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Pathol Res Pract. 2012 Jul 15;208(7):377-81. doi: 10.1016/j.prp.2012.04.006. Epub 2012 Jun 8.

The influence of physical activity in the progression of experimental lung cancer in mice

Renato Batista Paceli 1Rodrigo Nunes CalCarlos Henrique Ferreira dos SantosJosé Antonio CordeiroCassiano Merussi NeivaKazuo Kawano NagaminePatrícia Maluf Cury


Impact_Fator-wise_Top100Science_Journals

GRUPO_AF1 – GROUP AFA1 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 1 – GROUP AFAN1 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO_AF2 – GROUP AFA2 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 2 – GROUP AFAN 2 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

Slides – mestrado – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

CARCINÓGENO DMBA EM MODELOS EXPERIMENTAIS

DMBA CARCINOGEN IN EXPERIMENTAL MODELS

Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

https://pubmed.ncbi.nlm.nih.gov/22683274/

Abstract

Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.

https://medicalxpress.com/news/2020-03-coronavirus-vaccine-future.html?utm_content=121791399&utm_medium=social&utm_source=facebook&hss_channel=fbp-508209262538427&fbclid=IwAR1jNzMozPOSFe005MLWYky4gzJjzRx5JJyt7beuZDjHoIv-Ka9EUR7X_c8

NASA makes their entire media library publicly accessible and copyright free

Can AI Help in the Fight Against the Coronavirus?

5r

https://www.worldometers.info/coronavirus/

https://phys.org/news/2020-03-antiaging-biochemical-mechanism-mouse-naked.html?fbclid=IwAR1v7GixLOGfmva9oXQfrc_LJ61KUwpoAodzduxmVT9Pf8JeYkN8Z1zlnpY

https://phys.org/journals/proceedings-of-the-national-academy-of-sciences/

Naked mole-rats defy conventions of aging and reproduction

https://phys.org/news/2018-08-naked-mole-rats-defy-conventions-aging.html

Scientists explain why naked mole-rats’ longevity contradicts accepted aging theory

https://phys.org/news/2020-02-scientists-naked-mole-rats-longevity-contradicts.html

More information: Mikhail Y. Vyssokikh et al. Mild depolarization of the inner mitochondrial membrane is a crucial component of an anti-aging program, Proceedings of the National Academy of Sciences (2020). DOI: 10.1073/pnas.1916414117

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Antiaging biochemical mechanism found in mouse, bat and naked mole rat cells

Biochemical mechanism in mouse, bat and naked mole rat cells is a key component of the anti-aging program
Naked mole rat. Credit: Jan Zwilling, IZW

Aging is an inevitable part of life, yet some species are aging very differently than others, even than very similar ones.

For example, , east African rodents of a size comparable to moles or mice, show a strongly delayed process of aging and live up to 30 years. Scientists from Russia, Germany and Switzerland have now confirmed a mechanism in mouse, bat and naked mole rat cells—a “mild depolarization” of the inner mitochondrial membrane—that is linked to aging: Mild depolarization regulates the creation of mitochondrial reactive oxygen species (mROS) in cells and is therefore a mechanism of the anti-aging program. In mice, this mechanism falls apart at the age of one year, while in naked mole rats, this does not occur until around 20 years. This newly confirmed mechanism is described in detail in a paper published in the Proceedings of the National Academy of Sciences.

Mitochondrial reactive oxygen species (mROS) such as hydrogen peroxide are byproducts of cell respiration and, in , associated with diseases and aging processes. There are mechanisms at the inner and outer mitochondrial membranes that regulate mROS production. the key function of cell respiration is energy production in the form of adenosine triphosphate (ATP) through coupling of mitochondrial respiratory chain complexes with ATP synthase.

Mitochondrial intermembrane space enzymes (hexokinases I + II and creatine kinase) have now been confirmed to slightly lower the membrane potential of the inner mitochondrial membrane (mild depolarization). This means that the differences in the electric load between the inner and the outer space of the mitochondria are lowered, and the  through ATP synthesis is reduced to some extent. At the same time, this leads to the cessation of mROS production. “The proof of this effect is implying that mild depolarization is a  of the anti-aging program, effectively slowing down aging processes in the cell,” says senior author Vladimir Skulachev (Lomonosov Moscow State University).

The research team was able to show that both biochemical mechanisms do not operate in the same intensity and efficiency in different species and tissues and at different ages: The researchers examined the hexokinases I + II and creatine kinase mechanisms in various tissues (lung, kidney, brain, skeletal muscles, heart, and others) in mice,naked mole rats, and Seba’s short-tailed bats.

They found interesting differences: Mild depolarization significantly starts decreasing after one year of age in mice with negligible levels after 24 months in skeletal muscles, diaphragm, heart, brain, and spleen. In lung and kidney tissue, mild depolarization decreases to a lesser extent with aging.

“The crumbling of the anti-aging program in the cells starts after only a third of the average lifespan in mice, while the naked mole rats and Seba’s short-tailed bats maintain mild depolarization and hence the suppression of mROS production up to high ages,” explain co-authors Thomas Hildebrandt and Susanne Holtze from the Leibniz Institute for Zoo and Wildlife Research (Leibniz-IZW). “This contributes to the extraordinary longevity of these species.”

These biochemical mechanisms explain how the aging and the anti-aging programs within  function and are regulated. However, it has not yet been determined where and how these processes are activated and controlled. “The master biological clock has not yet been identified,” says lead author Mikhail Vyssokikh (Lomonosov Moscow State University). “We suspect it to be located in the suprachiasmatic nucleus of the hypothalamus, which is responsible for the circadian and seasonal rhythms.”

This question and some other yet unknown components of the aging and anti-aging programs will be targets of high interest for future gerontological investigations.


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Scientists explain why naked mole-rats’ longevity contradicts accepted aging theory


More information: Mikhail Y. Vyssokikh et al. Mild depolarization of the inner mitochondrial membrane is a crucial component of an anti-aging program, Proceedings of the National Academy of Sciences (2020). DOI: 10.1073/pnas.1916414117

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The Proceedings of the National Academy of Sciences of the United States of America, usually referred to as PNAS, is the official journal of the United States National Academy of Sciences (NAS). PNAS is an important scientific journal that printed its first issue in 1915 and continues to publish highly cited research reports, commentaries, reviews, perspectives, feature articles, profiles, letters to the editor, and actions of the Academy. Coverage in PNAS broadly spans the biological, physical, and social sciences. Although most of the papers published in the journal are in the biomedical sciences, PNAS recruits papers and publishes special features in the physical and social sciences and in mathematics. PNAS is published weekly in print, and daily online in PNAS Early Edition. PNAS was established by NAS in 1914, with its first issue published in 1915. The NAS itself had been founded in 1863 as a private institution, but chartered by the US Congress, with the goal to “investigate, examine, experiment, and report upon any subject of science or art.” By 1914, the Academy was well established.

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United States National Academy of Sciences
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1914 – present
Website
http://www.pnas.org/
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Proceedings of the National Academy of Sciences

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Turtle ant soldiers look like real-life creatures straight out of a Japanese anime film. These tree-dwelling insects scuttle to and fro sporting shiny, adorably oversized heads, which they use to block the entrances of their …

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Scientists explain why naked mole-rats’ longevity contradicts accepted aging theory

Scientists explain why naked mole-rats’ longevity contradicts accepted aging theory

Credit: afagen, CC BY-NC-SA 2.0

Dr. Chen Hou and his research collaborators have found an answer to the decades-old question of why naked mole-rats with high oxidative damage live 10 times longer than mice of comparative weight.

“The long lifespan of the East African naked mole-rats raises one of the most serious paradoxes in the study of aging,” says Hou, an associate professor of biological sciences at Missouri S&T. “And geriatric researchers are asking if the  theory is dead.”

The widely accepted theory of aging is based on a negative correlation between oxidative stress and animal lifespan. This theory posits that aging occurs because of accumulated  caused by the byproducts of oxidative metabolism—or the way we burn oxygen to produce energy. When a certain threshold of oxidative damage is reached, animals will die.

“We’ve observed the correlation between damage level and lifespan is the dynamic process of damage accumulation, which is largely determined by the animal’s growth and metabolism,” says Hou. “Besides offering a simple explanation to the ‘naked mole-rats paradox’ that has puzzled scientists for years, our results provide a starting point for new comparative aging studies.”

To explain the contradiction, the researchers developed a data-based theoretical model that estimates oxidative damage accumulation with age. Their model highlights a tradeoff between the metabolic energy cost of growth versus damage repair. The tested hypothesis is if animals expend too much energy on growth, less will be available to repair their oxidative damage, which will accumulate. It also suggests that high metabolism leads to faster damage accumulation.

Scientists explain why naked mole-rats’ longevity contradicts accepted aging theory

During growth, Animal A (black curve) accumulates less damage than Animal B (red curve), but during adulthood the damage slope of Animal A is steeper than that of Animal B. Thus, two curves cross at the green dot, which may occur below the damage threshold for death (horizontal dotted line). The black and red arrows indicate when the lifespans of two animals are reached when damage levels reach the damage threshold. Credit: Missouri University of Science and Technology

The study illustrates that during growth, naked mole-rats expend more energy than mice, and by the end of their growth, have accumulated greater oxidative damage than mice. It also shows that during adulthood, the low metabolism of naked mole-rats significantly slows the speed of damage accumulation to less than that of mice.

Hou says that this observation led to his hypothesis that mice have lower oxidative damage than naked mole-rats for a large portion of their life, but the oxidative damage of  will reach the threshold sooner than , which causes them to die sooner. Hou calls it “the simple answer to the paradox.”

Hou says the discovery that a large portion of the lifetime oxidative damage accumulates during growth is especially important for large species, including humans, due to their long growth periods.

“If our hypothesis is proven, the model can become a  to learn how differences in children’s developmental traits—such as growth rate, birth-to-adult weight ratio, and the energetic cost of biosynthesis—will affect their adult health and lifespan,” says Hou.

Hou is corresponding author and co-investigator of the project with Wenyun Zao, a basic life research scientist at Stanford University, and Xialong Tang, a lecturer in the Institute of Biochemistry and Molecular Biology at Lanzhou University in Lanzhou, China. The paper, titled “Why Naked Mole-Rats Have High Oxidative Damage but Live a Long Life: a Simple Explanation Based on the Oxidative Stress Theory of Aging,” was published in the Hapres journal, Advances in Geriatric Medicine and Research on Jan. 7.


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Naked mole rat found to defy Gompertz’s mortality law


More information: Why Naked Mole-Rats Have High Oxidative Damage but Live a Long Life: A Simple Explanation Based on the Oxidative Stress Theory of Aging. Adv Geriatr Med Resdoi.org/10.20900/agmr20200006

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Naked mole-rats defy conventions of aging and reproduction

<img style="box-sizing:border-box;vertical-align:middle;border-style:none;max-width:100%;height:auto;position:relative;transition:opacity .3s ease-in-out 0;" title="Female mole rat. Credit: Jedimentat44/flickr/CC BY 2.0” src=”https://scx1.b-cdn.net/csz/news/800/2018/1-nakedmolerat.jpg&#8221; alt=”Naked mole rat”>

Female mole rat. Credit: Jedimentat44/flickr/CC BY 2.0

Naked mole-rats live in colonies of two breeders and around 300 non-breeding workers. Although the breeding pair carries the metabolic cost of reproduction and, in the queen’s case, lactation, they live longer than non-breeders and remain fertile throughout their lives. Researchers at the Leibniz Institute on Aging in Germany investigated the genetic mechanisms beneath this apparent paradox. Their findings are published in the open access journal BMC Biology.

Dr. Martin Bens, the corresponding author said: “Our results indicate that when  mature into breeders, it changes their aging rates, meaning that breeders are able to live longer than non-breeders. This is surprising, as evidence from other species suggest that reproduction, which ensures the survival of the species as a whole, reduces the lifespan of the individual. In naked mole-rats reproduction appears to prolong the breeders’ lifespan. This goes against the common expectation that mammals either invest resources in a long life or in reproduction.”

The researchers analyzed the transcriptomes—the sum of all transcribed genes—for tissue samples taken from a range of organs, including heart, liver, and gonads. They compared the transcriptomes of naked mole-rat breeders to that of non-breeders, as well as to breeding and non-breeding guinea pigs, which are close relatives of the naked mole-rat but have a shorter lifespan.

The authors found that genes related to aging were expressed differently in samples from breeding naked mole-rats than those from guinea pigs and non-breeding naked mole-rats. For example, a gene related to muscle regeneration showed higher expression in naked mole-rat breeders which may be linked to higher resistance to muscle loss during aging. Gene expression changes like this may contribute to the exceptionally long lifespan of naked mole-rat breeders.

Dr. Bens said: “Unlike non-breeding guinea pigs and other rodents, non-breeding naked mole-rats are not sexually dimorphic; they show no differences in body size, body mass or external genitalia, as well as few behavioral differences. One of the main and surprising findings of our study is that transcribed genes in non-breeding naked mole-rats also show no significant differences between females and males. However, we found that the transcriptome changes significantly when they mature into breeders.”

When the authors separated non-breeding naked mole-rats from colonies and paired them with naked mole-rats of the opposite sex, the workers transitioned into breeders. The transition was accompanied by physical and behavioral changes that differed between males and females—the animals became sexually dimorphic. Sexual maturation was also associated with a change in gene expression levels linked to extended life and health span.

Dr. Bens said: “Deeper investigations of naked mole-rat transcriptome data can help us understand how sexual maturation is regulated. This could potentially help us better understand sexual maturation in humans, where the onset of puberty varies between individuals and is influenced by a variety of factors such as stress and nutrition. Variations in puberty onset have implications for the risk for diseases such as breast cancer or cardiovascular diseases. Our data may help identify targets to mitigate these variations.”

In another study titled ‘Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging,’ published in BMC Biology on the same day, Dr. Bens and colleagues compared the liver of naked mole-rats with those of guinea pigs to further investigate the molecular mechanisms that underlie naked mole-rat longevity.

Alessandro Ori, the corresponding author of the study said: “We found that naked mole-rat livers have a unique expression pattern of mitochondrial proteins that result in distinct metabolic features of their mitochondria, including an increased capacity to utilize fatty acids. We were also able to show that similar molecular networks are affected during aging in both naked mole-rats and humans, which suggests that there may be a direct link between these networks and the longevity of these species, both of which would be expected to have much shorter lives based on their body mass.”


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Naked mole rat found to defy Gompertz’s mortality law


More information: Martin Bens et al, Naked mole-rat transcriptome signatures of socially suppressed sexual maturation and links of reproduction to aging, BMC Biology (2018). DOI: 10.1186/s12915-018-0546-zIvonne Heinze et al. Species comparison of liver proteomes reveals links to naked mole-rat longevity and human aging, BMC Biology (2018). DOI: 10.1186/s12915-018-0547-y

Journal information: BMC Biology
Provided by BioMed Central

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COVID-19 CORONAVIRUS OUTBREAK
Last updated: March 14, 2020, 16:00 GMT
Case Graphs – Death Graphs – Countries – Death Rate – Incubation – Age – Symptoms – News

Coronavirus Cases:

150,157

Deaths:

5,617

Recovered:

73,731
ACTIVE CASES
70,809
Currently Infected Patients

65,080 (92%)

in Mild Condition

5,729 (8%)

Serious or Critical

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Jan 22Feb 11Mar 02Jan 27Feb 01Feb 06Feb 16Feb 21Feb 26Mar 07Mar 12050k100k

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CLOSED CASES
79,348
Cases which had an outcome:

73,731 (93%)

Recovered / Discharged

5,617 (7%)

Deaths

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Feb 02Feb 06Feb 10Feb 14Feb 18Feb 22Feb 26Mar 01Mar 05Mar 09Mar 130%100%

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Total Coronavirus CasesTotal Cases(Linear Scale)Jan 22Feb 09Feb 27Jan 31Feb 18Mar 07050k100k150k200kCasesFeb 01● Cases: 14,553
Total Coronavirus DeathsTotal Deaths(Linear Scale)Jan 22Feb 15Mar 10Jan 30Feb 07Feb 23Mar 0202k4k6kDeaths
The charts above are updated after the close of the day in GMT+0. Latest data is provisional, pending delayed reporting and adjustments from China’s NHC.

Confirmed Cases and Deaths by Country, Territory, or Conveyance

The coronavirus COVID-19 is affecting 149 countries and territories around the world and 1 international conveyance (the Diamond Princess cruise ship harbored in Yokohama, Japan). The day is reset after midnight GMT+0.

Highlighted in green
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The “New” columns for China display the previous day changes (as China reports after the day is over). For all other countries, the “New” columns display the changes for the current day while still in progress.

