**Do the downloads!! Share!! The diffusion of very important information and knowledge is essential for the world progress always!! Thanks!**!

- – – > > Mestrado – Dissertation – Tabelas, Figuras e Gráficos – Tables, Figures and Graphics –
**´´My´´ Dissertation #Innovation #Countries #Time #Researches #Reference #Graphics #Ages #Age #Mice #People #Person #Mouse #Genetics #PersonalizedMedicine #Diagnosis #Prognosis #Treatment #Disease #UnknownDiseases #Future #VeryEfficientDrugs #VeryEfficientVaccines #VeryEfficientTherapeuticalSubstances #Tests #Laboratories #Investments #Details****#HumanLongevity #DNA #Cell #Memory #Physiology #Nanomedicine #Nanotechnology #Biochemistry #NewMedicalDevices #GeneticEngineering #Internet #History #Science****#World**

**Pathol Res Pract. 2012 Jul 15;208(7):377-81. doi: 10.1016/j.prp.2012.04.006. Epub 2012 Jun 8.**

# The influence of physical activity in the progression of experimental lung cancer in mice

Renato Batista Paceli^{ 1}, Rodrigo Nunes Cal, Carlos Henrique Ferreira dos Santos, José Antonio Cordeiro, Cassiano Merussi Neiva, Kazuo Kawano Nagamine, Patrícia Maluf Cury

- PMID:
**22683274** - DOI: 10.1016/j.prp.2012.04.006

Impact_Fator-wise_Top100Science_Journals

GRUPO_AF1 – **GROUP AFA1 – Aerobic Physical Activity** **– Atividade Física Aeróbia –** **´´My´´ Dissertation **– Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 1 – **GROUP AFAN1 – Anaerobic Physical Activity** – **Atividade Física Anaeróbia – ´´My´´ Dissertation **– Faculty of Medicine of Sao Jose do Rio Preto

GRUPO_AF2 – **GROUP AFA2 – Aerobic Physical Activity** – **Atividade Física Aeróbia –** **´´My´´ Dissertation **– Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 2 – **GROUP AFAN 2 – Anaerobic Physical Activity** – **Atividade Física Anaeróbia** – **´´My´´ Dissertation **– Faculty of Medicine of Sao Jose do Rio Preto

Slides – mestrado – **´´My´´ Dissertation **– Faculty of Medicine of Sao Jose do Rio Preto

CARCINÓGENO DMBA EM MODELOS EXPERIMENTAIS

DMBA CARCINOGEN IN EXPERIMENTAL MODELS

Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo – **´´My´´ Dissertation **– **Faculty of Medicine of Sao Jose do Rio Preto**

https://pubmed.ncbi.nlm.nih.gov/22683274/

## Abstract

**Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.**

**Copyright © 2012 Elsevier GmbH. All rights reserved.**Mestrado – ´´My´´ Dissertation – Tabelas, Figuras e Gráficos – Tables, Figures and Graphics – Faculty of Medicine of Sao Jose do Rio Preto BaixarRedefine Statistical SignificanceBaixar

**´´We propose to change the default P-value threshold for statistical significance from 0.05 to 0.005 for claims of new discoveries.´´** https://www.nature.com/articles/s41562-017-0189-z Published:

**Daniel J. Benjamin, James O. Berger, […]Valen E. Johnson Nature Human Behaviour volume 2, pages6–10 (2018)**

Um mundo além de p < 0,05 « Sandra Merlo – Fonoaudiologia da Fluência

Article – ´´My´´ dissertation – Faculty of Medicine of Sao Jose do Rio Preto

My suggestion of a very important Project…

A Psicossomática Psicanalítica – Faculty of Medicine of Sao Jose do Rio Preto

ÁCIDO HIALURÔNICO – HIALURONIC ACID – Faculty of Medicine of Sao Jose do Rio Preto

Slides – Mestrado final – ´´My´´ dissertation – Faculty of Medicine of Sao Jose do Rio Preto

O Homem como Sujeito da Realidade da Saúde – Redação – Faculty of Medicine of Sao Jose do Rio Preto

Aula_Resultados – Results – FAMERP – Faculty of Medicine of Sao Jose do Rio Preto

As credenciais da ciência – The credentials of Science – Faculty of Medicine of Sao Jose do Rio Preto BaixarFrases que digitei – Phrases I typed

Frases que digitei – Tecnologia – Informations about blog I did

Keynote-The-Future-of-Space-Exploration(1)

Nanomedicine an evolving research (Opinion article I typed)

journal-of-nanomedicine–nanotechnology-flyer

Will you embrace AI fast enough

MICROBIOLOGIA – MICROBIOLOGY – Faculty of Medicine of Sao Jose do Rio Preto

Genes e Epilepsia – Genes and epilepsy – Faculty of Medicine of Sao Jose do Rio Preto

