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The influence of physical activity in the progression of experimental lung cancer in mice
- PMID: 22683274
- DOI: 10.1016/j.prp.2012.04.006
GRUPO_AF1 – GROUP AFA1 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO AFAN 1 – GROUP AFAN1 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO_AF2 – GROUP AFA2 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
GRUPO AFAN 2 – GROUP AFAN 2 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
Slides – mestrado – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
DMBA CARCINOGEN IN EXPERIMENTAL MODELS
Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto
Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.
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Overview Of Longevity Warriors
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675 0Posted on Jan 23, 2020, 5 p.m.
Recently the Aging Analytics Agency released their 285 page open access analytical case study which was jointly produced along with the Gerontology Research Group entitled the “Supercentenarians Landscape Overview” which is a comprehensive analysis and overview of the top 100 longest lived supercentenarians, the top 100 currently living longevity warriors, and the 25 most socially and professionally active centenarians.
This report is an overview of the history and data concerning the longevity warrior population which also takes a deeper look at these individuals that have been verified and recognized, as well as those who are still under investigation to provide trends such as gender and geographic distribution, and first hand accounts on how they lived their exceptionally long lives.
There have always been stories of those who lived to be 110 years of age or older, but a codified system of tracking and verifying their claims did not always exist to separate fact from fiction and human error regarding claims of longevity. L. Stephen Coles, MD, PhD, created the GRG in 1990 to verify and catalogue such claims as part of a mission to “slow and ultimately reverse age-related decline for more healthy years of life.”
Among the many trends and conclusions derived from the analysis across all continents the gender distribution of supercentenarians tends to favor females heavily by 90%; even when the overall numbers are low as seen in Africa and Australia the disparity remains. This trend carries across all cultures and disparate environmental factors; even within the supercentenarian group those at the oldest ages tend to be exclusively female.
The majority of socially active supercentenarians also appear to be female, both males and females in this longevity warrior grouping appear to have very little chronic age related conditions that would have otherwise rendered them immobile at these more advanced ages including cardiovascular diseases and myocardial infarction, but they also have no history of strokes or other severe physical issues.
According to this report there are 1579 female and 160 male verified longevity warriors: 800 being 110 years old, 441 being 111 years old, 248 being 112 years old, 124 at 113 years old, 83 at 114 years old, 23 have reached 115 years old, 12 have reached 116 years old, and 2 have reached the age of 117+ years old.
National demographics of all time top 100 supercentenarians has USA in the lead, but not as a dominant leader outpacing the next six nations due to population size, per capita Japan does better. Longest lived distributed per nation: USA 43, Japan 25, France 8, UK and Italy 5, Canada 3, Portugal and Puerto Rico as well as other countries 2.
Supercentenarians also have an equally super and strong immune system, a recent study has revealed their immune cells have very unique characteristics that may be endowed with high resistance to non-communicable diseases such as cardiovascular disease, cancer, and stroke.
Another feature of their healthy long lifespan is maintaining relatively high cognitive function and physical independence even in later years. Basically these longevity warriors are spending their lives almost completely in good health due to the delayed onset of age related diseases and compression of morbidity.
Key findings suggest that there are several factors that contribute to longevity:
- Relationships, social inclusion, kindness, love, optimistic mindset, and a strong sense of community make you healthier and happier; numerous studies back this up with strong evidence showing associations between good health and positive emotions showing loneliness is harmful to health.
- Socio-economic status level appears to have an important effect on longevity indicators include higher overall economic development, public expenditure on health, standard of living, and the use of improved sanitation facilities.
- Brain activity has roles on aging and longevity that have a significant influence on lifespan; neural activity is higher among those with shorter lifespan and lower in those who love longer.
- Regular physical exercise is important as it delivers huge health benefits ranging from keeping brain cells healthy by delivering more blood and oxygen to keeping muscles strong.
- After the age of 80 health, longevity, and almost everything in advanced ages is primarily due to genetic factors while lifestyle was found to play almost no factor from that point on.
- Following a healthy balanced diet rich in whole grains, fruits, and vegetables is important to maintain a healthy body weight and shape; take supplements if required/recommended.
