Cutting-edge CRISPR gene editing appears safe in three cancer patients @ A.I. translation tool sheds light on the secret language of mice @ Tech entrepreneur Richard Wang talked about the skills gap, the future of work, and re-thinking traditional four-year college degree programs. He spoke via video link from Seattle, Washington @ How particle physics could prevent financial fraud – A new collaboration agreement sees CERN data analytics used to help protect commodity and financial markets from fraud @ Physiological discoveries abound within NASA samples ´´ In an effort to further the research progress on this topic, the NASA BSP coordinated the sharing of mouse eyes from the STS-133 Shuttle mission. The study led by Susana Zanello1 conducted histological examinations of the mouse eyes from post-flight days 1, 5 and 7. Gene expression analysis suggested that reversible molecular damage occurs in the retina of mice exposed to the spaceflight environment, and that protective cellular pathways are induced in the retina and optic nerve in response to these changes. While correlation of research findings in the mouse tissues to human astronauts presents a set of challenges, the mouse model is an excellent way to characterise underlying changes at the cellular and molecular levels that are simply not available with the human crew.´´

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  • – > Mestrado – Dissertation – Tabelas, Figuras e Gráficos – Tables, Figures and Graphics – ´´My´´ Dissertation @ #Innovation #energy #life #health #Countries #Time #Researches #Reference #Graphics #Ages #Age #Mice #People #Person #Mouse #Genetics #PersonalizedMedicine #Diagnosis #Prognosis #Treatment #Disease #UnknownDiseases #Future #VeryEfficientDrugs #VeryEfficientVaccines #VeryEfficientTherapeuticalSubstances #Tests #Laboratories #Investments #Details #HumanLongevity #DNA #Cell #Memory #Physiology #Nanomedicine #Nanotechnology #Biochemistry #NewMedicalDevices #GeneticEngineering #Internet #History #Science #World

Pathol Res Pract. 2012 Jul 15;208(7):377-81. doi: 10.1016/j.prp.2012.04.006. Epub 2012 Jun 8.

The influence of physical activity in the progression of experimental lung cancer in mice

Renato Batista Paceli 1, Rodrigo Nunes Cal, Carlos Henrique Ferreira dos Santos, José Antonio Cordeiro, Cassiano Merussi Neiva, Kazuo Kawano Nagamine, Patrícia Maluf Cury


Impact_Fator-wise_Top100Science_Journals

GRUPO_AF1 – GROUP AFA1 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 1 – GROUP AFAN1 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO_AF2 – GROUP AFA2 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 2 – GROUP AFAN 2 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

Slides – mestrado – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

CARCINÓGENO DMBA EM MODELOS EXPERIMENTAIS

DMBA CARCINOGEN IN EXPERIMENTAL MODELS

Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

https://pubmed.ncbi.nlm.nih.gov/22683274/

Abstract

Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.

http://www.google.com https://www.physoc.org/magazine-articles/physiological-discoveries-abound-within-nasa-samples/?fbclid=IwAR2zT7514Un-EjaszvM-b_6Z6JaOjAL_IowfpDk4QFRPQfaNdhgMYbCNIHI

https://www.c-span.org/video/?467768-5/washington-journal-richard-wang-discusses-skills-gap-future-work&fbclid=IwAR3Bu1K_6HXyuFq7oCB6PWtjpIfiMR1shLEDjHCURD5kf2ll6LnOFbZekqM
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Immune cells (brown) attack a cancer cell. Using CRISPR could make the immune cells more potent. STEVE GSCHMEISSNER/SCIENCE SOURCE

Cutting-edge CRISPR gene editing appears safe in three cancer patients

By Jennifer Couzin-FrankelFeb. 6, 2020 , 2:00 PM

Launching a new chapter in the fast-moving cancer immunotherapy field, scientists have blended two cutting-edge approaches: CRISPR, which edits DNA, and T cell therapy, in which sentries of the immune system are exploited to destroy tumors. Two women and one man, all in their 60s—one with sarcoma and two with the blood cancer multiple myeloma—received CRISPR-altered versions of their own cells last year, researchers report online in Science this week.

For these pioneers, the benefits were limited: One has since died, and the disease has worsened in the others. But the clinical trial, which underwent years of regulatory scrutiny, wasn’t designed to try to cure cancer, says Carl June, a cancer researcher at the University of Pennsylvania (UPenn) who co-led the work. Rather, its goal was to show that the strategy appeared feasible and safe.

By that measure, scientists agree, it succeeded. “This is a Rubicon that has been decisively crossed,” says Fyodor Urnov, a genome editor at the University of California (UC), Berkeley. The study, he says, the first of its kind in the United States, answers “questions that have frankly haunted the field.”

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The researchers used CRISPR alongside another strategy that incorporates new DNA into immune cells. June’s team helped pioneer that strategy in 2010, when it added DNA to T cells from three men with chronic leukemia and returned those cells to the patients. The results were remarkable: Two men are still alive and healthy today. Others were testing the same approach, called CAR-T cell therapy—after the inserted chimeric antigen receptor gene that helps the infused T cells latch onto and destroy cancer cells with a specific protein on their surface. Two CAR-T cell therapies are now approved for patients with leukemia and lymphoma.

But with time, the therapy’s limitations have come into focus. Not every cancer patient is helped, and even those who are can suffer a relapse, says Edward Stadtmauer, who treats blood cancers at UPenn and co-led the new study. And solid tumors like those in the brain and pancreas have proved tough to treat.

Using CRISPR to knock out selected genes while also adding DNA, it was hoped, might make T cells even more powerful and persistent. But CRISPR brought its own uncertainties. Lab studies have revealed “off-target” effects, in which unintended DNA gets modified. No one knew whether T cells with sliced and diced genes could even survive in the human body. Last year, Vertex Pharmaceuticals and CRISPR Therapeutics announced that two patients treated for inherited blood diseases with CRISPR-edited cells were doing well. But details were sparse.

June, Stadtmauer, and their colleagues began by hunting for patients whose tumors produced a protein called NY-ESO-1, a target for the gene the researchers would add to their T cells. The patients also needed to carry a specific version of human leukocyte antigen, an immune gene complex that could help the infused T cells flourish. The four patients who qualified were all extremely ill, as is the norm for such a novel therapy. A woman with multiple myeloma had undergone three bone marrow transplants. Another, in her late 30s with sarcoma, became too sick to treat while her cells were being prepped in the lab, a process that takes 4 to 6 weeks. She entered hospice care and died.

To try to rev up the patients’ T cells against their disease, the scientists used CRISPR to knock out two genes that encode what’s known as the T cell receptor. The group also crippled a third gene, for a protein called PD-1. PD-1 puts the brakes on immune responses, and eliminating its effects, June’s team theorized, might enrich the T cells’ powers. Then, they inserted the gene for a different T cell receptor that would target NY-ESO-1.

