Nobel Prize in Medicine 2019 | Oxygen sensors @ ´´Reference is a relationship between objects in which one object designates, or acts as a means by which to connect to or link to, another object. The first object in this relation is said to refer to the second object. It is called a name for the second object. The second object, the one to which the first object refers, is called the referent of the first object. A name is usually a phrase or expression, or some other symbolic representation. Its referent may be anything – a material object, a person, an event, an activity, or an abstract concept.´´References feature in many spheres of human activity and knowledge, and the term adopts shades of meaning particular to the contexts in which it is used. Some of them are described in the sections below.´´@ Over the past century, the mouse has developed into the premier mammalian model system for genetic research. Scientists from a wide range of biomedical fields have gravitated to the mouse because of its close genetic and physiological similarities to humans, as well as the ease with which its genome can be manipulated and analyzed.´´ @ Links and Images

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Do the downloads!! Share!! The diffusion of very important information and knowledge is essential for the world progress always!! Thanks!!

  • – – > > Mestrado – Dissertation – Tabelas, Figuras e Gráficos – Tables, Figures and Graphics – ´´My´´ Dissertation #Innovation #Countries #Time #Researches #Reference #Graphics #Ages #Age #Mice #People #Person #Mouse #Genetics #PersonalizedMedicine #Diagnosis #Prognosis #Treatment #Disease #UnknownDiseases #Future #VeryEfficientDrugs #VeryEfficientVaccines #VeryEfficientTherapeuticalSubstances #Tests #Laboratories #Investments #Details #HumanLongevity #DNA #Cell #Memory #Physiology #Nanomedicine #Nanotechnology #Biochemistry #NewMedicalDevices #GeneticEngineering #Internet #History #Science #World

Pathol Res Pract. 2012 Jul 15;208(7):377-81. doi: 10.1016/j.prp.2012.04.006. Epub 2012 Jun 8.

The influence of physical activity in the progression of experimental lung cancer in mice

Renato Batista Paceli 1, Rodrigo Nunes Cal, Carlos Henrique Ferreira dos Santos, José Antonio Cordeiro, Cassiano Merussi Neiva, Kazuo Kawano Nagamine, Patrícia Maluf Cury


Impact_Fator-wise_Top100Science_Journals

GRUPO_AF1 – GROUP AFA1 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 1 – GROUP AFAN1 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO_AF2 – GROUP AFA2 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 2 – GROUP AFAN 2 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

Slides – mestrado – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

CARCINÓGENO DMBA EM MODELOS EXPERIMENTAIS

DMBA CARCINOGEN IN EXPERIMENTAL MODELS

Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

https://pubmed.ncbi.nlm.nih.gov/22683274/

Abstract

Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.

´´We propose to change the default P-value threshold for statistical significance from 0.05 to 0.005 for claims of new discoveries.´´ https://www.nature.com/articles/s41562-017-0189-z Published:  Daniel J. Benjamin, James O. Berger, […]Valen E. Johnson Nature Human Behaviour volume 2, pages6–10 (2018)

Um mundo além de p < 0,05 « Sandra Merlo – Fonoaudiologia da Fluência

´´My´´ Monografia – Monograph – Induction of benznidazole resistance in human Trypanosoma cruzi isolates – Indução de resistência ao benzonidazol em isolados humanos de Trypanosoma cruzi – UFTM – Federal University of Triangulo Mineiro – Uberaba 

Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo

Article – ´´My´´ dissertation – Faculty of Medicine of Sao Jose do Rio Preto

Feedback positivo de pessoas sobre minha dissertação pelo Messenger – Facebook. Positive feedback of people about my dissertation, blog and YouTube channel by Facebook – Messenger. Year – Ano: 2018

LISTA DE NOMES DE PESSOAS QUE ME DERAM FEEDBACK POSITIVO SOBRE A LISTA DE EMAILS QUE FIZ EM 2015 (PROJETO) – PEOPLE´S NAMES (POSITIVE FEEDBACK ABOUT THE EMAIL LIST I DID IN 2015) – E-MAIL LIST – LISTA DE E-MAILS – PROJECT – PESQUISA -RESEARCH

My suggestion of a very important Project…

Apostila – Pubmed

A Psicossomática Psicanalítica – Faculty of Medicine of Sao Jose do Rio Preto

ÁCIDO HIALURÔNICO – HIALURONIC ACID – Faculty of Medicine of Sao Jose do Rio Preto

Slides – Mestrado final – ´´My´´ dissertation – Faculty of Medicine of Sao Jose do Rio Preto

Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo

O Homem como Sujeito da Realidade da Saúde – Redação – Faculty of Medicine of Sao Jose do Rio Preto

Aula_Resultados – Results – FAMERP – Faculty of Medicine of Sao Jose do Rio Preto