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Latest Updates

March 14 (GMT):

  • 4 new cases in Kuwait: 2 men who had traveled to the UK, a woman who had traveled to Qatar and France, and an Indian national in contact with a person from Azerbaijan [source]
  • 1 new case in the Maldives: a person staying at the Kuredu Island Resort [source] [source]
  • 41 new cases in Malaysia [source]
  • 57 new cases in Portugal [source]
  • Indonesia: Transportation Minister tests positive for coronavirus [source]
  • 1 new death in Iraq: an elderly man who had recently visited Iran [source]
  • 2 new cases in Russia [source]
  • 5 new cases in Albania [source]
  • 3 new cases in Taiwan: all had recently returned from Europe [source]
  • 4 new cases in Sri Lanka [source]
  • 17 new cases in Qatar [source]
  • 14 new cases in South Africa [source]
  • 3 new cases in Palestine [source]
  • 12 new cases in Singapore [source]
  • 151 new cases in Austria [source]
  • 130 new cases and 1 new death in Belgium [source]
  • 278 new cases in Germany [source]
  •  97 new deaths and 1365 new cases in Iran [source]
  •  342 new cases and 10 new deaths in the UK. The ten patients who died were all over the age of 60s and belonging to “at-risk groups”
    [source]
     [source]
  • 1 new case in Trinidad and Tobago: a 66-year-old male with recent travel history [source]
  • 7 new cases in Thailand:
    – a 33-year old woman
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    – a 4-year old girl
    – actor Matthew Deane Chanthavanij
    – 63-year-old woman who is the mother of one of the previous cases
    – a 20-year-old student who had returned from Japan
    [source]
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    – a 25-year-old man in Ho Chi Minh City in contact with a previously confirmed case
    – a 30-year-old stewardess who was on a flight from the UK to Vietnam
    – a 43-year-old woman who is a house helper of a previously announced case
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    – a man from the Czech Republic who reported being in contact with an Italian citizen before coming to Vietnam
    [source] [source] [source] [source]
  •  1st case in Rwanda: an Indian citizen who arrived from Mumbai, India [source]
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    – a young woman who had traveled to Brussels
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     [source]
  • 2 new cases in Armenia: one with pneumonia [source]
  •  2 new deaths in Greece: a 67-year-old man who had returned from Israel, and a 90-year-old man with severe health complications [source]
  • 25 new cases in Poland
    Beginning March 14:
    – only grocery stores, pharmacies, laundromats and banks will remain open
    – restaurants, pubs and clubs will be closed except those offering delivery or take-out food
    Beginning March 16:
    – borders closed to all foreigners
    – full border control reintroduced for the next 10 days
    – international air and rail travel suspended
    – 14-day quarantine ordered for Poles returning from abroad
    – gatherings of more than 50 people banned
    [source] [source] [source]
  • 21 new cases in Israel [source]
  • 1 new case in Algeria: a 36-year-old man who had recently returned from France [source]
  • 2 new cases in Lithuania [source]
  • 2 new cases in Romania: a 47-year-old woman in contact with a previously confirmed case and a 39-year-old man who had returned from Brescia, Italy [source]
  • 3 new cases in Afghanistan [source]
  • 9 new cases in the Czech Republic [source]
  • 5 new cases in Croatia: all connected to previously confirmed cases [source]
  • 7 new cases in Sweden [source]
  • Russia: Land borders with Poland and Norway will close at midnight to all international visitors traveling “for professional, private, study or tourist reasons.” The measures will not apply to Belarusians, members of official delegations and residents of Russia. The border with Finland remains open. Citizens returning home are ordered to self-isolate for two weeks even if they do not show any symptoms. [source] [source]
    Commercial flights will be limited to EU capitals and only from and to Sheremetyevo Airport in Moscow.
  • New Zealand: As of midnight Sunday every person entering New Zealand, including its returning citizens and residents, will be required to self isolate for 14 days [source]
  • 9 new cases in Panama [source]
  • Hungary:
    – all primary and secondary schools in Hungary will be closed from 16 March
    –  the entry ban already in place for Iran, China, South Korea and Italy will be extended to Israel
    – the construction of a new hospital has been announced
    [source]
  • United States: The U.S. House of Representatives passed a coronavirus aid package that would provide free testing and paid sick leave. If it passes the Senate next week it would provide
    paid sick and family leave for 2 weeks for those affected by the virus [source]
  • 70 new cases in Finland [source]
  • 22 new cases in Iceland [source]
  • 3 new cases in Martinique [source]
  • 3 new cases in Costa Rica [source]
  • 5 new cases in Armenia: all patients are in satisfactory condition, with only one having pneumonia [source]
  • 2 new cases in Kazakhstan: a man who had flown from Moscow, Russia and a woman who had flown from Warsaw, Poland [source]
  •  Denmark shuts its borders until April 13. Air, ferry and train traffic will also be partially stopped [source]
  • 1 new case in Morocco: a 64-year-old French citizen, who arrived March 2 from France [source]
  • 1 new death in the United States (California): a woman in her 80s in Santa Clara County. [source]US death toll from coronavirus reaches 50: 37 deaths in Washington State, 6 in California, 2 in Florida, 1 in Colorado, 1 in Georgia, 1 in Kansas, 1 in New Jersey, and 1 in South Dakota
  • 1 new death in the Philippines: a 54-year-old Filipino male with no known travel history abroad. He was admitted to the hospital on March 3, more than a week after exhibiting symptoms [source]
  •  First 3 cases in Puerto Rico [source]
  • 107 new cases and 5 new deaths in South Korea [source]
  • 11 new cases13 new deaths (all in Hubei) and 1,430 new discharges occurred in China on March 13, as reported by the National Health Commission (NHC) of China [source]

March 13:

UNITED STATES DECLARES NATIONAL EMERGENCY [source]


Coronavirus expert Dr. Anthony Fauci said:

“These kind of things generally run out in a few monthsHopefully, we’ll make it several weeks. Eight, nine, whatever weeks, but I can’t give you a number, because it depends on how successful we are” (with mitigation and containment measures). Earlier today, Dr. Fauci had said that: [video]

  • It’s certainly going to get worse before it gets better
  • Crisis will last for at least several weeks and possibly 2 months or more
  • Complete shut down like in Italy and China is not off the table. “We just have to respond as things evolve over the days and over the weeks”

Worst Case Scenario by CDC (if no actions taken) [source]

Between 160 million and 214 million people in the U.S. could be infected (Worst case scenario). Dr. Lawler, an infectious diseases specialist, provided a “best guess” projections of 96 million people

Could last months or even over a year

As many as 200,000 to 1.7 million people could die. Dr. Lawler’s calculations: 480,000 deaths, which he said was conservative

By contrast, 20,000 to 50,000 people have died from flu-related illnesses this season according to CDC.

2.4 million to 21 million people in the U.S. could require hospitalization, potentially crushing the nation’s medical system, which has only about 925,000 staffed hospital beds. Fewer than a tenth of those are for people who are critically ill

INTERNATIONAL TRAVEL SHUTTING DOWN

  • Czech Republic closes its borders: almost no-one will be allowed to enter or leave the country [source]
  • Turkey: all flights from Turkey to Germany, France, Spain, Norway, Denmark, Belgium, Austria, Sweden and the Netherlands are halted until 17 April [source]
  • Pakistan shuts land borders and limits flights [source]
  • Oman has already suspended tourist visas for all visitors for 1 month [source]
  • Iraq adds Germany and Qatar to its coronavirus entry ban list, which now includes 13 countries [source]
  • Qatar already banned entry of people coming from India and 13 other nations [source]
  • Ukraine closes borders to foreign visitors for 2 weeks [source]
  • Slovakia closes borders for non-residents [source]
  • Israel on March 9 ordered a 14-day quarantine for anyone entering country [source]
  • India: effective today, all tourist visas and OCI entries are suspended until at least April 15. 14-day quarantine for citizens returning from seven countries: China, Italy, Iran, South Korea, Spain, France and Germany [source] India had already banned, on March 3, entry to nationals of Italy, Iran, South Korea, and Japan [source]
  • United Statestravel ban from Europe goes into effect today at 23:59 ET [original document] Applies to foreign nationals that have been to a country within the Schengen area in the past 14 days
  •  First 4 cases in Uruguay: all the cases had returned from Milan, Italy between March 3 and March 6 [source]
  •  1st case in Guatemala: a Guatemalan who arrived from northern Italy [source]
  •  1st case in St. Lucia [source]
  •  1st case in Suriname [source]
  •  1st case in Curaçao [source]
  •  First 2 cases in Aruba: both traveled in from New York. Schools closed next week. Flights to Europe cancelled [source]
  •  1st case in Kenya
  • 1 new death in India: a 68-year-old woman who had come in contact with her son who got infected after travelling to Switzerland and Italy last month [source]
  • Europe has become the epicenter of the global Covid-19 pandemic. More cases are now reported every day in Europe than in China at the height of its epidemic (Video: WHO daily briefing on Covid-19)
  • 1 new death in Argentina: a 61-year-old man who had other pathologies [source]
  • Spain declares State of Emergency [source]
  • 1 new death in the U.K., first in Scotland [source]
  •  2,547 new cases and 250 new deaths in ItalyHighest number of deaths per day in the world ever (including China at its peak) has been reported in Italy in each of the last four days.
  • 73 new cases in Greece [source]
  •  1st case in Antigua & Barbuda: a woman who had come from the UK on a British Airways flight and is currently in isolation [source]
  • Brazilian President Jair Bolsonaro says he tested negative [source] after earlier reports of him testing positive. Bolsonaro, Wajngarten (who tested positive), and staffers were guests at Mar-a-Lago over the weekend. Wajngarten posed for a photo on Saturday with both the President and Vice President of the United States
  • 10 new cases in Chile [source]
  • 39 new cases in Malaysia [source]
    Canada: Ontario’s publicly funded schools will close from March 14 to April 5 [source]
  • 2 new cases in Cambodia: a 49-year old Canadian man and a 33-year old Belgian man who are now in quarantine in Phnom Penh [source]
  • 3 new cases in Turkey [source]
  •  1st case in Guinea: a member of the EU delegation in the country [source]
  • .Switzerland is closing all schools until at least April 4
  • Germany: most schools will be closed from Monday
  • United States: at least 9 states are closing schools: Pennsylvania, Delaware, Ohio, Michigan, Oregon, Maryland, Kentucky and New Mexico
  •  1,188 new cases and 36 new deaths in Spain, which declares a 15-day State of Emergency [source]
  • 4 new cases in Colombia [source]
  • 74 new cases in Brazil [source]
  • 208 new cases in the UK [source] English Premier League suspended until at least April 3. Scotland, Wales and Northern Ireland halt games [source]
  •  1st case and 1st death in Sudan: a man in his 50s had visited the United Arab Emirates [source]
  • 7 new cases in Bosnia and Herzegovina: a young person and a child from Banja Luka [source]
  • 3 new cases in North Macedonia: people from Debar in their 50s [source]
  • 11 new cases in Russia: all cases visited Italy, France, Austria [source]
  • 45 new cases in Slovenia [source]
  •  1st death in Ukraine: a 71-year-old woman from the Zhytomyr region [source]
  • Moldova immediately suspends flights from Spain and France and, from Sunday, from all European destinations [source]
  •  190 new cases and 5 new deaths in the Netherlands [source] Measures introduced: [source[source]
    – people with a cold, cough, sore throat or fever should stay at home
    – meetings with more than 100 people are canceled
    – recommended to work from home as much as possible
    – vulnerable persons should avoid large groups and public transport
    – colleges and universities are requested to offer education online
    – schools in primary, secondary and secondary vocational education and childcare will remain open
  • 9 new cases in Slovakia [source]
  • 3 new cases in Sri Lanka: a 41-year-old Sri Lankan male who had arrived from Germany, a 37-year-old and a 43-year-old male who had arrived from Italy and were put into quarantine [source]
  • 3 new cases in Vietnam [source]
  • 160 new cases in Belgium [source]
    National Security Council’s measures:
    – all recreational, sporting and cultural events have been canceled
    – everyone is advised to work from home if possible
    – all school lessons are suspended until after the Easter holidays
    – childcare is guaranteed during school hours for healthcare and emergency personnel
    – crèches will remain open
    – Universities and colleges will give lectures online
    [source]
  • 14 new cases in Romania
    – Romania’s interim government is self-isolating for 14 days after a senator tested positive. Some members of the National Liberal Party (PNL) will also self-quarantine [source] [source]
  • 2 new cases in Armenia [source]
  • 10 new cases in Albania [source]
  • 3 new cases in Lithuania: a female Spanish citizen who had come from Madrid, Spain, a man who had returned from Italy, and a woman who had returned from Tenerife, Spain [source]
  • 43 new cases in Portugal [source]
  • 4 new cases in Azerbaijan: all 4 had returned from Iran or Italy [source]
  • 1 new case in the Democratic Republic of Congo: a man who had visited France [source]
  • 8 new cases in South Africa:
    – a 39-year-old female who had traveled to Switzerland and Austria
    – a 50-year-old male who had traveled to Austria
    ⁃ a 21-year-old female who had traveled to Italy
    ⁃ a 57-year-old male who had traveled to Switzerland
    – a 79-year-old male who had traveled to Greece and Italy
    ⁃ a 52-year-old male who had traveled to Switzerland
    ⁃ a 50-year-old male who had traveled to Switzerland and Austria
    ⁃ a 46-year-old male who had traveled to Italy[source]
  •  1st case in Ethiopia [source]
  • 12 new cases in Brunei [source]
  • 13 new cases 39 new cases in Bahrain [source]
  •  85 new deaths and 1289 new cases in Iran [source]
  • 39 new cases in Australia including a patient in Victoria who had not been overseas [source]
  • 35 new cases and 3 new deaths in Indonesia: a  37-year old woman, a 57-year old woman and a 59-year old man [source]
  • 1 new case in the Faeroe Islands [source]
  • 4 new cases in Cyprus [source]
  • 1 new case in Pakistan: a 52-year-old man in Sindh who had traveled to Islamabad [source]
  •  1st case in Guadeloupe: a 36-year-old woman who had returned from a cruise [source]
  •  1st case in the Cayman Islands: an individual who was removed from a ship after a cardiac event and taken directly to a hospital where he was tested [source]
  • 3 new cases in Malta [source]
  • 9 new cases in Lebanon [source]
  • 1 new case in La Réunion [source]
  • 2 new cases in French Polynesia: a Swiss tourist who had arrived in Fenua last weekend and a woman returning from France in contact with Tahiti parliamentarian Maina Sage, the first case of coronavirus in the country [source]
  • 46 new cases in Finland [source]
  • 3 new cases in India [source]
  •  First 4 cases in Kazakhstan including 2 men and a woman who had all returned from Germany [source]
  • 4 new cases in Croatia: 2 people from Zagreb with close connections to previously confirmed cases, 1 person from Pula who had returned from Italy, 1 person, also from Pula, who came into contact with a Swiss citizen that had tested positive at home [source]
  • 3 new cases in Hungary [source]
  • 7 new cases in Serbia [source]
  • 17 new cases in Israel [source]
  • 17 new cases in Poland [source]
  • 1 new death in Indonesia: a 59-year-old man with no history of traveling overseas and no contact with foreigners [source]
  • 1 new case in the Czech Republic where the government has extended mandatory quarantine for citizens returning from high-risk areas and banned foreigners from entering the country [source]
  • 41 new cases in Estonia [source]
  • 1 new case in Latvia [source]
  •  1st case in Kenya: a female student who had traveled from the United States via London [source]
  • 1 new case in Taiwan: a 50-year-old American male who works in Taiwan. After receiving 4 American friends (two couples) from Feb. 24 to Feb 26, he developed chills, cough, and fever on Feb 27, March 4, and 7, when he was admitted to the hospital. One of the couples already had chills, cough, and fatigue on Feb. 24, the other developed symptoms upon returning to the US [source]
  • United States new cases include: 1 new case in Georgia: a 29-year-old female from Charlton County who came to the Camden Campus ER with respiratory symptoms on Saturday, March 7. She was treated and released, but then returned to the hospital on Monday, March 9, with worsening symptoms. The patient has no travel history or known exposure [source]

    – 1 new case in Nebraska
    : a man in his 50s who was on the same connecting flight as the person who is Nebraska’s first case [source]– 15 new cases in Florida [source]– 1 case in New Mexico: a Santa Fe County woman in her 50s with known recent international travel to Italy [source]

    – 6 new cases in San Diego, California “With these new positive cases, the evidence is pointing to the very likely reality that we have community spread here in San Diego County,” County Supervisor Nathan Fletcher said. “This changes both our posture and also accelerates our action.” [source]

    – 9 new cases in Michigan: 1 adult female from Ingham County with history of travel on a cruise; 2 adult females from Kent County and 1 adult male, all with history of international travel; 1 adult female from Montcalm with history of international travel; 2 adult males from Oakland County: one with no travel history and one with domestic travel; one adult female and one adult male from Washtenaw County; one with history of domestic travel and one with history of international travel [source]

    – 1st case in Alaska identified as person from a cargo flight, “a foreign national individual who was transiting through” [source]

  • 5 new cases in Thailand [source]
  • 6 new cases in Jamaica. Ministry of Health says they are tracing contacts and places to define the potential spread geographically and quantitatively, and to implement quarantine measures as necessary [source]
  • 11 new cases in Romania including a 39-year-old man who came into contact with another person who traveled to Germany, a 53-year-old man office colleague of a member of the patient’s family who was admitted to the Gerota Hospital, a 48-year-old woman and a 22-year-old, members of the 53-year-old man’s family, and a 23-year-old, contact of the man’s family [source] [source]
  • Second case in Turkey: from the immediate circle of the first diagnosed patient[source] [source]
  • 2 new cases in Ecuador [source]
  • 13 new cases in Panama: total cases double in the last 24 hours [source]
  • 17 new cases in Saudi Arabia: a contact of a previously confirmed case, an expatriate coming from Portugal via Turkey, a citizen coming from Iran via Oman, a citizen coming from Turkey via Lebanon where she spent 5 days and developed symptoms upon arriving, 2 Saudi women coming from Iraq, and 11 Egyptian nationals, without symptoms, from the same group of the Egyptian visitor previously confirmed [source]
  • 1 new case in India: a 26-year-old Google employee in Bangalore who had returned from Greece honeymoon on March 6 [source] [source]
  • 1 new death in Hong Kong: an 80-year-old man with underlying health problems who lived in the same building in North Point that houses a Buddhist temple linked to a Covid-19 cluster of more than a dozen cases [source]
  • 110 new cases and 177 recoveries in South Korea [source] [source] For the first time since its outbreak emerged in January, South Korea reported more new recoveries than new infections, a possible start of a downward trend [source]
  • 15 new cases (difference between today’s reported total of 80,813 confirmed cases and yesterday’s reported total of 80,793 cases, for a net change of 20 cases), 7 new deaths (6 in Hubei) and 1,318 new discharges (same exact number as yesterday) occurred in China on March 12, as reported by the National Health Commission (NHC) of China [source]

