 Best Universities In The World 2019 & Top 100 University In The World Ranking 2019 @ Top 100 QS World University Rankings in 2020 (2020年世界大學前100排名) & Information teleported between two computer chips for the first time @ Facebook message for me

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Do the downloads!! Share!! The diffusion of very important information and knowledge is essential for the world progress always!! Thanks!!

  • – – > > Mestrado – Dissertation – Tabelas, Figuras e Gráficos – Tables, Figures and Graphics – ´´My´´ Dissertation #Innovation #Countries #Time #Researches #Reference #Graphics #Ages #Age #Mice #People #Person #Mouse #Genetics #PersonalizedMedicine #Diagnosis #Prognosis #Treatment #Disease #UnknownDiseases #Future #VeryEfficientDrugs #VeryEfficientVaccines #VeryEfficientTherapeuticalSubstances #Tests #Laboratories #Investments #Details #HumanLongevity #DNA #Cell #Memory #Physiology #Nanomedicine #Nanotechnology #Biochemistry #NewMedicalDevices #GeneticEngineering #Internet #History #Science #World

Pathol Res Pract. 2012 Jul 15;208(7):377-81. doi: 10.1016/j.prp.2012.04.006. Epub 2012 Jun 8.

The influence of physical activity in the progression of experimental lung cancer in mice

Renato Batista Paceli 1, Rodrigo Nunes Cal, Carlos Henrique Ferreira dos Santos, José Antonio Cordeiro, Cassiano Merussi Neiva, Kazuo Kawano Nagamine, Patrícia Maluf Cury


Impact_Fator-wise_Top100Science_Journals

GRUPO_AF1 – GROUP AFA1 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 1 – GROUP AFAN1 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO_AF2 – GROUP AFA2 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 2 – GROUP AFAN 2 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

Slides – mestrado – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

CARCINÓGENO DMBA EM MODELOS EXPERIMENTAIS

DMBA CARCINOGEN IN EXPERIMENTAL MODELS

Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

https://pubmed.ncbi.nlm.nih.gov/22683274/

Abstract

Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.

´´We propose to change the default P-value threshold for statistical significance from 0.05 to 0.005 for claims of new discoveries.´´ https://www.nature.com/articles/s41562-017-0189-z Published:  Daniel J. Benjamin, James O. Berger, […]Valen E. Johnson Nature Human Behaviour volume 2, pages6–10 (2018)

Um mundo além de p < 0,05 « Sandra Merlo – Fonoaudiologia da Fluência

´´My´´ Monografia – Monograph – Induction of benznidazole resistance in human Trypanosoma cruzi isolates – Indução de resistência ao benzonidazol em isolados humanos de Trypanosoma cruzi – UFTM – Federal University of Triangulo Mineiro – Uberaba 

Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo

Article – ´´My´´ dissertation – Faculty of Medicine of Sao Jose do Rio Preto

Feedback positivo de pessoas sobre minha dissertação pelo Messenger – Facebook. Positive feedback of people about my dissertation, blog and YouTube channel by Facebook – Messenger. Year – Ano: 2018

LISTA DE NOMES DE PESSOAS QUE ME DERAM FEEDBACK POSITIVO SOBRE A LISTA DE EMAILS QUE FIZ EM 2015 (PROJETO) – PEOPLE´S NAMES (POSITIVE FEEDBACK ABOUT THE EMAIL LIST I DID IN 2015) – E-MAIL LIST – LISTA DE E-MAILS – PROJECT – PESQUISA -RESEARCH

My suggestion of a very important Project…

Apostila – Pubmed

A Psicossomática Psicanalítica – Faculty of Medicine of Sao Jose do Rio Preto

ÁCIDO HIALURÔNICO – HIALURONIC ACID – Faculty of Medicine of Sao Jose do Rio Preto

Slides – Mestrado final – ´´My´´ dissertation – Faculty of Medicine of Sao Jose do Rio Preto

Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo

O Homem como Sujeito da Realidade da Saúde – Redação – Faculty of Medicine of Sao Jose do Rio Preto

Aula_Resultados – Results – FAMERP – Faculty of Medicine of Sao Jose do Rio Preto

As credenciais da ciência – The credentials of Science – Faculty of Medicine of Sao Jose do Rio Preto BaixarFrases que digitei – Phrases I typed

Frases que digitei – Tecnologia – Informations about blog I did

Keynote-The-Future-of-Space-Exploration(1)

2019-01-hormone-alzheimer(1)

mojap-02-00034

ajpheart.00349.2013

aging – animal models

Nanomedicine an evolving research (Opinion article I typed)

journal-of-nanomedicine–nanotechnology-flyer

Will you embrace AI fast enough

MICROBIOLOGIA – MICROBIOLOGY – Faculty of Medicine of Sao Jose do Rio Preto

Genes e Epilepsia – Genes and epilepsy – Faculty of Medicine of Sao Jose do Rio Preto

Dr.A.M.S

Flav_R03

BIOGRAFIA – BIOGRAPH – DR. DOMINGO MARCOLINO BRAILE

p-Value – Valor de p

european-respiratory-society

redefine-statistical-significance

https://www.facebook.com/rethinkbiology/

https://www.facebook.com/groups/233625514114242/?source_id=114684782561519

https://newatlas.com/quantum-computing/quantum-teleportation-computer-chips/?fbclid=IwAR1AQnMR6xfM2NKCAehra2HkL7IpEGkrcfW7oypuKsIxaf4tvUrgZZZTVR0

https://time.com/

https://www.youtube.com/user/Harvard

https://www.youtube.com/user/harvardmedicalschool

https://hms.harvard.edu/

https://www.guinnessworldrecords.com.br/

http://www.linkedin.com http://www.google.com http://www.gmail.com http://www.yahoo.com http://www.forbes.com http://www.harvard.edu http://www.mit.edu http://www.ucla.edu http://www.nobelprize.org http://www.nasa.gov http://www.stanford.edu http://www.caltech.edu http://www.facebook.com http://www.twitter.com http://www.youtube.com http://www.instagram.com http://www.facebook.com/scientificblog http://www.wordpress.com http://www.science1984.wordpress.com http://www.princeton.edu http://www.ox.ac.uk/ https://www.cam.ac.uk/ https://www.manchester.ac.uk/ https://www.energy.gov/ https://www.usa.gov/ https://www.darpa.mil/ https://www.timeshighereducation.com/world-university-rankings/2019/world-ranking https://www.topuniversities.com/subject-rankings/2019 https://www.wikipedia.org/ https://exame.abril.com.br/

https://www.linkedin.com/in/rodrigo-nunes-cal-81433b168/

  • Sheraz Khan
  •  Conexão de 1º grau1º
  • Sheraz tem uma conta

Digital Medicine, Drug Development, Real World Evidence, Data Science, Faculty at Harvard