As credenciais da ciência – The credentials of Science – Faculty of Medicine of Sao Jose do Rio Preto BaixarFrases que digitei – Phrases I typed

Frases que digitei – Tecnologia – Informations about blog I did

Keynote-The-Future-of-Space-Exploration(1)

2019-01-hormone-alzheimer(1)

mojap-02-00034

ajpheart.00349.2013

aging – animal models

Nanomedicine an evolving research (Opinion article I typed)

journal-of-nanomedicine–nanotechnology-flyer

Will you embrace AI fast enough

MICROBIOLOGIA – MICROBIOLOGY – Faculty of Medicine of Sao Jose do Rio Preto

Genes e Epilepsia – Genes and epilepsy – Faculty of Medicine of Sao Jose do Rio Preto

Dr.A.M.S

Flav_R03

BIOGRAFIA – BIOGRAPH – DR. DOMINGO MARCOLINO BRAILE

p-Value – Valor de p

european-respiratory-society

redefine-statistical-significance

https://en.wikipedia.org/wiki/Reference

https://www.briefscience.com/2019/11/nobel-prize-in-medicine-2019-oxygen_9.html?fbclid=IwAR3HKkMA6Nao1XCZMPsq7kCWrXrUg705UNG24LgR6nlwYQCa8LQHzQUJRz0

  •  Dec 31, 2019

BRIEF SCIENCE

HomeNobel prizeNobel Prize in Medicine 2019 | Oxygen sensors

Nobel Prize in Medicine 2019 | Oxygen sensors

BRIEF SCIENCESATURDAY, NOVEMBER 09, 2019Oxygen is essential for life. We use oxygen to create energy, digest food, and eliminate toxins from the body. People look for fresh air in the morning to be active, but in low oxygen levels, we feel choking or headache. Our looking for how the body adapts in low oxygen levels is very important and deserves the Nobel Prize for this year. Gregg Semenza, William Kaelin and Peter Ratcliffe explain the story of the adaptation of oxygen levels.
The story started when C. Heymans showed how the carotid body work as oxygen sensor and control in respiration by connecting to the brain, and in 20th-century scientists known that EPO (erythropoietin Hermon) increase red blood cells (RBSc) as a response for low oxygen levels. They thought EPO gene regulates oxygen levels, but how the process happens still a mystery.
Genes have a promotor (a DNA sequence responsible for turn a specific gene on or off). When Gregg Semenza studied EPO gene, he found that the promotor of the EPO gene regulates and sense oxygen level -not the EPO gene as was thinking-. He called this promotor HIF “hypoxia-inducible factor”. Then in 1995 Semenza identify the gene encoding HIF which made up of 2 proteins: HIF-1α and ARNT. Now researchers have great tools to go forward.

 How HIF Work ?

As a sensor for oxygen, HIF-1α affect oxygen levels. It decreases in high oxygen levels and increase in low oxygen levels. When oxygen is at a low level, HIF-1α turns EPO gene on to regulate oxygen levels.Now oxygen at a normal level and the rest of HIF-1α will activate EPO gene, EPO will increase RBCs so oxygen will be very high what effect on breathing. An organelle called proteasome (a cell machine destroy the excess molecules) destroys excess HIF-1α.When the EPO gene makes oxygen at a high level again, the proteasome destroys HIF-1α when ubiquitin tags it to stop activating the EPO gene.Ubiquitin is a protein that linked proteins targeted for intracellular degradation by proteasome.William Kaelin found that another molecule is necessary to tag HIF-1α to destroyed. This molecule is called VHL.
Three research groups showed the relationship between the HIF-1α and VHL gene (a gene encodes a protein that prevents the onset of cancer).
i. William Kaelin showed that the cancer cells that lack of VHL gene lose the ability to control in genes that regulate oxygen levels (HIF-1α genes), but when cancer cells take back VHL gene, normal levels back again.
ii. Several research groups showed that VHL gene tags HIF-1α with ubiquitin to proteasome to destroy.
iii. Sir Peter J. Ratcliffe showed that HIF-1α and VHL gene physically interact and proteasome must find VHL with HIF-1α in normal oxygen levels to destroy.
In 2001, William Kaelin and Peter Ratcliffe showed how VHL sense HIF-1α in normal oxygen levels. In normal oxygen levels, hydroxyl (OH-) groups bind to HIF-1α and recognize it to VHL what makes HIF-1α in normal oxygen levels destroyed.

– The figure above shows the whole process. You can follow the steps with the article explanation

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Reference

From Wikipedia, the free encyclopediaJump to navigationJump to searchFor other uses, see Reference (disambiguation).

Reference is a relationship between objects in which one object designates, or acts as a means by which to connect to or link to, another object. The first object in this relation is said to refer to the second object. It is called a name for the second object. The second object, the one to which the first object refers, is called the referent of the first object. A name is usually a phrase or expression, or some other symbolic representation. Its referent may be anything – a material object, a person, an event, an activity, or an abstract concept.

