Scientists race to use zero gravity to kill the worst cancers – A 2020 space mission wants to use zero gravity to disable some of the hardest cancers to fight @ Defense Advanced Research Projects Agency @ History of the Internet – From the early days of ARPANET to today’s mobile technologies, here we share some of the different histories of the Internet from various personalities and organizations @ Brief History of the Internet & Camera on Cancer Research: Using Mice Models to Fight Thyroid Cancer @ Mouse Models of Human Disease: From Cancer to Neuropsychiatric Disorders @ ´´Biomedical research depends heavily on model organisms and the most of these are rodents, particularly in infectious disease and immunological research. ´´It is generally known that animal models are an essential component to all areas of biomedical research. These models can provide results that allow us to deduce knowledge to study a particular disease state in humans. ´´With the development of biotechnologies, genetic manipulations further strengthen the predominant utilization of rodents.´´ & Links, videos and images

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  • – – > > Mestrado – Dissertation – Tabelas, Figuras e Gráficos – Tables, Figures and Graphics – ´´My´´ Dissertation #Innovation #Countries #Time #Researches #Reference #Graphics #Ages #Age #Mice #People #Person #Mouse #Genetics #PersonalizedMedicine #Diagnosis #Prognosis #Treatment #Disease #UnknownDiseases #Future #VeryEfficientDrugs #VeryEfficientVaccines #VeryEfficientTherapeuticalSubstances #Tests #Laboratories #Investments #Details #HumanLongevity #DNA #Cell #Memory #Physiology #Nanomedicine #Nanotechnology #Biochemistry #NewMedicalDevices #GeneticEngineering #Internet #History #Science #World

Pathol Res Pract. 2012 Jul 15;208(7):377-81. doi: 10.1016/j.prp.2012.04.006. Epub 2012 Jun 8.

The influence of physical activity in the progression of experimental lung cancer in mice

Renato Batista Paceli 1Rodrigo Nunes CalCarlos Henrique Ferreira dos SantosJosé Antonio CordeiroCassiano Merussi NeivaKazuo Kawano NagaminePatrícia Maluf Cury


Impact_Fator-wise_Top100Science_Journals

GRUPO_AF1 – GROUP AFA1 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 1 – GROUP AFAN1 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO_AF2 – GROUP AFA2 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 2 – GROUP AFAN 2 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

Slides – mestrado – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

CARCINÓGENO DMBA EM MODELOS EXPERIMENTAIS

DMBA CARCINOGEN IN EXPERIMENTAL MODELS

Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

https://pubmed.ncbi.nlm.nih.gov/22683274/

Abstract

Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.

´´We propose to change the default P-value threshold for statistical significance from 0.05 to 0.005 for claims of new discoveries.´´ https://www.nature.com/articles/s41562-017-0189-z Published:  Daniel J. Benjamin, James O. Berger, […]Valen E. Johnson Nature Human Behaviour volume 2, pages6–10 (2018)

Um mundo além de p < 0,05 « Sandra Merlo – Fonoaudiologia da Fluência

´´My´´ Monografia – Monograph – Induction of benznidazole resistance in human Trypanosoma cruzi isolates – Indução de resistência ao benzonidazol em isolados humanos de Trypanosoma cruzi – UFTM – Federal University of Triangulo Mineiro – Uberaba 

Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo

Article – ´´My´´ dissertation – Faculty of Medicine of Sao Jose do Rio Preto

Feedback positivo de pessoas sobre minha dissertação pelo Messenger – Facebook. Positive feedback of people about my dissertation, blog and YouTube channel by Facebook – Messenger. Year – Ano: 2018

LISTA DE NOMES DE PESSOAS QUE ME DERAM FEEDBACK POSITIVO SOBRE A LISTA DE EMAILS QUE FIZ EM 2015 (PROJETO) – PEOPLE´S NAMES (POSITIVE FEEDBACK ABOUT THE EMAIL LIST I DID IN 2015) – E-MAIL LIST – LISTA DE E-MAILS – PROJECT – PESQUISA -RESEARCH

My suggestion of a very important Project…

Apostila – Pubmed

A Psicossomática Psicanalítica – Faculty of Medicine of Sao Jose do Rio Preto

ÁCIDO HIALURÔNICO – HIALURONIC ACID – Faculty of Medicine of Sao Jose do Rio Preto

Slides – Mestrado final – ´´My´´ dissertation – Faculty of Medicine of Sao Jose do Rio Preto

Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo

O Homem como Sujeito da Realidade da Saúde – Redação – Faculty of Medicine of Sao Jose do Rio Preto