Contact

Harvard University
Massachusetts General Hospital
Massachusetts Institute of Technology (MIT)

Cell: +1 339-221-6501
Tel:  +1 617-643-5634
Fax: +1 617-948-5966
sheraz@nmr.mgh.harvard.edu
sheraz@mit.edu

Khan Lab: http://khan.mit.edu

   sheraz@mit.edu

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http://sheraz.mit.edu/funding

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https://www.linkedin.com/in/sherazmit/

https://www.cnbc.com/2019/06/11/amazon-beats-apple-and-google-to-become-the-worlds-most-valuable-brand.html

Best Brands

https://www.cnbc.com/2019/12/27/linkedin-ceo-jeff-weiner-is-ok-with-microsofts-hands-off-approach.html

The world’s most valuable brands 2019

  1. Amazon $315.5 billion
  2. Apple $309.5 billion
  3. Google $309 billion
  4. Microsoft $251.2 billion
  5. Visa $177.9 billion
  6. Facebook $159 billion
  7. Alibaba $131.2 billion
  8. Tencent $130.9 billion
  9. McDonald’s $130.4 billion
  10. AT&T $108.4 billion

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Microsoft paid $26 billion for LinkedIn, then mostly left it alone—and CEO Jeff Weiner is good with that

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Microsoft paid $26 billion for LinkedIn, then mostly left it alone—and CEO Jeff Weiner is good with that

PUBLISHED FRI, DEC 27 20192:36 PM ESTUPDATED 4 HOURS AGOJordan Novet@JORDANNOVET

KEY POINTS

  • Microsoft closed its $26.2 billion LinkedIn acquisition three years ago this month.
  • LinkedIn has done some things to integrate with its parent, and more tie-ins are coming.

LinkedIn CEO Jeff Weiner participates in a question-and-answer interview during the seventh annual Washington Ideas Forum at the Harman Center for the Arts October 1, 2015 in Washington, DC.Chip Somodevilla | Getty Images News | Getty Images

Microsoft told investors what it could do with LinkedIn in a PowerPoint presentation it showed on the day the $26.2 billion deal was announced. It was June 13, 2016.

Some of those ideas have been implemented since the deal was finalized, three years ago this month. Others are still on the way, LinkedIn CEO Jeff Weiner told CNBC in an interview this fall at his office in Sunnyvale, California.

He turned to the Microsoft Surface Studio PC on his desk, brought up Microsoft’s Outlook email service in a browser window and then, with a few clicks, accessed information from LinkedIn about people with whom he had exchanged messages.

“It’s a really powerful way to just stay in touch and to just understand who’s reaching out and what they’re up to,” said Weiner, who became LinkedIn’s CEO in 2009, a year after joining the company from Yahoo.

Although that integration exists on the web and in Outlook’s iOS app, other promises have yet to materialize, such as an “Intelligent Newsfeed” in LinkedIn that draws from information in Office apps, and tools for managers to understand what their employees are doing at work.

The slowness points to Microsoft’s current desire to not screw up its biggest acquisition yet, suggesting a change in approach under CEO Satya Nadella.

Microsoft has had acquisitions go wrong in the past.

In 2012 Microsoft announced a $6.2 billion write-down of goodwill that was mostly related to aQuantive, a digital advertising company it had bought for $6.3 billion in 2007 in its biggest transaction yet at the time. Microsoft posted its first-ever quarterly loss as a result of the write-down.

Microsoft also reported a quarterly loss in 2015 after announcing $8.3 billion in charges tied to the restructuring of its phone hardware business, following Microsoft’s $9.5 billion purchase of Nokia Devices and Services business.

Both of those deals were signed before Nadella replaced Steve Ballmer as CEO in 2014.

“Of course, we’ll learn from the past,” said Nadella about LinkedIn — he spoke from experience, as one of the executives responsible for Microsoft’s advertising push following the close of the aQuantive deal.

Amy Hood, Microsoft’s finance chief, said the main goal of the acquisition was to accelerate growth at LinkedIn, as well as the Office 365 and Dynamics 365 product lines.

As part of the deal, LinkedIn got to retain its independence and Weiner remained in charge. Weiner received a spot on Microsoft’s senior leadership team and started reporting directly to Nadella, while keeping his CEO title.

“Satya has made good on every single thing we talked about prior to the acquisition,” Weiner said.

Microsoft took a somewhat similar approach with its $7.5 billion acquisition last year of code-sharing service GitHub, emphasizing that it would run independently. It tapped Nat Friedman, formerly CEO of mobile development start-up Xamarin, which Microsoft bought in 2016, to run GitHub, as GitHub had previously said it was looking for a new leader.

On the day the GitHub acquisition was announced, Friedman said Microsoft technologies would come to GitHub’s marketplace, while GitHub would bring new capabilities to Microsoft’s Visual Studio Code text editor.

A long time horizon for integration

LinkedIn was a special asset. Salesforce also wanted to buy it, and a months-long bidding war ensued. Following the loss, Salesforce CEO Marc Benioff suggested Microsoft’s plans to bundle LinkedIn data with other products were anticompetitive.

Three years after the deal closed, Benioff’s worst fears have not come true. By and large, LinkedIn still operates as a separate entity from the rest of the company.

But Weiner says it’s still early.

“We have a members-first approach,” he said. “So it’s all about making sure we’re maintaining the trust of our membership. Microsoft has a very similar ethos with regard to how they secure the data of their customers, and just being very thoughtful in terms of the right way to roll this out and make sure that we create the right experience. So there’s just been a lot of testing happening.”

Potential integrations were definitely part of Microsoft’s original pitch for buying the company. The presentation featured six “illustrations” of the two companies’ products coming together:

  • A connection between LinkedIn’s Sales Navigator and Microsoft Dynamics sales software. This technology is available, and teams have enhanced the connection between the services. People can also use Sales Navigator data in Microsoft’s PowerApps and Power BI tools.
  • A unified professional profile that would show LinkedIn details in Windows and Office applications. Microsoft has made inroads here, and the LinkedIn integration will be coming to the Outlook app for Android in 2020.
  • An “Intelligent Newsfeed” in LinkedIn that draws on activity from Microsoft Office apps. This isn’t available today, although LinkedIn has tapped Microsoft services such as translation to enhance the feed.
  • Microsoft’s Cortana virtual assistant telling users about relevant LinkedIn information. This isn’t available today.
  • Tools that managers can use to better understand employees’ work activity. This isn’t available today.
  • LinkedIn Learning content inside Office applications. This isn’t available today, but Weiner said bringing Learning content to Office apps “feels like it makes a lot of sense.”