References can take on many forms, including: a thought, a sensory perception that is audible (onomatopoeia), visual (text), olfactory, or tactile, emotional state, relationship with other,[1] spacetime coordinate, symbolic or alpha-numeric, a physical object or an energy projection. In some cases, methods are used that intentionally hide the reference from some observers, as in cryptography.[citation needed]

References feature in many spheres of human activity and knowledge, and the term adopts shades of meaning particular to the contexts in which it is used. Some of them are described in the sections below.

Contents

Etymology and meanings[edit]

The word reference is derived from Middle English referren, from Middle French référer, from Latin referre, “to carry back”, formed from the prefix re– and ferre, “to bear”.[2] A number of words derive from the same root, including refer, referee, referential, referent, referendum.

The verb refer (to) and its derivatives may carry the sense of “link to” or “connect to”, as in the meanings of reference described in this article. Another sense is “consult”; this is reflected in such expressions as reference work, reference desk, job reference, etc.

Semantics[edit]

Further information: Sense and reference and Theory of referenceThe triangle of reference, from the influential book The Meaning of Meaning (1923) by C. K. Ogden and I. A. Richards.

In semantics, reference is generally construed as the relationships between nouns or pronouns and objects that are named by them. Hence, the word “John” refers to the person John. The word “it” refers to some previously specified object. The object referred to is called the referent of the word.[3] Sometimes the word-object relation is called “denotation“; the word denotes the object. The converse relation, the relation from object to word, is called “exemplification“; the object exemplifies what the word denotes. In syntactic analysis, if a word refers to a previous word, the previous word is called the “antecedent“.

Meaning[edit]

Gottlob Frege argued that reference cannot be treated as identical with meaning: “Hesperus” (an ancient Greek name for the evening star) and “Phosphorus” (an ancient Greek name for the morning star) both refer to Venus, but the astronomical fact that ‘”Hesperus” is “Phosphorus”‘ can still be informative, even if the “meanings” of “Hesperus” and “Phosphorus” are already known. This problem led Frege to distinguish between the sense and reference of a word. Some cases seem to be too complicated to be classified within this framework; the acceptance of the notion of secondary reference may be necessary to fill the gap. See also Opaque context.

Linguistic sign[edit]

The very concept of the linguistic sign is the combination of content and expression, the former of which may refer entities in the world or refer more abstract concepts, e.g. thought. Certain parts of speech exist only to express reference, namely anaphora such as pronouns. The subset of reflexives expresses co-reference of two participants in a sentence. These could be the agent (actor) and patient (acted on), as in “The man washed himself”, the theme and recipient, as in “I showed Mary to herself”, or various other possible combinations.

Computer science[edit]

Main article: Reference (computer science)

In computer science, references are data types that refer to an object elsewhere in memory and are used to construct a wide variety of data structures, such as linked lists. Generally, a reference is a value that enables a program to directly access the particular data item. Most programming languages support some form of reference. For the specific type of reference used in the C++ language, see reference (C++).

The notion of reference is also important in relational database theory; see referential integrity.

Library and information sciences[edit]

See also: Reference work and Reference desk

References to many types of printed matter may come in an electronic or machine-readable form. For books, there exists the ISBN and for journal articles, the Digital object identifier (DOI) is gaining relevance. Information on the Internet may be referred to by a Uniform Resource Identifier (URI).

Psychology[edit]

In terms of mental processing, a self-reference is used in psychology to establish identification with a mental state during self-analysis. This seeks to allow the individual to develop own frames of reference in a greater state of immediate awareness. However, it can also lead to circular reasoning, preventing evolution of thought.[4]

According to Perceptual Control Theory (PCT), a reference condition is the state toward which a control system’s output tends to alter a controlled quantity. The main proposition is that “All behavior is oriented all of the time around the control of certain quantities with respect to specific reference conditions.”[5]

Scholarship[edit]

In academics and scholarship, a reference or bibliographical reference is a piece of information provided in a footnote or bibliography of a written work such as a book, article, essay, report, oration or any other text type, specifying the written work of another person used in the creation of that text. A bibliographical reference mostly includes the full name of the author, the title of their work and the year of publication. The primary purpose of references is to allow readers to examine the sources of a text, either for validity or to learn more about the subject. Such items are often listed at the end of a work in a section marked References or Bibliography.

References are particularly important as for the use of citations, since copying of material by another author without proper reference and / or without required permissions is considered plagiarism, and may be tantamount to copyright infringement, which can be subject to legal proceedings. A reference section contains only those works indeed cited in the main text of a work. In contrast, a bibliographical section often contains works not cited by the author, but used as background reading or listed as potentially useful to the reader.