BIOGRAFIA – BIOGRAPH – DR. DOMINGO MARCOLINO BRAILE

redefine-statistical-significance

https://en.wikipedia.org/wiki/Quantum_computing

LOG INTHE MAGAZINESHOPLOGINREGISTERSTAY CURIOUSSUBSCRIBETHE SCIENCESMINDTECHNOLOGYHEALTHENVIRONMENTPLANET EARTHTHE SCIENCES

# Quantum Computers Finally Beat Supercomputers in 2019

### #16 in our top science stories of 2019.

By Stephen OrnesDecember 28, 2019 1:00 PM

LSU physicist Jonathan Dowling (right), shown with alumnus Todd Moulder, has pushed the growth rate in quantum computing. (Credit: LSU)

## Newsletter

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In his 2013 book, *Schrödinger’s Killer App*, Louisiana State University theoretical physicist Jonathan Dowling predicted what he called “super exponential growth.” He was right. Back in May, during Google’s Quantum Spring Symposium, computer engineer Hartmut Neven reported the company’s quantum computing chip had been gaining power at breakneck speed.

The subtext: We are venturing into an age of quantum supremacy — the point at which quantum computers outperform the best classical supercomputers in solving a well-defined problem.

Engineers test the accuracy of quantum computing chips by using them to solve a problem, and then verifying the work with a classical machine. But in early 2019, that process became problematic, reported Neven, who runs Google’s Quantum Artificial Intelligence Lab. Google’s quantum chip was improving so quickly that his group had to commandeer increasingly large computers — and then clusters of computers — to check its work. It’s become clear that eventually, they’ll run out of machines.

Case in point: Google announced in October that its 53-qubit quantum processor had needed only 200 seconds to complete a problem that would have required 10,000 years on a supercomputer.

Neven’s group observed a “double exponential” growth rate in the chip’s computing power over a few months. Plain old exponential growth is already really fast: It means that from one step to the next, the value of something multiplies. Bacterial growth can be exponential if the number of organisms doubles during an observed time interval. So can computing power of classical computers under Moore’s Law, the idea that it doubles roughly every year or two. But under double exponential growth, the exponents have exponents. That makes a world of difference: Instead of a progression from 2 to 4 to 8 to 16 to 32 bacteria, for example, a double-exponentially growing colony in the same time would grow from 2 to 4 to 16 to 256 to 65,536.

Neven credits the growth rate to two factors: the predicted way that quantum computers improve on the computational power of classical ones, and quick improvement of quantum chips themselves. Some began referring to this growth rate as “Neven’s Law.” Some theorists say such growth was unavoidable.

We talked to Dowling (who suggests a more fitting moniker: the “Dowling-Neven Law”) about double exponential growth, his prediction and his underappreciated Beer Theory of Quantum Mechanics.

**Q: You saw double exponential growth on the horizon long before it showed up in a lab. How?**

**A: **Anytime there’s a new technology, if it is worthwhile, eventually it kicks into exponential growth in *something.* We see this with the internet, we saw this with classical computers. You eventually hit a point where all of the engineers figure out how to make this work, miniaturize it and then you suddenly run into exponential growth in terms of the hardware. If it doesn’t happen, that hardware falls off the face of the Earth as a nonviable technology.

**Q: So you weren’t surprised to see Google’s chip improving so quickly?**

A: I’m only surprised that it happened earlier than I expected. In my book, I said within the next 50 to 80 years. I guessed a little too conservatively.

**Q: You’re a theoretical physicist. Are you typically conservative in your predictions?**

People say I’m fracking nuts when I publish this stuff. I like to think that I’m the crazy guy that always makes the *least *conservative prediction. I thought this was far-out wacky stuff, and I was making the most outrageous prediction. That’s why it’s taking everybody by surprise. Nobody expected double exponential growth in processing power to happen this soon.

**Q: Given that quantum chips are getting so fast, can I buy my own quantum computer now?**

**A: **Most of the people think the quantum computer is a solved problem. That we can just wait, and Google will sell you one that can do whatever you want. But no. We’re in the [prototype] era. The number of qubits is doubling every six months, but the qubits are not perfect. They fail a lot and have imperfections and so forth. But Intel and Google and IBM aren’t going to wait for perfect qubits. The people who made the [first computers] didn’t say, “We’re going to stop making bigger computers until we figure out how to make perfect vacuum tubes.”

**Q: What’s the big deal about doing problems with quantum mechanics instead of classical physics? **

**A: **If you have 32 qubits, it’s like you have 232 parallel universes that are working on parts of your computation. Or like you have a parallel processor with 232 processors. But you only pay the electric bill in our universe.

**Q: Quantum mechanics gets really difficult, really fast. How do you deal with that?**

**A: **Everybody has their own interpretation of quantum mechanics. Mine is the Many Beers Interpretation of Quantum Mechanics. With no beer, quantum mechanics doesn’t make any sense. After one, two or three beers, it makes perfect sense. But once you get to six or 10, it doesn’t make any sense again. I’m on my first bottle, so I’m in the zone.