In addition, during a CNBC appearance alongside Nadella on acquisition day, Weiner mentioned several Microsoft products that it would be “incredibly exciting” to integrate with, including Active Directory and Skype. To date LinkedIn has not touted integrations with those things.

During that appearance, one Microsoft product Weiner didn’t talk about integrating with was the Azure public cloud, which competes with market leader Amazon Web Services. Earlier this year, though, LinkedIn said it would adopt Azure after depending on its own infrastructure for years.

The move to Azure could enable additional integration points.

“We’re going to be building out an infrastructural capability on Azure so that Microsoft customers, in a private, in a secure, in a trusted environment, are going to be able to leverage LinkedIn data relevant to their employees with their own data as an organization,” Weiner said. “And when you start to commingle that data, it becomes more valuable. So organizations will be able to run analysis and queries, and there’s some really interesting things that can be done on that front.”

Internally, Microsoft recently deployed a new version of its corporate directory, called Who Plus, that draws on LinkedIn, Weiner said. LinkedIn could turn that integration into a product for non-Microsoft employees to use, he said.

Weiner said LinkedIn profile information will become available in more of Microsoft’s Outlook applications, including the Android app. And LinkedIn can improve the existing Outlook integrations.

“Once we’ve nailed that, we can potentially expand that into other Office applications, especially as Office continues to grow its collaborative capabilities — the ability to see who you’re talking to, who you’re contacting, who’s reaching out to you, who you need to reach out to by virtue of their skills, their knowledge, etc. I think that can create a lot of value for folks,” Weiner said.

Weiner said the team is still thinking about how to integrate LinkedIn more into Windows, which is one of the less prominent possibilities Microsoft originally pointed to in its 2016 presentation to investors. He talked about enabling the right kind of news experience and delivering “active notifications.”

Little change but steady growth

So far, though, LinkedIn doesn’t appear to have changed all that much for end users. But it might not need to.

LinkedIn is still growing its user base — there are now 660 million members, up 52% from when Microsoft bought it — and LinkedIn contributed $6.75 billion in revenue in the 2019 fiscal year (which ended June 30), up 28.4% on an annualized basis. Although revenue growth hasn’t exploded under Microsoft, ranging between 25% and 37% since 2018, growth was slowing down significantly when Microsoft bought it.

Weiner says its performance is ahead of plan for the last three years.

“One thing I know is that by virtue of becoming a part of Microsoft, we were almost immediately able to focus increasingly on a longer-term horizon, and not be as focused on the immediate term, on the quarter-to-quarter performance,” he said. “At the time of the close and shortly thereafter, at least for the first couple of quarters, our growth continued to decelerate. It was a couple of quarters later that it started to stabilize. And then it started to meaningfully accelerate.”

He continued, “So, if we were still public and there was that deceleration, what kind of response would we have seen from the Street? How would that have impacted the company? How would that have impacted our talent? It’s hard to say. But — didn’t happen, so don’t spend a lot of time thinking about it.”

LinkedIn also hasn’t done much for Microsoft’s bottom line. In its fiscal year ended June 2018, Microsoft said that LinkedIn’s fiscal-year operating loss widened by $63 million to $987 million — a drop in the bucket compared with Microsoft’s overall net income of $16.57 billion that year. The company didn’t provide an update on LinkedIn’s profit or loss this year.

Weiner said LinkedIn could improve its profitability by modernizing its billing infrastructure.

The LinkedIn and Microsoft sales teams could also work more closely.

“I think there’s opportunities to do that where we have a different customer set and different customer relationships, where Microsoft can potentially open doors by virtue of their relationships,” Weiner said.

WATCH: LinkedIn CEO on the company’s growth and the state of the US economyVIDEO03:52LinkedIn CEO on the company’s growth and the state of the US economy

Follow @CNBCtech on Twitter for the latest tech industry news.TRENDING NOW

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  3. Bill Gates sent an 81-pound package to his Reddit Secret Santa—here’s what was inside
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      Amazon beats Apple and Google to become the world’s most valuable brand

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      Amazon beats Apple and Google to become the world’s most valuable brand

      PUBLISHED TUE, JUN 11 20193:16 AM EDTUPDATED TUE, JUN 11 20195:43 AM EDTLucy Handley@LUCYHANDLEY

      KEY POINTS

      • Amazon has overtaken Google and Apple to become the world’s most valuable brand at $315.5 billion.
      • Apple comes second, valued at $309.5 billion
      • Google is in third place, at $309 billion.
      GP: Amazon 190329 ASIA

      View of Amazon officeNurPhoto | Getty Images

      Amazon has overtaken Google and Apple to become the world’s most valuable brand at $315.5 billion, according to a ranking of global companies, up 52% on last year.

      Apple comes second, valued at $309.5 billion, with Google in third place, at $309 billion, according to the BrandZ Top 100 Most Valuable Global Brand ranking 2019, compiled by WPP research agency Kantar and released Tuesday.

      Google and Apple had spent a combined 12 years at the top of the list, with Google taking the top spot in 2018.

      Doreen Wang, Kantar’s global head of BrandZ, said Amazon’s jump was due to it selling a variety of services. “Amazon’s phenomenal brand value growth of almost $108 billion in the last year demonstrates how brands are now less anchored to individual categories and regions. The boundaries are blurring as technology fluency allow brands, such as Amazon, Google and Alibaba, to offer a range of services across multiple consumer touchpoints,” she said in a statement emailed to CNBC.

      Amazon has been increasing investments in a range of companies as its core business slows, including self-driving car start-up Aurora and electric truck company Rivian, as well as expanding Amazon Air, its airplane business. It bought online pharmacy PillPack for $753 million in 2018 and last month led a $575 million funding round into food delivery company Deliveroo.

      WATCH NOWVIDEO03:15Amazon tops list of most valuable brands for first time in 12 years

      Four of the BrandZ top ten were made up of more traditional brands including Visa, McDonald’s and AT&T. Microsoft comes in at fourth place, as it did in 2018.

      Technology companies have always dominated the ranking, with Microsoft taking the top spot when BrandZ began in 2006. This year, Alibaba (valued at $131.2 billion) overtook Tencent ($130.9 billion) to become the most valuable Chinese brand. There is a total of 15 Chinese brands in the list of 100 companies, including mobile handset company Xiaomi (valued at $19.8 billion) and Meituan ($18.8 billion), a tech platform people can use to order food deliveries, book hotel rooms and arrange bike rentals.