 

March 12:

  • United States:
    – New Mexico to close all K-12 public schools for 3 weeks
    – Washington State Governor orders schools to close until April 24 in KingPierce and Snohomish Counties [source]
    – Maryland will close all schools for 2 weeks starting Monday
    – Ohio governor closes schools Monday through at least April 3 [source]
    – California: many schools in the Bay Area close due to the coronavirus outbreak [source]
    – Kentucky Governor asks all schools to close for at least 2 weeks [source]
    – Massachusetts: a number of schools are closing [source]
    – Coronavirus outbreak “could easily be a a 6 month crisis” said New York Mayor Bill de Blasio as he declared a state of emergency in the city on Thursday, adding that New Yorkers should expect “major changes” from day-to-day because there’s a pattern of “extraordinary new information on what now feels like an hourly basis” With at least 328 total cases in New York, of which more than 100 added today, the number of cases in the city is projected to rise to 1,000 by next week, de Blasio said [source]
  • In the UK, the infection is expected to build to a peak in May or June. Chris Whitty, the chief medical officer, said that worst-case scenario planning projected that 80% of the country would contract the virus, with a 1% mortality rate. This equates to more than 500,000 deaths in the UK [source]
  • Jamaica to close all schools [source]
  • Lithuania (3 cases total) and Latvia (16 cases total) close schools, ban large public gatherings over coronavirus [source]
  •  1st case in Trinidad and Tobago: a 52-year old man who had returned from Switzerland and had self-isolated before showing symptoms [source]
  •  Virus can remain viable “in aerosols up to 3 hours, up to 4 hours on copper, up to 24 hours on cardboard and up to 2-3 days on plastic and stainless steel” a Princeton study awaiting peer review has found [source]
  •  1stdeath in India: a 76-year old man from Karnataka [source]
  • France to close all schools and universities beginning Monday, March 16. Employers urged to let staff work from home [source]
  • Israel is closing all schools and university beginning Friday, March 13 [source]
  • Greece is closing all the courthouses, theaters, cinemas, gyms, children playgrounds and nightclubs in the country, after having already closed the schools two days ago [source]
  • UK – Boris Johnson has addressed the nation today: [source]
    called coronavirus “worst public health crisis for a generation
    warned “many families are going to lose loved ones before their time
    UK is 4 weeks behind Italy
    true UK cases likely up to 10,000
    if you have symptoms stay home
    more drastic measures to come
  • 2 new deaths in Germany [source] [source]
  •  1st death in Norway, as the country shuts down for 2 weeks [source] [source] [source]
  • Turkey has closed all schools for 1 week and universities for 3 weeks [source]
  • 2 new cases in Armenia: they had been in close contact with a previously confirmed case of a woman who had arrived from Italy. They had fever and later tested positive for coronavirus. They now feel well and have no fever [source]
  •  2,651 new cases, 189 new deaths, and 213 new recoveries in ItalyDeath toll tops 1,000 [source]
  • United StatesNBA suspended its season indefinitely after a player on the Utah Jazz has tested positive for COVID-19 earlier today [source] Later during the day, a second Utah Jazz player tested positive for coronavirus, as a suspended NBA considers next steps [source]
  • United States updates include:
     1st death in Kansas
     1st death in 
    Georgia: a 67-year old year old man who was hospitalized at WellStar Kennestone Hospital. He had underlying medical conditions [source]
    – 1st case in Maine: a woman who recently returned from an outbreak area [source]
    – 3 new cases in Washington State, for a total of 379
    – 13 new cases in Massachusetts, for a total of 108
    – 11 new cases in Colorado, for a total of 45
    – 6 new cases in New Jersey, for a total of 29
    – 9 in Tennessee, for a total of 18
    – 5 in North Carolina, for a total of 14
    – 3 in Nevada, for a total of 10
    – 4 in Minnesota, for a toal of 9
    – 1 in New Hampshire, for a total of 6
    – 5 in Arkansas, for a total of 6
    – 2 new in Utah, for a total of 5 (2 Utah Jazz players)
    – 1 in Oklahoma, for a total of 3
    – 2 new in Texas, for a total of 25 [source]
    – 6 new in Pennsylvania, for a total of 22 [source]
    – 7 new in Virginia (including a Longwood student), for a total of 18 [source]
    – 1 new in Louisiana, for a total of 14 [source]
    – 3 new in Kansas, for a total of 4 [source]
    – 1 new in New Mexico, for a total of 5 [source]
    – 3 new in Delaware, for a total of 4 [source]
    – at least 5 new cases in North Carolina for a total of 14 [source] [source] [source]
    – 3 in Wisconsin, for a total of 6 [source]
    – at least 112 new in New York State, for a total of 328 in the state [source]
    – 4 in Florida for a total of 35 [source] [source]
    – 13 in California (Riverside County) for a total of 197 cases and 4 deaths [source]
    – 1st case in Mississippi: a Forrest county adult male who recently traveled to Florida [source]
  • 1 new death in Azerbaijan: a 51-year old woman who had been quarantined after returning from Iran [source] 4 new cases [source]
  •  31 new deaths and 782 new cases in Spain [source] Total cases surpass 3,000
  • Lithuania (3 cases in total) closes all schools for 2 weeksbans mass events, and recommends to avoid travel to high risk countries (China, Iran, Japan, South Korea, Singapore, Italy, France, Germany and Spain) [source]. Capital City of Vilnius also closes museums, cinemas, sport clubs, etc. Recommends to organise work from home to all companies. City administration is to provide its services online and via phone only [source]
  • US travel ban from Europe (read original document), which does not apply to the UK and Ireland, will go into effect on Friday March 13 (tomorrow) at 23:59 ET (midnight). Americans returning from Europe “will be funneled through 13 different airports,” be subject to screening, and asked “to self-quarantine for 14 days” said Pence [source]
  • 2 new deaths and 130 new cases in the UK [source]
  • 1 new case in Cyprus: a person who had recently arrived from the UK [source]
  • 167 new cases in Sweden[source] which announced that testing for Covid-19 will cease unless you are hospitalized or belong to one of the risk groups. Even if you report corona-like symptoms [source]
  • 1 new case in Pakistan: a 31 year-old man who returned from Iran [source]
  • 2 new cases in Czech Republic, bringing the total to 96. State of Emergency declared [source]
  • 1 new case in Senegal: a Senegalese national who returned to Dakar from Italy [source]
  • 1 new case in Estonia [source]
  • 111 new cases in the Netherlands [source]
  • 1 new case in the Republic of Moldova: a young man who recently returned from Italy [source]
  • 85 new cases in Belgium [source]
  • Republic of Ireland announces that all schools will be closed for 17 days starting today. Indoor gatherings of more than 100 people and outdoor gatherings of more than 500 should be canceled [source]
  • 1 new case in Sri Lanka (second in the country): a 44-year-old man shared a hotel room in Dambulla with the first confirmed case [source]
  • At least 3 Albanians have died in Italy so far, including a 55-year-old who had diabetes, according to reports [source]
  • 1 new case in Palestine: a 20 year-old woman in Bethlehem [source]
  • 11 new cases in the UAE: 2 Italians, 2 Filipinos, 1 Montenegrin, Canadian, German, Pakistani, Emirati, Russian and British citizen [source]
  •  1st death in Austria: a 69 year-old man in Vienna [source] 115 new cases, total over 300 [source]
    Schools will be closed
    , over 1 million students will stay at home until at least April 12. Chancellor Sebastian Kurz appealed that grandparents should not take care of the children, so that the elderly be protected against the coronavirus. Children are “much less at risk when it comes to illnesses, but at the same time we know that children are strong multipliers,” said Health Minister Anschober [source]
  • 18 new cases in Iceland [source]
  • 8 new cases in Albania: all have connections with Italy [source]
  • 3 new cases in Armenia: a 51 year-old Italian man and 45 and 27 year-old Armenians that returned from Italy [source]
  • 6 new cases in Slovakia, declares ‘state of emergency’ [source]
  • 32 new cases in Slovenia[source] [source]
    – the government will declare an epidemic
    – all educational institutions will close
    – those forced to stay at home will be paid 80 percent of their salary
  •  1st death and 20 new cases in Poland: a 57 year-old woman dies [source] [source]
  • 75 deaths, 1,075 new cases, and 317 new recoveries in Iran [source]
  • Over 100 new cases in Denmark [source]
  • 3 new cases in the Philippines [source]
  • 12 new cases in Luxembourglocal transmission was noted for 2 cases [source]
  •  2 deaths in Lebanon: one of the victims a 55 year-old teacher [source]
  • 1 new case in the Channel Islands (Jersey): a person returning from north-west Italy [source]
  • 4 new cases in Bosnia and Herzegovina: 2 of the cases are a man and a woman returned from skiing in Austria [source]
  • 1 new case in Serbia [source]
  • 1 new case in Taiwan: a woman in her 40s who traveled to Ireland and Belgium [source]
  • 4 new cases in South Africa: 38 year-old male living in Turkey and visiting family, a 27 year-old female who traveled to the United States, a 43 year-old male who traveled to New York via Dubai, a 32 year-old male who came in contact with a Chinese businessman [source]
  • 8 new cases in Kuwait: cases connected by travel to Azerbaijan and Iran [source]
  •  1st death and 4 new cases in Algeria: infected by a visiting relative from France [source]
  •  56 new cases in Austria [source]
  •  1st death in Greece: a 66 year-old citizen [source]
  • 3 new cases in Israel [source]
  • 28 new cases in Australia, including actor Tom Hanks and his wife Rita Wilson [source]
  • 7 new cases in Norway: 2 cases related to outbreaks abroad [source]
  • new cases in Peru [source]
  • 114 new cases and 6 new deaths in South Korea [source]
  • 15 new cases11 new deaths (10 in Hubei) and 1,318 new discharges occurred in China on March 11, as reported by the National Health Commission (NHC) of China [source]

 

March 11:

WHO press briefing:

“PANDEMIC”

But not the time for countries to move to mitigation
Must still try to suppress transmission, continue with containment efforts

All Travel from Europe to the United States suspended for 30 Days

Ban will not apply to the UK

Trump had said earlier: “I am fully prepared to use the full power of the Federal Government to deal with our current challenge of the CoronaVirus!” [source]

Pence: “All the insurance companies […] have agreed to waive all copays on coronavirus testing, and extend coverage for coronavirus treatment in all of their benefit plans,”

Dr. Anthony Fauci, director of the National Institute of Allergy and Infectious Diseases:

Things will get worse.” How much worse it will get depends on 2 things, he said:

1. containing the influx of infected people coming from other countries2. containing local outbreaks within the U.S.

When pressed by lawmakers for an estimate of eventual fatalities in the U.S., Fauci said it will be “totally dependent upon how we respond to it.”

“I can’t give you a number,” he said. “I can’t give you a realistic number until we put into the factor of how we respond. If we’re complacent and don’t do really aggressive containment and mitigation, the number could go way up and be involved in many, many millions.”

[source]

  • UK: Boris Johnson calls emergency meeting to rule on closing schools and telling everyone to work from home [source]
  • 73 new cases in the UKbiggest daily rise [source] NHS to ramp up testing capacity from 1,500 to 8,000 tests per day [source]
  •  2 new deaths in the UK [source]
  • Germany: Merkel warns that up to 70% of Germany’s population could contract the coronavirus, which would amount to 58 million people (population of 83.7 million people) [source] [Germany Population]
  • 343 new cases and 1 new death in Germany [source]
  •  2,313 new cases and 196 new deaths in Italy. About 600 new cases can be ascribed to the previous day’s delay in reporting [source]
  •  582 new cases and 19 new deaths in Spain [source]
  •  497 new cases and 15 new deaths in France [source]
  •  252 new cases in Denmark:
    Government closes all schools and universities
    All public employees will be sent home beginning on March 13 [source]
  • Hungary declares State of Emergency[source]
    – closes all Universities
    – bans indoor events for more than 100 people
    – bans outdoor events for more than 500 people
    – stops flights, trains and buses from Slovenia and Austria
    – tightens control of the border with Croatia
    – requires quarantine for Hungarian citizens returning from Italy, China, South Korea and Iran
  •  1st death and 9 new cases in Ireland [source]
  •  1st case in Ivory Coast: a 45-year old man in Abidjan [source]
  •  1st death in Ireland: a woman in the east of the country [source]
  •  1st death in Bulgaria: a 66-year old woman [source]
  • 4 new cases in Israel including a man in his 60s from central Israel whose contagion source is unknown [source]
  • New cases in Canada include:
    2 in Ontarioa radiation oncologist in Hamilton who had returned from a trip to Hawaii [source], and a man in his 50s [source]
    2 in Montreal
    , raising the total to 7 confirmed in Quebec [source]
  • 10 new cases in Greece, raising the total to 99, with at least 2 patients in intensive care [source]
  • 238 new cases in Qatar (total cases jumps from 24 to 262) [source]
  •  1st death in Sweden: an elderly patient [source]
  • 1 new case in Tunisia: a person who had traveled to Egypt [source]
  • 4 new cases in Cyprus: 3 men and 1 woman [source]
  •  3 new deaths in Belgium: a 90-year-old patient, a 73-year old patient and an 86-year old patient [source] [source47 new cases [source]
  • 1 new case in Brazil: a 52-year old patient in critical condition hospitalized in the Regional Hospital of Asa Norte [source]
  • 5 new cases in Brunei: 3 had attended the same religious gathering in Malaysia with the first confirmed patient, the other 2 had no history of travel [source]
  • 5 new cases in Hong Kong, including a Cathay Pacific flight attendant and members of an Egypt tour group [source]
  •  1st case in La Réunion: an 80-year-old man, returning from the United States who transited through Paris [source]
  • 6 new cases in Colombia [source]
  •  1 new death and 121 new cases in the Netherlands [source]
  • 3 new cases in Slovakia [source]
  • 9 new cases in Poland, including 3 persons in Cieszyn, 1 of which had potential contacts with schoolchildren (for which a decision was made to close all schools in town), a young man from the province Masovian (Warsaw), and a young woman from Łańcut [source] [source] All schools, as well as museums and cinemas, will close starting on Monday to curtail the spread of the coronavirus, Poland’s Prime Minister Mateusz Morawiecki said [source]
  • 23 new cases in Slovenia [source]
  • India: a 76-year-old man suspected to be infected with coronavirus dies in Karnataka ‘s Kalaburagi [source]
  • 2 new cases in Latvia: part of a group traveling back from northern Italy [source]
  • 12 new cases in Singapore: 8 cases, including 3 Republic of Singapore Air Force (RSAF) servicemen who were in France on duty, were imported. One other case is linked to the private dinner function at the Joy Garden restaurant at Safra Jurong, Singapore’s biggest coronavirus cluster [source]
  • 4 new cases in Iceland, all related to international skiing trips [source]
  • 3rd death in Germany [source] and 57 new cases [source], including the first German professional football player to test positive for coronavirus [source]
  • 34 new cases in Norway [source]
  • 6 new cases in Romania: including a 43-year-old woman doctor, contact of the patient who was admitted to the Dimitrie Gerota Hospital in Bucharest, and a 42-year-old man from Iasi who returned from Venice, Italy [source]
  • 1 new case in Saudi Arabia: an Egyptian man who was passing through King Abdul Aziz Airport in Jeddah on the way to Cairo from New York [source]
  • 18 new cases in Portugal, 83 people awaiting laboratory results and 471 suspected cases [source]
  • 19 new cases in Finland [source]
  •  1st death in Albania: a 73 year-old woman from Durres who had returned from Italy. Reports say she was suffering from severe health complications [source]
  • 122 new cases in Sweden [source]
  •  958 new cases63 new deaths and 228 new recoveries in Iran. Total cases reach 9,000 [source]
  • 1 new case in Croatia: a young male hairdresser who returned from Munich, Germany [source]
  • 2 new cases in Morocco: a wife and son of a previously confirmed case [source]
  • 2 new cases in Albania [source]
  • 1 new case in Malta: a man who contracted the infection while on holiday in Italy [source]
  • 7 new cases in Indonesia: all imported [source]
  • 7 new cases in Serbia [source]
  • 79 new cases in Bahrain, including 77 Bahrain citizens evacuated from Iran (out of the 165 total evacuees) [source]
  • 16 new cases in the Philippines [source]
  • 4 new case in Vietnam:
    – a 64-year old woman, 37-year old woman, and 28-year old man, contacts of a previous case [source]
    – a 29-year old woman who had direct contact with 2 British nationals at a supermarket [source]
  •  1 new death in Lebanon: a 55-year-old man who was infected from one of his students coming from abroad. Reports note that he was not suffering from any pre-existing condition, but “his immune system was weak” and he had transmitted the infection to his wife and 2 children [source]
  • 24 new cases in Austria [source]
  • 6 new cases in South Africa: a 33 year old woman who returned from a trip to Italy, a 34 and 33 year-old couple who traveled to Germany, a 57 year-old man who traveled to Austria and Italy, a 40 year old man who traveled to Portugal, and a 36 year old man who traveled to multiple countries including Germany, Austria, Switzerland and Turkey [source]
  •  First 2 cases in Honduras [source]
    – a 42-year-old Honduran pregnant woman who entered the country asymptomatically on March 4 on a flight from Spain. At this time she is hospitalized, clinically stable
    – a 37-year-old Honduran who entered the country on March 5 on a flight from Switzerland. The patient has a clinical picture of mild disease and has remained in home self-isolation, with medical surveillance since entering the country
  • 1 new case in Israel, bringing the total to 76 [source] [source]
    – Mass events canceled, no gatherings over 2,000 people
    – Police will help catch Israelis who break quarantine
    – Hundreds of schoolchildren quarantined