*[This story originally appeared in print as “The Rules of the Road to Quantum Supremacy.”]*

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# Quantum computing

From Wikipedia, the free encyclopediaJump to navigationJump to search

This article’s tone or style may not reflect the encyclopedic tone used on Wikipedia. See Wikipedia’s guide to writing better articles for suggestions. (November 2019) (Learn how and when to remove this template message) |

Quantum computer based on superconducting qubits developed by IBM Research in Zürich, Switzerland. The device shown here will be inserted into a dilution refrigerator and cooled to under 1 kelvin.

**Quantum Computing** is the use of quantum-mechanical phenomena such as superposition and entanglement to perform computation. A **quantum computer** is used to perform such computation, which can be implemented theoretically or physically^{[1]}^{:I-5} There are two main approaches to physically implementing a quantum computer currently, analog and digital. Analog approaches are further divided into quantum simulation, quantum annealing, and adiabatic quantum computation. Digital quantum computers use quantum logic gates to do computation. Both approaches use quantum bits or qubits.^{[1]}^{:2–13}

Qubits are fundamental to quantum computing and are somewhat analogous to bits in a classical computer. Qubits can be in a 1 or 0 quantum state. But they can also be in a superposition of the 1 and 0 states. However, when qubits are measured the result is always either a 0 or a 1; the probabilities of the two outcomes depends on the quantum state they were in.

Quantum computing began in the early 1980s, when physicist Paul Benioff proposed a quantum mechanical model of the Turing machine.^{[2]} Richard Feynman and Yuri Manin later suggested that a quantum computer had the potential to simulate things that a classical computer could not.^{[3]}^{[4]} In 1994, Peter Shor developed a quantum algorithm for factoring integers that had the potential to decrypt all secured communications.^{[5]}

Despite ongoing experimental progress since the late 1990s, most researchers believe that “fault-tolerant quantum computing [is] still a rather distant dream”.^{[6]} On 23 October 2019, Google AI, in partnership with the U.S. National Aeronautics and Space Administration (NASA), published a paper in which they claimed to have achieved quantum supremacy.^{[7]} While some have disputed this claim, it is still a significant milestone in the history of quantum computing.^{[8]}

The field of quantum computing is a subfield of quantum information science, which includes quantum cryptography and quantum communication.

## Contents

- 1Quantum operations
- 2Potential
- 3Obstacles
- 4Developments
- 5Relation to computational complexity theory
- 6See also
- 7References
- 8Further reading
- 9External links

## Quantum operations[edit]

The Bloch sphere is a representation of a qubit, the fundamental building block of quantum computers.

The prevailing model of quantum computation describes the computation in terms of a network of quantum logic gates. What follows is a brief treatment of the subject based upon Chapter 4 of Nielsen and Chuang.^{[9]}

A memory consisting of {\textstyle n} bits of information has {\textstyle 2^{n}} possible states. A vector representing all memory states has hence {\textstyle 2^{n}} entries (one for each state). This vector should be viewed as a *probability vector* and represents the fact that the memory is to be found in a particular state.

In the classical view, one entry would have a value of 1 (i.e. a 100% probability of being in this state) and all other entries would be zero. In quantum mechanics, probability vectors are generalized to density operators. This is the technically rigorous mathematical foundation for quantum logic gates, but the intermediate quantum state vector formalism is usually introduced first because it is conceptually simpler. This article focuses on the quantum state vector formalism for simplicity.

We begin by considering a simple memory consisting of only one bit. This memory may be found in one of two states: the zero state or the one state. We may represent the state of this memory using Dirac notation so that{\displaystyle |0\rangle :={\begin{pmatrix}1\\0\end{pmatrix}};\quad |1\rangle :={\begin{pmatrix}0\\1\end{pmatrix}}}A quantum memory may then be found in any quantum superposition {\textstyle |\psi \rangle } of the two classical states {\textstyle |0\rangle } and {\textstyle |1\rangle }:{\displaystyle |\psi \rangle :=\alpha \,|0\rangle +\beta \,|1\rangle ={\begin{pmatrix}\alpha \\\beta \end{pmatrix}};\quad |\alpha |^{2}+|\beta |^{2}=1.}In general, the coefficients {\textstyle \alpha } and {\textstyle \beta } are complex numbers. In this scenario, one qubit of information is said to be encoded into the quantum memory. The state {\textstyle |\psi \rangle } is not itself a probability vector but can be connected with a probability vector via a measurement operation. If the quantum memory is measured to determine if the state is {\textstyle |0\rangle } or {\textstyle |1\rangle } (this is known as a computational basis measurement), the zero state would be observed with probability {\textstyle |\alpha |^{2}} and the one state with probability {\textstyle |\beta |^{2}}. The numbers {\textstyle \alpha } and {\textstyle \beta } are called quantum amplitudes.