      David Roth, chair of BrandZ, said the companies that did well were those that mastered this new model of different services. “Brands need to understand the value this type of model can create and should embrace its approach to be successful in the future,” he said in an emailed statement.

      Tech, finance and retail brands dominate the overall ranking, making up more than two-thirds of its value, while luxury is the fastest-growing category.

      To qualify for the ranking, brands must be publicly traded, or publish their financial results. BrandZ’s list combines measures of brand equity based on interviews with more than 3 million consumers about thousands of brands, with analysis of each company’s business and financial performance, using data from Kantar Worldpanel.

      The world’s most valuable brands 2019

      1. Amazon $315.5 billion
      2. Apple $309.5 billion
      3. Google $309 billion
      4. Microsoft $251.2 billion
      5. Visa $177.9 billion
      6. Facebook $159 billion
      7. Alibaba $131.2 billion
      8. Tencent $130.9 billion
      9. McDonald’s $130.4 billion
      10. AT&T $108.4 billion

      Source: BrandZTRENDING NOW

      1. Elizabeth Warren’s campaign sounds the alarm as fundraising slows about 30% in fourth quarter
      2. This is why filing your income tax return will never be the same
      3. Bill Gates sent an 81-pound package to his Reddit Secret Santa—here’s what was inside
      4. Russia claims its new hypersonic weapon is ready for war
      5. Democrats need to accept these 3 truths to beat Trump in 2020

      by TaboolaSponsored LinksFROM THE WEBO jogo mais viciante do ano!Forge of Empires – Jogo Online GrátisGenius Japanese Invention Allows You To Instantly Speak 43 LanguagesInstant Voice Translator

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      • Sheraz Khan
      •  Conexão de 1º grau1º
      • Sheraz tem uma conta

      Digital Medicine, Drug Development, Real World Evidence, Data Science, Faculty at Harvard

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      Dr. Khan is the director of the Khan Lab @ Harvard, MGH and MIT (http://khan.mit.edu). Khan Lab develops digital biomarkers for accurately & objectively assessing neurodevelopmental and neurodegenerative disorders.

      From digital health tools to mobile applications for drug development, Khan Lab provides best in class, interactive and innovative digital assessment technologies that capture meaningful and patient relevant data. 

      Artigos e atividade

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      Maturation Trajectories of Cortical Resting-State Networks Depend on the Mediating Frequency BandSheraz KhanPublicado no LinkedInIn this study, we mapped graph theory based large-scale characteristics of developing resting state brain networks using magnetoencephalography (MEG), which has a millisecond time resolution, in 131 subjects, ages 7-29. Using this approach, we discovered previously un-mapped frequency-dependent properties of the maturation trajectories of resting state networks. Most notably we found: Beta and gamma band mediated networks followed distinct maturation trajectories; Short-range local functional connectivity increased with age in beta band mediated networks, promoting network segregation, whereas long-range global connectivity increased in gamma band mediated networks, promoting integration across distinct cortical regions. Contrary to prior studies, we found that small world property (a measure of the optimization of the balance between global and local connectivity) of brain networks did change with development, but in opposite directions for the beta and gamma band mediated networks. The same was true for network resilience (vulnerability of brain networks), a network property that is likely relevant to onset and trajectory of psychiatric disease. Using machine learning, we showed that the maturation trajectory is actually composed of two distinct curves. While the gamma band mediated resting state, networks followed an asymptotic trajectory, in contrast beta band mediated networks remained linear through age 29, and did not asymptote even in adulthood. The combined results accounted for 55% of the variance in the data. Preprint for the Study: https://www.biorxiv.org/content/early/2018/02/13/264416

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      Experiência

      • InstructorNome da empresaHarvard Medical SchoolPeríodo2015 – o momentoDuração do emprego4 anosLocalidadeBoston, MA• Developed and maintained platform independent and open source python-packages for analyzing large scale neuroimaging datasets, currently being used by over 100 labs across the world
        • Developed and maintained high performance computing and big data storage infrastructure at both local and cloud level (AWS)
        • Conceptualized and conducted neuroimaging experiments; Acquired functional and structural data from electroencephalography (EEG), MEG and MRI, from healthy and autistic populations
        • Fused information from various neuroimaging modalities in single multivariate Bayesian model for easy inference
        • Analyzed multimodal neuroimaging data to investigate how autistic brains differ functionally and structurally. Connectivity features were used to build classification and regression models to diagnose autism and its severity
        • Discovered that both local and long range functional connectivity during face processing differ between autistic and typically developing children, and are potential biomarkers for autism. Developed a discriminative linear discriminant classifier for detection of Autism. These findings were published in PNAS and were widely reported in media. As of 2017 this is one of the most cited autism MEG study
        • Discovered that functional connectivity in autism during motor and somatosensory processing were both abnormally increased and decreased simultaneously, depending upon directionality of connectivity stream. These findings were published in BRAIN
        • Analyzed large human resting state neuroimaging dataset consisting of more than one billion sample points. This cross sectional multi-modal neuroimaging (MEG, EEG, and MRI) and behavioral dataset contained more than 1000 subjects spread across the entire human life span from 4 to 90 year. Developed a discriminative random forest regression model from this data to detect early markers of neurodegenerative disorders
        • Published and communicated research findings in high impact journals and top conferences…visualizar mais
      • Graduate ResearcherNome da empresaEcole Polytechnique, Pitié-Salpêtrière HospitalPeríodoago de 2006 – set de 2009Duração do emprego3 anos 2 mesesLocalidadeParis Area, France• Extended mathematical framework of optical flow and Helmholtz-Hodge decomposition (image processing techniques currently use extensively in stereo computer vision and self driving cars) to non-flat surfaces using Riemannian manifold embedding
        • Developed and maintained Matlab based toolbox for 2-Riemannian optical flow
        • Supported and extended brainstorm (https://github.com/brainstorm-tools/brainstorm3); Matlab based MEG/EEG processing toolbox
        • Designed and conducted MEG, EEG and ECoG experiments to investigate high Frequency oscillations in epileptic patients
        • Developed models to detect epileptogenic foci by finding critical points in divergence scalar field estimated by decomposing optical flow motion field using Helmholtz-Hodge decomposition
        • Provided technical and software support to MEG users and wrote user manuals…visualizar mais

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      I am graduated in biomedicine (2003-2007), Master´s Degree in lung cancer research in mice (2008-2012) and nowadays I work as Inspector of students since 2012. Maybe I can do a doctorate to work as professor and researcher abroad or in Brazil.

