Cancer Cells Switch Sugar for Fatty Acids to Spread Around the Body. The study was published in Nature Communications and funded by Breast Cancer Now. The study focussed on breast cancer cells, but high levels of AKR1B10 are also seen in liver, lung, and pancreatic cancers @ ´´Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.[2][8] These contrast with benign tumors, which do not spread.[8] Possible signs and symptoms include a lump, abnormal bleeding, prolonged cough, unexplained weight loss, and a change in bowel movements.[1] While these symptoms may indicate cancer, they can also have other causes.[1] Over 100 types of cancers affect humans.[8] Tobacco use is the cause of about 22% of cancer deaths.[2] Another 10% are due to obesity, poor diet, lack of physical activity or excessive drinking of alcohol.[2][9][10] Other factors include certain infections, exposure to ionizing radiation and environmental pollutants.[3]´´ https://en.wikipedia.org/wiki/Cancer

Do the downloads!! Share!! The diffusion of very important information and knowledge is essential for the world progress always!! Thanks!!

  • – – > > Mestrado – Dissertation – Tabelas, Figuras e Gráficos – Tables, Figures and Graphics – ´´My´´ Dissertation #Innovation #Countries #Time #Researches #Reference #Graphics #Ages #Age #Mice #People #Person #Mouse #Genetics #PersonalizedMedicine #Diagnosis #Prognosis #Treatment #Disease #UnknownDiseases #Future #VeryEfficientDrugs #VeryEfficientVaccines #VeryEfficientTherapeuticalSubstances #Tests #Laboratories #Investments #Details #HumanLongevity #DNA #Cell #Memory #Physiology #Nanomedicine #Nanotechnology #Biochemistry #NewMedicalDevices #GeneticEngineering #Internet #History #Science #World

Pathol Res Pract. 2012 Jul 15;208(7):377-81. doi: 10.1016/j.prp.2012.04.006. Epub 2012 Jun 8.

The influence of physical activity in the progression of experimental lung cancer in mice

Renato Batista Paceli 1Rodrigo Nunes CalCarlos Henrique Ferreira dos SantosJosé Antonio CordeiroCassiano Merussi NeivaKazuo Kawano NagaminePatrícia Maluf Cury


Impact_Fator-wise_Top100Science_Journals

GRUPO_AF1 – GROUP AFA1 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 1 – GROUP AFAN1 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO_AF2 – GROUP AFA2 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 2 – GROUP AFAN 2 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

Slides – mestrado – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

CARCINÓGENO DMBA EM MODELOS EXPERIMENTAIS

DMBA CARCINOGEN IN EXPERIMENTAL MODELS

Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

https://pubmed.ncbi.nlm.nih.gov/22683274/

Abstract

Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.

´´We propose to change the default P-value threshold for statistical significance from 0.05 to 0.005 for claims of new discoveries.´´ https://www.nature.com/articles/s41562-017-0189-z Published:  Daniel J. Benjamin, James O. Berger, […]Valen E. Johnson Nature Human Behaviour volume 2, pages6–10 (2018)

Um mundo além de p < 0,05 « Sandra Merlo – Fonoaudiologia da Fluência

´´My´´ Monografia – Monograph – Induction of benznidazole resistance in human Trypanosoma cruzi isolates – Indução de resistência ao benzonidazol em isolados humanos de Trypanosoma cruzi – UFTM – Federal University of Triangulo Mineiro – Uberaba 

Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo

Article – ´´My´´ dissertation – Faculty of Medicine of Sao Jose do Rio Preto

Feedback positivo de pessoas sobre minha dissertação pelo Messenger – Facebook. Positive feedback of people about my dissertation, blog and YouTube channel by Facebook – Messenger. Year – Ano: 2018

LISTA DE NOMES DE PESSOAS QUE ME DERAM FEEDBACK POSITIVO SOBRE A LISTA DE EMAILS QUE FIZ EM 2015 (PROJETO) – PEOPLE´S NAMES (POSITIVE FEEDBACK ABOUT THE EMAIL LIST I DID IN 2015) – E-MAIL LIST – LISTA DE E-MAILS – PROJECT – PESQUISA -RESEARCH