The state of this one-qubit quantum memory can be manipulated by applying quantum logic gates, analogous to how classical memory can be manipulated with classical logic gates. One important gate for both classical and quantum computation is the NOT gate, which can be represented by a matrix{\displaystyle X:={\begin{pmatrix}0&1\\1&0\end{pmatrix}}.}Mathematically, the application of such a logic gate to a quantum state vector is modelled with matrix multiplication. Thus {\textstyle X|0\rangle =|1\rangle } and {\textstyle X|1\rangle =|0\rangle }.

The mathematics of single qubit gates can be extended to operate on multiqubit quantum memories in two important ways. One way is simply to select a qubit and apply that gate to the target qubit whilst leaving the remainder of the memory unaffected. Another way is to apply the gate to its target only if another part of the memory is in a desired state. These two choices can be illustrated using another example. The possible states of a two-qubit quantum memory are{\displaystyle |00\rangle :={\begin{pmatrix}1\\0\\0\\0\end{pmatrix}};\quad |01\rangle :={\begin{pmatrix}0\\1\\0\\0\end{pmatrix}};\quad |10\rangle :={\begin{pmatrix}0\\0\\1\\0\end{pmatrix}};\quad |11\rangle :={\begin{pmatrix}0\\0\\0\\1\end{pmatrix}}.}The CNOT gate can then be represented using the following matrix:{\displaystyle CNOT:={\begin{pmatrix}1&0&0&0\\0&1&0&0\\0&0&0&1\\0&0&1&0\end{pmatrix}}.}As a mathematical consequence of this definition, {\textstyle CNOT|00\rangle =|00\rangle }, {\textstyle CNOT|01\rangle =|01\rangle }, {\textstyle CNOT|10\rangle =|11\rangle }, and {\textstyle CNOT|11\rangle =|10\rangle }. In other words, the CNOT applies a NOT gate ({\textstyle X} from before) to the second qubit if and only if the first qubit is in the state {\textstyle |1\rangle }. If the first qubit is {\textstyle |0\rangle }, nothing is done to either qubit.

In summary, a quantum computation can be described as a network of quantum logic gates and measurements. Any measurement can be deferred to the end of a quantum computation, though this deferment may come at a computational cost. Because of this possibility of deferring a measurement, most quantum circuits depict a network consisting only of quantum logic gates and no measurements. More information can be found in the following articles: universal quantum computer, Shor’s algorithm, Grover’s algorithm, Deutsch–Jozsa algorithm, amplitude amplification, quantum Fourier transform, quantum gate, quantum adiabatic algorithm and quantum error correction.

Any quantum computation can be represented as a network of quantum logic gates from a fairly small family of gates. A choice of gate family that enables this construction is known as a universal gate set. One common such set includes all single-qubit gates as well as the CNOT gate from above. This means any quantum computation can be performed by executing a sequence of single-qubit gates together with CNOT gates. Though this gate set is infinite, it can be replaced with a finite gate set by appealing to the Solovay-Kitaev theorem.

## Potential[edit]

### Cryptography[edit]

Integer factorization, which underpins the security of public key cryptographic systems, is believed to be computationally infeasible with an ordinary computer for large integers if they are the product of few prime numbers (e.g., products of two 300-digit primes).^{[10]} By comparison, a quantum computer could efficiently solve this problem using Shor’s algorithm to find its factors. This ability would allow a quantum computer to break many of the cryptographic systems in use today, in the sense that there would be a polynomial time (in the number of digits of the integer) algorithm for solving the problem. In particular, most of the popular public key ciphers are based on the difficulty of factoring integers or the discrete logarithm problem, both of which can be solved by Shor’s algorithm. In particular, the RSA, Diffie–Hellman, and elliptic curve Diffie–Hellman algorithms could be broken. These are used to protect secure Web pages, encrypted email, and many other types of data. Breaking these would have significant ramifications for electronic privacy and security.

However, other cryptographic algorithms do not appear to be broken by those algorithms.^{[11]}^{[12]} Some public-key algorithms are based on problems other than the integer factorization and discrete logarithm problems to which Shor’s algorithm applies, like the McEliece cryptosystem based on a problem in coding theory.^{[11]}^{[13]} Lattice-based cryptosystems are also not known to be broken by quantum computers, and finding a polynomial time algorithm for solving the dihedral hidden subgroup problem, which would break many lattice based cryptosystems, is a well-studied open problem.^{[14]} It has been proven that applying Grover’s algorithm to break a symmetric (secret key) algorithm by brute force requires time equal to roughly 2^{n/2} invocations of the underlying cryptographic algorithm, compared with roughly 2^{n} in the classical case,^{[15]} meaning that symmetric key lengths are effectively halved: AES-256 would have the same security against an attack using Grover’s algorithm that AES-128 has against classical brute-force search (see Key size).