Keeping a diary allows an individual to use references for personal organization, whether or not anyone else understands the systems of reference used. However, scholars have studied methods of reference because of their key role in communication and co-operation between different people, and also because of misunderstandings that can arise. Modern academic study of bibliographical references has been developing since the 19th century.[6]

Law[edit]

In patent law, a reference is a document that can be used to show the state of knowledge at a given time and that therefore may make a claimed invention obvious or anticipated. Examples of references are patents of any country, magazine articles, Ph.D. theses that are indexed and thus accessible to those interested in finding information about the subject matter, and to some extent Internet material that is similarly accessible.

Arts[edit]

In art, a reference is an item from which a work is based. This may include:

  • an existing artwork
  • a reproduction (i.e., a photo)
  • a directly observed object (e.g., a person)
  • the artist’s memory

Another example of reference is samples of various musical works being incorporated into a new one.

See also[edit]

References[edit]

  1. ^ Treanor, Brian (2006). Aspects of alterity: Levinas, Marcel, and the contemporary debate. Fordham University Press. p. 41.
  2. ^ Klein, Ernest, A comprehensive etymological dictionary of the English language, Vol II, Elsevier publishing company, Amsterdam, 1969, p.1317
  3. ^ Saeed, John. Semantics. Blackwell. p. 12. ISBN 0-631-22693-1.
  4. ^ Engle, Eric (2010). Lex Naturalis, Ius Naturalis: Law as Positive Reasoning & Natural Rationality. Melbourne, Australia: The Rlias Clark Group. p. 75.
  5. ^ Powers, William (2005). Behavior: The Control of Perception (2nd ed.). New Canaan, Connecticut: Benchmark Publications. pp. 47 & 299.
  6. ^ Reimer, Marga (2009). “Reference”. Stanford Encyclopedia of Philosophy.

External links[edit]