      My blog: http://www.science1984.wordpress.com There are very important, updated and interesting information! There are 832 posts, 85 followers and 5.4 thousands of comments approved by me. I started to elaborate it in 2018. The blog content is very good with very high quality. Many people of different countries have visited it.

      I never earned money with blogs I did and social networkings for example.

      The human expectancy of life needs to increase so much faster in a short time with more efficient and detailed researches.

      Twitter: @CalZole
      Instagram: @rodrigoncal84 @calrodrigonunes
      E-mails: rodrigonunescal@yahoo.com rodrigoncal1984@gmail.com
      Curriculum Lattes: http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4240145A2

      I was invited by Internet through direct message to participate in 73 very important events in 32 cities of different countries in less than 2 years because of the relevant researches I participated in Brazil. My dissertation and monograph were very important and innovative researches.

      I typed an opinion article: Nanomedicine: An Evolving Research that was published in the Journal of Nanomedicine & Biotherapeutic Discovery: https://www.longdom.org/open-access/nanomedicine–an-evolving-research-2155-983X-1000160.pdf I did not know about the credibility of this journal. I did not received any money for it.

      I did very important graphics about variations of all mice weights during all experimental time related to my dissertation but they aren´t in the scientific article about my dissertation nor in my dissertation as well as details of exercise time and rest of the animals. The influence of physical activity in the progression of experimental lung cancer in mice – Pathol Res Pract. 2012 Jul 15; 208 (7): 377-81. These data can be an excellent reference for researches.

      The age of the human, of the animal and the genetics influence in certain ways in the physiology and in other aspects.
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      Show SearchQUANTUM COMPUTING

      Information teleported between two computer chips for the first time

      By Michael IrvingDecember 26, 2019

      Researchers have managed to quantum teleport information between two computer chips for the first time

      Researchers have managed to quantum teleport information between two computer chips for the first timenicholashan/DepositphotosVIEW 1 IMAGES

      Scientists at the University of Bristol and the Technical University of Denmark have achieved quantum teleportation between two computer chips for the first time. The team managed to send information from one chip to another instantly without them being physically or electronically connected, in a feat that opens the door for quantum computers and quantum internet.

      This kind of teleportation is made possible by a phenomenon called quantum entanglement, where two particles become so entwined with each other that they can “communicate” over long distances. Changing the properties of one particle will cause the other to instantly change too, no matter how much space separates the two of them. In essence, information is being teleported between them.

      Hypothetically, there’s no limit to the distance over which quantum teleportation can operate – and that raises some strange implications that puzzled even Einstein himself. Our current understanding of physics says that nothing can travel faster than the speed of light, and yet, with quantum teleportation, information appears to break that speed limit. Einstein dubbed it “spooky action at a distance.”

      Harnessing this phenomenon could clearly be beneficial, and the new study helps bring that closer to reality. The team generated pairs of entangled photons on the chips, and then made a quantum measurement of one. This observation changes the state of the photon, and those changes are then instantly applied to the partner photon in the other chip.

      “We were able to demonstrate a high-quality entanglement link across two chips in the lab, where photons on either chip share a single quantum state,” says Dan Llewellyn, co-author of the study. “Each chip was then fully programmed to perform a range of demonstrations which utilize the entanglement. The flagship demonstration was a two-chip teleportation experiment, whereby the individual quantum state of a particle is transmitted across the two chips after a quantum measurement is performed. This measurement utilizes the strange behavior of quantum physics, which simultaneously collapses the entanglement link and transfers the particle state to another particle already on the receiver chip.”

      The team reported a teleportation success rate of 91 percent, and managed to perform some other functions that will be important for quantum computing. That includes entanglement swapping (where states can be passed between particles that have never directly interacted via a mediator), and entangling as many as four photons together.

      Information has been teleported over much longer distances before – first across a room, then 25 km (15.5 mi), then 100 km (62 mi), and eventually over 1,200 km (746 mi) via satellite. It’s also been done between different parts of a single computer chip before, but teleporting between two different chips is a major breakthrough for quantum computing.

      The research was published in the journal Nature Physics.

      Source: University of Bristol

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      Michael IrvingMichael has always been fascinated by space, technology, dinosaurs, and the weirder mysteries the universe. With a Bachelor of Arts in Professional Writing and several years experience under his belt, he joined New Atlas as a staff writer in 2016.8 COMMENTSSign in to post a comment.RobWoods DECEMBER 27, 2019 06:58 AMMy hope is that this new technology of quantum entanglement with it’s instant communication can be successfully used for instant communication between computers and personnel in long space flights great distances apart.Jerome Morley Larson Sr eAIA DECEMBER 27, 2019 08:23 AMI thought that quantum entanglement was between photons that had been split in two different directions; to me it was obvious that there would be instant communication between them via the light stream itself since no time elapses between particles traveling apart from each other at the speed of light — methinks we are being … um… bullwinked — 91% in a computer = zero.Rainer Kordmaa DECEMBER 27, 2019 09:03 AM”and yet, with quantum teleportation, information appears to break that speed limit” Citation needed, the paper does not make that claim, this is pure fiction.ANC DECEMBER 27, 2019 09:27 AMSplit photons get entangled by gravitons sustaining the orbit around them. The graviton is the medium quantum of entanglement and smallest/fastest particle than a photon. A laser or optic fiber solenoid will generate a perpendicular wave of gravitons just like an electron solenoid generates a perpendicular wave of photons. My Atomic-Cosmic quantum theory is superior than “strange teleportation” or “spooky action at a distance”: http://www.sandaero.com/sandaero_028.htmTroublesh00ter DECEMBER 27, 2019 09:44 AMAs has been previously noted, this technology would make for hack-proof communications, both a good thing if your a good guy or a bad thing if your a bad guy, trying to keep good guys from your schemes. The real loaded question is: Can this technology be made practical for general use, or would it be reserved for ultra-secure military and/or government communications?Expanded Viewpoint DECEMBER 27, 2019 10:47 AMI would like to see some videos of this hardware in action, before I buy any stock in it. Or is all of this just some simulations and wild conjectures flying about the room?? Methinks that the emperor might be standing before us, very naked.Worzel DECEMBER 27, 2019 11:28 AMIgnoring the, ”abduction/anal probe” reports, it’s often asked, if the universe is possibly so full of life, why dont we see flocks of alien space ships visiting us? Well, as physical transportation is not really viable for travel between stars and galaxies, then an advanced society wouldn’t use it. What they would use, eventually, is teleportation, as all good scifi stories predict. The natural extension of information teleportation, is matter transportation, as matter is, effectively, only electronic information in dense lumps. So, the reason that we dont see flocks of space ships, is, because they dont exist. They are superseded by matter transporters, which I think is the natural development from quantum teleportation. Sorry, but ‘Star Trek’ is just fantasy, not even fiction.Douglas Rogers DECEMBER 27, 2019 01:40 PMThe wave function can collapse instantaneously because no time travel paradox is created.