Aula_Resultados – Results – FAMERP – Faculty of Medicine of Sao Jose do Rio Preto

As credenciais da ciência – The credentials of Science – Faculty of Medicine of Sao Jose do Rio Preto BaixarFrases que digitei – Phrases I typed

Frases que digitei – Tecnologia – Informations about blog I did

Keynote-The-Future-of-Space-Exploration(1)

2019-01-hormone-alzheimer(1)

mojap-02-00034

ajpheart.00349.2013

aging – animal models

Nanomedicine an evolving research (Opinion article I typed)

journal-of-nanomedicine–nanotechnology-flyer

Will you embrace AI fast enough

MICROBIOLOGIA – MICROBIOLOGY – Faculty of Medicine of Sao Jose do Rio Preto

Genes e Epilepsia – Genes and epilepsy – Faculty of Medicine of Sao Jose do Rio Preto

Dr.A.M.S

Flav_R03

BIOGRAFIA – BIOGRAPH – DR. DOMINGO MARCOLINO BRAILE

p-Value – Valor de p

european-respiratory-society

redefine-statistical-significance

https://www.creative-biolabs.com/drug-discovery/therapeutics/rodent-models.htm?gclid=CjwKCAiA-P7xBRAvEiwAow-VaTmAaLsRJUBS1K6xCne1O6Bgm25nnRajxKTQnTd4bLtp8DN4-xH0RBoCsH0QAvD_BwE

http://www.youtube.com http://www.gmail.com http://www.yahoo.com http://www.forbes.com http://www.nobelprize.org http://www.nasa.gov http://www.harvard.edu http://www.ucla.edu http://www.mit.edu http://www.stanford.edu http://www.caltech.edu https://www.internetsociety.org/internet/history-internet/?gclid=CjwKCAiAo7HwBRBKEiwAvC_Q8UigQEEkoGgnqcT6-9UXgv7yyNu-ort9diVUowjLIcOI0lTDRVB74xoCvBwQAvD_BwE

http://www.google.com https://www.internetsociety.org/internet/history-internet/brief-history-internet/

https://www.internetsociety.org/internet/history-internet/?gclid=CjwKCAiAo7HwBRBKEiwAvC_Q8UigQEEkoGgnqcT6-9UXgv7yyNu-ort9diVUowjLIcOI0lTDRVB74xoCvBwQAvD_BwE

https://pt.wikipedia.org/wiki/Defense_Advanced_Research_Projects_Agency

https://www.darpa.mil/about-us/about-darpa

https://www.darpa.mil/

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A DNA helix

Scientists race to use zero gravity to kill the worst cancers

A 2020 space mission wants to use zero gravity to disable some of the hardest cancers to fight.

PAUL RATNER28 December, 2019

Left: June Tripp, small cell cancer survivor, demonstrates the radiation mask she used during her radiation therapy. Right: Step-one of a six-step sequence of the death of a cancer cell.Left: U.S. Air Force photo/Heidi Hunt). Right: Source Dr. Raowf Guirguis. National Cancer Institute

  • An Australian research mission, launched in 2020 by Elon Musk’s SpaceX, will study effects of zero gravity on four cancers.
  • Other missions with similar objectives are set to launch in 2022 aboard the new China Space Station.
  • In earlier experiments, scientists found that microgravity can kill cancer cells.

Can being in zero gravity help beat cancer? A growing field of research, including an upcoming research mission to the International Space Station, is hoping to prove just that.

Joshua Chou, a biomedical engineer from the University of Technology Sydney in Australia, has conducted successful trials in a lab environment, and aims to establish that zero-g can kill cancer cells.

Zero gravity or weightlessness occurs in the absence of the sensation of weight, when no contact forces act upon an object (or a body).

Chou’s work looks to pinpoint the sensors by which cancer cells find each other and grow into tumors within a body. He thinks these receptors are dependent on gravity and once it’s removed, the cancer can be stopped as the cells won’t be able to “sense” each other.

To study this approach further, a graduate student working with Chou created the first microgravity device in Australia. The apparatus is a tissue box-sized spinning container. The researcher described it as “something that looks like the pods astronauts train in.”

Joshua Chou with a prototype of Australia’s first microgravity device.

Photo by Sissy Reyes.

The device has allowed Chou’s team to investigate how microgravity affects different diseases. The scientists report it has been tremendously effective so far in eliminating cancer cells.

“When placed in a microgravity environment, 80 to 90 per cent of the cells in the four different cancer types we tested – ovarian, breast, nose and lung – were disabled,” said Chou.