    – Law enforcement will monitor Israelis returning from abroad
    – 25 diagnosed with coronavirus on Tuesday, including Israeli returning from U.S.
  • 3 new cases in Kuwait [source]
  • 2 new cases in the Maldives [source]
  •  1 new death in Indonesia: a 53-year-old woman with underlying health conditions
  • 6 new cases in Thailand [source]
  • 1 new case in Mexico: a 47-year-old man who arrived from a trip from Italy [source]
  • New cases in Australia include:
    – 3 new cases in Queensland: a 42-year-old female partner of a 38-year-old woman who tested positive and recently travelled from London through Dubai, as well as a 22-year-old man who attended a nightclub for multiple times over the weekend. Queensland Health is asking anyone who attended the CBD nightclub in Brisbane between 6pm last Friday and 11pm on Monday to contact 13 HEALTH if they become unwell [source]
    – 
    2 new cases in South Australia: men in their 60s and 70s who traveled abroad and will most likely be taken to the Royal Adelaide
    – 4 new cases in New South Wales: 3 women in their 20s and 30s who returned from Italy together and 1 resident of a nursing facility in his 70s [source]
  • 1 new case in Taiwan: a woman in her 30s who had traveled to the UK [source]
  • 1 new case in Sri Lanka: a 52-year old Sri Lankan tour guide who had worked with a group of Italian tourists [source]
  • United States new cases include:
    – 1 new case in Virginia [source]
    – 3 new cases in Louisiana [source]
    – 5 new cases in Georgia [source]
    – 8 new cases in Florida [source]
    – First 2 cases in Michigan(Oakland and Wayne counties), Michigan: Gov. Whitmer declared a state of emergency [source]
  • 242 new cases in South Korea [source]
  • 24 new cases22 new deaths (all in Hubei) and 1,578 new discharges occurred in China on March 10, as reported by the National Health Commission (NHC) of China [source]
  •  7 new cases, including 1 death, in Panama [source]
  • 3 new cases in Paraguay [source]

 

March 10:

  •  First 2 cases in Bolivia: a 65-year old woman from Oruro and a woman from San Carlos. They had both recently returned from Italy [source]
  •  UK Health minister Nadine Dorries tests positive to coronavirus [source]
  • 2 new cases in Argentina (Buenos Aires): both imported [source]
  • 1 new case in Martinique: a 51-year-old woman from the commune of Trinité [source]
  • 2 new cases in Bulgaria: a 66-year-old woman and a 77-year-old man in Sofia, who worked for Ilientsi, now hospitalized at the metropolitan Pirogov Hospital [source]
  • 18 new cases in Canada, bringing the total to 95: 39 cases in B.C., 36 cases in Ontario, 14 in Alberta, and 5 in Quebec. Air Canada suspended all flights to and from Italy. New cases include:
    – 7 new cases in B.C. 
    [source]
    – 7 new cases in 
    Alberta, all involving people who were travelling in either France, the Netherlands, Egypt, Iran, Taiwan, Germany, Malaysia, Trinidad and Tobago, Panama, Philippines and the United States [source] [source]
  • 2 new cases in Lithuania [source]
  •  1st case in Turkey: a male Turkish citizen with recent travel history to Europe, now in isolation with mild semptoms [source]
  • United States new cases include:
    – 5 new cases, including 1 death in South Dakota (Pennington County): a man in his 60s and with underlying health problems [source]
    – 3 new cases in  Tennessee: 2 in Middle Tennessee, 1 in Sullivan County (East Tennessee)  [source]
    – 2 new cases in Louisiana, all in the New Orleans area [source]
    – 3 cases in Texas in the Dallas-Fort Worth area, all in same family: a man in his 30s, his wife, and their 3-year-old child (one of the family’s 4 children) [source]
    – 1 new case in Oregon [source]
    – 74 new cases and 2 new deaths in Washington state
    – 8 new cases in Illinois [source]
    – 51 new cases in Massachusetts [source]
    – 5 new cases in Iowa [source]
    – 1 new case in Minnesota (Anoka County) [source]
    – 1 new case in Virginia (Loudoun County) [source]
    – 1 new death in Washington (King County): a resident of the Life Care Center [source]
    – 6 new cases in California (Santa Clara County) [source]
    – 1 new case in Maryland (Prince George’s County) [source]
    – 1 new case in Florida (Volusia County) [source]
    – 2 new cases in Kentucky [source]
    – 1 in Oklahoma: a woman in her 20’s in Tulsa [source]
  •  341 new cases in Germany [source]
  • 64 new cases in Austria [source]
  • 20 new cases in Australia [source]
  • 372 new cases and 3 new deaths in France. “We are at the very beginning of the epidemic“, announces Emmanuel Macron. All matches in the French Ligue 1 and Ligue 2 football championships will be held behind closed doors until April 15 [source] [source]
  •  977 new cases and 168 new deaths in Italy*, bringing total cases to over 10,000 [source]
    * The data are partial because some labs in the most affected regions have yet to communicate the results
  • 11 new cases in the Republic of San Marino [source]
  • 1st case in Jamaica: a woman who had returned from the UK on March 4 [source]
  • 3 new cases in Vietnam
  • 1st case in the Democratic Republic of Congo: a foreign national who had visited Belgium. The person was apparently in good health but was screened upon entering the country [source]
  •  1st death in New Jersey (United States): a man in his 60s [source]
  • Graphs:
    – Comparing case progression from day 1 in Hubei, Italy, Germany and France

    – Daily totals in Germany and Italy
  • 1 new case in Paraguay: an 83-year-old man who entered the country from Argentina [source]
  • 172 new cases in Denmark [source]
  • 2 new cases in Luxembourg [source]
  • United States: 4,856 coronavirus tests have been run in public health labs, said CDC Director Dr. Robert Redfield. “We’ve got a new reporting system that has CDC, public health labs. We’re going to get direct dumps from LabCorp and Quest so people are going to see all the tests done, where they are done. We will have a surveillance system that does that” Redfield said [source]
  • 1 new case in Tunisia [source], while one of the current cases left, on Monday evening, the Tunisian territory in direction of the city of Strasbourg in France, thus causing a state of panic at the Tunis-Carthage airport [source]
  • First case in Jersey, second in the Channel Islands [source]
  •  464 new cases and 6 new deaths in Spain. Government prohibits direct flights from Italy to Spain. Congress suspends parliamentary activity one week [source] [source]
  • 4 new cases in Chile [full list]
  • 95 new cases in Sweden [source]. First patient in intensive care reported [source]
  • 4 new cases in Costa Rica, including 2 children [source]
  • 4 new cases in Poland [source] including the General commander of the Polish army [source]
  • Portugal: 100,000 inhabitants placed in lockdown in Lousada and Felgueiras, an hour and a half by car from Vigo in northern Portugal [source]
  • 4 new deaths in South Korea, including a woman in her 50s without underlying conditions [source]
  • 1 new case in Croatia: a young man who had been on a ski trip to Austria [source]
  • 1 new case in Afghanistan (northern Samangan province)
  • 2 new cases in Moldova: two Moldovans, a man and a woman, returning from Italy [source]
  • 1 new case in Brazil: a 60-year-old man in the Metropolitan Region of Porto Alegre. He developed symptoms on Feb 29, after a trip to Milan, Italy between Feb 16 and 23. The patient arrived at the care unit with the mask, with cough and fever [source]
  • 1 new case in Malta: the 16-year-old daughter of the man who tested positive for the coronavirus yesterday after returning from Trentino Alto Adige (northern Italy). The daughter had not gone to school since returning [source]
  •  Testing positive after being declared clear of the infection: a 31-year-old evacuee from the Diamond Princess cruise ship was first infected on Feb 18 while aboard, but later appeared to have recovered and tested negative on March 4 and 6 in Japan before returning to Hong Kong on March 7. On March 9, she was found to be still infected. Disease expert Dr Joseph Tsang Kay-yan said several reasons such as sampling error and “insufficiently sensitive” tests could have accounted for the woman’s “false negative” results in Japan. “Perhaps the swab was not done properly, or an antibody blood test was not done.” In any case she would have to be tested for a particular type of antibody 21 days after the diagnosis, before results can be conclusive that she was clear of the virus. He believes the woman was not reinfected as her antibodies upon recovering would give her immunity for a period of time [source]
  • 2 new cases in Hong Kong
  • 1 new case in Cambodia (third in the country): a 65-year-old British woman has tested positive for COVID-19 in Kampong Cham province [source]
  • 8 new cases in Romania, all in Bucharest: 3 are related to the case of Gerota, 1 is contact of the first infected in Bucharest, 4 are citizens who have traveled to Israel, Germany and the United Kingdom [source]
  • 12 new cases in Malaysia, bringing the total to 129 [source]
  • 2 new cases in Peru: two brothers, aged 21 and 15, who have recently returned from a trip to Europe [source]
  •  1 new death in the UK: an 89-year old patient at the Watford General Hospital (West Hertfordshire) with underlying health conditions [source]
  •  First death in Morocco: an 89-year old woman in Casablanca [source]
  • 61 new cases in the Netherlands [source]
  • 23 new cases in the Czech Republic [source]
  • 9 new cases in Slovenia [source]
  • 3 new cases in Belarus [source]
  • 2 new cases in Azerbaijan [source]
  •  881 new cases and 54 new deaths in Iran [source]
  • 25 new cases in Israe[source]
  • 4 new cases in Albania [source]
  • 11 new cases in Iceland [source]
  • 2 new cases in Portugal [source]
  • 8 new cases in Indonesia [source]
  • 5 new cases in Brazil [source]
  • 28 new cases in Belgium [source]
  • 1 new death in Switzerland (third in the country): an 80-year-old man in Ticino with other pathologies [source]
  • 15 new cases in the UAE: 3 Italians, 2 Emiratis, 2 Sri Lankan, 2 Brits, 2 Indians, 1 from Germany, 1 from South Africa, 1 from Tanzania, and 1 from Iran [source]
  • 3 new cases in Estonia including two adult Tallinners from northern Italy and France [source]
  • 2 new cases in North Macedonia [source]
  • 1 new case in Poland. All mass events canceled. Poland’s president will not hold big election rallies due to coronavirus [source]
  •  1st death in Lebanon: a patient who had returned from Egypt. Also reporting 11 new cases [source]
  • 5 new cases in Greece, four of which were in contact with the group of pilgrims from the Peloponnese who had traveled to Israel. 700 schools in the prefectures of Ilia and Achaia in Peloponnese and the island of Zakynthos are closed [source]
  • The Czech Republic closes all schools and events with more than 100 participants. The measure is valid until further notice [source]
  • 2 new cases in Latvia who returned on March 7 from the Italian mountain resort Cervinia [source]
  • 5 new cases in Finland [source]
  • 9 new cases in India. Meanwhile, an Indian Air Force aircraft airlifted 58 Indians from Iran to Ghaziabad (about 30 km from Delhi) as the central government started evacuating hundreds of citizens stuck in the country [source]
  • 4 new cases in Kuwait: 1 has recently traveled to Iran, 1 is an Egyptian national, contact of a previous case with travel history to Azerbaijan, 2 are Kuwaiti males who recently arrived from Egypt [source]
  • 1 new case in Morocco: a French tourist currently hospitalized in Marrakech [source]
  • 9 new cases in the Philippines, bringing the total to 33. Previous report was corrected by DOH [source] Only 2,000 test kits available (earlier this week, down from 4,500 previously) for a population of 109 million people [source]
  • 1 new case in Northern Cyprus: a 65-year-old German woman on holiday, part of a group of 30 people from Balingen, Germany who was staying at a hotel in Famagusta. Statistics for Northern Cyprus (which is only recognized by Turkey) are not included in the reports by the internationally-recognized Greek Cypriot government in the island’s south [source] [source]
  • 3 new cases in Thailandall linked to Italy. A couple: the 46-year-old wife returned from Italy on Feb 28 and did not feel well. Her 47-year-old husband fell sick on Saturday with a high fever and body ache. The other case is a 41-year-old woman who was in close contact with a previously confirmed case who returned from Italy [source]
  • 2 new cases in Finland:  both had traveled to northern Italy, with one of the patients having symptoms already during the return flight from Italy [source]
  • 2 new cases in Serbia: two young women in Belgrade who have been in contact with an infected person (who is now abroad) [source]
  •  1st case in Panama [source]
  •  1st case in Mongolia: a French national who traveled to Mongolia from France through Moscow. The government has identified 42 people the patient has met with and another 120 individuals who had close contact with the person [source]
  • 35 new cases and 1 new death in South Korea [source]
  • 19 new cases17 new deaths (all in Hubei) and 1,297 new discharges occurred in China on March 9, as reported by the National Health Commission (NHC) of China. [source]

March 9:

 ALL OF ITALY NOW IN EMERGENCY LOCKDOWN [source]

  • Strict quarantine measures extended to all regions
  • Public told to stay home
  • Schools closed until April 3rd
  • No travel unless with a valid work or family reason
  • All public gatherings and sports events suspended
  •  During today’s White House press briefing, US Surgeon General Jerome Adams said:
    “People over the age of 60 are much more likely to develop complications from the coronavirus and to be hospitalized. The average age of death is age 80 […] If you are a child or young adult you are more likely to die from the flu – if you get it – than you are to die from coronavirus. So there is something about being young that is protective Source: US Coronavirus Task Force Press Briefing
  •  1st case in Burkina Faso, which becomes the sixth country in sub-Saharan Africa affected by the virus [source]
  • United States:
    – 1st death in Santa Clara County, CA: a woman in her 60s in Mountain View
     [source]
    – 3 new deaths and 33 new cases in King County, Washington state
     [source]
    – Rhode Island 
    announces state of emergency
    – 1st case in Louisiana
    : a Jefferson Parish resident [source]
    – 1 new case in Indiana 
    (Noble County) [source]
    – first 3 cases in Ohio
    : all in Cuyahoga County and in their 50s. Ohio Gov. Mike DeWine declares a state of emergency [source]
    – 4 new cases in Georgia (Fulton County, Cherokee County, and Cobb County) [source]
    – 1 new case in Hawaii
    . This second case is not connected to the first one and the cruise ship, but to the Washington state outbreak [source]
    –  1 new case in Texas (Harris County) a travel-related case is associated with the known group from the M.S. A’sara cruise (traveling to and from Aswan, Egypt)  [source]
  • 11 new cases in Israel. All people entering Israel now must be quarantined. Prime Minister Benjamin Netanyahu said: “After a day of complex discussions, we have made a decision: Whoever arrives in Israel from abroad will enter quarantine for 14 days. This is a difficult decision but it is essential to maintaining public health, which takes precedence over everything. This decision will be in effect for two weeks. At the same time, we will make decisions to safeguard the Israeli economy” [source]
  •  557 new cases and 13 new deaths in Spain. Total cases top 1,000, doubling in a day [source]
    – The Basque Government closes all schools in Vitoria for 2 weeks [source]
  • Costa Rica: Government orders all public employees to work from home. All public gatherings and activities cancelled [source]
  •  184 new cases and first 2 deaths in Germany [source]
    2 deaths: an 89-year old woman in Essen and a patient in the Heinsberg region [source]
    Coronavirus has been in Germany since Wednesday last week. Our priority now is to slow its spread. The slower the virus spreads, the better the healthcare system can cope.” Health Minister Jens Spahn said on Sunday adding “Consider also what in your daily life is so important that you can’t do without it for the next three months, whether that’s an evening clubbing, a family birthday or a club meeting” [source]
  • 2 new cases in India (in Pune) [source]
  • 1 new case in Croatia: a Croatian national who works in Italy and is hospitalized in Pula [source]
  • 6 new cases, 1 new death, and 2 new recoveries in Iraq [source]
  •  1st death in Canada (B.C.) [source]
  • Romania closes schools for 10 days and suspends all flights to and from Italy for at least 2 weeks [source] [source]
  •  203 new cases and 11 new deaths in France [source]
  •  1 new death in the UK: a patient in their 70s, hours after another patient in their 70s died from the virus [source]
  • 1 new case in the United States (Colorado) [source]
  • 3 new cases in Russia: they had all traveled to Italy [source]
  •  1,797 new cases and 97 new deaths in Italy [source] [video]
  • 4 new cases in Portugal [source]
  • 2 new cases in Israel: 1 person who had traveled to Switzerland, 1 person who had traveled to Austria [source]
  • 3 new cases in Canada (Alberta) [source]
  • Just ended: WHO daily media briefing on COVID-19
  • 55 new cases in Denmark. Total cases more than double, reaching 90 [source] [source]
  • 1 new case in the United States (Virginia): an Arlington County resident in their 60s who had recently returned from international travel [source]
  • 2 new cases including in Bosnia-Herzegovina, including a high school student from Celinac [source]
  •  First 2 cases in Cyprus: a 25-year-old man from Limassol and a 64-year-old health professional from Nicosia [source]
  •  1st case in Brunei Darussalam: a 53 year old man who had recently returned from Kuala Lumpur [source]
  • 2 new cases in Oman: they had both traveled to Iran [source]
  • United States: total cases in New York state surpass 100. Mayor de Blasio said that the city’s public health apparatus “is already planning on the assumption that we will be at hundreds of cases over the next two or three weeks” [source]
  • 2 new cases in Iceland: they both traveled on the same flight from Verona, Italy, as 3 previously confirmed cases [source]
  • 7 new cases in Slovenia [source]
  •  1st in the Channel Islands. The patient, from Guernsey, started to experience symptoms – a cough, fever and shortness of breath – after returning from Tenerife [source]
  • 1 new case in North Macedonia: the director of a clinic for skin diseases who went to work for 5 working days after returning from Italy [source]
  • 14 new cases in the UAE: 4 Emiratis, 3 Italians, 2 each from Bangladesh and Nepal, and 1 Russian, Syrian and Indian [source]
  • 2 new cases in the United Kingdom (Wales[source] Boris Johnson holds emergency Cobra meeting. Pubs, church halls and schools could be closed and football matches called off as the UK Government prepares to ramp up efforts to stop the coronavirus spreading [sourceCoronavirus area-by-area breakdown as UK cases soars to 280 with 51 in London.
  • 39 new cases in Belgium. Community spread has started, with people who have returned from Italy living almost everywhere in Belgium, local circulation is ongoing in different places of the territory [source]
  • 4 new cases in Poland [source]
  • 595 new cases and 43 new deaths in Iran. Among the infected is the head of Iran’s crisis management agency, Esmaeel Najjar, who was discharged from the hospital and is self-quarantined at home [source] [source]
  • 24 new cases in Bahrain [source]
  • 18 new cases in Malaysia [source]
  • 13 new cases in Indonesia [source]
  • 28 new cases and 2 new deaths in Japan
  • New cases in Australia include:
    – 7 in NSW, including 3 other Sydney students at two different schools [source] [source]
    – 3 in Victoria: 2 are returned travelers from the USA and 1 from Iran [source]
  • New case in Canada:
    – 1 in Peel Region, Ontario [source]
  • 1 new case in Ecuador [source]
  • 165 new cases and 3 new deaths in South Korea, including the death of: a 74 year-old man who had underlying health conditions and a 68-year-old woman who appeared to have no underlying health conditions. Pace of new infections is slowing [source] [source] [source]
  • 4 new cases in Saudi Arabia [source]
  • 40 new cases22 new deaths (of which 21 in Hubei) and 1,525 new discharges occurred in China on March 8, as reported by the National Health Commission (NHC) of China. [source]