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      Published by ciencia100

      ´´The world people need to have very efficient researches and projects resulting in very innovative drugs, vaccines, therapeutical substances, medical devices and other technologies according to the age, the genetics and medical records of the person. So, the treatment, diagnosis and prognosis will be very efficient and better, of course´´. Rodrigo Nunes Cal ´´O mundo precisa ter pesquisas e projetos muito eficientes que resultem em medicamentos, vacinas, substâncias terapêuticas, dispositivos médicos e outras tecnologias muito inovadoras de acordo com a idade, a genética e o prontuário da pessoa. Assim, o tratamento, o diagnóstico e o prognóstico serão bem mais eficientes e melhores, é claro´´. Rodrigo Nunes Cal ´´As you know, the world needs to have very efficient researches resulting new therapeutical substances, medical devices, prevention, diagnostic and prognostic methods, drugs and vaccines, for example. Very detailed researches are fundamental in this process. So, high impact innovations are essential to the world people!!´´ Rodrigo Nunes Cal  ´´Como você sabe, o mundo precisa de pesquisas muito eficientes que resultem em novas substâncias terapêuticas, aparelhos médicos, métodos de prevenção, de diagnósticos e de prognósticos, medicamentos e vacinas, por exemplo. Pesquisas muito detalhadas são fundamentais neste processo, obviamente. Portanto, inovações de grande impacto são essenciais para as pessoas do mundo todo!!´´ Rodrigo Nunes Cal ´´Ter grandes metas, muitas das quais ditas como impossíveis é muito importante porque pode induzir de várias maneiras em diferentes intensidades na sociedade científica mundial o surgimento de grandes descobertas científicas para toda a humanidade, beneficiando significativamente a vida das pessoas e fazendo com que a expectativa de vida humana aumente significativamente. Dessa forma, doenças conhecidas hoje como sendo fatais e incuráveis, podem se tornar doenças curáveis, com a obtenção de novas tecnologias altamente eficazes de prevenção, diagnóstico, prognóstico e de tratamento´´. Rodrigo Nunes Cal ´´Having big goals, many of which are said to be impossible, is very important because it can induce, in different ways, in different intensities in the world scientific society, the emergence of great scientific discoveries for all of humanity, significantly benefiting people's lives and causing the increase of human life expectancy significantly. Thus, diseases known today as being fatal and incurable, can become curable diseases, with the achievement of highly effective prevention, diagnosis, prognosis and treatment technologies´´. Rodrigo Nunes Cal * ´´The very unknown path may be the best path to take in life´´. Rodrigo Nunes Cal ´´O caminho muito desconhecido pode ser o melhor caminho a seguir na vida´´. Rodrigo Nunes Cal ´´A Ciência abre um leque de possibilidades dos mais variados assuntos e dos mais variados níveis de dificuldades. Sendo assim, a compreensão total dos mecanismos fisiológicos envolvidos na patogênese das doenças, destacando-se as doenças fatais que ocorrem em humanos, é de suma importância para a humanidade, com toda certeza. Quem sabe num futuro próximo essa compreensão seja muito bem entendida e quem sabe, como muitas pessoas sonham na imortalidade física, dentre elas cientistas, essa grande conquista pode ser adquirida. Como você sabe, a humanidade necessita urgentemente de novas descobertas científicas, destacando-se a aquisição de medicamentos e vacinas altamente eficazes contra um grande número de doenças, dentre elas as doenças desconhecidas e silenciosas, a obtenção de aparelhos médicos muito eficientes de diagnóstico, prognóstico e tratamento de doenças, entre outros. Com certeza, precisamos ter esperança e motivação para a realização de ótimos trabalhos e para uma qualidade de vida bem melhor e uma expectativa de vida cada vez maior´´. Rodrigo Nunes Cal ´´Science opens up a range of possibilities for the most varied subjects and the most varied levels of difficulties. Therefore, the full understanding of the physiological mechanisms involved in the pathogenesis of diseases, highlighting the fatal diseases that occur in humans, is of paramount importance for humanity, for sure. Maybe in the near future this understanding will be very well understood and who knows, as many people dream of physical immortality, among them scientists, this great achievement can be acquired. As you know, humanity urgently needs new scientific discoveries, highlighting the acquisition of highly effective medicines and vaccines against a large number of diseases, including unknown and silent diseases, obtaining very efficient medical devices for diagnosis, prognosis and treatment of diseases, among others. Certainly, we need to have hope and motivation to do great work and for a much better quality of life and an ever-increasing life expectancy´´. Rodrigo Nunes Cal - Note: The statistics on the number of people who visited this blog in 2018 were not entirely based on real visitors. As estatísticas sobre número de pessoas que acessaram este blog no ano de 2018 não foram totalmente baseadas em visitantes reais. ´´Great difficulties may have come, but it is of great importance to have in mind the possibility of great victories in the future, bringing happiness and health for a long time´´. Rodrigo Nunes Cal ´´O caminho muito desconhecido pode ser o melhor caminho a seguir na vida´´. Rodrigo Nunes Cal ´´Understanding the great difficulties of a given subject can be a very long process, however, of great value for the progress of Science in all aspects´´. Rodrigo Nunes Cal ´´Entender as grandes dificuldades de um determinado assunto pode ser um processo muito longo, mas de grande valor para o progresso da Ciência em todos os seus aspectos´´. Rodrigo Nunes Cal My Curriculum Lattes: http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4240145A2 My Facebook Page: www.facebook.com/scientificblog IT´S A VERY EASY, FAST AND PRACTICAL WAY TO KNOW EXCELLENT INFORMATION ABOUT SCIENCE, TECHNOLOGY AND INNOVATION, AS AN EXAMPLE, APPLYING THE SEARCH MECHANISM Ctrl + F IN THIS BLOG FOR A WORD OR WORDS. SO, THIS BLOG SHARING IS VERY IMPORTANT TO THE WORLD SOCIETY! I hope in some way with this blog to help significantly in the socio-economic and technical-scientific development of the countries. E-mails: rodrigoncal1984@gmail.com rodrigonunescal@yahoo.com calrodrigonunes@gmail.com rodrigoncal1984@yahoo.com ´´NÃO VÁ PARA ONDE O CAMINHO PODE TE LEVAR. VÁ ONDE NÃO HÁ CAMINHO E DEIXE UMA TRILHA. ´´ ´´DON'T GO WHERE THE PATH CAN TAKE YOU. GO WHERE THERE IS