My suggestion of a very important Project…

Apostila – Pubmed

A Psicossomática Psicanalítica – Faculty of Medicine of Sao Jose do Rio Preto

ÁCIDO HIALURÔNICO – HIALURONIC ACID – Faculty of Medicine of Sao Jose do Rio Preto

Slides – Mestrado final – ´´My´´ dissertation – Faculty of Medicine of Sao Jose do Rio Preto

Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo

O Homem como Sujeito da Realidade da Saúde – Redação – Faculty of Medicine of Sao Jose do Rio Preto

Aula_Resultados – Results – FAMERP – Faculty of Medicine of Sao Jose do Rio Preto

As credenciais da ciência – The credentials of Science – Faculty of Medicine of Sao Jose do Rio Preto BaixarFrases que digitei – Phrases I typed

Frases que digitei – Tecnologia – Informations about blog I did

Keynote-The-Future-of-Space-Exploration(1)

2019-01-hormone-alzheimer(1)

mojap-02-00034

ajpheart.00349.2013

aging – animal models

Nanomedicine an evolving research (Opinion article I typed)

journal-of-nanomedicine–nanotechnology-flyer

Will you embrace AI fast enough

MICROBIOLOGIA – MICROBIOLOGY – Faculty of Medicine of Sao Jose do Rio Preto

Genes e Epilepsia – Genes and epilepsy – Faculty of Medicine of Sao Jose do Rio Preto

Dr.A.M.S

Flav_R03

BIOGRAFIA – BIOGRAPH – DR. DOMINGO MARCOLINO BRAILE

p-Value – Valor de p

european-respiratory-society

redefine-statistical-significance

https://en.wikipedia.org/wiki/Cancer

We’ve updated our Privacy Policy to make it clearer how we use your personal data.

We use cookies to provide you with a better experience, read our Cookie PolicyI UNDERSTAND

  •  
  •  
  •  
  •  
  •  

Cancer Researchfrom TECHNOLOGY NETWORKS

  •  

Cancer Cells Switch Sugar for Fatty Acids to Spread Around the Body

NEWS   Jul 19, 2019 | Original story from ICR

Cancer Cells Switch Sugar for Fatty Acids to Spread Around the Body

 Read Time: 2 min

Scientists have uncovered a crucial change in cancer cells that allows them to spread around the body – by switching from sugar to fatty acids to fuel their growth.

Changing their ‘diet’ in this way allows tumour cells to set up shop at new sites where resources such as glucose – their preferred food source – are limited.

Researchers at The Institute of Cancer Research, London, found that a protein called AKR1B10 helps cells adapt the ways in which they get their energy.

When cancer cells have high levels of AKR1B10, it reduces their dependency on sugar and increases their ability to use fatty acids as a fuel source instead.

Shutting down cell food sources

The research raises the opportunity to screen breast cancer patients for increased levels of AKR1B10, which may help identify patients at an increased risk of metastatic relapse.

It could also lead to the development of new treatment options  that shut down cells’ ability to use fatty acids – which the study showed could reduce relapse rates in mice.

The study was published in Nature Communications and funded by Breast Cancer Now. The study focussed on breast cancer cells, but high levels of AKR1B10 are also seen in liver, lung, and pancreatic cancers.

The researchers first identified AKR1B10 in a screen for proteins which, when expressed at high levels, helped cancer get ahead at new locations, while low levels of the protein hinder its growth in new organs.

Cells normally avoid using fatty acids for fuel as there are toxic side effects. High levels of AKR1B10 limit these toxic side effects, allowing cancer cells to thrive in new areas in the body.

The opposite is also true – switching off the cancer cells’ ability to use fatty acids reduces their ability to form tumours at new sites in the body.