Intensive monitoring of the patients, including blood draws to study their altered T cells, confirmed that CRISPR had left some off-target changes. But they were few, and the number of cells with these unintended DNA changes faded over time. Encouragingly, the CRISPR-edited cells persisted at least 9 months—versus about 2 months in comparable CAR-T cell therapy studies. Imaging showed “beautiful, healthy T cells,” June says, that in lab studies beat back cancer months after they’d been infused.

But in patients, outcomes were modest. The best response was in the sarcoma patient, whose primary tumor shrank, though his cancer later progressed. “It wasn’t like you turned off those genes and those T cells started doing things that were amazing,” says Antoni Ribas, an oncologist at UC Los Angeles. Ribas, June, and others offer potential reasons, including the small number of patients treated, possible limitations of NY-ESO-1 as a target—selected in part for its safety record—and the failure to knock out all three genes in many of the cells.

Some of the authors are working with companies to commercialize the method. But much experimentation lies ahead. “This whole area is just teeming with different ideas,” Stadtmauer says. A handful of other trials, including several in China, are offering CRISPR-modified cells to patients with cancer or other diseases. A company called PACT Pharma, which Ribas helped found, is running a trial that uses CRISPR to target gene mutations within solid tumors.

What June’s group offers is “a needed start” for giving patients CRISPR-edited T cells, Ribas says. From now on, he adds, “It’s going to be easier—because they did it first.”Posted in: 

doi:10.1126/science.abb1990

Jennifer Couzin-Frankel

Jennifer Couzin-Frankel

Staff Writer

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Emerging Tech

A.I. translation tool sheds light on the secret language of mice

By Luke DormehlFebruary 19, 2020

Ever wanted to know what animals are saying? Neuroscientists at the University of Delaware have taken a big leap forward in decoding the sounds made by one particular animal in a way that takes us a whole lot closer than anyone has gotten so far. The animal in question? The humble mouse.

To study mouse vocalizations, the team gathered data as groups of four mice — two males and two females — interacted. They interacted for five hours at a time in a chamber that was kitted out with eight microphones and a video camera. In total, the researchers recorded encounters between a total of 44 mice. Starting with the enormous amounts of ensuing video and audio data, the researchers then used machine learning A.I. to develop a system that’s able to connect specific sounds with distinct animal behaviors. In short, it could work out which mouse was squeaking, where, and in what scenario.

“To link mouse vocalizations to specific actions, we needed multiple technological advances,” University of Delaware neuroscientist Joshua Neunuebel told Digital Trends. “First, we needed to be able to assign specific vocalizations to individual mice that were socially interacting. To do this, we developed a sound source localization system that simultaneously recorded mouse ultrasonic vocalizations on eight different microphones, as well as the position of the mice with a video camera.”

The combination of microphones and camera allowed the team to estimate the location of where a particular vocal signal was emitted and then assign the signal to a specific mouse. Once they were able to assign vocalizations to specific animals, the team used an unsupervised learning algorithm that groups items with similar features to categorize them. Finally, they used a tool called JAABA, the Janelia Automatic Animal Behavior Annotator, to automatically extract specific social behaviors with high fidelity.

“It’s not necessarily a translational tool per se, but it’s a tool that helps us interpret mouse social behaviors,” Neunuebel said. “However, this being said, mice are good models for understanding the neural basis of social behavior, which may ultimately shed light upon how the brain circuitry of humans is functioning.”

The work is the subject of two new papers published in the journals Nature Neuroscience and Scientific Reports. Both papers report on different aspects of the work on how communication shapes social behavior and the neural networks that encode this information.

As Neunuebel says, they haven’t developed a full-fledged human-to-mouse translation tool. Nonetheless, this work — alongside similar research into communications of animals like dolphins — certainly brings us closer to understanding the subtleties of animal chat.

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JANUARY 3, 2020

Richard Wang on the Skills Gap and Future of Work

Tech entrepreneur Richard Wang talked about the skills gap, the future of work, and re-thinking traditional four-year college degree programs. He spoke via video link from Seattle, Washington.Report Video Issue 42:00