- Being conscientious may help to lower blood pressure and fewer psychiatric conditions, as well as lower the risk of diabetes and heart or joint problems. Being conscientious is referring to the ability to be goal oriented, positive, efficient, organized, and self disciplined.
Currently Kane Tanka from Japan is the world’s oldest person. She is 116 years old as of August 27, 2019, putting her 7 years away from the all time record of 122 years old held by France’s Jeannne Louise Calment. Only 8 people have lived passed the age of 116, and only 2 people have been verified to have lived passed the age of 117.
While only 2 people have been verified to have lived passed the age of 117, the fact that it has opens the door for others to aspire to live beyond that age and surpass the record. Thanks to advancements in healthcare and discoveries made in research it is very possible that someone alive right now could live, laugh, and love their way to become a longevity warrior aged 125 or more, especially if they follow a healthy lifestyle which includes keeping stress in check, being both physically and socially active, getting enough sleep, having a positive mindset, and following a healthy balanced diet.
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This article is not intended to provide medical diagnosis, advice, treatment, or endorsement.
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From Wikipedia, the free encyclopediaJump to navigationJump to search“Human longevity” redirects here. For the company, see Human Longevity.Comparison of male and female life expectancy at birth for countries and territories as defined in the 2011 CIA Factbook, with selected bubbles labelled. The green dotted line corresponds to equal female and male life expectancy. The apparent 3D volumes of the bubbles are linearly proportional to their population. (In the SVG file, hover over a bubble to highlight it and show its data.)
The word “longevity” is sometimes used as a synonym for “life expectancy” in demography. However, the term longevity is sometimes meant to refer only to especially long-lived members of a population, whereas life expectancy is always defined statistically as the average number of years remaining at a given age. For example, a population’s life expectancy at birth is the same as the average age at death for all people born in the same year (in the case of cohorts). Longevity is best thought of as a term for general audiences meaning ‘typical length of life’ and specific statistical definitions should be clarified when necessary.
Reflections on longevity have usually gone beyond acknowledging the brevity of human life and have included thinking about methods to extend life. Longevity has been a topic not only for the scientific community but also for writers of travel, science fiction, and utopian novels.
There are many difficulties in authenticating the longest human life span ever by modern verification standards, owing to inaccurate or incomplete birth statistics. Fiction, legend, and folklore have proposed or claimed life spans in the past or future vastly longer than those verified by modern standards, and longevity narratives and unverified longevity claims frequently speak of their existence in the present.
- 1Life expectancy, as of 2010
- 2Long-lived individuals
- 3Major factors
- 4Change over time
- 5Limited longevity
- 6Longevity myths
- 8Non-human biological longevity
- 9See also
- 12External links
Life expectancy, as of 2010
For a more comprehensive list, see List of countries by life expectancy.
Various factors contribute to an individual’s longevity. Significant factors in life expectancy include gender, genetics, access to health care, hygiene, diet and nutrition, exercise, lifestyle, and crime rates. Below is a list of life expectancies in different types of countries:
- Developed countries: 77–90 years (e.g. Canada: 81.29 years, 2010 est.)
- Developing countries: 32–80 years (e.g. Mozambique: 41.37 years, 2010 est.)
- Australia: 80 years in 2002, 81.72 years in 2010
- France: 79.05 years in 2002, 81.09 years in 2010
- Germany: 77.78 years in 2002, 79.41 years in 2010
- Italy: 79.25 years in 2002, 80.33 years in 2010
- Japan: 81.56 years in 2002, 82.84 years in 2010
- Monaco: 79.12 years in 2002, 79.73 years in 2011
- Spain: 79.06 years in 2002, 81.07 years in 2010
- UK: 80 years in 2002, 81.73 years in 2010
- USA: 77.4 years in 2002, 78.24 years in 2010
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The Gerontology Research Group validates current longevity records by modern standards, and maintains a list of supercentenarians; many other unvalidated longevity claims exist. Record-holding individuals include:
- Eilif Philipsen (1682–1785, 102 years, 333 days): first person to reach the ages of 100, 101, and 102 (on July 21, 1782) and whose age could be validated.