March 8:

 ITALY EMERGENCY MEASURES

16 days after the beginning of the outbreak, the Italian government took decree today to take exceptional measures to contain about 16 million Italians living in 14 provinces in the north of the country, as well as restrictive measures covering the whole country. [source]

Northern Italy under lockdown

– Lombardy region (entire region, all provinces)
– Piedmont (provinces of Alessandria, Asti, Novara, Verbano Cusio Ossola, and Vercelli)
– Veneto
(provinces of PaduaTreviso, and Venice)
– Emilia Romagna (provinces of Modena, ParmaPiacenza, Reggio Emilia, and Rimini)
– Marche 
(province of Pesaro Urbino)

In the above areas:

  • Travel in and out of the area, as well as within the area, will only be possible in response to “duly verified professional requirements, emergency situations, or for health reasons”
  • People with symptoms of respiratory disease and fever of 37.5 Celsius or above are strongly encouraged to stay at home and limit social contact as much as possible, and contact their doctor
  • Avoid gathering
  • All schools and universities must be closed
  • All museums and places of culture will be closed
  • All cultural, religious or festive events are suspended
  • Cinemas, pubs, theaters, dance schools, game rooms, casinos, nightclubs and other similar places shall remain closed
  • All sporting events and competitions are suspended
  • Ski resorts are closed until further notice
  • Swimming pools, sports halls, thermal baths, cultural centers and wellness centers must suspend their activities
  • Bars and restaurants can remain open from 8 a.m. to 6 p.m. provided they respect the safety distance of at least 1 meter between customers – this provision also concerns other commercial activities
  • Shopping centers and department stores must remain closed on public holidays and the days preceding them
  • Places of worship remain open, provided that the safety distance of at least 1 meter is respected, but religious ceremonies (marriage, baptism) are prohibited until further notice

National restrictions

  • As in the north of the country, cinemas, theaters, museums, pubs, game rooms, dance schools, discos and other similar places will be closed
  • Sports competitions are suspended with some exceptions
  •  First 2 cases in Albania: father and son traveling from Florence, Italy to Tirana [source]
  • United States:
    – 1 new case in Illinois, the first community-transmitted case of the virus in Chicago: ab, currently hospitalized in serious condition. Officials say that the man has not traveled to any countries impacted by coronavirus, and that he has no connection to any other existing cases [source]
    – 3 new cases in Kentucky [source]
    – Washington state:
    — 20 new cases, 2 of which in Pierce County [source]
    — 3 new deaths (1 of which in Grant County) [source] [source]
    – 1 new case in Minnesota (Carver County) [source]
    – First 3 cases in Iowa [source]
    – 2 new cases in Tennessee (Davidson County and first in Shelby County) [source]
    – 2 new cases in Maryland [source]
    – 15 new cases in Massachusetts, all connected to the Biogen employee conference in late February [source]
    – 7 new cases in California:
    —- 5 in Contra Costa County [source]
    —- 1 in Riverside County (locally acquired) [source]
    —- 1 
    in Fresno County (travel related) [source]
    – 2 new cases in New Jersey [source]
    – 1 new case in Connecticut (Wilton) [source]
    – 7 new cases in Oregon. Governor declares state of emergency which will last for 60 days [source]
    – 1 new case in Virginia (Fairfax City) [source]
    – 1 new case in Indiana (Hendricks County) [source]
    – 16 new cases in New York state [source]
    – 2 new cases in New Hampshire: an adult male from Grafton County who had contact with a confirmed case at Hope Bible Fellowship in West Lebanon, NH on March 1st at the morning service, and an adult male from Rockingham County who traveled to Italy [source]
    1st in Vermont
     [source]
    1st in Missouri
     (Louis County) [source]
    4 in Florida:
    – 1 in  Broward County [source]
    – 1 in Manatee County [source]
    – 2: 1 in Okaloosa County and 1 in Volusia County, both with a recent history of travel [source]
  •  1 new death in the UK: a man in his 60s with existing conditions and who had recently traveled to Italy [source]
  • 14 new cases in Israel. Prime Minister is now considering mandatory quarantine for all entrants. Decision expected on Monday [source]
  • 1 new case in Canada (Ontario) [source]
  • 2 new cases in Ireland [source]
  •  1,492 new cases and 133 new deaths in Italy [source]
  • 16 new cases in Norway [source]
  • 3 new cases in Russia [source]
  •  1 new death (a new case) in EgyptFirst death in Africa. A 60-year-old German who arrived in Egypt last week, on March 1, was hospitalized with a fever on Friday, suffered respiratory failure caused by acute pneumonia on Saturday, and died on Sunday [source]
  •  177 new cases and 3 new deaths in France, total tops 1,000 [source]
  •  240 new cases in Germany, including 67 new cases in Bavaria, bringing the total to over 1,000 cases nationwide [source] [source]
  • 2 new cases in Romania: a 70-year-old woman who returned from Italy (Bologna and Ancona) and a 42-year-old woman from Bucharest who came in contact with the 49-year-old man who returned from Rome, Italy [source]
  • 4 new cases in the Philippines[source]
    – a 38-year-old Taiwanese male, contact of a Taiwanese who visited the Philippines and tested positive in Taiwan
    – a 32-year-old Filipino male with history of travel to Japan
    – an 86-year-old American male with pre-existing hypertension and history of travel to USA and South Korea
    – a 57-year-old Filipino male with no history of travel overseas
  • 1 new case in Brazil, increasing the total from 19 to 20, distributed as follows: São Paulo (13), Rio de Janeiro (3), Bahia (2) , Espírito Santo (1) and Distrito Federal (1). One patient is in critical condition. [source]
  • 6 new cases in Iraq [source]
  • 3 new cases in Qatar [source]
  • 3 new cases in Canada: 2 in Alberta and 1 in Quebec [source] [source]
  • 3 new cases in Dominican Republic: three Dominicans who visited Italy [source]
  • 2 new deaths in Iraq [source]
  • 4 new cases in Lebanon [source]
  • 5 new cases in Iceland [source]
  • 7 new cases in Greece [source]
  • 6 new cases in India, bringing the total to 40, of which 14 are Italian tourists who are quarantined in Delhi [source]
  • 4 new cases in Slovenia [source]
  • 5 new cases in the Czech Republic, the latest being a married couple who has been skiing in Val Gardena, Italy. 77% of cases (24 out of 31) in the Czech Republic are related to Italy. The remaining 4 have links to Boston, USA. Starting Saturday, all people returning from Italy (both Czech citizens and foreigners) must report to the doctor and remain in the two-week quarantine [source]
  • 4 new cases in 1 new death in Hong Kong: a 76-year-old woman who had developed fever, shortness of breath, cough and abdominal pain on Feb. 28 and was admitted to hospital the same day [source]
  • 1 new case in Algeria: an Algerian national who has stayed in Spain [source]
  • 7 new cases in Portugal:
    – 3 latest: a 18-year-old woman, a pharmacy student, and two men, 37 and 52 years old, with connections to the shoe factory in Lousada which was closed three days ago because of the outbreak [source]
    – 4 earlier today: 3 women and 1 man, aged between 40 and 70 years, all admitted to the Hospital de São João, in Porto
    – A man who contracted the virus in Italy was responsible, directly or indirectly, for the contagion of 10 people in Portugal [source]
  • 10 new cases in Vietnam: All foreigners, and all from the same flight (Viet Nam Airlines VN0054, which departed from the UK on March 2): 7 from England, 1 from Mexico, and 1 from Iceland, aged between 58-74 [source]
  • 64 new cases in the United Kingdom [source]
  • 2 new cases in Kuwait [source]
  • 12 new cases in Singapore [source]
  • 42 new cases in Sweden, of which 1 is believed to have been infected in the United States [source]
  • 1 new death in Switzerland: a 76-year-old man with several chronic diseases [source]
  • 77 new cases and 2 new deaths in the Netherlands [source]
  • 2 new cases in Hungary: a 22-year-old Iranian male student who attended a birthday party on Feb. 28 along with the Iranian pharmacist student first diagnosed in Hungary, and the 59-year-old Hungarian wife of a British man who got infected in Milan, Italy [source]
  • 8 new cases in Denmark [source]
  • 2 new cases in Poland: a woman (who is not a Polish national) who came from Germany and a man who returned from Italy [source]
  • 41 new cases and 1 new death in Japan
  • 6 new cases and 1 new recovery in Malaysia [source]
  • 10 new cases in San Marino [source]
  • 88 new cases and 7 new deaths in Spain. The first new cases have been confirmed by the Minister of Health, Salvador Illa, and the director of the Center for Health Alerts and Emergencies, Fernando Simón. The first 3 new deaths (aged 73, 77, and 78 years old) have been reported by the Community of Madrid [source] 3 woman died In Euskadi (aged 87, 88, and 92 years old, all with pre-existing conditions) and the Aragonese Government has reported the death of an 85-year-old man with previous pathologies [source]
  • 10 new cases in San Marino [source]
  • F1 Bahrain Grand Prix (March 20-22) will be held in “the sole presence of the participants” and without audience
  •  743 new cases and 49 new deaths in Iran [source] [source]
  •  First 3 cases in Bangladesh: 2 members of a family who returned from Italy and a third person contracted the virus after coming in contact with the two affected people. The three have been admitted to Kurmitola General Hospital [source]
  • 1 new case in Latvia: a woman who was infected at an Italian resort in Cervinia, in northern Italy near the Swiss border, where she had gone with a group from Feb. 29 to March 7 [source]
  • 2 new cases in Australia (New South Wales): a man in his 70s with no recent overseas travel (source of infection is under investigation) and a man in his 40s who has traveled overseas recently [source]
  • 1 new case in South Africa (second case in the country): a direct contact of the first case, part of a group of 10 people who had traveled to Italy [source]
  • 4 new cases in Saudi Arabia: 3 women (contacts of a previous case) and 1 men who returned from Iran via the United Arab Emirates, but his presence in Iran had not been disclosed at the Saudi port [source]
  • 4 new cases in Finland: 2 in the Helsinki and Uusimaa Hospital District, 1 in the Pirkanmaa Hospital District related to a previous case in the Northern Savonia Hospital District, 1 related to tourism in Northern Italy [source]
  • 2 new cases in Indonesia: a 55-year-old man and a 36-year-old man who is thought to have contracted the virus while working as a crew for the Diamond Princess cruise ship in Japan [source]
  • 5 new cases in India
  • 2 new cases in Bulgaria: a 27-year-old man and a 61-year-old man with a severe form of pneumonia. The “zero” patient is being actively searched [source]
  • 23 new cases in Austria [source]
  • 4 new cases in Costa Rica, bringing the total in the country to 5 [source] [source]
  • 1 new case in Mexico [source] [source]
  • 272 new cases and 2 new deaths in South Korea [source] [source]
  • 1 new case in Kuwait [source]
  • 44 new cases27 new deaths (all in Hubei) and 1,661 new discharges occurred in China on March 7, as reported by the National Health Commission (NHC) of China. [source]
  • 1 new case in Australia (Queensland): a man who recently returned from Iran [source]

March 7:

  • 1 new death of a former passenger of theDiamond Princess cruise ship [source]
  • 5 new cases in Peru: 4 are connected to the first case, 1 is in the Arequipa region [source]
  • 3rd death in Australia: a NSW man in his 80s who contracted the virus in his nursing home [source]
  • 116 new cases and 4 new deaths in the United States, including:
    1st case in Virginia, in Fairfax County: a U.S Marine assigned to Fort Belvoir, VA [source]
    1st case in Kansas [source]
    34 new cases in New York [source] New York governor declares state of emergency
    2 new cases in Pennsylvania, Montgomery County [source]
    1st case in Washington, D.C. [source]
    1 in Connecticut: a community physician in the Bridgeport area [source]
    1 new case in Florida (Charlotte County) [source]
    6 in Massachusetts, including 1 in Berkshire County [source] [source]
    1 new death and 3 new cases in Florida (first deaths on the east coast) [source]
    22 new cases and 3 new deaths in Washington state [source]
    17 new cases in California:
    – 8 in Santa Clara County 
    [source]
    – 6 in San Francisco 
    [source]
    – 1 in Los Angeles County 
    [source]
    – 1 in Madera County
     [source]
    – 1 in Alameda County
    : a former passenger on the now-quarantined Grand Princess cruise ship, an older adult who has underlying health conditions and is currently hospitalized. Alameda County’s Public Health Department is urging all residents who were on the Grand Princess cruise from Feb. 11 to Feb. 21 to get tested if they are experiencing any symptoms [source]
    First 2 cases in South Carolina: an elderly woman in Kershaw County who has been hospitalized and an adult woman from Charleston County who had recently traveled to France and Italy [source]
    1 new case in Illinois: a woman in her 50s who works as an aide at a Chicago high school [source]
    1st case in Utah: the patient was a passenger of the Grand Princess cruise ship [source]
    6 new cases in Colorado [source]
    1st case in Hawaii: a former passenger of the Grand Princess cruise ship (that docked on Oahu in late February) who did not feel well after a few days after returning home and went to see their doctor. The Department of Health said, “We don’t believe the patient had close contact with anyone else, but we’re still investigating.” [source]
    1 in New Jersey: a male in his 50s hospitalized at Englewood Hospital and Medical Center in Bergen County [source]
  • 1 new case in Luxembourg with a “lien epidemiologic” with the north of Italy [source]
  •  First 2 cases in Bulgaria: a 27-year old man and a 75-year old woman [source]
  •  1st death in Argentina: a 64-year old man who had traveled to France [source]
  • 4 new cases in Israel: 2 had recently traveled to Spain, 1 to Italy, 1 to Greece [source]
  •  Italy has authorized new emergency measures against the spread of coronavirus:
    – the entire region of Lombardy is in lockdown. It is possible to enter and exit only in case of emergency
    – the “red zone” is extended to 11 additional provinces: Modena, Parma, Piacenza, Reggio Emilia, Rimini, Pesaro e Urbino, Venezia, Padova, Treviso, Asti e Alessandria. The measures will be in place until April 3 [source]
  •  1st case in Moldova: a 48-year old woman who fell ill while on a Wizzair flight from Milan to Chișinău [source]
  • 21 new cases in Greece: 13 are located in the prefectures of Achaia and Elis, 7 in the Attica, 1 in Euboea [source]
  • 6 new cases in Canada (British Columbia) including 2 residents of a North Vancouver long-term care home [source]
  •  296 new cases and 7 new deaths in France [source] 2 members of France’s National Assembly tested positive for coronavirus [source]
  • 33 new cases in Egypt: they are all passengers of a cruise ship in the River Nile [source]
  • 1 new case in Ireland: a man in the east of Ireland associated with travel from northern Italy [source]
  •  1st case in Paraguay [source]
  • Uganda has canceled all international conferences, including the G77 summit that was scheduled to take place in April, with participants from 136 member states. Furthermore, any traveler from Italy, Iran, South Korea, France, China, Germany, and Spain will be subjected to self-quarantine for 14 days on arrival in Uganda even if they do not exhibit symptoms of COVID-19 [source]
  • 8 new cases in Iraq [source]
  •  1,247 new cases and 36 new deaths in Italy [source]
    Percentage of deaths by age group:
    90+ years old: 6% of deaths
    80 – 89 years old: 42% of deaths
    70 – 79 years old: 35% of deaths
    60 – 69 years old: 16% of deaths– Among the 5,061 active cases, 3,218 (55%) are hospitalized, 567 of which (representing 11% of active cases) are in intensive care- Among the 822 closed cases, 589 (72%) have recovered, 233 (28%) have diedNicola Zingaretti, leader of Italy’s Democratic Party, tested positive to coronavirus [source]