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00:00:00LIVE CAMPAIGN 20 COVERAGE CONTINUES TODAY AT 1:00 EASTERN. SENATOR BERNIE SANDERS IS IN I WOULD. AT 5:00, PRESIDENT TRUMP LAUNCHES THE EVANGELICALS FOR TRUMP… Show Full Text
00:00:00WASHINGTON JOURNAL CONTINUES.
00:00:06John McArdleJohn McArdleRICHARD WANG JOINS US FROM SEATTLE FOR DISCUSSION ON THE FUTURE OF WORK AND THE SKILLS GAP. YOUR DAY JOB IS AS CEO OF THE CODING DOJO. EXPLAIN WHAT YOU… Show Full Text
00:00:25Richard WangRichard WangI HAVE AN ORGANIZATION THAT PROVIDES TECH TRAINING FOR NO ONE WITH ANY BACKGROUND. WE TRAIN THEM FOR THREE MONTHS AND GET THEM READY. AFTER COMING OUT… Show Full Text
00:00:50John McArdleJohn McArdleYOU WRITE A COLUMN FOR FORBES TECHNOLOGY. WHAT RECENT COLUMNS, YOU TALKED ABOUT A SKILLS GAP IN THE COUNTRY AND HOW APPRENTICE PROGRAMS MIGHT BE A WAY… Show Full Text
00:01:05WE ARE IN THE FOURTH INDUSTRIAL REVOLUTION. WE ARE LOOKING AT VIRTUAL REALITY, BIOSCIENCE, ROBOTICS. EVERYTHING UNDERNEATH THE SLAYER IS POWERING THE ECONOMY. STUDENTS… Show Full Text
00:02:17John McArdleJohn McArdleIT’S A CLASSIC REMEDY FOR THE MODERN SKILLS GAP FOR A PUBLIC FOCUSED ON THE TRADITIONAL FOUR-YEAR COLLEGE ROUTE. HOW DO YOU THINK THESE PROGRAMS COULD… Show Full Text
00:02:31Richard WangRichard WangI THINK WE HAVE ABOUT 9% THAT GO INTO A TRADE SCHOOL. WHEN YOU LOOK AT GERMANY, THAT IS 60%. WE HAVE THIS NEGATIVE CONNOTATION TOWARD TRADE SCHOOLS. WHEN… Show Full Text
00:03:31John McArdleJohn McArdleTHOSE WHO ARE ACTIVELY PARTICIPATING IN THOSE PROGRAMS, THE 2018 NUMBERS. 585,000 ACTIVE APPRENTICESHIPS IN THE COUNTRY IN 2018. DO YOU SEE THAT COMPETING… Show Full Text
00:03:57Richard WangRichard WangWHEN YOU DO A BETTER JOB IN TERMS OF PROVIDING YOUNG PEOPLE WITH BETTER SOLUTIONS, THE UNIVERSITY HAS A STRONG BRAND. I THINK OUR PARENTS WANT US TO GO… Show Full Text
00:05:09John McArdleJohn McArdleWE SPLIT OUR PHONE LINES BY YOUR OWN EDUCATION. WE WANT TO HEAR FROM VIEWERS WHO WENT TO TECHNICAL SCHOOLS, THAT NUMBER IS (202) 748-8000. THOSE WHO HAVE… Show Full Text
00:06:03Richard WangRichard WangWITH THE SPEED OF TECHNOLOGY CHANGING RIGHT NOW, WE HAVE A SIMPLER SKILL ECONOMY. THAT MEANS WE INCENTIVIZE EMPLOYERS TO UPSCALE THE WORKFORCE. WE CREATE… Show Full Text
00:07:14John McArdleJohn McArdleARE THERE SPECIFIC WAYS TO DO THAT, ESPECIALLY PEOPLE WHO CAN’T GO BACK TO SCHOOL EVERY 7-10 YEARS. WHAT SPECIFICALLY IN THE GOVERNMENT DO? ARE WE TALKING… Show Full Text
00:07:39Richard WangRichard WangEXACTLY. WE HAVE PILOT PROGRAMS WITH FAMILY SERVICES. WE PROVIDE FREE TUITION. THIS PROVIDED THE WRAPAROUND SERVICES AND THE PAYMENT. THEY GOT PAID WHILE… Show Full Text
00:08:39John McArdleJohn McArdleHOW MUCH IS THAT GOING TO COST AND WHERE YOU GET THE MONEY?
00:08:43Richard WangRichard WangI THINK WE SPEND ENOUGH MONEY IN TERMS OF THE DEFENSE BUZZ IT AND OTHER THINGS — BUDGET. WE CAN ALLOCATE SOME MONEY FOR EDUCATION. WHEN PEOPLE GET RETRAINED… Show Full Text
00:09:23John McArdleJohn McArdleA CONVERSATION ABOUT THE SKILLS GAP. THIS IS GIVING VIEWERS A CHANCE TO CHAT WITH A TECH ENTREPRENEUR, RICHARD WANG IN SEATTLE THIS MORNING. HE IS THE… Show Full Text
00:09:48THIS GUY IS RIGHT. I WANT TO START A COMPUTER SCHOOL. MY GUIDANCE COUNSELOR, ALL OF THEM SAID GO TO COLLEGE. THANK YOU.
00:10:32John McArdleJohn McArdleTHANK YOU FOR CALLING IN AND BRINGING THAT UP. NOT ONE PERSON SAID TO GO TO A TECHNICAL SCHOOL. EVERYONE SAID GO TO COLLEGE. HOW DO YOU CHANGE THAT?
00:10:45Richard WangRichard WangTHERE IS A PROBLEM RELATING TO TRADE SCHOOL AND TECHNICAL SCHOOLS. THIS IS WHERE THE GOVERNMENT CAN DO A LOT OF GOOD IN TERMS OF PROVIDING DIFFERENT OPTIONS. IF… Show Full Text
00:11:25John McArdleJohn McArdleDO YOU THINK THERE IS A STIGMA ABOUT A NONCOLLEGE ROUTE?
00:11:30Richard WangRichard WangABSOLUTELY.
00:11:33John McArdleJohn McArdleGIVE ME AN EXAMPLE THAT AND HOW PEOPLE IN YOUR AREA ARE LOOKING TO CHANGE THAT?
00:11:43Richard WangRichard WangI THINK IN THE PAST 4-5 YEARS, IT IS MORE WELL-KNOWN IN A CITY LIKE SEATTLE OR SILICON VALLEY, NEW YORK. HOW DO I GET TO BE A SOFTWARE DEVELOPER? MAYBE… Show Full Text
00:12:43John McArdleJohn McArdleWHAT KIND OF PROGRAM?
00:12:44CALLER: IT WAS 30 YEARS AGO. 30 YEARS AGO WHEN I WAS A FRESHFACED YOUNG MAN, I WAS RAISED BY THE INTERNATIONAL BROTHERHOOD OF ELECTRICAL WORKERS. I UNDERSTOOD… Show Full Text
00:15:07Richard WangRichard WangI THINK THAT’S GREAT. WE ARE SEEING INCREASING OVER TIME THE NUMBER OF APPRENTICES. ONE THING WE HAVE TO THINK ABOUT IS YOUNG GRADUATES OUT OF COLLEGE,… Show Full Text
00:16:51John McArdleJohn McArdleYOU TALK ABOUT THOSE GOING TO COLLEGE. THE AVERAGE TUITION AMONG NATIONAL UNIVERSITIES, IN 2024 PRIVATE NATIONAL UNIVERSITIES, IT IS $41,000 PER YEAR. OUT… Show Full Text
00:17:30Richard WangRichard WangI DON’T THINK THAT COUNTS FOR ROOM AND BOARD AND FOOD AND TUITION. WHEN YOU DO AN ANALYSIS, YOU ARE CARRYING $300,000 DEBT. THAT’S A LOT OF MONEY. EVEN… Show Full Text
00:17:58John McArdleJohn McArdleHOW MUST IS IT COST FOR SOMEONE TO ENROLL IN THE CODING DOJO PROGRAM? HOW LONG DOES IT TAKE?
00:18:04Richard WangRichard WangTHE PROGRAM IS $10,000-$12,000. IT’S ABOUT 14 WEEKS THAT WE TRAIN ANYONE TO CODE. WE INVEST THREE YEARS IN DEVELOPMENT BEHIND THE TECHNOLOGY AND CONTENT. HOW… Show Full Text