Quantum cryptography could potentially fulfill some of the functions of public key cryptography. Quantum-based cryptographic systems could, therefore, be more secure than traditional systems against quantum hacking.^{[16]}

### Quantum search[edit]

Besides factorization and discrete logarithms, quantum algorithms offering a more than polynomial speedup over the best known classical algorithm have been found for several problems,^{[17]} including the simulation of quantum physical processes from chemistry and solid state physics, the approximation of Jones polynomials, and solving Pell’s equation. No mathematical proof has been found that shows that an equally fast classical algorithm cannot be discovered, although this is considered unlikely.^{[18]} However, quantum computers offer polynomial speedup for some problems. The most well-known example of this is *quantum database search*, which can be solved by Grover’s algorithm using quadratically fewer queries to the database than that are required by classical algorithms. In this case, the advantage is not only provable but also optimal, it has been shown that Grover’s algorithm gives the maximal possible probability of finding the desired element for any number of oracle lookups. Several other examples of provable quantum speedups for query problems have subsequently been discovered, such as for finding collisions in two-to-one functions and evaluating NAND trees.

Problems that can be addressed with Grover’s algorithm have the following properties:

- There is no searchable structure in the collection of possible answers,
- The number of possible answers to check is the same as the number of inputs to the algorithm, and
- There exists a boolean function which evaluates each input and determines whether it is the correct answer

For problems with all these properties, the running time of Grover’s algorithm on a quantum computer will scale as the square root of the number of inputs (or elements in the database), as opposed to the linear scaling of classical algorithms. A general class of problems to which Grover’s algorithm can be applied^{[19]} is Boolean satisfiability problem. In this instance, the *database* through which the algorithm is iterating is that of all possible answers. An example (and possible) application of this is a password cracker that attempts to guess the password or secret key for an encrypted file or system. Symmetric ciphers such as Triple DES and AES are particularly vulnerable to this kind of attack.^{[citation needed]} This application of quantum computing is a major interest of government agencies.^{[20]}

### Quantum simulation[edit]

Since chemistry and nanotechnology rely on understanding quantum systems, and such systems are impossible to simulate in an efficient manner classically, many believe quantum simulation will be one of the most important applications of quantum computing.^{[21]} Quantum simulation could also be used to simulate the behavior of atoms and particles at unusual conditions such as the reactions inside a collider.^{[22]}

### Quantum annealing and adiabatic optimization[edit]

Quantum annealing or Adiabatic quantum computation relies on the adiabatic theorem to undertake calculations. A system is placed in the ground state for a simple Hamiltonian, which is slowly evolved to a more complicated Hamiltonian whose ground state represents the solution to the problem in question. The adiabatic theorem states that if the evolution is slow enough the system will stay in its ground state at all times through the process.

### Solving linear equations[edit]

The Quantum algorithm for linear systems of equations or “HHL Algorithm”, named after its discoverers Harrow, Hassidim, and Lloyd, is expected to provide speedup over classical counterparts.^{[23]}

### Quantum supremacy[edit]

John Preskill has introduced the term *quantum supremacy* to refer to the hypothetical speedup advantage that a quantum computer would have over a classical computer in a certain field.^{[24]} Google announced in 2017 that it expected to achieve quantum supremacy by the end of the year though that did not happen. IBM said in 2018 that the best classical computers will be beaten on some practical task within about five years and views the quantum supremacy test only as a potential future benchmark.^{[25]} Although skeptics like Gil Kalai doubt that quantum supremacy will ever be achieved,^{[26]}^{[27]} in October 2019, a Sycamore processor created in conjunction with Google AI Quantum was reported to have achieved quantum supremacy,^{[28]} with calculations more than 3,000,000 times as fast as those of Summit, generally considered the world’s fastest computer.^{[29]} Bill Unruh doubted the practicality of quantum computers in a paper published back in 1994.^{[30]} Paul Davies argued that a 400-qubit computer would even come into conflict with the cosmological information bound implied by the holographic principle.^{[31]}

## Obstacles[edit]

There are a number of technical challenges in building a large-scale quantum computer,.^{[32]} David DiVincenzo listed the following requirements for a practical quantum computer:^{[33]}

- scalable physically to increase the number of qubits;
- qubits that can be initialized to arbitrary values;
- quantum gates that are faster than decoherence time;
- universal gate set;
- qubits that can be read easily.