- Geert Adriaans Boomgaard (1788–1899, 110 years, 135 days): first person to reach the age of 110 (on September 21, 1898) and whose age could be validated.
- Margaret Ann Neve, (18 May 1792 – 4 April 1903, 110 years, 346 days) the first validated female supercentenarian (on 18 May 1902).
- Jeanne Calment (1875–1997, 122 years, 164 days): the oldest person in history whose age has been verified by modern documentation.[note 1] This defines the modern human life span, which is set by the oldest documented individual who ever lived.
- Sarah Knauss (1880–1999, 119 years, 97 days): the second oldest documented person in modern times and the oldest American.
- Jiroemon Kimura (1897–2013, 116 years, 54 days): the oldest man in history whose age has been verified by modern documentation.
Elderly couple in Portugal.
Evidence-based studies indicate that longevity is based on two major factors, genetics and lifestyle choices.
Twin studies have estimated that approximately 20-30% the variation in human lifespan can be related to genetics, with the rest due to individual behaviors and environmental factors which can be modified. Although over 200 gene variants have been associated with longevity according to a US-Belgian-UK research database of human genetic variants, these explain only a small fraction of the heritability. A 2012 study found that even modest amounts of leisure time physical exercise can extend life expectancy by as much as 4.5 years.
Lymphoblastoid cell lines established from blood samples of centenarians have significantly higher activity of the DNA repair protein PARP (Poly ADP ribose polymerase) than cell lines from younger (20 to 70 year old) individuals. The lymphocytic cells of centenarians have characteristics typical of cells from young people, both in their capability of priming the mechanism of repair after H2O2 sublethal oxidative DNA damage and in their PARP gene expression. These findings suggest that elevated PARP gene expression contributes to the longevity of centenarians, consistent with the DNA damage theory of aging.
Change over time
In preindustrial times, deaths at young and middle age were more common than they are today. This is not due to genetics, but because of environmental factors such as disease, accidents, and malnutrition, especially since the former were not generally treatable with pre-20th-century medicine. Deaths from childbirth were common for women, and many children did not live past infancy. In addition, most people who did attain old age were likely to die quickly from the above-mentioned untreatable health problems. Despite this, there are many examples of pre-20th-century individuals attaining lifespans of 85 years or greater, including Benjamin Franklin, Thomas Jefferson, John Adams, Cato the Elder, Thomas Hobbes, Eric of Pomerania, Christopher Polhem, and Michelangelo. This was also true for poorer people like peasants or laborers. Genealogists will almost certainly find ancestors living to their 70s, 80s and even 90s several hundred years ago.
For example, an 1871 census in the UK (the first of its kind, but personal data from other censuses dates back to 1841 and numerical data back to 1801) found the average male life expectancy as being 44, but if infant mortality is subtracted, males who lived to adulthood averaged 75 years. The present life expectancy in the UK is 77 years for males and 81 for females, while the United States averages 74 for males and 80 for females.
Studies have shown that black American males have the shortest lifespans of any group of people in the US, averaging only 69 years (Asian-American females average the longest). This reflects overall poorer health and greater prevalence of heart disease, obesity, diabetes, and cancer among black American men.
Women normally outlive men. Theories for this include smaller bodies (and thus less stress on the heart), a stronger immune system (since testosterone acts as an immunosuppressant), and less tendency to engage in physically dangerous activities.
There is debate as to whether the pursuit of longevity is a worthwhile health care goal. Bioethicist Ezekiel Emanuel, who is also one of the architects of ObamaCare, has argued that the pursuit of longevity via the compression of morbidity explanation is a “fantasy” and that longevity past age 75 should not be considered an end in itself. This has been challenged by neurosurgeon Miguel Faria, who states that life can be worthwhile in healthy old age, that the compression of morbidity is a real phenomenon, and that longevity should be pursued in association with quality of life. Faria has discussed how longevity in association with leading healthy lifestyles can lead to the postponement of senescence as well as happiness and wisdom in old age.