00:18:35John McArdleJohn McArdleHOW MUCH DO PEOPLE MAKE AFTER THEY GO THROUGH YOUR PROGRAM?
00:18:43Richard WangRichard WangWE OPERATE IN 10 DIFFERENT LOCATIONS AROUND THE COUNTRY. ADJUSTED FOR COST-OF-LIVING IN THE AREA, AVERAGE SALARY IS ABOUT $75,000 PER YEAR.
00:18:58John McArdleJohn McArdleHOW WE PEOPLE HAVE GONE THROUGH THE PROGRAM?
00:19:02Richard WangRichard WangPROBABLY ABOUT 6000 PEOPLE HAVE GRADUATED FROM OUR PROGRAM.
00:19:06John McArdleJohn McArdleRICHARD WANG IS THE CEO OF CODING DOJO. WE ARE TALKING ABOUT THE FUTURE OF EDUCATION THROUGH THE COLLEGE ROUTE. GOOD MORNING.
00:19:17GOOD MORNING. I AM IN THE I.T. FIELD. I’M ABOUT TO GO INTO THE OFFICE. IT’S A SAD FACT THAT THE VAST MAJORITY OF THE PEOPLE MAKING HIRING DECISIONS ARE… Show Full Text
00:21:37John McArdleJohn McArdleTHANK YOU FOR THE QUESTION. I WANT TO GIVE MR. WANG A CHANCE TO ANSWER SO YOU’RE NOT LATE TO WORK.
00:21:47Richard WangRichard WangIT IS GOING TO BE HARD. ESPECIALLY WHEN YOU HAVE A BIAS WITHIN THE MANAGEMENT RANKS. THEY ARE MORE LIKELY TO HIRE PEOPLE, THAT IS THE HUMAN BIAS. WE ARE… Show Full Text
00:23:55John McArdleJohn McArdleTHE AVERAGE SALARY IS ABOUT $75,000 PER YEAR. WE ASKED ON TWITTER CAN’T IT BE OUTSOURCED?
00:24:03Richard WangRichard WangIT CAN BE. A CERTAIN PART OF CODING CAN BE OUTSOURCED, SOME STAYS IN HOUSE. OVER THE YEARS, THERE IS A HEAVY OPERATIONAL COST. IS SOMEBODY ELSE DOING WORK… Show Full Text
00:25:03John McArdleJohn McArdleMARY WENT TO A TECHNICAL SCHOOL. GOOD MORNING.
00:25:08I WENT TO A VOCATIONAL TECHNICAL SCHOOL 50 YEARS AGO IN THE EARLY 1970’S. TODAY, THEY ARE CALLED CTE, CAREER AND TECHNICAL EDUCATION. I STUDIED NURSING. THE… Show Full Text
00:26:05John McArdleJohn McArdleWHAT WAS THE BIGGEST BENEFIT?
00:26:07IT HELPED HER HAVE A GOOD SALARY, A WAGER IN HER. THE PARTICULAR DEGREE WASN’T THAT GREAT. IT WASN’T A BONEHEAD. THE FACT THAT SHE HAD THE DEGREE FROM… Show Full Text
00:26:52Richard WangRichard WangWE ARE NOT DISCREDITING THE VALUE OF A FOUR-YEAR DEGREE. I THINK IT’S GREAT FOR YOUR DAUGHTER. IF YOU CATCH THE STATS, 33% OF AMERICANS HAVE A COLLEGE… Show Full Text
00:27:50John McArdleJohn McArdleWE HAVE ONE MORE CHART TO SHOW VIEWERS. THIS IS THE TOTAL LOAN DEBT IN THIS COUNTRY, THE BLUE LINE IS FROM THE EARLY 2000’S UP THROUGH 2018. THAT IS THE… Show Full Text
00:28:37Richard WangRichard WangI THINK THE NUMBERS SPEAK FOR THEMSELVES. I THINK IT WILL BE INTERESTING TO SEE THE RETURN INVESTMENT. ESSENTIALLY, IT’S NOT JUST ABOUT SPENDING MONEY… Show Full Text
00:29:27John McArdleJohn McArdleWE’VE GOT ABOUT 10 MINUTES LEFT IN OUR PROGRAM THIS MORNING. WE WILL TAKE AS MANY CALLS AS WE CAN, INCLUDING CHARLES WHO WENT THROUGH AN APPRENTICESHIP PROGRAM. GOOD… Show Full Text
00:29:41GOOD MORNING. I WENT TO A PROGRAM WHERE THE NATIONALS STADIUM WAS. I WAS ABLE TO LEARN HEAVY EQUIPMENT OPERATION. WHEN YOU LOOK AT THE CONSTRUCTION GOING… Show Full Text
00:30:58Richard WangRichard WangABSOLUTELY. I THINK THAT’S GREAT. WE ARE IN THAT ECONOMY NOW. MANY JOBS WILL BE TAKEN AWAY BY AI. IT’S NOT GOING TO TAKE MANY TRADE SKILL JOBS. THAT’S… Show Full Text
00:32:12John McArdleJohn McArdleIN TERMS OF WHAT THIS ADMINISTRATION HAS PUSHED, WHAT IS THE ACT?
00:32:21Richard WangRichard WangCOULD YOU REPEAT THAT?
00:32:26John McArdleJohn McArdleTHE PERKINS CAREER AND EDUCATION ACT SIGNED IN 2018, $1.2 BILLION A YEAR FOR WORKFORCE DEVELOPMENT.
00:32:37Richard WangRichard WangMY REACTION TO THAT, I DON’T KNOW WHERE THE MONEY IS BEING SENT OR BEING SOURCED. AS YOU KNOW, WE ARE FACING SUCH A BIG PROBLEM. I’M NOT SURE THAT WILL… Show Full Text
00:33:24John McArdleJohn McArdleWHAT WAS YOUR EDUCATION PATH?
00:33:27Richard WangRichard WangIN TERMS OF ME, I WAS STRONGLY INFLUENCED BY MY PARENTS. I CAME TO THE NINE STATES WHEN I WAS SEVEN YEARS OLD. — UNITED STATES WHEN I WAS SEVEN YEARS… Show Full Text
00:34:26John McArdleJohn McArdleJUST SOUTH OF WASHINGTON DC, YOU WENT TO THE COLLEGE REP. GO AHEAD.
00:34:33GOOD MORNING. THIS IS A BUTTON FOR ME. I HAVE A STORY AND A QUESTION. I CAME FROM A SITUATION WHERE I WAS PUSHED BY MY FAMILY. I WAS ENCOURAGED BY MY FAMILY… Show Full Text
00:36:25John McArdleJohn McArdleTHANKS FOR THE CALL.
00:36:29Richard WangRichard WangI THINK YOU HIT THE NAIL ON THE HEAD. YOU LEARN 90% OF STUFF. IT’S ALL BASED ON THEORY. WE CAN RELATE THAT. WE LEARNED ON THE GO. WHAT WE TRY TO DO IS… Show Full Text
00:37:35John McArdleJohn McArdleWE HAVE TWO MINUTES LEFT AND ONE MORE CALL.
00:37:41THANK YOU SO MUCH FOR HAVING THIS CONVERSATION. I AM FORTUNATE ENOUGH TO COUNT MYSELF AS HAVING MY CAKE AND EATING IT TOO. I ATTENDED A VOCATIONAL SCHOOL IN… Show Full Text
00:39:41Richard WangRichard WangTHIS GOES BACK TO MY PROPOSAL. WE HAVE TO CREATE A CIRCULAR ECONOMY WHERE EVERYONE HAS THE OPPORTUNITY TO HAVE A CHANCE TO. — HAS A CHANCE TO WIN. WE… Show Full Text
00:41:16John McArdleJohn McArdleRICHARD WANG CEO OF CODING DOJO. THAT WOULD DO IT FOR OUR PROGRAM — THAT WILL DO IT FOR OUR PROGRAM. HAVE A GREAT FRIDAY. [CAPTIONS COPYRIGHT NATIONAL CABLE… Show Full Text
00:41:44FOR 40 YEARS, C-SPAN HAS BEEN PROVIDING AMERICA UNFILTERED COVERAGE OF CONGRESS, THE WHITE HOUSE, THE SUPREME COURT, AND PUBLIC POLICY EVENTS FROM WASHINGTON,… Show Full Text