Sourcing parts for quantum computers is very difficult: Quantum computers need Helium-3, a nuclear research byproduct, and special cables that are only made by a single company in Japan.^{[34]}

### Quantum decoherence[edit]

Main article: Quantum decoherence

One of the greatest challenges is controlling or removing quantum decoherence. This usually means isolating the system from its environment as interactions with the external world cause the system to decohere. However, other sources of decoherence also exist. Examples include the quantum gates, and the lattice vibrations and background thermonuclear spin of the physical system used to implement the qubits. Decoherence is irreversible, as it is effectively non-unitary, and is usually something that should be highly controlled, if not avoided. Decoherence times for candidate systems in particular, the transverse relaxation time *T*_{2} (for NMR and MRI technology, also called the *dephasing time*), typically range between nanoseconds and seconds at low temperature.^{[35]} Currently, some quantum computers require their qubits to be cooled to 20 millikelvins in order to prevent significant decoherence.^{[36]}

As a result, time-consuming tasks may render some quantum algorithms inoperable, as maintaining the state of qubits for a long enough duration will eventually corrupt the superpositions.^{[37]}

These issues are more difficult for optical approaches as the timescales are orders of magnitude shorter and an often-cited approach to overcoming them is optical pulse shaping. Error rates are typically proportional to the ratio of operating time to decoherence time, hence any operation must be completed much more quickly than the decoherence time.

As described in the Quantum threshold theorem, if the error rate is small enough, it is thought to be possible to use quantum error correction to suppress errors and decoherence. This allows the total calculation time to be longer than the decoherence time if the error correction scheme can correct errors faster than decoherence introduces them. An often cited figure for the required error rate in each gate for fault-tolerant computation is 10^{−3}, assuming the noise is depolarizing.

Meeting this scalability condition is possible for a wide range of systems. However, the use of error correction brings with it the cost of a greatly increased number of required qubits. The number required to factor integers using Shor’s algorithm is still polynomial, and thought to be between *L* and *L*^{2}, where *L* is the number of qubits in the number to be factored; error correction algorithms would inflate this figure by an additional factor of *L*. For a 1000-bit number, this implies a need for about 10^{4} bits without error correction.^{[38]} With error correction, the figure would rise to about 10^{7} bits. Computation time is about *L*^{2} or about 10^{7} steps and at 1 MHz, about 10 seconds.

A very different approach to the stability-decoherence problem is to create a topological quantum computer with anyons, quasi-particles used as threads and relying on braid theory to form stable logic gates.^{[39]}^{[40]}

Physicist Mikhail Dyakonov has expressed skepticism of quantum computing as follows:So the number of continuous parameters describing the state of such a useful quantum computer at any given moment must be… about 10^{300}… Could we ever learn to control the more than 10^{300} continuously variable parameters defining the quantum state of such a system? My answer is simple. *No, never.*^{[41]}

## Developments[edit]

### Quantum computing models[edit]

There are a number of quantum computing models, distinguished by the basic elements in which the computation is decomposed. The four main models of practical importance are:

- Quantum gate array (computation decomposed into a sequence of few-qubit quantum gates)
- One-way quantum computer (computation decomposed into a sequence of one-qubit measurements applied to a highly entangled initial state or cluster state)
- Adiabatic quantum computer, based on quantum annealing (computation decomposed into a slow continuous transformation of an initial Hamiltonian into a final Hamiltonian, whose ground states contain the solution)
^{[42]} - Topological quantum computer
^{[43]}(computation decomposed into the braiding of anyons in a 2D lattice)

The quantum Turing machine is theoretically important but the direct implementation of this model is not pursued. All four models of computation have been shown to be equivalent; each can simulate the other with no more than polynomial overhead.

### Physical realizations[edit]

For physically implementing a quantum computer, many different candidates are being pursued, among them (distinguished by the physical system used to realize the qubits):

- Superconducting quantum computing
^{[44]}^{[45]}(qubit implemented by the state of small superconducting circuits (Josephson junctions)) - Trapped ion quantum computer (qubit implemented by the internal state of trapped ions)
- Optical lattices (qubit implemented by internal states of neutral atoms trapped in an optical lattice)
- Quantum dot computer, spin-based (e.g. the Loss-DiVincenzo quantum computer
^{[46]}) (qubit given by the spin states of trapped electrons) - Quantum dot computer, spatial-based (qubit given by electron position in double quantum dot)
^{[47]} - Coupled Quantum Wire (qubit implemented by a pair of Quantum Wires coupled by a Quantum Point Contact)
^{[48]}^{[49]}^{[50]} - Nuclear magnetic resonance quantum computer (NMRQC) implemented with the nuclear magnetic resonance of molecules in solution, where qubits are provided by nuclear spins within the dissolved molecule and probed with radio waves
- Solid-state NMR Kane quantum computers (qubit realized by the nuclear spin state of phosphorus donors in silicon)
- Electrons-on-helium quantum computers (qubit is the electron spin)
- Cavity quantum electrodynamics (CQED) (qubit provided by the internal state of trapped atoms coupled to high-finesse cavities)
- Molecular magnet
^{[51]}(qubit given by spin states) - Fullerene-based ESR quantum computer (qubit based on the electronic spin of atoms or molecules encased in fullerenes)
- Linear optical quantum computer (qubits realized by processing states of different modes of light through linear elements e.g. mirrors, beam splitters and phase shifters)
^{[52]} - Diamond-based quantum computer
^{[53]}^{[54]}^{[55]}(qubit realized by the electronic or nuclear spin of nitrogen-vacancy centers in diamond) - Bose-Einstein condensate-based quantum computer
^{[56]} - Transistor-based quantum computer – string quantum computers with entrainment of positive holes using an electrostatic trap
- Rare-earth-metal-ion-doped inorganic crystal based quantum computers
^{[57]}^{[58]}(qubit realized by the internal electronic state of dopants in optical fibers) - Metallic-like carbon nanospheres based quantum computers
^{[59]}

A large number of candidates demonstrates that the topic, in spite of rapid progress, is still in its infancy. There is also a vast amount of flexibility.