Cancer survival mechanisms


Professor Clare Isacke, Professor of Molecular Cell Biology in the Breast Cancer Now Toby Robins Research Centre at the ICR, said:

“Cancer cells have to work hard to take root and form a tumour. When tumour cells head on the move to other parts of the body, a process called metastasis, they have to work even harder to adapt to the energy and nutrient sources available to them wherever they find themselves, as well as surviving the journey.

“Our study has shown the importance of cancer cell learning how to use different nutrients and energy sources in order to survive.

“We found that high levels of the protein AKR1B10 help tumour cells adjust to new environments as cancer spreads from the breast to other organs such as the lungs.

“This research significantly improves our understanding of cancer cell metabolism and metastatic relapse and could lead to new avenues of exploration for new therapies and treatments for patients with metastatic breast cancer.”

Reference: Antoinette van Weverwijk, et al. Metabolic adaptability in metastatic breast cancer by AKR1B10-dependent balancing of glycolysis and fatty acid oxidation. Nature Communications (2019) DOI: https://doi.org/10.1038/s41467-019-10592-4

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

RELATED ARTICLES

Hep-C Infection May No Longer Rule Out Organ DonationNEWS

Patients who were transplanted with hearts from hepatitis C-positive donors had comparable outcomes after one year to patients who received hearts from donors that didn’t have the disease. With effective direct-acting antiviral therapies this presents an opportunity to expand the donor pool, shorten wait times for organs and ensure that fewer people die waiting for them.READ MORE 


Yin and Yang Protein Solves Skin Cancer MysteryNEWS

Scientists are using powerful supercomputers to uncover the mechanism that activates cell mutations found in about 50 percent of melanomas. The scientists say they’re hopeful their study can help lead to a better understanding of skin cancer and to the design of better drugs.READ MORE 


First-in-Human Trial for Novel Lung Cancer ImmunotherapyNEWS

Cancer Research UK and Vaccitech Oncology have announced a new partnership to bring a novel immunotherapeutic vaccine strategy to patients with lung cancer.READ MORE 


Like what you just read? You can find similar content on the communities below.CELL SCIENCE


To personalize the content you see on Technology Networks homepage, Log In or Subscribe for FreeLOGINSUBSCRIBE FOR FREE

RELATED CONTENTGaining Insights into Disease Biology for Target Identification and Validation using Seahorse XF Technology

APPLICATION NOTEREAD MORE 


In Vitro Differentiation of Human iPS Cells into Colon Organoids in Serum-free Cell Culture Conditions

WHITE PAPERREAD MORE 


Tips To Optimize Imaging with Antibodies

HOW TO GUIDEREAD MORE 


The Viral Origins of the Placenta

VIDEOWATCH NOW 


The Science of Christmas: Rudolph’s Red Nose

FUN VIDEOWATCH NOW 


Gaining Insights into Disease Biology for Target Identification and Validation using Seahorse XF Technology

APPLICATION NOTEREAD MORE 


CBT for Social Anxiety May Protect Against Cellular Aging

NEWS   Dec 19, 2019READ MORE 


Why Do Fatty Meals Disrupt the Gut’s Communication With the Body?

NEWS   Dec 19, 2019READ MORE 


Solving the Mysteries of Autoimmune Disease

NEWS   Dec 19, 2019READ MORE 


ABOUT US

LINKS

Privacy Policy & DisclaimerCookie Policy©2019 Technology Networks, all rights reserved

8 Comments

  1. Thanks on your marvelous posting! I truly enjoyed reading it, you’re a great author.
    I will be sure to bookmark your blog and will come back in the future.
    I want to encourage that you continue your great writing, have a nice evening!

    Like

Leave a Reply

Fill in your details below or click an icon to log in:

WordPress.com Logo

You are commenting using your WordPress.com account. Log Out /  Change )

Google photo

You are commenting using your Google account. Log Out /  Change )

Twitter picture

You are commenting using your Twitter account. Log Out /  Change )

Facebook photo

You are commenting using your Facebook account. Log Out /  Change )

Connecting to %s