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CERN Accelerating science

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News News Topic: Knowledge sharing

How particle physics could prevent financial fraud

A new collaboration agreement sees CERN data analytics used to help protect commodity and financial markets from fraud

20 FEBRUARY, 2020

CERN PHOTOWALK 2010 - Computer Centre - Roger Claus
Similarities between the billions of particle collisions in CERN’s Large Hadron Collider and the high-speed trading on commodity futures markets have led to a new research collaboration. (Image: Roger Claus/CERN)

Every day, commodity markets trade millions of food ingredients and more, so detecting fraud can be challenging. A new collaboration agreement between CERN, the Commodity Risk Management Expertise Center (CORMEC) and Wageningen University & Research (WUR) will now use advanced data analytics from particle physics to help protect commodity and financial markets from fraud. The insights gained could be used by governments and regulators to improve market stability.

During a visit to CERN, WUR economics professor Joost Pennings realised the similarities between the billions of particle collisions in CERN’s Large Hadron Collider and the high-speed trading on commodity futures markets. Most transactions, or collisions, show no anomalies. But when they do, this may lead to new ground-breaking insights for both economists and physicists.

Hence this new collaboration plans to combat fluctuations in markets caused by anomalies, by combining the unique commodity and financial market data and understanding from CORMEC and WUR with CERN’s ROOT data analysis expertise and techniques.

“We see that ROOT, CERN’s scientific big data analytics framework, has the potential to be a game changer for finance data analytics. It’s exciting that ROOT can serve society also outside its core domain of high-energy physics.”

– Dr Axel Naumann, CERN senior applied physicist and ROOT project leader

This collaboration will use data analytics to diagnose manipulation in commodity and financial markets. This should enable regulators to create safer and more stable environments for trading, leading to improved regulation and market integrity. The research may also lead to new diagnostic tools for predicting financial instability, which will indirectly help risk management.

The three-year knowledge-transfer project is named HighLo (High Energy Physics Tools in Limit Order Book Analysis) and is supported by the Province of Limburg in the Netherlands. The first results are expected at the end of 2020.Find out more on the CERN Knowledge Transfer websiteKnowledge transfer

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CERN Accelerating science

home

News News Topic: Knowledge sharing

How particle physics could prevent financial fraud

A new collaboration agreement sees CERN data analytics used to help protect commodity and financial markets from fraud

20 FEBRUARY, 2020

CERN PHOTOWALK 2010 - Computer Centre - Roger Claus
Similarities between the billions of particle collisions in CERN’s Large Hadron Collider and the high-speed trading on commodity futures markets have led to a new research collaboration. (Image: Roger Claus/CERN)

Every day, commodity markets trade millions of food ingredients and more, so detecting fraud can be challenging. A new collaboration agreement between CERN, the Commodity Risk Management Expertise Center (CORMEC) and Wageningen University & Research (WUR) will now use advanced data analytics from particle physics to help protect commodity and financial markets from fraud. The insights gained could be used by governments and regulators to improve market stability.

During a visit to CERN, WUR economics professor Joost Pennings realised the similarities between the billions of particle collisions in CERN’s Large Hadron Collider and the high-speed trading on commodity futures markets. Most transactions, or collisions, show no anomalies. But when they do, this may lead to new ground-breaking insights for both economists and physicists.

Hence this new collaboration plans to combat fluctuations in markets caused by anomalies, by combining the unique commodity and financial market data and understanding from CORMEC and WUR with CERN’s ROOT data analysis expertise and techniques.

“We see that ROOT, CERN’s scientific big data analytics framework, has the potential to be a game changer for finance data analytics. It’s exciting that ROOT can serve society also outside its core domain of high-energy physics.”

– Dr Axel Naumann, CERN senior applied physicist and ROOT project leader

This collaboration will use data analytics to diagnose manipulation in commodity and financial markets. This should enable regulators to create safer and more stable environments for trading, leading to improved regulation and market integrity. The research may also lead to new diagnostic tools for predicting financial instability, which will indirectly help risk management.

The three-year knowledge-transfer project is named HighLo (High Energy Physics Tools in Limit Order Book Analysis) and is supported by the Province of Limburg in the Netherlands. The first results are expected at the end of 2020.Find out more on the CERN Knowledge Transfer websiteKnowledge transfer

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Physiological discoveries abound within NASA samples

News and Views

Elizabeth Keller
NASA Ames Research Center, CA, USA

Ryan Scott
NASA Ames Research Center, CA, USA

Before humans risked their lives launching into space aboard the Vostok Program and Mercury Project, various organisms were flown to determine if it was possible for life to survive spaceflight. For decades, NASA, along with international partners, have continued sending biological experiments to space. Potential biological hazards from spaceflight include decreased gravity, increased exposure to radiation, altered light-dark cycles, and loads experienced during launch and landing. It is imperative to understand the basic science and health risks associated with spaceflight, along with developing countermeasures, as humanity ventures back to the Moon, and then to Mars and beyond.

NASA Ames Research Center houses an Institutional Scientific Collection (ISC) of spaceflight biological specimens and tissues. Through NASA’s Biospecimen Sharing Program (BSP), the samples in this biological repository are available for request by all researchers, including those based outside the United States.

A number of newly identified biological knowledge gaps and astronaut health risks have emerged from extended exposure to microgravity from long-duration missions. Of particular concern to NASA is the loss of visual acuity, which a significant number of astronauts have unexpectedly experienced. NASA is keen on getting researchers to work on elucidating the underlying cause(s) of this issue. In an effort to further the research progress on this topic, the NASA BSP coordinated the sharing of mouse eyes from the STS-133 Shuttle mission. The study led by Susana Zanello1 conducted histological examinations of the mouse eyes from post-flight days 1, 5 and 7. Gene expression analysis suggested that reversible molecular damage occurs in the retina of mice exposed to the spaceflight environment, and that protective cellular pathways are induced in the retina and optic nerve in response to these changes. While correlation of research findings in the mouse tissues to human astronauts presents a set of challenges, the mouse model is an excellent way to characterise underlying changes at the cellular and molecular levels that are simply not available with the human crew.

The costly effort of sending organisms into space makes space-flown biological specimens a rare and valuable resource. Quite often, when life science samples are retrieved from completed missions, there are surplus tissues which remain unused by the Principal Investigators and collaborators. In this scenario the tissues are harvested, preserved, and archived in the NASA ISC at the Ames Research Center to ensure the maximum scientific return from space missions in the belief that new discoveries can be made from the samples.

An important recent finding was made possible by the study of what would have previously been considered waste: rodent fecal pellets. Through NASA’s BSP, Martha Vitaterna, from Northwestern University obtained mouse fecal pellets from a 37-day mission aboard the International Space Station and examined them for the effects of spaceflight on gastrointestinal microbiota2. Findings from previous studies have demonstrated a change in the gut microbial diversity and community structure during spaceflight, but it was unclear what the functional relevance of those microbiome changes were. Using 16S rRNA gene amplicon sequencing, Vitaterna and her team profiled the microbiome of the fecal samples. They then compared the microbiome changes to other relevant datasets and integrated the gut microbiome data with publicly available transcriptomic data in the liver of the same animals for a systems-level analysis. Observations from her analyses shed light on the specific environmental factors that contributed to a robust effect on the gut microbiome during spaceflight, with important implications for mammalian metabolism.