Look up reference in Wiktionary, the free dictionary.
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´´A thorough, logical and reflective analysis of a sentence thought and/or described by a particular person can significantly influence the way they see and reflect the world around them´´. Rodrigo Nunes Cal ´´A análise minuciosa, lógica e reflexiva de uma frase pensada e/ou descrita por uma determinada pessoa pode influenciar significativamente no modo de ver e refletir o mundo ao seu redor´´. Rodrigo Nunes Cal “Para uma ideia que não parece insana à primeira vista, não há esperança.” Albert Einstein - “For an idea that does not first seem insane, there is no hope.” ― Albert Einstein - “A verdadeira lógica deste mundo está no cálculo de probabilidades.” James Clerk Maxwell “The true logic of this world is in the calculus of probabilities.” —James Clerk Maxwell - Virtual Induction Into The Human Mind = Indução Virtual Na Mente Humana #Probability #probabilidade(s) #Internet - Virtual Induction Of The Human Mind = Indução Virtual Da Mente Humana @ #probability #probabilities #RealFacts #RealFact #vision #thinking #Thoughts #NegativeFacts #PositiveFacts #analysis #research #researches #reference #people #communication #person #law #countries #country #Internet #work #team #pionner #pionners #blog #videos #video #photo #photos #information #knowledge #money #price #intelligence #TrueFacts #FalseFacts #HumanEvolution I N T E R N E T #Intenções #Imaginations #Thoughts #Pensamento(s) #Imaginações #Influences #Influência(s) -- Nem sempre o que fazemos na Internet com seus vários tipos de influências, faremos no ´´Mundo Real´´, obviamente. - Not always what we do on the Internet with its various types of influences, we will do in the ´´Real World´´, obviously. - “The true logic of this world is in the calculus of probabilities.” —James Clerk Maxwell * Nothing is better than reading and gaining more and more knowledge.” — Stephen Hawking #time #data #messages #information #knowledge #intentions #reading #probability #people #mind #photo #name #image #video #influences #actions #health #person #life #speak #write #researches #reference #type #listen #InternetHistory #objectives #improvement #longevity #imaginations #thinking #reality #Internet #ScientificDiscoveries #books #journals #importance #websites #analysis #SocialNetworks #links #blogs #countries #innovations #graphics #feedbacks #facts #science #technologies #ScienceEvents #poster #abstract #methodology #article #publications #team #DirectInvitations #speaker #Delegate #cities #feelings #energy #pionner #lives #work #contribuitions #pionners #minds #WorldHistory #ranking #economy ´´The world people need to have very efficient researches and projects resulting in very innovative drugs, vaccines, therapeutical substances, medical devices and other technologies according to the age, the genetics and medical records of the person. So, the treatment, diagnosis and prognosis will be very efficient and better, of course´´. Rodrigo Nunes Cal ´´O mundo precisa ter pesquisas e projetos muito eficientes que resultem em medicamentos, vacinas, substâncias terapêuticas, dispositivos médicos e outras tecnologias muito inovadoras de acordo com a idade, a genética e o prontuário da pessoa. Assim, o tratamento, o diagnóstico e o prognóstico serão bem mais eficientes e melhores, é claro´´. Rodrigo Nunes Cal ´´As you know, the world needs to have very efficient researches resulting new therapeutical substances, medical devices, prevention, diagnostic and prognostic methods, drugs and vaccines, for example. Very detailed researches are fundamental in this process. So, high impact innovations are essential to the world people!!´´ Rodrigo Nunes Cal  ´´Como você sabe, o mundo precisa de pesquisas muito eficientes que resultem em novas substâncias terapêuticas, aparelhos médicos, métodos de prevenção, de diagnósticos e de prognósticos, medicamentos e vacinas, por exemplo. Pesquisas muito detalhadas são fundamentais neste processo, obviamente. Portanto, inovações de grande impacto são essenciais para as pessoas do mundo todo!!´´ Rodrigo Nunes Cal ´´Ter grandes metas, muitas das quais ditas como impossíveis é muito importante porque pode induzir de várias maneiras em diferentes intensidades na sociedade científica mundial o surgimento de grandes descobertas científicas para toda a humanidade, beneficiando significativamente a vida das pessoas e fazendo com que a expectativa de vida humana aumente significativamente. Dessa forma, doenças conhecidas hoje como sendo fatais e incuráveis, podem se tornar doenças curáveis, com a obtenção de novas tecnologias altamente eficazes de prevenção, diagnóstico, prognóstico e de tratamento´´. Rodrigo Nunes Cal ´´Having big goals, many of which are said to be impossible, is very important because it can induce, in different ways, in different intensities in the world scientific society, the emergence of great scientific discoveries for all of humanity, significantly benefiting people's lives and causing the increase of human life expectancy significantly. Thus, diseases known today as being fatal and incurable, can become curable diseases, with the achievement of highly effective prevention, diagnosis, prognosis and treatment technologies´´. Rodrigo Nunes Cal * ´´The very unknown path may be the best path to take in life´´. Rodrigo Nunes Cal ´´O caminho muito desconhecido pode ser o melhor caminho a seguir na vida´´. Rodrigo Nunes Cal ´´A Ciência abre um leque de possibilidades dos mais variados assuntos e dos mais variados níveis de dificuldades. Sendo assim, a compreensão total dos mecanismos fisiológicos envolvidos na patogênese das doenças, destacando-se as doenças fatais que ocorrem em humanos, é de suma importância para a humanidade, com toda certeza. Quem sabe num futuro próximo