  • 6 new cases in Lebanon [source]
  • 1 new case in Russia: a woman residing in Moscow who had traveled to Switzerland [source]
  • 3 new cases in San Marino [source]
  • 130 new cases in Germany [source]
  • 124 new cases and 2 new deaths in Spain [source] [source]
  • 5 new cases in Iceland: 2 had traveled abroad, 3 had contacts with preciously confirmed cases who had been abroad [source]
  • 1 new case in Romania, the 1st in Bucharest: a 49-year-old man who flew back from Rome, Italy on Feb. 27. No quarantine was required since the city was not (and is still not) considered at risk for coronavirus within Italy. A week after returning, he started having diarrhea and fever. The man went last night to the National Institute of Infectious Diseases Matei Balș with fever but with symptomatology that “does not fit into the case definition of COVID-19.” He was nevertheless tested since he had traveled to Italy [source]
  •  First 2 cases in the Maldives. Both are in quarantine in Farukolhufushi. 3 islands currently on temporary lockdown [source]
  • 7 new cases in Portugal:
    2 latest: a 44-year-old man and a 39-year-old woman, both linked to the Barrosas footwear factory in Felgueiras [source]
    3 reported earlier: two men and a woman [source]
    2 reported this morning: a 20-year-old and a 60-year-old women admitted to the hospital in São João, both with connections to one of the infected people in the same hospital [source]
  • 5 new cases in the Czech Republic, including: [source]
    – a woman, tenant of a previously infected person
    – a resident of Passo Tonale, Trentino, Italy
  • 3 new cases in Palestine who were in contact with the patients at the Angel Hotel in Beit Jala. They were placed in the National Center for Quarantine in Bethlehem [source]
  • 15 new cases in Austria [source]
  • 42 new cases in the UK [source]
  • 6 new cases in Denmark [source]
  • United States: only 1,895 people have been tested so far, The Atlantic found
  • 60 new cases in the Netherlands [source]
  • 1 new case in Cambodia: a 38-year old man who had come into contact with the first case [source]
  • 8 new cases and 8 new discharges in Singapore [source]
  • 2 new cases in Saudi Arabia coming from Iran and Iraq [source]
  • 24 new cases in Sweden [source]
  • 2 new cases in Romania: [source]
    – 
    15-year-old young woman in in Timisoara attending the same school (but in another class) where 2 other students have already been diagnosed with Covid-19. She had a fever of 39.5 degrees and coughing, but her conditions are improving.
    – the 16-year-old daughter of the 40-year-old man who tested positive in Hunedoara. They had also traveled on the same plane. She is asymptomatic for now
  • 4 new cases in Slovenia[source]
    – a Slovenian citizen who traveled to Italy (including Venice) for two weeks
    – a close contact with an infected doctor from Metlika
    – a Slovenian citizen who came from Austria, where he fell ill
    a man who traveled through Italy to Spain with his family
  • 1 new case in Poland: a person traveling with patient “zero” in the bus from Germany to Poland [source]
  •  60 new cases in Belgium [source] bringing the total to 169 “Most of the positive patients have recently traveled, but we are seeing more and more local infections,” said a FPS Public Health official, adding that “the number of cases detected has not doubled. It is therefore possible that the return effect from travelers from northern Italy may end” [source]
  • 1 new case in South Africa: a 39-year-old woman from Gauteng who was part of the same group of 10 people that recently traveled from Italy [source]
  • 25 new cases in Bahrain [source]
  • 3 new cases in India: 2 are from Ladakh with travel history to Iran and one is from Tamil Nadu with travel history to Oman[source]
  • 3 new cases in Afghanistan in the western province of Herat which borders Iran. Afghanistan’s health ministry spokesman, Wahidullah Mayar, expressed concern about the vulnerability of Afghanistan’s border with Iran and added that the cost of testing would be a strain on Afghanistan’s resource-strapped health system. Each test kit – which can test around 50 cases – cost around $1600, he said [source]
  • 1 new case in Croatia: a person in Varaždin who is a close contact of a previous case. “Patient zero” in Croatia is a young man who came from Italy [source]
  • 4 new cases in Finland: 2 adults in Pirkanmaa who were on the same traveling group from northern Italy as those previously infected in Finland, and 2 man in Uusimaa who returned from northern Italy [source]
  • 4 new cases in Georgia “Please, don’t panic. There is no reason to panic” said the Head of the Georgian National Centre for Disease Control Amiran Gamkrelidze, noting that the most dangerous country for Georgia for now is Italy as most people who have tested positive for COVID-19 have arrived from there [source] [source]
  •  1,076 new cases and 21 new deaths in Iran [source]
  • 2 new cases in Slovakia: the son and wife of the man who was diagnosed yesterday. The son, who had been to Venice, Italy between February 14 and 15 and did not show any symptoms of the virus, has been identified as “patient zero” (the first contact patient in Slovakia). All flights from the Slovak international airports to Italy will be banned as of Monday, March 9 [source]
  • 10 new cases in Malaysia [source]
  • 3 new cases in Vietnam [source] including a 27-year-old patient who had been to the South Korean city of Daegu, returned to Vietnam on a Vietjet flight on Wednesday and was quarantined upon his landing, the ministry said in a statement [source]
  • 2 new cases in the Philippines of local transmission, prompting the Department of Health to raise the nationwide alert level. New cases are a 59-year-old man and a 62-year-old Filipino man from Cainta (Rizal province) with no recent travel history abroad. The government’s contract tracing teams have yet to determine how he contracted the virus [source]
  • 1 new case in Qatar: a Qatari citizen who had returned from Iran recently [source]
  • 1 new case in Hungary: a 70-year-old Hungarian man with pre-existing diseases, currently being quarantined and treated at the Central Hospital of Southern Pest. “He was probably infected by his son living abroad, who visited him in mid-February after visiting Italy and Paris” according to the Hungarian government’s report [source]
  • 3 new cases in Kuwait [source]
  •  First 3 cases reported in Malta: a 12-year-old Italian girl and both her parents who had returned, via Rome, from a holiday trip in northern Italy on Tuesday. They were in self-quarantine and are now isolated in an infectious disease unit at Mater Dei Hospital. “The children did not go to school and the parents did not go to work or leave the house. Their contact with other people was minimal” [source]
  • 2 new cases in Thailand: “both are Thai males aged 40″ according to the Ministry of Public Health [source]
  • 2 new cases in Algeria: 1 belongs to the same family as the 16 already infected last week; 1 comes from Europe (specific country not provided) [source]
  • 1 new case in Ecuador [source]
  • 2 new cases in Switzerland [source]
  • 29 new cases in Norway [source]
  • 15 new cases in Japan [source] [source]
  • 5 new cases in Brazil, including:: a patient in Rio de Janeiro who had recently traveled abroad [source]
  • 448 new cases and 5 new deaths in South Korea [source]
  • 1 new case in New Zealand: a woman in her 40s, partner of the third case [source]
  • 11 new cases in Australia, including [source]
    1 in Victoria: a doctor who had recently returned from the US [source]
  • 99 new cases (74 in Hubei), 28 new deaths (all in Hubei) and 1,678 new discharges occurred in China on March 6, as reported by the National Health Commission (NHC) of China. [source]

March 6:

  • 98 new cases and 3 new deaths in the United States, including:
    – 1 new case in Arizona (third in the state) [source]
    – 1 new case in Rhode Island
     (third in the state): a female in her 60s, now at home with mild symptoms. who had direct, face-to-face contact with a confirmed case in New York in late February [source]
    – 1st case in Nebraska:
     a woman in her 30s from Douglas county who recently returned from England at the end of February. She started experiencing symptoms and was hospitalized at Methodist Hospital on March 5 [source]
    – 1st case in Connecticut
    : a nurse at Danbury Hospital [source]
    – 9
     new cases and 3 new deaths in Washington state [source] [source]
    – 1st case in Oklahoma
    : a man in his 50s resident in Tulsa County [source]
    – 11 new cases in Calfornia:

    – 4 in Santa Clara County [source]
    – 3 in Contra Costa County [source]
    – 1 in Yolo County [source]
    – 3 in Placer County who had traveled on the Grand Princess cruise ship from San Francisco to Mexico Feb. 11-21. Two had mild symptoms that have already resolved; the third currently has mild symptoms. All three are isolated at home and none required hospitalization. [source]

    – 21 on the Grand Princess cruise ship off California [source]
    – 1st case in Kentucky, Lexington [source]
    – 3 in Colorado: 2 residents of Denver [source] and of Colorado Springs: a man in his 40s who had traveled recently to California [source]
    – 1st case in Minnesota: an elderly person who had traveled on a cruise ship that had a confirmed case [source]
    – 1 in Nevada: the case has a family member who is a student at Huffaker Elementary School in Reno, which has been closed “out of an abundance of caution” [source]
    – 1 in Massachusetts: a parent in Wellesley with children in the Upham and Wellesley middle schools, were students were dismissed early in order to fully clean and sanitize the buildings [source]
    – 1 in Georgia [source]
    – 1 in Indiana (1st in the state): an adult from Marion County who had traveled to Boston recently and had been at an event (Cambridge-based Biogen’s Boston conference) where other people have also tested positive. They returned to Indiana on Wednesday, March 4. [source]
    – 1 in North Carolina (Chatham County): a man who had recently returned from Italy
    – 2 in Pennsylvania (1st in the state) [source]
    – 22 in New York state [source] [source]

    – 8 in Westchester County
    – 3 in Nassau County [source]
    – 11 connected to the original New Rochelle case

    – first 2 cases in Colorado (Summit County): 1 is a 30-year old man who had traveled to Italy in February and was in contact with a confirmed case outside of Colorado. [source]
    – first 3 cases in Maryland 
    (Montgomery County): they had all recently traveled overseas [source]

  • 8 new cases and 1 new death in Iraq [source]
  •  1st case in Costa Rica: an American woman from New York [source]
  • 1 new case in Luxembourg [source]
  • 5 new cases in Argentina: 4 in Buenos Aires, 1 in Córdoba. They had all recently traveled to Europe [source]
  •  1st case in Colombia: a 19-year-old girl in Bogotá who was studying in Milan, Italy [source] [source]
  • 23 new cases in Austria [source] Several students and teachers affected. From now on, direct flights to Iran, South Korea and the two northern Italian cities of Milan and Bologna will no longer be carried. In addition, there are going to be “one-off health checks” on the borders with Italy. Those arriving from regions where there are travel warnings must provide confirmation from a doctor that they are not infected[source]
  • 5 new cases in Ireland[source]
    a male associated with travel from northern Italy
    a female who is a contact of a confirmed case
    a female healthcare worker in the south of the country who was in contact with a confirmed case
    a male from the south of the country with a travel history which is being investigated
    a female associated with travel from northern Italy
  • 2 new cases in North Macedonia [source]
  • 9 new cases in Palestine (Bethlehem) [source]
  •  230 new cases and 2 new deaths in France [source]
  • 119 new cases and 5 new deaths in Spain [source]
  •  778 new cases and 49 new deaths in Italy. Total cases: 4,636. Total deaths: 197. Active cases: 3,916.
    – Among the 3,916 active cases, 2,394 (61%) are hospitalized, 462 of which (representing 12% of active cases) are in intensive care.
    – Among the 720 closed cases, 523 (73%) have recovered, 197 (27%) have died.
  • 6 new cases in Lebanon[source]
  • 1 new case in Slovenia:
    – a doctor who had traveled abroad and had returned home via Italy [source]
    – a healthcare worker [source]
  • 1 new case in Vietnam: a 23-year old woman who had traveled to France, the UK and Italy [source]
  • 4 new cases in Israel [source]
  • 1 new case in Bosnia and Herzegovina: a middle-aged person who lives in Celinac who was in close contact with a previously confirmed case [source]
  • 94 new cases in Switzerland [source]
  • 4 new cases in Poland[source]
    – a man who rode on the same bus as the first case
    – two people who had recently returned from Italy
    – 1 person from Wrocław
  • 17 new cases in the United Arab Emirates including a 17-year old student [source]
  • 3 new cases in Romania:
    latest case: a 40-year old man from Hunedoara who had recently visited Bergamo, Italy [source]
    – a 51-year-old woman, admitted to Craiova, who came in contact with the Suceava case [source]
    – a young classmate of the 16-year-old boy who was diagnosed with coronavirus previously. The young woman has been transferred to the Victor Babes hospital in Timisoara [source]
  • 1 new case in Croatia [source]
  • 3 new cases in Qatar: 2 Qatari citizens and a family member of another nationality who had been evacuated from Iran. They are in isolation and in stable condition [source]
  • 8 new cases in Iceland [source]
  •  1st case in Togo: a 42-year old woman from Lome who had visited Benin, Germany, France and Turkey in late February and early March. [source]
  • 6 new cases in the Czeck Republic (3 added while the press conference announcing 3 new cases was in progress[source] [source]
  • 47 new cases and 1 new death in the UK, including: [source]
    – First Birmingham coronavirus case [source]
    – 5 new cases in Scotland, bringing the total to 11: Tayside, Ayrshire and Arran, Forth Valley, Greater Glasgow and Clyde, Grampian, Fife and Lothian [source]
    – 2 British Airways baggage handlers [source]
  • 4 new cases in Portugal: 3 are in the hospital center of São João, in Porto and “have an epidemiological link to previous cases”, which indicates that the source of the infection is in Italy. The other case, for which no information was provided, is receiving treatment in a health care in Lisbon. [source]
  • 125 new cases in Germany [source]
  • 64 new cases and 2 new deaths in Spain [source]
  • 1 new case in Taiwan: a woman in her 50s [source]
  • 1 new case in Thailand: British businessman who left London on Feb. 28 and changed planes in Hong Kong on Feb. 29 before arriving in Thailand. He was in Hong Kong for about eight hours. [source]
  • 5 new cases in Bahrain [source]
  • 1 new case in the Dominican Republic (second case in the country): a Canadian tourist who was staying at a hotel in Bayahibe [source]
  • 6 new cases in Russia. All newly detected cases of coronavirus in the Russian Federation are “imported” from Italy [source] [source]
  • 46 new cases and 1st death in the Netherlands: an 86-year-year old man in Rotterdam whose source of infection is unknown [source] [source]
  • 2 new cases in San Marino [source]
  •  1st case in Peru: a 25-year-old man who was in SpainFrance and the Czech Republic [source]
  • 5 new cases in Brazil including the first in Bahia: a 34-year-old woman, resident of Feira de Santana, who was in Italy and returned to Brazil on Feb. 25 [source] [source] [source]
  • 3 new cases in Denmark [source]
  • 13 new cases in Singapore (largest single-day increase) [source]
  • 14 new cases in Greece (Zakynthos): part of the travel group who returned from the Holy Land in Israel. 3 from this group are in serious condition [source]
  • 3 new cases in Azerbaijan: they had all recently traveled to Iran [source]
  • 12 new cases in Egypt on a Nile cruise ship heading to the southern city of Luxor from Aswan [source]
  •  1st case in Slovakia: a patient aged 52 from a small, unspecified town in Slovakia, who has been hospitalized at the infectology clinic of the University Hospital in Bratislava. No recent travel history abroad, but his son – who does not show any symptoms of the virus – has been to Venice, Italy [source] [source]
  • 59 new cases in Belgium: total more than doubled since yesterday [source]
  • Total number of COVID-19 cases worldwide tops 100,000
  •  1,234 new cases and 16 new deaths in Iran [source]
  • 28 new cases in Malaysia [source]
  • 1 new case and 3 new recoveries in Taiwan [source]
  • 5 new cases in Estonia [source]
  • 42 new cases in Sweden. Total now tops 100 [source]
  • 2 new cases in Indonesia [source]
  •  1st case in Cameroon: a 58 years old French man who entered the country from France on Feb. 24 [source]
  •  1st case in Serbia: a 43-year-old man who traveled to Budapest [source] [source]
  •  1st case in Vatican City [source]
  • 1 new case in India: a person who has travelled to Thailand and Malaysia [source]
  • 1 new case in Pakistan [source]
  • 3 new cases in Finland [source]
  • 56 new cases in Japan
  •  309 new cases and 1 death in South Korea [source] [source]
  • 2 new cases in Norway (Bærum, Viken County). Total now tops 100 [source]
  • 2 new cases in the Philippines: a 48-year-old male Filipino with travel history to Japan and a 62-year-old male Filipino with no overseas travel history [source]
  • 17 new cases in Canada, including: [source]
    1 in Ontario: 
    a person who traveled to Las Vegas for an international conference [source]
    8 in British Columbia
    : 1 has no travel history, 2 had recently returned from Iran, 4 are linked to a previously confirmed case, 1 is connected to University Canada West where a presumptive case is being investigated [source]
    1 in Alberta: a woman in her 50s from the Calgary area who had been on board of the Grand Princess cruise ship, which is currently quarantined off the coast of California awaiting tests for all passengers and crew [source]
  •  1st case in Bhutan: a 76-year old American tourist who arrived in Bhutan on March 2 via India. [source]
  • 143 new cases (126 in Hubei), 30 new deaths (29 in Hubei) and 1,681 new discharges occurred in China on March 5, as reported by the National Health Commission (NHC) of China. [source]