Available tissues for physiology research
The NASA ISC at Ames Research Center currently stores over 32,000 specimens. Most come from Shuttle and International Space Station flight investigations, but also included in the collection are ground-based specimens from spaceflight-model experiments. Tissues are predominantly from mice and rats, though samples are also available from bacteria and quail. The specimens include tissues from many systems including musculoskeletal, neurosensory, reproductive, respiratory, circulatory, and digestive. The samples are stored at -80°C, -20°C, or +4°C, depending on the fixative used. Detailed metadata are available for all samples. Historically, these tissues have been used for a wide range of analyses, including histology, genomics, and transcriptomics. The NASA Ames Life Sciences Data Archive (ALSDA) has been shipping samples to investigators since 1995.

How to request tissues from the NASA ISC
Tissue requests are initiated by submitting an online Biospecimen or Data Request. If the requested tissues are available, the requestor will be sent instructions for submission of a short proposal. Visit the NASA ISC website for more information: nasa.gov/ames/research/space-biosciences/isc-bsp Contact the ALSDA team: arc-dl-alsda@mail.nasa.gov

References

  1. Zanello SB et al. (2013). Spaceflight effects and molecular responses in the mouse eye: observations after shuttle mission STS-133. Gravitational and Space Research 1(1), 29 – 46.
  2. Jiang P et al. (2019). Reproducible changes in the gut microbiome suggest a shift in microbial and host metabolism during spaceflight. Microbiome 7(1), 113. DOI: 10.1186/s40168-019-0724-4