NO PATH AND LEAVE A TRAIL. ´´ @ KNOWING THE UNKNOWN.. CONHECENDO O DESCONHECIDO.. The world needs very innovative ideas to people live better and longer more and more. I have been invited as a Speaker/Delegate in numerous International Conferences and Congresses. * DISCOVERING HOW THE INITIAL STAGES OF A CERTAIN DISEASES WORK, SUCH AS A FATAL DISEASES, IS OF HUGE IMPORTANCE FOR SCIENCE, FOR SURE. THERE ARE SEVERAL BIOLOGICAL FACTORS CONNECTED IN THE HUMAN BODY THAT ACTING IN A VERY COMPLEX FORM. THEREFORE, IT IS OF GREAT NECESSITY TO CARRY OUT NEW SCIENTIFIC RESEARCHES MUCH MORE DETAILED AND MODERN, WITH A HIGH DEGREE OF PRECISION, EVEN IF THERE IS NO SIGNIFICANT STATISTICAL DIFFERENCE BETWEEN CERTAIN FACTORS. * DESCOBRIR COMO FUNCIONA OS ESTÁGIOS INICIAIS DE DETERMINADAS DOENÇAS, TAIS COMO AS DOENÇAS FATAIS, É DE ENORME IMPORTÂNCIA PARA A CIÊNCIA , COM CERTEZA. HÁ VÁRIOS FATORES BIOLÓGICOS INTERLIGADOS NO CORPO HUMANO QUE ATUAM DE FORMA MUITO COMPLEXA. PORTANTO, É DE GRANDE NECESSIDADE A REALIZAÇÃO DE NOVAS PESQUISAS CIENTÍFICAS MUITO MAIS MINUCIOSAS E MODERNAS, COM ALTO GRAU DE PRECISÃO, MESMO QUE NÃO HAJA DIFERENÇA ESTATÍSTICA SIGNIFICATIVA ENTRE DETERMINADOS FATORES. * The discussion of certain facts in science envolving stastistics is fundamental to the scientific community, for example, the analysis and interpretation of very important, innovative and interesting graphics with no statistical difference between them can have a big value to the researches and to the future researches. So, the quality and efficiency of researches can increase so much in a little time, increasing the possiblities of excellent references and new scientific discoveries. The facts veracity and the disclosure of them are essential for the scientific community, of course. Reconhecer o(s) erro(s) cometido(s) e não praticá-lo(s) novamente é um ato de grande sabedoria e importância para si mesmo e para a(s) outra(s) pessoa(s). Acknowledging mistakes and not doing them again is an act of great wisdom and importance for yourself and to the other person or people. ´´O IMPOSSÍVEL PODE SER POSSÍVEL´´. ´´THE IMPOSSIBLE CAN BE POSSIBLE´´. I have received positive feedbacks about this blog by LinkedIn, Twitter, Facebook, E-mails and Instagram. ´´EVERYONE DIES. THE GOAL IS NOT TO LIVE FOREVER. THE GOAL S TO CREATE SOMETHING THAT WILL´´ # time #time #internet #technologies #HighTechnologies #Cell Phones #Computer #Notebook  # Television #radio #communication #tempo  #InternetSociety # Society #person # people # age #ages #genetics #longevity #investigations #researches #efficiency #projects #ideas #reference #references #article #articles #journal # journals #magazines #websites #blogs #sites #links #SocialNetworks #energy #graphics #dissertation #monograph #citations #ImpactFactor #pesquisa #pesquisas #tecnologias #DiferentesPercepções #DifferentPerceptions #mind #mente #minds #MentesHumanas #emails #email e-mails reading #MenteHumana leitura mensagem mensagens probabilidade(s) probabilities messages message importance importância relevância assunto(s) subject subjects issue tema reflexão reflections vision visão pioneirismo pionners prêmio(s) prizes awards innovations inovações Grupos de Estudo Grupos Controle saúde doença(s) nome(s) tempo(s) Início da doença - Momento inicial da doença - Momento(s) inicial(ais) da(s) doença(s) humana(s) - Semelhança genética com camundongos - Mice researches - vaccines - drugs - eficiência - medicamento(s) - vacina(s) - High efficiency - Fatal diseases - Doenças fatais - Investments - investimentos - laboratórios - industries - indústrias - laboratories - Centros de Pesquisa - Países - cidades - cities - longevidade - desafio(s) - challenges - gráficos detalhados - interações biológicas - fatores biológicas - análise minuciosa - Very detailed analysis @ Initial moment of disease - Initial moments of human diseases - No Name @ discussion - discussão científica - science facts - detailed graphics - fatos científicos - publicação de trabalhos científicos - publications - hard work - better results - better science - diagnóstico - prognósticos - Diferença Estatística Significativa 100 Diferença Estatística Significativa @ Significant Statistical Difference - V X I Interpretations interpretações intenções intenions countries EU 100 gene Sem genes Cem genes 1 0 0 gene(s) time(s) times 100 limites limite(s) limits 1 0 0 limit NO LIMIT 10 0 @ 100 genes @ 100 gene & NO GENE NO TEMPO NOS TEMPOS NO(S) TEMPO(S) NOS TIMES NO TIME 100 GENE No Time # no time @ nos genes no(s) gene(s) * no(s) limite(s) - words- palavra(s) - listen - write - type - fala - escuta - ler - virtualidade - virtuality - reality - realidade - mundo real - mundo virtual - vida real - virtual life - real life - vida virtual - imaginations - thoughts - pensamento(s) - imaginações - melhoria - improvement - respect - respeito - speak - nome(s) - trabalho(s) - dinheiro - money - team - equipe - objetivo(s) - Best Universities of the World - Scientific Discoveries - Brazil - World - RNA - Cell - DNA - Idade biológica - biological age - pessoas - idade - idade(s) - pessoa - História da Computação Mundial - Harvard - Names - Places - City - researches - scientists - professors - pesquisador(es) - cientistas - professores - professor(es) - Produção científica - Fatores de Impacto - feelings - logic - sentimento(s) - lógica - história - world history - difficulties - dificuldades - Scientific community - comunidade científica mundial - vidas humanas - vida(s) humana(s) - trabalho(s) - human lives - life - human life - única - one life - person people @ momentos - moments memories memory memória longevidade energias energia(s) Many people liked my Twitter and Facebook comments that I informed this blog like great professors, scientists and researchers around the world who work in human health area! Many data about it aren´t in this blog. #database #system #time #data #search #information #InternetHistory #contribuitions #improvement #analysis #intentions Intenções @ #person #people #age #longevity #work #reading #probabilities #energy #money #price #clicks #jobs #country #city #countries #cities #knowledge #HumanInterdependence #WorldHistory #communication #HumanRelations #websites #e-mails #SocialNetworks #ranking #links #images #photos #texts #messages #videos #writing #typing #speak #listen #think #feelings #ideas #ScientificDiscoveries #investigations #researches #articles #ImpactFactors #journals #citations #influence #dissertations #monographs #ScientificWorks #Inventions #graphics #subjects #books #references #blogs ´´Compreender as grandes dificuldades de um determinado assunto pode ser um processo muito