March 5:

  • 1 new case in Argentina: a 23-year old man who had recently traveled to Italy [source]
  • 1 new case in Chile: a Cook County resident in his 20s who flew into O’Hare after traveling from Italy where he caught the illness [source]’
  • 2 new cases in Hungary: including a man in Debrecen who works in Milan, Italy [source]
  • 1 new case in New Zealand: the partner of a previously confirmed case [source]’
  • 63 new cases and 1 new death in the United States, including at least:
    – 1st case in Colorado [source]’
    – 1 case in Middlesex County, Massachusetts
    – fifth case in Illinois a person who returned from Italy. He’s in isolation at Rush. [source]’
    – second case in New Jersey: a 32-year-old man from Fort Lee [source]’
    – 2 cases in Harris County, Texas: both are travel-related to Egypt [source]’
     1 new death in King County (Washington state): a woman in her 90s
    – a resident of Sonoma County (second case there) who traveled internationally on the Grand Princess ship from San Francisco to Mexico [source]
    – 4 in Los Angeles County, California [source]
    – the 1st cases in San Francisco, California [source]’
    – 11 in New York State: 3 are in serious condition and are treated in intensive care units [sourceNew cases include a man in his 40s and a woman in her 80s [source]
    – the 1st case in Nevada
     [source]
    – 1 in Tennessee (Williamson County) [source]
    – a Facebook worker in Seattle [source]
    – the 1st case in New Jersey: a man in his 30s hospitalized in Bergen County [source]
  •  138 new cases and 3 new deaths in France, including the first 3 cases in Corsica [source] [source]
  • 7 new cases in Ireland: including the first in Cork, with no recent history of travel, who is being treated in an intensive care unit. [source]
  • 1 new death in Iran today is of a senior Iranian politician, Hossein Sheikholeslam, Iran’s former ambassador to Syria and former advisor to current Foreign Minister Mohammad Javad Zarif. He was 67 years old [source]
  • 5 new cases in Brazil [source]
  • 1 new case in Luxembourg: a person who had recently returned from Northern Italy [source]
  •  283 new cases in Germany [source]
  •  First 7 cases in Palestine, West Bank. 5 new cases in addition to the first 2 reported earlier. Palestinian Authority closes Bethlehem churches and mosques for two weeks [source] [source]
  •  1st death in the UK, an older patient with pre-existing conditions. [source]
  •  769 new cases and 41 new deaths in Italy, which becomes the country with the largest daily increase in cases and deaths in the world. [source]
    Among the 3,296 active cases, 1,790 (54%) are hospitalized, 331 of which (representing 11% of active cases) are in intensive care.
    Among the 562 closed cases, 414 (74%) have recovered, 148 (26%) have died.
  • 42 new cases in Sweden, bringing the total number of cases in the country to 94. [source]
  • 5 new cases in Slovenia [source]
  • 5 new cases in Denmark including former Danish footballer Thomas Kahlenberg [source]
  • 28 new cases in the UK [source]
  • 2 new cases in Israel [source]
  • 3 new cases and 1 new death in Iraq: a 65-year-old person in Baghdad [source] [source] [source]
  • 1 new case in Israel [source]
  • 2 new cases and 1 new recovery in Canada (Ontario[source]
  • 3 new cases in Ecuador: all linked to the first confirmed case [source]
  • 1 new case in Oman: a man who had recently traveled to Milan, Italy [source]
  • Diamond Princess cruise ship: The Ministry of Health, Labor and Welfare has corrected the number of cases from 706 to 696. After examining the results of the virus test, it was reported that some people were counted twice. [source]
  • 4 new cases in the Czech Republic [source]
  • 1 new case in Lebanon: a Lebanese woman coming from Britain [source]
  • 3 new cases in Portugal: two males, aged between 40 and 50, admitted to São João Hospital in Porto, and a man in Lisbon who had recently traveled to Italy [source]
  • 44 new cases in the Netherlands [source]
  • 26 new cases and 1st death in Switzerland: 74-year-old woman who had been hospitalized since March 3. The woman suffered from a chronic illness. Source of infection still unclear. [source] [source]
  • 54 new cases and 1 death in Spain [source]
  • 33 new cases in Japan, including 8 in Tokyo and 8 in Aichi
  • 5 new cases in the Republic of San Marino bringing the total to 21: 15 are hospitalized, 3 are in serious condition. [source]
  • 1 new case in India (Ghaziabad) [source]
  • 22 new cases in Greece [source]
  • 1 new case in Canada (Québec) [source]
  • 5 new cases and 2 new recoveries in Singapore [source]
  • 3 new cases in Saudi Arabia [source]
  •  1st case in South Africa: a 38-year-old man who had traveled to Italy with his wife. They were part of a group of 10 who arrived back in South Africa on March 1. [source]
  • 9 new cases in Iceland [source]
  • 1 new case in Egypt, bringing the total to 3 [source]
  • 3 new cases and 3 new recoveries in Bahrain [source]
  • 5 new cases in Malaysia [source]
  • 27 new cases in Belgium [source]
  • 6 new case in Georgia: a person who had recently visited Italy[source]
  • 3 new cases in Azebaijan: they had all visited Iran. [source]
  • 3 new case in Estonia: including a resident of Tallinn who had been on the same flight from Bergamo, Italy, to Riga as the second confirmed case. [source]
  • 1 new case in Slovenia: a person who was in contact with the first case. [source]
  •  591 new cases and 15 new deaths in Iran
  • 5 new cases in Finland: 3 in the Helsinki and Uusimaa hospital district, 1 is in Pirkanmaa and 1 in Kanta-Häme. The case in Kanta-Häme is a child in Hämeenlinna who had returned from northern Italy with their family on Tuesday. [source]
  • 3 new cases in Scotland (UK) [source]
  • 1 new case in Russia: an Italian citizen [source]
  •  1st case in Bosnia and Herzegovina: a middle-aged man and his child who recently visited Italy. His wife tested negative. He is in stable condition, hospitalized in isolation in Banja Luka. School children who have had contact with the infected child will now be tested. [source]
  • 1 new case in Morocco: a Moroccan woman who recently returned to Casablanca from Italy[source]
  • 2 new cases in Kuwait [source] [source]
  • 11 new cases in Norway [source]
  • 15 new cases in Austria [source]
  • 4 new cases in Thailand [source]
    – a 29 year-old Italian man who arrived in Thailand on March 1
    – a 42 year-old Thai male office worker who returned from Italy
    – a 22 year-old Chinese male student who was screened with symptoms while in transit at Bangkok’s Suvarnabhumi Airport while traveling from Iran to China.
    – a 20 year-old Thai male student who arrived from Iran on Feb. 27
  • 467 new cases, 7 new deaths, and 47 new recoveries in South Korea [source] [source]
  • 139 new cases (134 in Hubei), 31 new deaths (all in Hubei) and 2,189 new discharges occurred in China on March 4, as reported by the National Health Commission (NHC) of China. [source]

March 4:

AMERICAS

  •  2 new deaths and 34 new cases in the United States
    1 new case in Texas: in Fort Bend County [source]
    1 new death in Washington state. [source]
    1 new death in Placer County, CA (first death in California): an elderly adult with underlying health conditions. [source]
    12 new cases in Washington state:
     [source]
    10 in King County
    2 in Snohomish County
    9 new cases in New York state including:

    5 in Westchester County [source]
    1: an attorney in his 50s in critical condition at New York-Presbyterian/Columbia University Irving Medical Center. The man has an underlying respiratory condition. The case is believed to be the city’s first case of community spread [source]
    1: a student at Yeshiva University [source]
    12 new cases in California:
    6
     in Los Angeles County [source] California declares state of emergency. [source]
    in Orange County in Southern California: a man in his 60s and a woman in her 30s who had recently traveled to countries that have widespread reports of COVID-19, officials said. [source]
    in Contra Costa County in Northern California [source]
    in Santa Clara County in Northern California [source]
  •  First 5 cases in French Guiana [source]
  • 4 new cases in Canada (British Columbia), including a woman in her 80s who is in critical condition at Vancouver General Hospital [source] [source]
  • 1 new case in Chile: the wife of the first case [source]
  • 1 new case in Brazil (São Paulo) [source]
  • 3 new cases in Ecuador: all relatives of a previously identified case. [source]

EUROPE

  • 1 new case in Croatia[source]
  •  First case in Slovenia: a person coming from Morocco via Italy. [source]
  • 4 new cases in Ireland [source]
  •  587 new cases and 28 new deaths in Italy. Total: 3,089 and 107 deaths [source] [source]
    Among the 2,706 active cases, 1,344 (50%) are hospitalized, 295 of which (representing 11% of active cases) are in intensive care.
    Among the 383 closed cases, 276 (72%) have recovered, 107 (28%) have died.
    All schools and universities in Italy closed until March 15 in an effort to contain the spread of coronavirus. [source]
  •  First 2 cases in Hungary: two Iranian students who are asymptomatic but have been transported to St. Laszlo Hospital, Prime Minister Viktor Orbán announced. [source]
  • 22 new cases in Sweden: in Stockholm, Värmland, Västra Götaland, Örebro county and in Skåne.
    he risk of an outbreak in Sweden is judged as “moderate.” All cases in Sweden as of earlier today were linked to recent travel abroad (‘import case’) or contact with a confirmed import case. [source] Sweden’s Public Health Agency expands its list of regions in Italy where recent travelers are advised to be vigilant about possible symptoms to include Aosta Valley, Liguria, Trentino-Alto Adige, Friuli Venezia Giulia and Tuscany. [source]
  • 63 new cases and 1 new death in Spain[source] [source]
  • 59 new cases in Germany [source]
  • 73 new cases in France [source]
  • 36 new cases in the UK: at least 29 were infected abroad. [source]
  • 23 new cases in Norway: many are related to outbreaks abroad, mainly in Italy[source] [source]
  • 12 new cases in Iceland:
    6 new cases [source]
    had come from Verona in northern Italy [source]
    2 had traveled from Austria through Munich.
    2: a male and a female in their 60s who also returned from Verona, Italy through Munich. “They have what can be called traditional flu symptoms, not very sick” [source]
  • 2 new cases and 1 new recovery in Romania. The first of the new cases, asymptomatic, is the 16-year-old nephew of the 47-year-old man from Timisoara diagnosed with coronavirus yesterday. [source] [source]
  • 15 new cases in the Netherlands [source]
  • 5 new cases in Denmark including the first in the Faroe Islands: a man who had been at a conference in Paris and returned on Feb. 24. [source]
  • 5 new cases in San Marino, bringing the total to 15, of which 3 (aged 81, 80, and 76 years old) are in critical condition [source]
  • 3 new cases in the Czech Republic: 2 are relatives of an infected case in Děčín, 1 is a woman from Prague. [source]
  • 2 new cases in Greece:
    – a person who had traveled to Israel and Egypt. He is hospitalized in Patras. [source]
    – the husband of the previously confirmed case. [source]
  • 10 new cases in Belgium, 9 of which returned from a trip to northern Italy and are now isolated at home after developing an upper respiratory infection with a relatively mild flu-like condition. 1 patient, who had not traveled but is a contact of a previous case who had traveled to Venice, developed a more severe respiratory infection and was therefore admitted to the Saint-Pierre hospital in Brussels. [source]
    The European Defense Agency (EDA) in Brussels has confirmed that one of its employees has tested positive after returning last week from a trip to Italy, where the official had a meeting with around 30 officials from other EU institutions. EDA has canceled all scheduled meetings at its premises until March 13. [source]
  •  1st case in Poland: a person who came from Germany and is now hospitalized in Zielona Góra (Lubusz Voivodeship) in good condition. All contacts have been placed into home quarantine. 584 tests have been performed in the country. [source]
  • 2 new cases in Portugal: a 44-year-old man who came from Italy and is hospitalized at the São João Hospital, in Porto in stable condition and a woman in her 40s who had also traveled to Italy and is hospitalized in Lisbon. [source[source]
  • 35 new cases in Switzerland [source]
  • 2 new cases in Belarus, briging the total to 6: 4 in Minsk and 2 in the Vitebsk Region. More than 5,000 tests have been carried out [source]
  • 2 new cases in Scotland (UK) [source]
  • 5 new cases in Austria [source]MIDDLE EAST
  • 1 new case in the United Arab Emirates: a 16-year old girl in Dubai [source]
  • 1 new case in Saudi Arabia: a Saudi citizen who had traveled to Iran [source]
  • 3 new cases in Oman: 1 Omani citizen, 2 Iranian citizens. [source]
  • 2 new deaths and 3 new cases in Iraq [source] [source] [source]
  • 2 new cases in Lebanon [source]
  • 3 new cases in Bahrain, bringing the total in the country to 52, including 1 recovered. [source]
  •  586 new cases, 15 new deaths, and 117 new recoveries in Iran [source]
  • 3 new cases in Israel: one of the patients returned from Italy on Feb. 29 and all three have been quarantined. [source]AFRICA
  • 2 new cases in Senegal [source]
  • 9 new cases in Algeria, bringing the total in the country to 17 [source]OCEANIA
  • 1 new case in New Zealand [source]
  • 1 new death in Australia (NSW): a 95-year old woman. It’s the 2nd death in Australia. [sourceand 14 new cases including: [source]
    in South Australia:
    – a 40-year old woman who had visited Iran and a 24-year old woman. [source]
    – an eight-month-old baby (youngest coronavirus case in Australia) a day after the baby’s mother tested positive to the disease. “The child is well, and both mother and baby are doing well in that facility,” Chief Public Health Officer Nicola Spurrier said. [source]
    – in Northern Territory: a 52-year-old tourist currently in isolation in Royal Darwin Hospital. [source]
    – in Queensland: a 26-year old man from Logan who had recently traveled to Iran[source]ASIA
  • 2 new cases in Singapore. [source]
  • 2 new cases in Hong Kong[source]
    – a 43-year-old man, who is the “master” of a Buddhist worship hall in North Point, where 16 people were infected previously.
    – a 57-year-old female domestic helper of two previously confirmed patients, who lived in southern Hong Kong Island.
  • 38 new cases in Japan [source] [source] [source] [source] [source] [source]
  • 14 new cases in Malaysia, all associated with a local cluster linked to case #26. So far, 21 out of the 50 cases have been linked to this cluster: 16 close contacts and 5 secondary contacts. [source]
  • 22 new cases in India, including a group of 15 Italian tourists [source] [source]
  • 119 new cases38 new deaths (37 in Hubei) and 2,652 new discharges occurred in China on March 3, as reported by the National Health Commission (NHC) of China. [source]
  • 435 new cases and 2 deaths in South Korea, including a 86 years old woman who had tested positive on Feb. 26. [source] [source] [source] [source]

March 3:

Bruce Aylward, World Health Organization Joint Mission to China:

“I think the key learning from China is speed — it’s all about the speed. The faster you can find the cases, isolate the cases, and track their close contacts, the more successful you’re going to be. […]

People keep saying [the cases are the] tip of the iceberg. But we couldn’t find that. We found there’s a lot of people who are cases, a lot of close contacts — but not a lot of asymptomatic circulation of this virus in the bigger population. And that’s different from flu. […]

China got patients in treatment early and have highly sophisticated health care treatment procedures. They are really good at keeping people alive with this disease. They have a survival rate (with a mortality rate of just under 1% outside of Hubei province) for this disease I would not extrapolate to the rest of the world. What you’ve seen in Italy and Iran is that a lot of people are dying.

Panic and hysteria are not appropriate. This is a disease that is in the cases and their close contacts. It’s not a hidden enemy lurking behind bushes. Get organized, get educated, and get working.”