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´´The world people need to have very efficient researches and projects resulting in very innovative drugs, vaccines, therapeutical substances, medical devices and other technologies according to the age, the genetics and medical records of the person. So, the treatment, diagnosis and prognosis will be very efficient and better, of course´´. Rodrigo Nunes Cal ´´O mundo precisa ter pesquisas e projetos muito eficientes que resultem em medicamentos, vacinas, substâncias terapêuticas, dispositivos médicos e outras tecnologias muito inovadoras de acordo com a idade, a genética e o prontuário da pessoa. Assim, o tratamento, o diagnóstico e o prognóstico serão bem mais eficientes e melhores, é claro´´. Rodrigo Nunes Cal ´´As you know, the world needs to have very efficient researches resulting new therapeutical substances, medical devices, prevention, diagnostic and prognostic methods, drugs and vaccines, for example. Very detailed researches are fundamental in this process. So, high impact innovations are essential to the world people!!´´ Rodrigo Nunes Cal  ´´Como você sabe, o mundo precisa de pesquisas muito eficientes que resultem em novas substâncias terapêuticas, aparelhos médicos, métodos de prevenção, de diagnósticos e de prognósticos, medicamentos e vacinas, por exemplo. Pesquisas muito detalhadas são fundamentais neste processo, obviamente. Portanto, inovações de grande impacto são essenciais para as pessoas do mundo todo!!´´ Rodrigo Nunes Cal ´´Ter grandes metas, muitas das quais ditas como impossíveis é muito importante porque pode induzir de várias maneiras em diferentes intensidades na sociedade científica mundial o surgimento de grandes descobertas científicas para toda a humanidade, beneficiando significativamente a vida das pessoas e fazendo com que a expectativa de vida humana aumente significativamente. Dessa forma, doenças conhecidas hoje como sendo fatais e incuráveis, podem se tornar doenças curáveis, com a obtenção de novas tecnologias altamente eficazes de prevenção, diagnóstico, prognóstico e de tratamento´´. Rodrigo Nunes Cal ´´Having big goals, many of which are said to be impossible, is very important because it can induce, in different ways, in different intensities in the world scientific society, the emergence of great scientific discoveries for all of humanity, significantly benefiting people's lives and causing the increase of human life expectancy significantly. Thus, diseases known today as being fatal and incurable, can become curable diseases, with the achievement of highly effective prevention, diagnosis, prognosis and treatment technologies´´. Rodrigo Nunes Cal * ´´The very unknown path may be the best path to take in life´´. Rodrigo Nunes Cal ´´O caminho muito desconhecido pode ser o melhor caminho a seguir na vida´´. Rodrigo Nunes Cal ´´A Ciência abre um leque de possibilidades dos mais variados assuntos e dos mais variados níveis de dificuldades. Sendo assim, a compreensão total dos mecanismos fisiológicos envolvidos na patogênese das doenças, destacando-se as doenças fatais que ocorrem em humanos, é de suma importância para a humanidade, com toda certeza. Quem sabe num futuro próximo essa compreensão seja muito bem entendida e quem sabe, como muitas pessoas sonham na imortalidade física, dentre elas cientistas, essa grande conquista pode ser adquirida. Como você sabe, a humanidade necessita urgentemente de novas descobertas científicas, destacando-se a aquisição de medicamentos e vacinas altamente eficazes contra um grande número de doenças, dentre elas as doenças desconhecidas e silenciosas, a obtenção de aparelhos médicos muito eficientes de diagnóstico, prognóstico e tratamento de doenças, entre outros. Com certeza, precisamos ter esperança e motivação para a realização de ótimos trabalhos e para uma qualidade de vida bem melhor e uma expectativa de vida cada vez maior´´. Rodrigo Nunes Cal ´´Science opens up a range of possibilities for the most varied subjects and the most varied levels of difficulties. Therefore, the full understanding of the physiological mechanisms involved in the pathogenesis of diseases, highlighting the fatal diseases that occur in humans, is of paramount importance for humanity, for sure. Maybe in the near future this understanding will be very well understood and who knows, as many people dream of physical immortality, among them scientists, this great achievement can be acquired. As you know, humanity urgently needs new scientific discoveries, highlighting the acquisition of highly effective medicines and vaccines against a large number of diseases, including unknown and silent diseases, obtaining very efficient medical devices for diagnosis, prognosis and treatment of diseases, among others. Certainly, we need to have hope and motivation to do great work and for a much better quality of life and an ever-increasing life expectancy´´. Rodrigo Nunes Cal - Note: The statistics on the number of people who visited this blog in 2018 were not entirely based on real visitors. As estatísticas sobre número de pessoas que acessaram este blog no ano de 2018 não foram totalmente baseadas em visitantes reais. ´´Great difficulties may have come, but it is of great importance to have in mind the possibility of great victories in the future, bringing happiness and health for a long time´´. Rodrigo Nunes Cal ´´O caminho muito desconhecido pode ser o melhor caminho a seguir na vida´´. Rodrigo Nunes Cal ´´Understanding the great difficulties of a given subject can be a very long process, however, of great value for the progress of Science in all aspects´´. Rodrigo Nunes Cal ´´Entender as grandes dificuldades de um determinado assunto pode ser um processo muito longo, mas de grande valor para o progresso da Ciência em todos os seus aspectos´´. Rodrigo Nunes Cal My Curriculum Lattes: http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4240145A2 My Facebook Page: www.facebook.com/scientificblog IT´S A VERY EASY, FAST AND PRACTICAL WAY TO KNOW EXCELLENT INFORMATION ABOUT SCIENCE, TECHNOLOGY AND INNOVATION, AS AN EXAMPLE, APPLYING THE SEARCH MECHANISM Ctrl + F IN THIS BLOG FOR A WORD OR WORDS. SO, THIS BLOG SHARING IS VERY IMPORTANT TO THE WORLD SOCIETY! I hope in some way with this blog to help significantly in the socio-economic and technical-scientific development of the countries. E-mails: rodrigoncal1984@gmail.com rodrigonunescal@yahoo.com calrodrigonunes@gmail.com rodrigoncal1984@yahoo.com ´´NÃO VÁ PARA ONDE O CAMINHO PODE TE LEVAR. VÁ ONDE NÃO HÁ CAMINHO E DEIXE UMA TRILHA. ´´ ´´DON'T GO WHERE THE PATH CAN TAKE YOU. GO WHERE THERE IS NO PATH AND LEAVE A TRAIL. ´´ @ KNOWING THE UNKNOWN.. CONHECENDO O DESCONHECIDO.. The world needs very innovative ideas to people live better and longer more and more. I have been invited as a Speaker/Delegate in numerous International Conferences and Congresses. * DISCOVERING HOW THE INITIAL STAGES OF A CERTAIN DISEASES WORK, SUCH AS A FATAL DISEASES, IS OF HUGE IMPORTANCE FOR SCIENCE, FOR SURE. THERE ARE SEVERAL BIOLOGICAL FACTORS CONNECTED IN THE HUMAN BODY THAT ACTING IN A VERY COMPLEX FORM. THEREFORE, IT IS OF GREAT NECESSITY TO CARRY OUT NEW SCIENTIFIC RESEARCHES MUCH MORE DETAILED AND MODERN, WITH A HIGH DEGREE OF PRECISION, EVEN IF THERE IS NO SIGNIFICANT STATISTICAL DIFFERENCE BETWEEN CERTAIN FACTORS. * DESCOBRIR COMO FUNCIONA OS ESTÁGIOS INICIAIS DE DETERMINADAS DOENÇAS, TAIS COMO AS DOENÇAS FATAIS, É DE ENORME IMPORTÂNCIA PARA A CIÊNCIA , COM CERTEZA. HÁ VÁRIOS FATORES BIOLÓGICOS INTERLIGADOS NO CORPO HUMANO QUE ATUAM DE FORMA MUITO COMPLEXA. PORTANTO, É DE GRANDE NECESSIDADE A REALIZAÇÃO DE NOVAS PESQUISAS CIENTÍFICAS MUITO MAIS MINUCIOSAS E MODERNAS, COM ALTO GRAU DE PRECISÃO, MESMO QUE NÃO HAJA DIFERENÇA ESTATÍSTICA SIGNIFICATIVA ENTRE DETERMINADOS FATORES. * The discussion of certain facts in science envolving stastistics is fundamental to the scientific community, for example, the analysis and interpretation of very important, innovative and interesting graphics with no statistical difference between them can have a big value to the researches and to the future researches. So, the quality and efficiency of researches can increase so much in a little time, increasing the possiblities of excellent references and new scientific discoveries. The facts veracity and the disclosure of them are essential for the scientific community, of course. Reconhecer o(s) erro(s) cometido(s) e não praticá-lo(s) novamente é um ato de grande sabedoria e importância para si mesmo e para a(s) outra(s) pessoa(s). Acknowledging mistakes and not doing them again is an act of great wisdom and importance for yourself and to the other person or people. ´´O IMPOSSÍVEL PODE SER POSSÍVEL´´. ´´THE IMPOSSIBLE CAN BE POSSIBLE´´. I have received positive feedbacks about this blog by LinkedIn, Twitter, Facebook, E-mails and Instagram. ´´EVERYONE DIES. THE GOAL IS NOT TO LIVE FOREVER. THE GOAL S TO CREATE SOMETHING THAT WILL´´ # time #time #internet #technologies #HighTechnologies #Cell Phones #Computer #Notebook  # Television #radio #communication #tempo  #InternetSociety # Society #person # people # age #ages #genetics #longevity #investigations #researches #efficiency #projects #ideas #reference #references #article #articles #journal # journals #magazines #websites #blogs #sites #links #SocialNetworks #energy #graphics #dissertation #monograph #citations #ImpactFactor #pesquisa #pesquisas #tecnologias #DiferentesPercepções #DifferentPerceptions #mind #mente #minds #MentesHumanas #emails #email e-mails reading #MenteHumana leitura mensagem mensagens probabilidade(s) probabilities messages message importance importância relevância assunto(s) subject subjects issue tema reflexão reflections vision visão pioneirismo pionners prêmio(s) prizes awards innovations inovações Grupos de Estudo Grupos Controle saúde doença(s) nome(s) tempo(s) Início da doença - Momento inicial da doença - Momento(s) inicial(ais) da(s) doença(s) humana(s) - Semelhança