All of the biological organisms have a limited longevity, and different species of animals and plants have different potentials of longevity. Misrepair-accumulation aging theory suggests that the potential of longevity of an organism is related to its structural complexity. Limited longevity is due to the limited structural complexity of the organism. If a species of organisms has too high structural complexity, most of its individuals would die before the reproduction age, and the species could not survive. This theory suggests that limited structural complexity and limited longevity are essential for the survival of a species.
Longevity myths are traditions about long-lived people (generally supercentenarians), either as individuals or groups of people, and practices that have been believed to confer longevity, but for which scientific evidence does not support the ages claimed or the reasons for the claims. A comparison and contrast of “longevity in antiquity” (such as the Sumerian King List, the genealogies of Genesis, and the Persian Shahnameh) with “longevity in historical times” (common-era cases through twentieth-century news reports) is elaborated in detail in Lucian Boia‘s 2004 book Forever Young: A Cultural History of Longevity from Antiquity to the Present and other sources.
After the death of Juan Ponce de León, Gonzalo Fernández de Oviedo y Valdés wrote in Historia General y Natural de las Indias (1535) that Ponce de León was looking for the waters of Bimini to cure his aging. Traditions that have been believed to confer greater human longevity also include alchemy, such as that attributed to Nicolas Flamel. In the modern era, the Okinawa diet has some reputation of linkage to exceptionally high ages.
Longevity claims may be subcategorized into four groups: “In late life, very old people often tend to advance their ages at the rate of about 17 years per decade …. Several celebrated super-centenarians (over 110 years) are believed to have been double lives (father and son, relations with the same names or successive bearers of a title) …. A number of instances have been commercially sponsored, while a fourth category of recent claims are those made for political ends ….” The estimate of 17 years per decade was corroborated by the 1901 and 1911 British censuses. Time magazine considered that, by the Soviet Union, longevity had been elevated to a state-supported “Methuselah cult”. Robert Ripley regularly reported supercentenarian claims in Ripley’s Believe It or Not!, usually citing his own reputation as a fact-checker to claim reliability.
The U.S. Census Bureau view on the future of longevity is that life expectancy in the United States will be in the mid-80s by 2050 (up from 77.85 in 2006) and will top out eventually in the low 90s, barring major scientific advances that can change the rate of human aging itself, as opposed to merely treating the effects of aging as is done today. The Census Bureau also predicted that the United States would have 5.3 million people aged over 100 in 2100. The United Nations has also made projections far out into the future, up to 2300, at which point it projects that life expectancies in most developed countries will be between 100 and 106 years and still rising, though more and more slowly than before. These projections also suggest that life expectancies in poor countries will still be less than those in rich countries in 2300, in some cases by as much as 20 years. The UN itself mentioned that gaps in life expectancy so far in the future may well not exist, especially since the exchange of technology between rich and poor countries and the industrialization and development of poor countries may cause their life expectancies to converge fully with those of rich countries long before that point, similarly to the way life expectancies between rich and poor countries have already been converging over the last 60 years as better medicine, technology, and living conditions became accessible to many people in poor countries. The UN has warned that these projections are uncertain, and cautions that any change or advancement in medical technology could invalidate such projections.
Recent increases in the rates of lifestyle diseases, such as obesity, diabetes, hypertension, and heart disease, may eventually slow or reverse this trend toward increasing life expectancy in the developed world, but have not yet done so. The average age of the US population is getting higher and these diseases show up in older people.
Jennifer Couzin-Frankel examined how much mortality from various causes would have to drop in order to boost life expectancy and concluded that most of the past increases in life expectancy occurred because of improved survival rates for young people. She states that it seems unlikely that life expectancy at birth will ever exceed 85 years. Michio Kaku argues that genetic engineering, nanotechnology and future breakthroughs will accelerate the rate of life expectancy increase indefinitely. Already genetic engineering has allowed the life expectancy of certain primates to be doubled, and for human skin cells in labs to divide and live indefinitely without becoming cancerous.
Reliable data from 1840 through 2002 indicates life expectancy has risen linearly for men and women, albeit more slowly for men. For women the increase has been almost three months per year, for men almost 2.7 months per year. In light of steady increase, without any sign of limitation, the suggestion that life expectancy will top out must be treated with caution. Scientists Oeppen and Vaupel observe that experts who assert that “life expectancy is approaching a ceiling … have repeatedly been proven wrong.” It is thought that life expectancy for women has increased more dramatically owing to the considerable advances in medicine related to childbirth.