Normally, these are the hardest cancers to fight. Chou’s experiments, without using any drugs, managed to either kill such cells or make them “float off because they can no longer hold on.”

Early in 2020, Chou and his team will be able to test their approach in space, launching a specially-designed module with the help of SpaceX. The module will be loaded with the four types of cancer cells (ovarian, breast, nose and lung). Once launched, the scientists will be able to monitor it from Earth via data feeds. The experiment is set to last seven days, after which the cells will be frozen and send back to Earth 21 days later on a shuttle. More studies will be conducted once the cells are back in the lab on the ground.

The research team, from left, Chelsea Ly, Carin Basirun, Jessica Domingo and Joshua Chou.

Photo: Joshua Chou.

If Chou and his team succeed, does that mean cancer patients will be sent to space for treatment? While there may be such eventualities as well, Chou’s vision is to develop a drug that patients can take while on Earth. He hopes to use it to “trick” cancer cells into behaving like they are in space.

Chou also thinks that this kind of therapy might not be a “magic bullet” that will work on its own, but rather in conjunction with existing treatments. “It could give current treatments like chemotherapy a big enough boost to kill the disease,” he adds in a recent article.

Chou’s research is not the only one of its kind. Nine research projects are going to study the effects of weightlessness on cancer aboard the new China Space Station (CSS), set for 2022. One such project is “Tumours in Space” that will look at how microgravity and cosmic radiation can affect the growth of tumors.

Tricia L. Larose from the Norwegian University of Science and Technology, who is the project’s Principal Investigator, explained their goal:

“The plan is to send three-dimensional stem cell organoids from both healthy and cancer tissue from the same person into space,” she said. “Here we will study mutations and look at how the cell’s DNA is affected by weightlessness and cosmic radiation.”

Organoids are three-dimensional cancerous tumors that can form small structures mimicking different organs.

Scientists in other countries are also looking at utilizing gravity on cancer. In 2017, a German team, led by professor Daniela Grimm from the University of Magdeburg, studied the effects of space on thyroid cancer cells. This was, in fact, the third time Grimm’s team sent such samples into space. Their objective, as Grimm expressed in an interview, is “to find growth-regulating proteins and certain receptors that express and secrete differently in space versus on Earth.” If they can find such proteins and receptors, they can develop new drugs to treat the cancers back on our home planet.

The Influence of short-term #Microgravity on Human Prostate Cancer

The Influence of short-term #Microgravity on Human Prostate Cancer Cells during a Parabolic Flight . By Prof. Daniela Grimm from University of Magdeburg . Dr…RELATED ARTICLES AROUND THE WEB

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 SearchHome / Lead Optimization / Pharmacology and Pharmacodynamics Studies / Rodent Models

Rodent Models

Biomedical research depends heavily on model organisms and the most of these are rodents, particularly in infectious disease and immunological research. With years of experience serving hundreds of clients all over the world, Creative Biolabs provides a breadth of quality Genetically Engineering Models (GEMs) and Non-Genetically Engineering Models (NON-GEMs) to clients around the world. Our scientists are willing to assist you in selecting the most appropriate one for your research.

Rodent models

It is generally known that animal models are an essential component to all areas of biomedical research. These models can provide results that allow us to deduce knowledge to study a particular disease state in humans. To ensure the full utilization, a model needs to reliably mimic the normal anatomy and physiology of human organs and tissues of interest, as well as accurately reflect the morphological and biochemical aspects of disease pathogenesis.

Rodents, especially rats and mice, have been the leading model organisms used in biomedical research for well over a century. Although other animals, such as non-human primates, zebrafish, fruit flies and roundworms, are also used, rodents have been regarded as a reliable research species mainly due to their small size, short life cycle, reproductive affluence, known genetic background, as well as relative ease of procurement, handling, and housing. With the development of biotechnologies, genetic manipulations further strengthen the predominant utilization of rodents. These manipulations have allowed the researcher to study rat or mice genetically suited specifically to the human disease model of their interests.

Rodent Models

Features

As an animal model, rodents have several important advantages over other mammalian models:

  • Small size
  • Inexpensive and easy to handle
  • Consistent disease manifestations
  • Reproduce rapidly and good-sized litters of offspring
  • Easy for genetic manipulation

Creative Biolabs offers a breadth of quality rodent models for our worldwide clients. With years of experience in the industry of animal model and excellent professional skills, our scientists are proud to help you identify the most appropriate rodent models for your research of interest. And you can also explore our extensive and broad-based library of rodent models to find the one you need.

If you have any special needs in the establishment of rodent models or be interested in learning more about Creative Biolabs’ animal models or drug discovery service, please contact us for more details.
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