essa compreensão seja muito bem entendida e quem sabe, como muitas pessoas sonham na imortalidade física, dentre elas cientistas, essa grande conquista pode ser adquirida. Como você sabe, a humanidade necessita urgentemente de novas descobertas científicas, destacando-se a aquisição de medicamentos e vacinas altamente eficazes contra um grande número de doenças, dentre elas as doenças desconhecidas e silenciosas, a obtenção de aparelhos médicos muito eficientes de diagnóstico, prognóstico e tratamento de doenças, entre outros. Com certeza, precisamos ter esperança e motivação para a realização de ótimos trabalhos e para uma qualidade de vida bem melhor e uma expectativa de vida cada vez maior´´. Rodrigo Nunes Cal ´´Science opens up a range of possibilities for the most varied subjects and the most varied levels of difficulties. Therefore, the full understanding of the physiological mechanisms involved in the pathogenesis of diseases, highlighting the fatal diseases that occur in humans, is of paramount importance for humanity, for sure. Maybe in the near future this understanding will be very well understood and who knows, as many people dream of physical immortality, among them scientists, this great achievement can be acquired. As you know, humanity urgently needs new scientific discoveries, highlighting the acquisition of highly effective medicines and vaccines against a large number of diseases, including unknown and silent diseases, obtaining very efficient medical devices for diagnosis, prognosis and treatment of diseases, among others. Certainly, we need to have hope and motivation to do great work and for a much better quality of life and an ever-increasing life expectancy´´. Rodrigo Nunes Cal - Very important note: The statistics on the number of people who visited this blog in 2018 were not entirely based on real visitors. - Observação muito importante: As estatísticas sobre número de pessoas que acessaram este blog no ano de 2018 não foram totalmente baseadas em visitantes reais. ´´Great difficulties may have come, but it is of great importance to have in mind the possibility of great victories in the future, bringing happiness and health for a long time´´. Rodrigo Nunes Cal ´´O caminho muito desconhecido pode ser o melhor caminho a seguir na vida´´. Rodrigo Nunes Cal ´´Understanding the great difficulties of a given subject can be a very long process, however, of great value for the progress of Science in all aspects´´. Rodrigo Nunes Cal ´´Entender as grandes dificuldades de um determinado assunto pode ser um processo muito longo, mas de grande valor para o progresso da Ciência em todos os seus aspectos´´. Rodrigo Nunes Cal My Curriculum Lattes: http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4240145A2 My Facebook Page: www.facebook.com/scientificblog IT´S A VERY EASY, FAST AND PRACTICAL WAY TO KNOW EXCELLENT INFORMATION ABOUT SCIENCE, TECHNOLOGY AND INNOVATION, AS AN EXAMPLE, APPLYING THE SEARCH MECHANISM Ctrl + F IN THIS BLOG FOR A WORD OR WORDS. SO, THIS BLOG SHARING IS VERY IMPORTANT TO THE WORLD SOCIETY! I hope in some way with this blog to help significantly in the socio-economic and technical-scientific development of the countries. My E-mail Accounts: rodrigoncal1984@gmail.com rodrigonunescal@yahoo.com rodrigoncal1984@yahoo.com ´´NÃO VÁ PARA ONDE O CAMINHO PODE TE LEVAR. VÁ ONDE NÃO HÁ CAMINHO E DEIXE UMA TRILHA. ´´ ´´DON'T GO WHERE THE PATH CAN TAKE YOU. GO WHERE THERE IS NO PATH AND LEAVE A TRAIL. ´´ @ KNOWING THE UNKNOWN.. CONHECENDO O DESCONHECIDO.. The world needs very innovative ideas to people live better and longer more and more. I have been invited as a Speaker/Delegate in numerous International Conferences and Congresses. * DISCOVERING HOW THE INITIAL STAGES OF A CERTAIN DISEASES WORK, SUCH AS A FATAL DISEASES, IS OF HUGE IMPORTANCE FOR SCIENCE, FOR SURE. THERE ARE SEVERAL BIOLOGICAL FACTORS CONNECTED IN THE HUMAN BODY THAT ACTING IN A VERY COMPLEX FORM. THEREFORE, IT IS OF GREAT NECESSITY TO CARRY OUT NEW SCIENTIFIC RESEARCHES MUCH MORE DETAILED AND MODERN, WITH A HIGH DEGREE OF PRECISION, EVEN IF THERE IS NO SIGNIFICANT STATISTICAL DIFFERENCE BETWEEN CERTAIN FACTORS. * DESCOBRIR COMO FUNCIONA OS ESTÁGIOS INICIAIS DE DETERMINADAS DOENÇAS, TAIS COMO AS DOENÇAS FATAIS, É DE ENORME IMPORTÂNCIA PARA A CIÊNCIA , COM CERTEZA. HÁ VÁRIOS FATORES BIOLÓGICOS INTERLIGADOS NO CORPO HUMANO QUE ATUAM DE FORMA MUITO COMPLEXA. PORTANTO, É DE GRANDE NECESSIDADE A REALIZAÇÃO DE NOVAS PESQUISAS CIENTÍFICAS MUITO MAIS MINUCIOSAS E MODERNAS, COM ALTO GRAU DE PRECISÃO, MESMO QUE NÃO HAJA DIFERENÇA ESTATÍSTICA SIGNIFICATIVA ENTRE DETERMINADOS FATORES. * The discussion of certain facts in science envolving stastistics is fundamental to the scientific community, for example, the analysis and interpretation of very important, innovative and interesting graphics with no statistical difference between them can have a big value to the researches and to the future researches. So, the quality and efficiency of researches can increase so much in a little time, increasing the possiblities of excellent references and new scientific discoveries. The facts veracity and the disclosure of them are essential for the scientific community, of course. Reconhecer o(s) erro(s) cometido(s) e não praticá-lo(s) novamente é um ato de grande sabedoria e importância para si mesmo e para a(s) outra(s) pessoa(s). Acknowledging mistakes and not doing them again is an act of great wisdom and importance for yourself and to the other person or people. ´´O IMPOSSÍVEL PODE SER POSSÍVEL´´. ´´THE IMPOSSIBLE CAN BE POSSIBLE´´. I have received positive feedbacks about this blog by LinkedIn, Twitter, Facebook, E-mails and Instagram. ´´EVERYONE DIES. THE GOAL IS NOT TO LIVE FOREVER. THE GOAL S TO CREATE SOMETHING THAT WILL´´ # time #time #internet #technologies #HighTechnologies #Cell Phones #Computer #Notebook  # Television #radio #communication #tempo  #InternetSociety # Society #person # people # age #ages #genetics #longevity #investigations #researches #efficiency #projects #ideas #reference #references #article #articles #journal # journals #magazines #websites #blogs #sites #links #SocialNetworks #energy #graphics #dissertation #monograph #citations #ImpactFactor #pesquisa #pesquisas #tecnologias #DiferentesPercepções #DifferentPerceptions #mind #mente #minds #MentesHumanas #emails #email e-mails reading #MenteHumana leitura mensagem mensagens probabilidade(s) probabilities messages message importance importância relevância assunto(s) subject subjects issue tema reflexão reflections vision visão pioneirismo pionners prêmio(s) prizes awards innovations inovações Grupos de Estudo Grupos Controle saúde doença(s) nome(s) tempo(s) Início da doença - Momento inicial da doença - Momento(s) inicial(ais) da(s) doença(s) humana(s) - Semelhança genética com camundongos - Mice researches - vaccines - drugs - eficiência - medicamento(s) - vacina(s) - High efficiency - Fatal diseases - Doenças fatais - Investments - investimentos - laboratórios - industries - indústrias - laboratories - Centros de Pesquisa - Países - cidades - cities - longevidade - desafio(s) - challenges - gráficos detalhados - interações biológicas - fatores biológicas - análise minuciosa - Very detailed analysis @ Initial moment of disease - Initial moments of human diseases - No Name @ discussion - discussão científica - science facts - detailed graphics - fatos científicos - publicação de trabalhos científicos - publications - hard work - better results - better science - diagnóstico - prognósticos - Diferença Estatística Significativa 100 Diferença Estatística Significativa @ Significant Statistical Difference - V X I Interpretations interpretações intenções intenions countries EU 100 gene Sem genes Cem genes 1 0 0 gene(s) time(s) times 100 limites limite(s) limits 1 0 0 limit NO LIMIT 10 0 @ 100 genes @ 100 gene & NO GENE NO TEMPO NOS TEMPOS NO(S) TEMPO(S) NOS TIMES NO TIME 100 GENE No Time # no time @ nos genes no(s) gene(s) * no(s) limite(s) - words- palavra(s) - listen - write - type - fala - escuta - ler - virtualidade - virtuality - reality - realidade - mundo real - mundo virtual - vida real - virtual life - real life - vida virtual - imaginations - thoughts - pensamento(s) - imaginações - melhoria - improvement - respect - respeito - speak - nome(s) - trabalho(s) - dinheiro - money - team - equipe - objetivo(s) - Best Universities of the World - Scientific Discoveries - Brazil - World - RNA - Cell - DNA - Idade biológica - biological age - pessoas - idade - idade(s) - pessoa - História da Computação Mundial - Harvard - Names - Places - City - researches - scientists - professors - pesquisador(es) - cientistas - professores - professor(es) - Produção científica - Fatores de Impacto - feelings - logic - sentimento(s) - lógica - história - world history - difficulties - dificuldades - Scientific community - comunidade científica mundial - vidas humanas - vida(s) humana(s) - trabalho(s) - human lives - life - human life - única - one life - person people @ momentos - moments memories memory memória longevidade energias energia(s) Many people liked my Twitter and Facebook comments that I informed this blog like great professors, scientists and researchers around the world who work in human health area! Many data about it aren´t in this blog. #database #system #time #data #search #information #InternetHistory #contribuitions #improvement #analysis #intentions Intenções @ #person #people #age #longevity #work #reading #probabilities #energy #money #price #clicks #jobs #country #city #countries #cities #knowledge #HumanInterdependence #WorldHistory #communication #HumanRelations #websites #e-mails #SocialNetworks #ranking #links #images #photos #texts #messages #videos #writing #typing #speak #listen #think #feelings #ideas #ScientificDiscoveries #investigations #researches #articles #ImpactFactors #journals #citations #influence #dissertations #monographs #ScientificWorks #Inventions #graphics #subjects #books #references #blogs ´´Compreender as grandes dificuldades de um determinado assunto pode ser um processo muito demorado, porém, de grande valia para o progresso da Ciência em todos os aspectos´´ Rodrigo Nunes Cal Observação/Note: I won a scholarship by FAPEMIG during the period of ´´my´´ monograph in Uberaba. Ganhei bolsa de estudo pela FAPEMIG durante o período da ´´minha´´ monografia em Uberaba. During the period that I participated of ´´my´´ dissertation at FAMERP, I didn't win a scholarship. Já durante o mestrado que fiz na FAMERP, não ganhei bolsa de estudo. ´´Os gráficos baseados em dados da ´´minha´´ dissertação que fiz podem ser uma excelente referência para muitos tipos de pesquisas e projetos, é claro !! Por exemplo, para pesquisas e projetos que tenham como objetivo analisar os tipos de influências das idades em camundongos e humanos (estudos genéticos, por exemplo) em relação a diferentes estágios de determinadas doenças, como aquelas em que a comunidade científica desconhece (doenças desconhecidas) e que poderão surgir no mundo. Outros tipos de pesquisas e projetos que podem ser feitos são aqueles que analisam a eficácia de diversos tipos de substâncias terapêuticas em camundongos e humanos nos diversos tipos de doenças com o objetivo de saber qual a melhor substância terapêutica para cada doença, levando em consideração a idade e genética, com certeza. Contudo, realizar pesquisas com o objetivo de avaliar qual é a influência da idade e da genética na eficiência terapêutica em animais de experimentação e em humanos, consequentemente, possui um grande valor, já que muitas pessoas adoecem e acabam falecendo mesmo sendo