Non-human biological longevity
Main article: List of long-living organisms
- A 5,069-year-old member of the species Pinus longaeva: Oldest known currently living non-clonal tree.
- Methuselah: 4,800-year-old bristlecone pine in the White Mountains of California, the second oldest currently living non-clonal tree.
- Possibly 250-million year-old bacteria, Bacillus permians, were revived from stasis after being found in sodium chloride crystals in a cavern in New Mexico.
- The quahog clam (Arctica islandica) is exceptionally long-lived, with a maximum recorded age of 507 years, the longest of any animal. Other clams of the species have been recorded as living up to 374 years.
- Lamellibrachia luymesi, a deep-sea cold-seep tubeworm, is estimated to reach ages of over 250 years based on a model of its growth rates.
- A bowhead whale killed in a hunt was found to be approximately 211 years old (possibly up to 245 years old), the longest-lived mammal known.
- Actuarial science
- Aging brain
- Alliance for Aging Research
- Anti-aging movement
- Biodemography of human longevity
- Calico (company)
- DNA damage theory of aging
- Genetics of aging
- Gerontology Research Group
- Hayflick limit
- Indefinite lifespan
- Life extension
- List of aging processes
- List of last survivors of historical events
- Longevity claims
- Longevity myths
- Maximum life span
- Oldest viable seed
- Reliability theory of aging and longevity
- Research into centenarians
- ^ Disputed. In 2018 it was alleged that Calment’s daughter Yvonne usurped her mother’s identity upon her actual death in 1934. See here for details.
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Chuan xiong … has long been a key herb in the longevity tradition of China, prized for its powers to boost the immune system, activate blood circulation, and relieve pain.
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Taoist devotion to immortality is important to us for two reasons. The techniques may be of considerable value to our goal of a healthy old age, if we can understand and adapt them. Secondly, the Taoist longevity tradition has brought us many interesting remedies.
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The Old Man of the Sea / Yaupa / a native of Futuna, one of the New Hebrides Islands / regularly worked his own farm at the age of 130 / He died in 1899 of measles — a children’s disease … Horoz Ali, the last Turkish gatekeeper of Nicosia, Cyprus, lived to the age of 120 … Francisco Huppazoli (1587–1702) of Casale, Italy, lived 114 years without a day’s illness and had 4 children by his 5th wife — whom he married at the age of 98
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- Lucian Boia (2005) Forever Young: A Cultural History of Longevity from Antiquity to the Present Door Reaktion Books. ISBN 1-86189-154-7.
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- James R. Carey (2003) Longevity. The biology and Demography of Life Span. Princeton University Press. ISBN 0-691-08848-9
- Gavrilova N.S., Gavrilov L.A. (2010) Search for Mechanisms of Exceptional Human Longevity. Rejuvenation Research, 13(2-3): 262–264.
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- Gavrilov LA, Gavrilova NS. (2006) Reliability Theory of Aging and Longevity. In: Masoro E.J. & Austad S.N.. (eds.): Handbook of the Biology of Aging, Sixth Edition. Academic Press. San Diego, CA, pp. 3-42.
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- John Robbins (2007) Healthy at 100 Ballantine Books, ISBN 0345490118 garners evidence from many scientific sources to account for the extraordinary longevity of Abkhasians in the Caucasus, Vilcambansns in the Andes, Burusho people in Hunza, Pakistan, and Okinawans.
- Roy Walford (2000), Beyond The 120-Year Diet. New York: Four Walls Eight Windows. ISBN 1-56858-157-2.
- American Federation for Aging Research
- The Okinawa Centenarian Study
- List of Longevity Genes
- Global Agewatch‘s country report cards have the most up-to-date, internationally comparable statistics on population ageing and life expectancy from 195 countries.
- Buettner, Dan (May 2015). Want Great Longevity and Health? It Takes a Village. “The secrets of the world’s longest-lived people include community, family, exercise and plenty of beans.” The Wall Street Journal
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