genética com camundongos - Mice researches - vaccines - drugs - eficiência - medicamento(s) - vacina(s) - High efficiency - Fatal diseases - Doenças fatais - Investments - investimentos - laboratórios - industries - indústrias - laboratories - Centros de Pesquisa - Países - cidades - cities - longevidade - desafio(s) - challenges - gráficos detalhados - interações biológicas - fatores biológicas - análise minuciosa - Very detailed analysis @ Initial moment of disease - Initial moments of human diseases - No Name @ discussion - discussão científica - science facts - detailed graphics - fatos científicos - publicação de trabalhos científicos - publications - hard work - better results - better science - diagnóstico - prognósticos - Diferença Estatística Significativa 100 Diferença Estatística Significativa @ Significant Statistical Difference - V X I Interpretations interpretações intenções intenions countries EU 100 gene Sem genes Cem genes 1 0 0 gene(s) time(s) times 100 limites limite(s) limits 1 0 0 limit NO LIMIT 10 0 @ 100 genes @ 100 gene & NO GENE NO TEMPO NOS TEMPOS NO(S) TEMPO(S) NOS TIMES NO TIME 100 GENE No Time # no time @ nos genes no(s) gene(s) * no(s) limite(s) - words- palavra(s) - listen - write - type - fala - escuta - ler - virtualidade - virtuality - reality - realidade - mundo real - mundo virtual - vida real - virtual life - real life - vida virtual - imaginations - thoughts - pensamento(s) - imaginações - melhoria - improvement - respect - respeito - speak - nome(s) - trabalho(s) - dinheiro - money - team - equipe - objetivo(s) - Best Universities of the World - Scientific Discoveries - Brazil - World - RNA - Cell - DNA - Idade biológica - biological age - pessoas - idade - idade(s) - pessoa - História da Computação Mundial - Harvard - Names - Places - City - researches - scientists - professors - pesquisador(es) - cientistas - professores - professor(es) - Produção científica - Fatores de Impacto - feelings - logic - sentimento(s) - lógica - história - world history - difficulties - dificuldades - Scientific community - comunidade científica mundial - vidas humanas - vida(s) humana(s) - trabalho(s) - human lives - life - human life - única - one life - person people @ momentos - moments memories memory memória longevidade energias energia(s) Many people liked my Twitter and Facebook comments that I informed this blog like great professors, scientists and researchers around the world who work in human health area! Many data about it aren´t in this blog. #database #system #time #data #search #information #InternetHistory #contribuitions #improvement #analysis #intentions Intenções @ #person #people #age #longevity #work #reading #probabilities #energy #money #price #clicks #jobs #country #city #countries #cities #knowledge #HumanInterdependence #WorldHistory #communication #HumanRelations #websites #e-mails #SocialNetworks #ranking #links #images #photos #texts #messages #videos #writing #typing #speak #listen #think #feelings #ideas #ScientificDiscoveries #investigations #researches #articles #ImpactFactors #journals #citations #influence #dissertations #monographs #ScientificWorks #Inventions #graphics #subjects #books #references #blogs ´´Compreender as grandes dificuldades de um determinado assunto pode ser um processo muito demorado, porém, de grande valia para o progresso da Ciência em todos os aspectos´´ Rodrigo Nunes Cal Observação/Note: I won a scholarship by FAPEMIG during the period of ´´my´´ monograph in Uberaba. Ganhei bolsa de estudo pela FAPEMIG durante o período da ´´minha´´ monografia em Uberaba. During the period that I participated of ´´my´´ dissertation at FAMERP, I didn't win a scholarship. Já durante o mestrado que fiz na FAMERP, não ganhei bolsa de estudo. ´´Os gráficos baseados em dados da ´´minha´´ dissertação que fiz podem ser uma excelente referência para muitos tipos de pesquisas e projetos, é claro !! Por exemplo, para pesquisas e projetos que tenham como objetivo analisar os tipos de influências das idades em camundongos e humanos (estudos genéticos, por exemplo) em relação a diferentes estágios de determinadas doenças, como aquelas em que a comunidade científica desconhece (doenças desconhecidas) e que poderão surgir no mundo. Outros tipos de pesquisas e projetos que podem ser feitos são aqueles que analisam a eficácia de diversos tipos de substâncias terapêuticas em camundongos e humanos nos diversos tipos de doenças com o objetivo de saber qual a melhor substância terapêutica para cada doença, levando em consideração a idade e genética, com certeza. Contudo, realizar pesquisas com o objetivo de avaliar qual é a influência da idade e da genética na eficiência terapêutica em animais de experimentação e em humanos, consequentemente, possui um grande valor, já que muitas pessoas adoecem e acabam falecendo mesmo sendo submetidas à ótimos sistemas de diagnóstico, tratamento e prognóstico, dependendo da doença que possui e do estágio da mesma´´. ´´A partir daí, ao comprovar que há influência significativa da idade e da genética, consequentemente, no processo de patogênese de doenças nos animais de experimentação e nos humanos, seria muito mais conveniente e lógico um grupo de indivíduos de certa faixa etária e histórico familiar e individual de doenças adquiridas e possíveis de serem adquiridas no decorrer do tempo serem tratados com outros tipos de medicamentos, substâncias terapêuticas, vacinas, dentre outros. Com certeza, para a realização destes tipos de pesquisa deve haver grande investimento financeiro nos laboratórios a fim de aquisição de aparelhos científicos altamente eficientes. Com certeza, pesquisas à nível genético e com relação à influência da idade do ser vivo na patogênese de doenças, até das doenças desconhecidas pelo mundo científico. O fato é que este tipo de pesquisa é muito importante porque como todos sabem, há muitas doenças que voltam a se manifestar nas pessoas mesmo depois de excelentes tratamentos, dos mais variados tipos. E outro ponto a ser refletido é a permanência de doenças fatais´´. ´´Assim, este tipo de influência da idade e consequentemente da genética na fisiopatologia das doenças hereditárias ou não hereditárias, um indivíduo de uma determinada idade será submetido a um tratamento terapêutico diferente de outro com a mesma doença mas com idade diferente da de até a pesquisa mostrou uma influência significativa na patogênese da doença, portanto, utilizará outro tipo de substância terapêutica, medicamentos, entre outros. Isso certamente acontecerá se a comunidade científica mundial comprovar cientificamente essas hipóteses por meio de várias pesquisas e projetos científicos. As pessoas precisam ter excelentes inovações para a expectativa de vida humana aumentar muito rapidamente cada vez mais. Portanto, quanto mais a medicina personalizada for, melhor será para cada um de nós´´. Rodrigo Nunes Cal ´´The graphics based on data from ´´my´´ dissertation I did can be an excellent reference for many types of researches and projects, of course!! For example, for researches and projects that the goals are analyse the type of influences of ages in mice and human (genetic studies, for example) in relation to different stages of determined diseases, like those that the scientific community do not know about them (unknown diseases). Other types of researches and projects that can be done is those that analyse the efficiency of many types of therapeutical substances in mice and human in many types of diseases with the objective of knowing which is the best therapeutic substance for each disease, taking into account age and genetics, for sure. For example, to carry out research with the objective of evaluating the influence of age and genetics on therapeutic efficiency in experimental animals and in humans´´. ´´Thus, by proving that there is a significant influence of age and genetics, consequently, in the process of pathogenesis of diseases in experimental animals and in humans, it would be much more convenient and logical to have a group of individuals of a certain age group and family and individual history of acquired diseases and possible to be acquired over time being treated with other types of drugs, therapeutic substances, vaccines, among others. Certainly, to carry out these types of research there must be a large financial investment in laboratories in order to acquire highly efficient scientific devices. Certainly, research at the genetic level and regarding the influence of the age of the living being on the pathogenesis of diseases, even diseases unknown to the scientific world. The fact is that this type of research is very important because as everyone knows, there are many diseases that come back to manifest in people even after excellent treatments, of the most varied types. And another point to be reflected on is the permanence of fatal diseases´´. ´´Taking into account this type of influence of age and consequently genetics on the pathophysiology of inherited or not inherited diseases, an individual of a certain age will be submitted to a different therapeutic treatment from another with the same disease but who has a different age than through the research has shown a significant influence on the pathogenesis of the disease, therefore, will use another type of therapeutic substance, medicine, among others. This will certainly happen if the world scientific community scientifically proves these hypotheses through various research and scientific projects. So, the people need to have excellent innovation to the human expectancy  of life increase so much faster more and more´´. Rodrigo Nunes Cal Note/Obs: I thought each person could do their own friend request permission setting since Facebook's technology is so big, for example. Eu achava que cada pessoa poderia fazer sua própria configuração de permissão de solicitação de amizade já que a tecnologia do Facebook é muito grande, por exemplo.

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