demorado, porém, de grande valia para o progresso da Ciência em todos os aspectos´´ Rodrigo Nunes Cal Observação/Note: I won a scholarship by FAPEMIG during the period of ´´my´´ monograph in Uberaba. Ganhei bolsa de estudo pela FAPEMIG durante o período da ´´minha´´ monografia em Uberaba. During the period that I participated of ´´my´´ dissertation at FAMERP, I didn't win a scholarship. Já durante o mestrado que fiz na FAMERP, não ganhei bolsa de estudo. ´´Os gráficos baseados em dados da ´´minha´´ dissertação que fiz podem ser uma excelente referência para muitos tipos de pesquisas e projetos, é claro !! Por exemplo, para pesquisas e projetos que tenham como objetivo analisar os tipos de influências das idades em camundongos e humanos (estudos genéticos, por exemplo) em relação a diferentes estágios de determinadas doenças, como aquelas em que a comunidade científica desconhece (doenças desconhecidas) e que poderão surgir no mundo. Outros tipos de pesquisas e projetos que podem ser feitos são aqueles que analisam a eficácia de diversos tipos de substâncias terapêuticas em camundongos e humanos nos diversos tipos de doenças com o objetivo de saber qual a melhor substância terapêutica para cada doença, levando em consideração a idade e genética, com certeza. Contudo, realizar pesquisas com o objetivo de avaliar qual é a influência da idade e da genética na eficiência terapêutica em animais de experimentação e em humanos, consequentemente, possui um grande valor, já que muitas pessoas adoecem e acabam falecendo mesmo sendo submetidas à ótimos sistemas de diagnóstico, tratamento e prognóstico, dependendo da doença que possui e do estágio da mesma´´. ´´A partir daí, ao comprovar que há influência significativa da idade e da genética, consequentemente, no processo de patogênese de doenças nos animais de experimentação e nos humanos, seria muito mais conveniente e lógico um grupo de indivíduos de certa faixa etária e histórico familiar e individual de doenças adquiridas e possíveis de serem adquiridas no decorrer do tempo serem tratados com outros tipos de medicamentos, substâncias terapêuticas, vacinas, dentre outros. Com certeza, para a realização destes tipos de pesquisa deve haver grande investimento financeiro nos laboratórios a fim de aquisição de aparelhos científicos altamente eficientes. Com certeza, pesquisas à nível genético e com relação à influência da idade do ser vivo na patogênese de doenças, até das doenças desconhecidas pelo mundo científico. O fato é que este tipo de pesquisa é muito importante porque como todos sabem, há muitas doenças que voltam a se manifestar nas pessoas mesmo depois de excelentes tratamentos, dos mais variados tipos. E outro ponto a ser refletido é a permanência de doenças fatais´´. ´´Assim, este tipo de influência da idade e consequentemente da genética na fisiopatologia das doenças hereditárias ou não hereditárias, um indivíduo de uma determinada idade será submetido a um tratamento terapêutico diferente de outro com a mesma doença mas com idade diferente da de até a pesquisa mostrou uma influência significativa na patogênese da doença, portanto, utilizará outro tipo de substância terapêutica, medicamentos, entre outros. Isso certamente acontecerá se a comunidade científica mundial comprovar cientificamente essas hipóteses por meio de várias pesquisas e projetos científicos. As pessoas precisam ter excelentes inovações para a expectativa de vida humana aumentar muito rapidamente cada vez mais. Portanto, quanto mais a medicina personalizada for, melhor será para cada um de nós´´. Rodrigo Nunes Cal ´´The graphics based on data from ´´my´´ dissertation I did can be an excellent reference for many types of researches and projects, of course!! For example, for researches and projects that the goals are analyse the type of influences of ages in mice and human (genetic studies, for example) in relation to different stages of determined diseases, like those that the scientific community do not know about them (unknown diseases). Other types of researches and projects that can be done is those that analyse the efficiency of many types of therapeutical substances in mice and human in many types of diseases with the objective of knowing which is the best therapeutic substance for each disease, taking into account age and genetics, for sure. For example, to carry out research with the objective of evaluating the influence of age and genetics on therapeutic efficiency in experimental animals and in humans´´. ´´Thus, by proving that there is a significant influence of age and genetics, consequently, in the process of pathogenesis of diseases in experimental animals and in humans, it would be much more convenient and logical to have a group of individuals of a certain age group and family and individual history of acquired diseases and possible to be acquired over time being treated with other types of drugs, therapeutic substances, vaccines, among others. Certainly, to carry out these types of research there must be a large financial investment in laboratories in order to acquire highly efficient scientific devices. Certainly, research at the genetic level and regarding the influence of the age of the living being on the pathogenesis of diseases, even diseases unknown to the scientific world. The fact is that this type of research is very important because as everyone knows, there are many diseases that come back to manifest in people even after excellent treatments, of the most varied types. And another point to be reflected on is the permanence of fatal diseases´´. ´´Taking into account this type of influence of age and consequently genetics on the pathophysiology of inherited or not inherited diseases, an individual of a certain age will be submitted to a different therapeutic treatment from another with the same disease but who has a different age than through the research has shown a significant influence on the pathogenesis of the disease, therefore, will use another type of therapeutic substance, medicine, among others. This will certainly happen if the world scientific community scientifically proves these hypotheses through various research and scientific projects. So, the people need to have excellent innovation to the human expectancy  of life increase so much faster more and more´´. Rodrigo Nunes Cal Note/Obs: I thought each person could do their own friend request permission setting since Facebook's technology is so big, for example. Eu achava que cada pessoa poderia fazer sua própria configuração de permissão de solicitação de amizade já que a tecnologia do Facebook é muito grande, por exemplo.

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