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The influence of physical activity in the progression of experimental lung cancer in mice
- PMID: 22683274
- DOI: 10.1016/j.prp.2012.04.006
GRUPO_AF1 – GROUP AFA1 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO AFAN 1 – GROUP AFAN1 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO_AF2 – GROUP AFA2 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO AFAN 2 – GROUP AFAN 2 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
Slides – mestrado – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
DMBA CARCINOGEN IN EXPERIMENTAL MODELS
Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.
Copyright © 2012 Elsevier GmbH. All rights reserved.Mestrado – ´´My´´ Dissertation – Tabelas, Figuras e Gráficos – Tables, Figures and Graphics – Faculty of Medicine of Sao Jose do Rio Preto BaixarRedefine Statistical SignificanceBaixar
´´We propose to change the default P-value threshold for statistical significance from 0.05 to 0.005 for claims of new discoveries.´´ https://www.nature.com/articles/s41562-017-0189-z Published: Daniel J. Benjamin, James O. Berger, […]Valen E. Johnson Nature Human Behaviour volume 2, pages6–10 (2018)
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Medical student surveys health of nomadic African group, thanks to goats
AuthorJody BergerPublished onDecember 4, 2019
Hannah Wild was a first-year medical student when she approached Michele Barry, MD, senior associate dean for global health, and asked for help. Wild wanted to design and implement a demographic and health study in the Omo River Valley of Ethiopia.
“I thought she was totally insane to go out alone in dangerous pastoralist areas of conflict,” Barry said. “I tried to dissuade her — and I am not one to avoid risk in global work.”
Turns out Wild wasn’t risk-averse either. A native Vermonter who grew up on a farm, she graduated from Harvard and moved to Africa to live and work with the Nyangatom people for 18 months before enrolling at Stanford’s School of Medicine. She knew the region. She knew the risks and she wanted to go back.
“She was one of the most persistent students I have met and had the background and fluency of culture that could make her effective,” Barry said.
The Nyangatom, and other pastoralist tribes, rarely show up in demographic studies because they’re on the move, almost all the time.
“As I set about trying to design a study, I tried to see what methods existed to generate representative sampling frames among nomadic groups,” Wild said. “I looked high and low thinking maybe I was just inexperienced and ignorant but there was really no solution to that. Several methods have been tried, but none had gone well or were scalable.”
Solving global health challenges almost always demands a multidisciplinary approach — physicians working with policymakers working with engineers and others. And all of them need data to guide their decisions.
To gather the data in the Omo River Valley, Wild needed expertise in satellite imagery and mapping. And Maples was eager to share.
“This is an ethos that imbues everything in the library system — serving everyone in a discipline agnostic way,” Maples said. “Librarians have always been the people who get information for people. That kind of leadership at the library level is a really important part of the innovation of projects at Stanford.”
I tell the story of their successful collaboration in a Stanford News article.
Together, Maples and Wild were able to determine where the Nyangatom would be in real-time and generate a sampling frame that was representative of the population. And with that, Wild was able to get into the field and gather information that will have real-world implications, both for the Nyangatom and other communities like theirs.
Photos in Africa by Luke Glowacki; Stanford photo courtesy of Hannah Wild
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