## Relation to computational complexity theory[edit]

Main article: Quantum complexity theoryThe suspected relationship of BQP to other problem spaces.^{[60]}

The class of problems that can be efficiently solved by quantum computers is called BQP, for “bounded error, quantum, polynomial time”. Quantum computers only run probabilistic algorithms, so BQP on quantum computers is the counterpart of BPP (“bounded error, probabilistic, polynomial time”) on classical computers. It is defined as the set of problems solvable with a polynomial-time algorithm, whose probability of error is bounded away from one half.^{[61]} A quantum computer is said to “solve” a problem if, for every instance, its answer will be right with high probability. If that solution runs in polynomial time, then that problem is in BQP.

BQP is contained in the complexity class *#P* (or more precisely in the associated class of decision problems *P ^{#P}*),

^{[62]}which is a subclass of PSPACE.

BQP is suspected to be disjoint from NP-complete and a strict superset of P, but that is not known. Both integer factorization and discrete log are in BQP. Both of these problems are NP problems suspected to be outside BPP, and hence outside P. Both are suspected to not be NP-complete. There is a common misconception that quantum computers can solve NP-complete problems in polynomial time. That is not known to be true, and is generally suspected to be false.^{[62]}

The capacity of a quantum computer to accelerate classical algorithms has rigid limits—upper bounds of quantum computation’s complexity. The overwhelming part of classical calculations cannot be accelerated on a quantum computer.^{[63]} A similar fact prevails for particular computational tasks, like the search problem, for which Grover’s algorithm is optimal.^{[64]}

Bohmian Mechanics is a non-local hidden variable interpretation of quantum mechanics. It has been shown that a non-local hidden variable quantum computer could implement a search of an *N*-item database at most in {\displaystyle O({\sqrt[{3}]{N}})} steps. This is slightly faster than the {\displaystyle O({\sqrt {N}})} steps taken by Grover’s algorithm. Neither search method will allow quantum computers to solve NP-Complete problems in polynomial time.^{[65]}

Although quantum computers may be faster than classical computers for some problem types, those described above cannot solve any problem that classical computers cannot already solve. A Turing machine can simulate these quantum computers, so such a quantum computer could never solve an undecidable problem like the halting problem. The existence of “standard” quantum computers does not disprove the Church–Turing thesis.^{[66]} It has been speculated that theories of quantum gravity, such as M-theory or loop quantum gravity, may allow even faster computers to be built. Currently, *defining* computation in such theories is an open problem due to the *problem of time*, i.e., there currently exists no obvious way to describe what it means for an observer to submit input to a computer and later receive output.^{[67]}^{[68]}

## See also[edit]

- Supercomputer
- Chemical computer
- D-Wave Systems
- DNA computing
- Electronic quantum holography
- Intelligence Advanced Research Projects Activity
- Kane quantum computer
- List of emerging technologies
- List of quantum processors
- Magic state distillation
- Natural computing
- Normal mode
- Photonic computing
- Post-quantum cryptography
- Quantum annealing
- Quantum bus
- Quantum cognition
- Quantum cryptography
- Quantum logic gate
- Quantum machine learning
- Quantum threshold theorem
- Rigetti Computing
- Soliton
- Theoretical computer science
- Timeline of quantum computing
- Topological quantum computer
- Valleytronics

## References[edit]

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## Further reading[edit]

This further reading section may contain inappropriate or excessive suggestions. Please ensure that only a reasonable number of balanced, topical, reliable, and notable further reading suggestions are given. Consider utilising appropriate texts as inline sources or creating a separate bibliography article. (May 2019) |