submetidas à ótimos sistemas de diagnóstico, tratamento e prognóstico, dependendo da doença que possui e do estágio da mesma´´. ´´A partir daí, ao comprovar que há influência significativa da idade e da genética, consequentemente, no processo de patogênese de doenças nos animais de experimentação e nos humanos, seria muito mais conveniente e lógico um grupo de indivíduos de certa faixa etária e histórico familiar e individual de doenças adquiridas e possíveis de serem adquiridas no decorrer do tempo serem tratados com outros tipos de medicamentos, substâncias terapêuticas, vacinas, dentre outros. Com certeza, para a realização destes tipos de pesquisa deve haver grande investimento financeiro nos laboratórios a fim de aquisição de aparelhos científicos altamente eficientes. Com certeza, pesquisas à nível genético e com relação à influência da idade do ser vivo na patogênese de doenças, até das doenças desconhecidas pelo mundo científico. O fato é que este tipo de pesquisa é muito importante porque como todos sabem, há muitas doenças que voltam a se manifestar nas pessoas mesmo depois de excelentes tratamentos, dos mais variados tipos. E outro ponto a ser refletido é a permanência de doenças fatais´´. ´´Assim, este tipo de influência da idade e consequentemente da genética na fisiopatologia das doenças hereditárias ou não hereditárias, um indivíduo de uma determinada idade será submetido a um tratamento terapêutico diferente de outro com a mesma doença mas com idade diferente da de até a pesquisa mostrou uma influência significativa na patogênese da doença, portanto, utilizará outro tipo de substância terapêutica, medicamentos, entre outros. Isso certamente acontecerá se a comunidade científica mundial comprovar cientificamente essas hipóteses por meio de várias pesquisas e projetos científicos. As pessoas precisam ter excelentes inovações para a expectativa de vida humana aumentar muito rapidamente cada vez mais. Portanto, quanto mais a medicina personalizada for, melhor será para cada um de nós´´. Rodrigo Nunes Cal ´´The graphics based on data from ´´my´´ dissertation I did can be an excellent reference for many types of researches and projects, of course!! For example, for researches and projects that the goals are analyse the type of influences of ages in mice and human (genetic studies, for example) in relation to different stages of determined diseases, like those that the scientific community do not know about them (unknown diseases). Other types of researches and projects that can be done is those that analyse the efficiency of many types of therapeutical substances in mice and human in many types of diseases with the objective of knowing which is the best therapeutic substance for each disease, taking into account age and genetics, for sure. For example, to carry out research with the objective of evaluating the influence of age and genetics on therapeutic efficiency in experimental animals and in humans´´. ´´Thus, by proving that there is a significant influence of age and genetics, consequently, in the process of pathogenesis of diseases in experimental animals and in humans, it would be much more convenient and logical to have a group of individuals of a certain age group and family and individual history of acquired diseases and possible to be acquired over time being treated with other types of drugs, therapeutic substances, vaccines, among others. Certainly, to carry out these types of research there must be a large financial investment in laboratories in order to acquire highly efficient scientific devices. Certainly, research at the genetic level and regarding the influence of the age of the living being on the pathogenesis of diseases, even diseases unknown to the scientific world. The fact is that this type of research is very important because as everyone knows, there are many diseases that come back to manifest in people even after excellent treatments, of the most varied types. And another point to be reflected on is the permanence of fatal diseases´´. ´´Taking into account this type of influence of age and consequently genetics on the pathophysiology of inherited or not inherited diseases, an individual of a certain age will be submitted to a different therapeutic treatment from another with the same disease but who has a different age than through the research has shown a significant influence on the pathogenesis of the disease, therefore, will use another type of therapeutic substance, medicine, among others. This will certainly happen if the world scientific community scientifically proves these hypotheses through various research and scientific projects. So, the people need to have excellent innovation to the human expectancy  of life increase so much faster more and more´´. Rodrigo Nunes Cal Note/Obs: I thought each person could do their own friend request permission setting since Facebook's technology is so big. Eu achava que cada pessoa poderia fazer sua própria configuração de permissão de solicitação de amizade já que a tecnologia do Facebook é muito grande. Very important note: I can earn money with this blog if the person do a donation to increase the dissemination of this blog and to recognize the hard work to do it. - Observação muito importante: Posso ganhar dinheiro com este blog se alguém fizer uma doação pra mim para aumentar a divulgação deste blog e pelo reconhecimento de fazer este blog. Foi um trabalho árduo pra fazer este blog.

11 Comments

  7. Great blog! Do you have any hints for aspiring writers? I’m planning to start my own site soon but I’m a little lost on everything. Would you recommend starting with a free platform like WordPress or go for a paid option? There are so many choices out there that I’m completely overwhelmed .. Any tips? Thanks!

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