- Abbot, Derek; Doering, Charles R.; Caves, Carlton M.; Lidar, Daniel M.; Brandt, Howard E.; Hamilton, Alexander R.; Ferry, David K.; Gea-Banacloche, Julio; Bezrukov, Sergey M.; Kish, Laszlo B. (2003). “Dreams versus Reality: Plenary Debate Session on Quantum Computing”.
*Quantum Information Processing*.**2**(6): 449–472. arXiv:quant-ph/0310130. doi:10.1023/B:QINP.0000042203.24782.9a. hdl:2027.42/45526. - Akama, Seiki (2014).
*Elements of Quantum Computing: History, Theories and Engineering Applications*. Springer International Publishing. ISBN 978-3-319-08284-4. - Ambainis, Andris (1998). “Quantum computation with linear optics”. arXiv:quant-ph/9806048.
- Ambainis, Andris (2000). “The Physical Implementation of Quantum Computation”.
*Fortschritte der Physik*.**48**(9–11): 771–783. arXiv:quant-ph/0002077. Bibcode:2000ForPh..48..771D. doi:10.1002/1521-3978(200009)48:9/11<771::AID-PROP771>3.0.CO;2-E. - Berthiaume, Andre (1997). “Quantum Computation”.
- Dibyendu Chatterjee; Arijit Roy (2015). “A transmon-based quantum half-adder scheme”.
*Progress of Theoretical and Experimental Physics*.**2015**(9): 093A02(16pages). Bibcode:2015PTEP.2015i3A02C. doi:10.1093/ptep/ptv122. - Benenti, Giuliano (2004).
*Principles of Quantum Computation and Information Volume 1*. New Jersey: World Scientific. ISBN 978-981-238-830-8. OCLC 179950736. - DiVincenzo, David P. (1995). “Quantum Computation”.
*Science*.**270**(5234): 255–261. Bibcode:1995Sci…270..255D. CiteSeerX 10.1.1.242.2165. doi:10.1126/science.270.5234.255. Table 1 lists switching and dephasing times for various systems. - Feynman, Richard (1982). “Simulating physics with computers”.
*International Journal of Theoretical Physics*.**21**(6–7): 467–488. Bibcode:1982IJTP…21..467F. CiteSeerX 10.1.1.45.9310. doi:10.1007/BF02650179. - Hiroshi, Imai; Masahito, Hayashi (2006).
*Quantum Computation and Information*. Berlin: Springer. ISBN 978-3-540-33132-2. - Jaeger, Gregg (2006).
*Quantum Information: An Overview*. Berlin: Springer. ISBN 978-0-387-35725-6. OCLC 255569451. - Nielsen, Michael; Chuang, Isaac (2000).
*Quantum Computation and Quantum Information*. Cambridge: Cambridge University Press. ISBN 978-0-521-63503-5. OCLC 174527496. - Keyes, R. W. (1988). “Miniaturization of electronics and its limits”.
*IBM Journal of Research and Development*.**32**: 84–88. doi:10.1147/rd.321.0024. - Landauer, Rolf (1961). “Irreversibility and heat generation in the computing process” (PDF).
- Lomonaco, Sam. Four Lectures on Quantum Computing given at Oxford University in July 2006
- Mitchell, Ian (1998). “Computing Power into the 21st Century: Moore’s Law and Beyond”.
- Moore, Gordon E. (1965). “Cramming more components onto integrated circuits”.
*Electronics Magazine*. - Nielsen, M. A.; Knill, E.; Laflamme, R. “Complete Quantum Teleportation By Nuclear Magnetic Resonance”.
- Sanders, Laura (2009). “First programmable quantum computer created”.
- Simon, Daniel R. (1994). “On the Power of Quantum Computation”. Institute of Electrical and Electronic Engineers Computer Society Press.
- “Simons Conference on New Trends in Quantum Computation”. Simons Center for Geometry and Physics, and C. N. Yang Institute for Theoretical Physics. November 15–19, 2010.
- Singer, Stephanie Frank (2005).
*Linearity, Symmetry, and Prediction in the Hydrogen Atom*. New York: Springer. ISBN 978-0-387-24637-6. OCLC 253709076. - Stolze, Joachim; Suter, Dieter (2004).
*Quantum Computing*. Wiley-VCH. ISBN 978-3-527-40438-4. - Vandersypen, Lieven M.K.; Yannoni, Constantino S.; Chuang, Isaac L. (2000).
*Liquid state NMR Quantum Computing*. arXiv:quant-ph/0012108. Bibcode:2000quant.ph.12108V. - Wichert, Andreas (2014).
*Principles of Quantum Artificial Intelligence*. World Scientific Publishing Co. ISBN 978-981-4566-74-2. - Indian Science News Association,
*Special Issue of “Science & Culture” on ‘A Quantum Jump in Computation’*, Vol. 85 (5-6), May–June (2019)

## External links[edit]

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Wikimedia Commons has media related to .Quantum computer |

- Stanford Encyclopedia of Philosophy: “Quantum Computing” by Amit Hagar and Michael E. Cuffaro.
- Ambainis, Andris (2013). “Quantum Annealing and Computation: A Brief Documentary Note”. arXiv:1310.1339 [physics.hist-ph].
- Hazewinkel, Michiel, ed. (2001) [1994], “Quantum computation, theory of”,
*Encyclopedia of Mathematics*, Springer Science+Business Media B.V. / Kluwer Academic Publishers, ISBN 978-1-55608-010-4 - Patenting in the field of quantum computing

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