Source: Vox Interview

 

  •  1st case in Gibraltar: a person returning from northern Italy [source]
  • 3 new cases in Belarus[source] [source]
  • The United States now has a total of 124 cases: 76 domestic and 48 repatriated (45 from the Diamond Princess cruise ship, and 3 from Wuhan, China). Domestic cases by state:
    27 in Washington State (including 9 deaths and 1 recovered)
    24 in California (including 2 recovered)
    4 in Illinois (including 2 recovered)
    3 in Florida
    3 in Oregon
    2 in Arizona (including 1 recovered)
    2 in Georgia
    2 in Massachusetts (including 1 recovered)
    2 in New York
    2 in Rhode Island
    2 in New Hampshire
    1 in North Carolina
    1 in Texas
    1 in Wisconsin (including 1 recovered)
  • 1 new case in New Zealand: The woman arrived in Auckland from Singapore on Feb. 25 with Air New Zealand flight NZ0283 on her return from Italy[source]
  • 3 new cases in Canada, bringing the total to 30 in the country: 20 in Ontario; 9 in British Columbia and 1 in Quebec. [source]
    1 in British Columbia: a man in his 50s who also recently returned from Iran [source]
    2 in Ontario: a woman in her 70s with travel history to Egypt and a man in his 50s who returned from Iran [source]
  • 1 new case in Ireland “a female in the east of the country and is associated with travel from northern Italy.” Dr Tony Holohan, Ireland’s chief medical officer told Reuters.
  •  1st case in Chile [source]
  •  1st case in North Carolina, United States. [source]Authorities said the case is linked to the Life Care Center in Kirkland, northeast of Seattle, where 5 residents (among the about 200 people living or working there), got infected and later died of the virus.[source]
  • 6 new cases in the United Arab Emirates. [source] Schools closed for 4 weeks [source] Concerts, sports events cancelled to reduce the spread of coronavirus [source]
  • Kenya suspends flights from Milan and Verona, Italy. [source]
  • 3 new cases in Algeria [source]
  • 1 new case in Senegal [source]
  • 6 new cases in Denmark including: [source]
    2 who had been on holiday in Northern Italy and both returned to Denmark on Saturday, Feb. 29 [source]
  • 2 new cases in Portugal: one in Lisbon and another one in Porto [source]
  • 1 new case in Estonia [source]
  • 6 new cases in Sweden, all in Stockholm [source]
  •  3 new deaths in the United States: for a total of 9 deaths, all in Washington State [source]
  • USA: a total of 108 cases and 6 deaths have been officially confirmed in 12 states of the United States[source]
    – 60 domestic cases (of which 22 travel-related, 11 person-to-person spread , and 27 under investigation)
    – 48 among persons repatriated (45 from the Diamond Princess cruise ship, and 3 from Wuhan, China)
  •  45 new cases and 1 new death (first in the country) in Spain [source]
  •  1st case in Argentina [source]
  • 5 new cases in Iraq [source]
  •  466 new cases and 27 new deaths in Italy, for a total of 2,502 cases and 79 deaths to date. [source] [source]
    Among the 2,263 active cases, 1,034 (46%) are hospitalized, 229 of which (representing 10% of active cases) are in intensive care.
    Among the 239 closed cases, 160 (67%) have recovered, 79 (33%) have died.
  • 1st case in Liechtenstein: a young man who had contacts with an infected person in Switzerland. [source]
  • 1st case in Sweden has recovered: a 20 year-old woman who had tested positive to the virus on Jan. 31 after returning home from Wuhan in China on Jan. 24. [source]
  • 6 new cases in Austria [source] [source]
  •  851 new cases and 4 new deaths in South Korea [source] [source] [source]
  •  21 new cases and 1 new death in France [source]
  • 2 new cases in Oman: all related to travel to Iran, four are Iranian nationals and two are Bahraini citizens [source]
  • 2 new cases in Iceland, and 1 new recovery (the first confirmed case in the country). The two new cases had boarded flights from Verona in Italy on Saturday and had stayed in ski areas in northern Italy[source]
  • 12 new cases in the UK. [source] The government is working on the basis that it will take 2 – 3 months after the first sustained human to human transmission for the outbreak to peak. That potentially key point on time frames was spelled out by Britain’s chief scientific adviser, Sir Patrick Vallance. After that, it would take another 2 – 3 months for it to taper off[source]1st case in Gibraltar. a person who had recently returned from Northern Italy. Recovery is proceeding well” [source] Public Health England previously reported the number of cases for March 2 as 40, however this dropped to 39 after a patient diagnosed over the weekend had a confirmatory test come back negative.  [source]
  • 2 new cases in Singapore [source]
  • China: Travelers from the virus hotspots of South KoreaJapanIran, and Italy arriving in the capital will have to be isolated and placed in a 14-day quarantine, a Beijing official said. Shanghai and Guangdong announced similar restrictions earlier. [source] Out of the 11 new cases confirmed in China outside of Hubei yesterday, 7 where Chinese citizens returning from Italy. They worked at a restaurant in Bergamo and were close contacts with a previous case [source]
  • 1 new case in Romania: a man from Timisoara, who came in contact with an already diagnosed patient, who recently returned from Italy [source]
  • 1 new cases in Croatia [source]
  • 2 new cases in San Marino [source]
  • 5 new cases in the Netherlands (an additional one previously reported was later retracted) [source]
  • 7 new cases in Belgium [source]
  • 8 new cases in Norway [source] [source]
  • 31 new cases in Germany [source]
  • 9 new cases in Sweden: 4 in  Stockholm County, 3 in Gothenburg County, 1 in Skane County, and 1 in Jonkoping County. All cases are linked to travel in Northern Italy[source] [source]
  •  1st case in Ukraine: a man who traveled from Italy, now hospitalized since Saturday, Feb. 29 n the western city of Chernivtsi.
  •  835 new cases, 11 new deaths, and 144 new recoveries in Iran [source]
  • 1 new case in the Czech Republic: a classmate of an infected American woman in Prague. She had tested negative the first time. The first Czech fell ill after returning from an Italian university.[source]
  • 28 new cases in Switzerland[source]
  • 6 new cases in Australia, of which at least 4 in New South Wales [source]
  • (2 new cases in Portugal, a 24-year-old doctor and a doctor from Vila Real, have not been confirmed[source]
  • 1 new case in India: the wife of the Italian tourist in Jaipu who tested positive yesterday. [source]
  • 1 new case in Qatar:  a Qatari citizen who was evacuated from Iran by Qatar on a private plane on Feb. 27. [source]
  • 1 new case and 1 new discharge in Hong Kong [source]
  • 7 new cases in Malaysia [source]
  • 1 new case in Taiwan [source]
  • 1 new case in Pakistan [source]
  • 19 new cases in Japan [source] [source] [source] [source] [source]
  • 8 new cases in the United States including:
    1 in New York [source]
    2 in Georgia
    : an individual who was in Milan, Italy and a close contact in the household. [source]
    1 in Massachusetts: a woman in her 20s who lives in Norfolk County and recently traveled to Italy with a school group. She is recovering at home. [source]
  • 1 new case in Ecuador [source]
  • 1 new case in Australia (Queensland) [source]
  • 125 new cases31 new deaths (all in Hubei) and 2,742 new discharges occurred in China on March 2, as reported by the National Health Commission (NHC) of China. [source]

[back to top ↑]

March 2:

  •  1st case in Morocco: a Moroccan national, resident of Italy, currently in stable condition in the isolation unit of Moulay Youssef Hospital in Casablanca. [source]
  •  22 new cases and 5 new deaths in the United States:
    9 cases and 5 deaths in Washington State. Deaths include: a man in his 70s, in Kirkland, King County, with underlying health conditions[source] Cases include: a man in his 40s hospitalized in critical condition in Kirkland. [source]
    1 in Illinois
    : a woman in her 70s, wife of the third case. She is in good condition and quarantined at home. [source]
    1 in New Hampshire
    : an adult from Grafton County who had recently visited Italy [source] [source]
    former passenger of the Diamond Princess cruise ship
    1 in Rhode Island
    , a teenager contact of the previous case. An additional contact is being tested. All three people went on the same trip to Italy. This is precisely why we are being so aggressive in identifying contacts, ensuring monitoring, and testing people who are symptomatic.” [source]
    4 in California:
    – 1 in Placer County 
    [source]
    – 3 
    in Santa Clara County, including a couple who has recently traveled to Egypt[source]
    2 in Oregon
    :
    – 1 is an adult resident from Umatilla County hospitalized in Walla Walla, WA. [source]
    – 1 is a contact of the first case in Oregon, recovering at home. [source]
    2 new cases (first) in Florida

    1 case
     (first) iNew York [source]
  • 1 new case in the Czech Republic
  • 1 new case in Finland
  • 2 new cases in Israel
  • 1 new case on the Diamond Princess cruise ship in Japan
  • 1 new case in Taiwan
  • 3 new cases in Canada (Ontario[source]
  • 3 new cases in Iceland: 2 women, 1 man in their 60s who arrived in the country on Saturday with Icelandair’s flight to Keflavik Airport from Verona, Italy[source]
  •  335 new cases and 11 new deaths in Italy, for a total of 2,036 cases and 52 deaths to date. Among the 1,835 active cases, 908 (49%) are hospitalized, 166 of which (representing 9% of active cases) are in intensive care. Among the 201 closed cases, 149 (74%) have recovered, 52 (26%) have died. [source] [source] Lombardy region urges people over 65 years of age to stay home and not go out for 2-3 weeks[source] New cases include:
    – Alessandro Mattinzoli, Councilor for Economic Development in Lombardy, has tested positive to the virus. All members of the council will undergo testing. [source]
    – a police officer in Rome who had been in contact with a friend from Lombardy. [source]
    – the first case in Sardinia, currently hospitalized in Cagliari. [source]
  •  61 new cases and 1 new death in France [source]
  • 1 new case in Sweden
  • 6 new cases in Norway: all 6 are linked to travel in outbreak areas. [source]
  •  1st case in Latvia
  •  1st case in Senegal
  •  1st case in Saudi Arabia: the person had come from Iran through Bahrain [source]
  • 2 new cases in Bahrain: 1 Bahraini citizen and 1 Saudi citizen. Both had traveled to Iran. [source]
  • 4 new cases in Qatar[source]
  • 3 new cases in India[source]
    1 in New Delhi (first case there) with travel history from Italy: a male passenger, who traveled from Vienna to Delhi.[source]
    a person in Telangana who traveled to Bengaluru from Dubai.
    an Italian national in the western Indian state of Rajasthan, a major tourist destination. [source]
  •  1st case in Tunisia: a 40-year-old Tunisian man who traveled from Italy[source] [sourceA week ago, Transport Minister Rene Trabelsi said they were considering whether to suspend some Italy flights, but nothing came of it. [source][source]
  • 3 new cases in Lebanon [source]
  • 6 new cases in Austria. [source] [source] [source]
  • 4 new cases in the UK [source]
  •  1st case in Jordan: a Jordanian coming from Italy.
  • 36 new cases in Spain. Total now exceeds 100. [source]
  • 2 new cases and 4 new discharges in Singapore[source]
  • 8 new cases in the Netherlands, almost all have traveled from northern Italy or are family contacts of a previous patient. [source] Cases include a 45-year-old woman in Helmond who returned from Lombardy, Italy. [source]
  • 1 new case in Russia (first in Moscow): a Russian citizen returning from Italy [source]
  •  First 2 cases in Portugal, both in Porto[source]
    – a 60-year-old man with “an epidemiological link to the north of Italy“, where he was on vacation. His first symptoms appeared on Feb. 29, and he is now hospitalized in stable condition at the Santo António Hospital in Porto.- a 33-year-old man with “an epidemiological link to Spain” whose symptoms appeared on Feb. 26 and is now at the Hospital de São João, in Porto.
  • 6 new cases in Belgium: all had returned from northern Italy [source]
  • UK: “It is likely that we will see in due course wide spread transmission in the UK. What we don’t know is exactly how wide spread that will be” Professor Paul Cosford from Public Health England told BBC [video]
  • 1 new case in Taiwan [source]
  • 18 new cases in Japan [source]
  •  523 new cases and 12 new deaths in Iran, Deputy Health Minister Alireza Raisi said in an announcement on state TV. [source]
  • 2 new cases in Iraq detected in Baghdad’s Rassafa district: they had recently visited Iran [source]
  • 6 new cases in Belgium: all had traveled to Italy[source]
  • 27 new cases in Germany [source]
  • 2 new cases in Spain (Barcelona): a 40-year-old woman and a 37-year-old man who came in contact with a German infected person. Both are in mild condition. [source]
  •  1st case in Andorra: a 20-year-old man who had been to Milan, Italy and was admitted to the Nuestra Señora de Meritxell Hospital on Saturday. Symptoms are light, according to the Andorran government. He will remain in the hospital until 2 negative tests are obtained within 24-48 hours. [source]
  • 1 new case in Croatia: believed to be connected to another case in Rijeka [source]
  • 10 new cases in Kuwait: all associated with travel to Iran and all in stable condition and recovering. [source]
  • 1 new death in Iran: a 71-year-old senior Iranian official, Seyyed Mohammad Mirmohammadi , who was a member of the sixth and seventh Iranian parliaments and was appointed in 2017 by Iran’s Supreme Leader Ayatollah Khamenei as a member of the Expediency Discernment Council. [source]
  • 4 new cases in Australia:
    first in Tasmania: a man who had recently returning from Iran[source]
  • 1 new case in Thailand: a 22-year-old Thai woman who works with another Thai patient, a Thai driver for foreign tourists. [source]
  • 599 new cases and 5 deaths in South Korea[source] [source] [source]
  • 202 new cases42 new deaths (all in Hubei) and 2,837 new discharges occurred in China on March 1, as reported by the National Health Commission (NHC) of China. [source]

March 1:

EUROPE
  •  7 new cases and 1 death in San Marino: a 88-year-old man who was hospitalized in Rimini since Feb. 25 [source]
  • 51 new cases in Germany, including the first in Berlin [source] [source]
  • 1 new case in Denmark: a close contact of the previously confirmed case of a man who had returned from a skiing holiday in Northern Italy on Feb. 15 and became ill with cough and fever on Feb. 18. The man called his physician on Feb. 27 – nine days after the first symptoms – and was then referred to Rigshospitalet, where a throat swab confirmed that the person was infected. [source]
  • 26 new cases in Spain for a total of 84 cases, of which 5 in critical condition. [source]
  •  1st case in Scotland (UK) a “resident of the Tayside area and has recently travelled from northern Italy” [source]
  • 12 other new cases in the UK [source]
    – 6 had traveled to Italy
    – 2 had traveled to Iran
    – 3 are close contacts of a known case
    – 1 (in Essex) has no travel history and no clear link to cases. Being investigated.
  • 30 new cases in France. Among the 114 active cases, 9 (8%) are in critical condition. Among the 14 closed cases, the outcome has been: 12 discharged (86%) and 2 deaths (14%).
     Schools closed in 9 Oise municipalities (where there are 47 cases)
    – French authorities invite to “postpone non-essential trips outside the EU
    In terms of distribution, 72 are part of a chain of transmission or a cluster, 35 are returning from areas abroad where the virus is circulating, 23 recent cases are under investigation, 7 have been detected by the systematic test for severe pneumonia or acute respiratory distress,” said Jérôme Salomon, Director of Health. [source]
  •  573 new cases and 12 new deaths in Italy, for a total of 1,701 cases. Among the 1,577 active cases, 779 (49%) are hospitalized140 of which (representing 9% of active cases) are in intensive care. Among the 124 closed cases, 83 (67%) have recovered, 41 (33%) have died. The number of deaths reported in the press conference [source] [sourcewas later rectified from 34 to 41 (31 in Lombardy, 8 in Emilia Romagna, and 2 in Veneto), when Lombardy’s councilor corrected the initial report of 24 deaths to 31 deaths for Lombardy. [source] [source] The total number of cases has been adjusted as well, to reflect this correction.
  • 1 new case in Iceland: a man in his 60s who arrived from Verona, Italy, yesterday with Icelandair. [source]
  • 5 new cases in Finland: including an elderly person and a school-aged child, both related to a previous case who had travelled to northern Italy [source] [source]
  •  First 3 cases in Czech Republic. They had all recently traveled to Northern Italy: [source]
    • A 67-year-old man who attended a conference at the University of Udine, Italy, where the infection was confirmed in one of his Italian colleagues. He is now hospitalized in Bulovka, Prague.
    • A 20 year old woman from the USA who studies in Milan and was staying at an Airbnb in Prague. According to the Prime Minister, “She went to the hospital herself and we don’t want that,” Babis said.
    • a 43-year-old Czech national in Prague who returned from a ski holiday in Auronzo di Cadore in Veneto, Italy, a risky region. He traveled by car with his wife and four children, who are still asymptomatic but have been placed in home quarantine.
  • 3 new cases in the Netherlands
  • 1 new case in Belgium [source]
  • 4 new cases in Austria [source] [source]
  • 2 new cases in Norway [source]

UKCoronavirus outbreak could force UK to shut down entire cities, health secretary admits. He also said a research paper suggesting half a million people in the UK could die in the event of a flu pandemic was a “reasonable worst-case scenario.”

American Airlines has announced it is suspending flights to and from Milan, Italy from both New York and Miami from March 1, 2020 until April 25, 2020, citing reduced demand. The announcement comes only hours after the U.S. State Department said it was raising its travel warning to Level 4: Do Not Travel for parts of Italy due to the coronavirus outbreak. [source]

Mar. 1 News ↑ ]

MIDDLE EAST
  • 3 new cases in Israel.
  • 2 new cases in Qatar: they had both been evacuated from Iran on Feb. 27 [source]
  • 6 new cases in Bahrain: 3 female Bahraini nationals, 2 male Bahraini nationals and 1 male Saudi national, arriving at Bahrain International Airport via indirect flights from Iran[source]
  • 6 new cases in Iraq: 2 in Baghdad, 4 in Sulaimaniya. They had all recently traveled to Iran[source]
  • 3 new cases in Lebanon, all three had visited Iran.
  •  1st case in Armenia [source]
  • 1 new case in Kuwait
  •  385 new cases and 11 new deaths in Iran [source]

Mar. 1 News ↑ ]

AFRICA
  • 1 new case in Egypt: a foreigner citizen.
  • 3 new cases in Algeria[source] [source]
    2: a woman and her daughter aged 53 and 24 years respectively.
    1: An Italian citizen On Saturday, it was reported that another Italian national who tested positive for coronavirus on his arrival in Algeria had been transferred to his home country. [source] This came after Algeria announced on Tuesday that the 61-year-old Italian man, who works in projects involving Milan-based energy firm Eni, had become its first confirmed case of the virus.

Mar. 1 News ↑ ]

AMERICAS
  • 4 new cases in Canada (Ontario)
  • 1 new case in Ecuador
  • 5 new cases in the United States:
    2 in Washington State (bringing the total in King County to 6) both are in their 60s and in critical condition.
    1 in Rhode Island: a man in his 40s who had traveled to Italy in mid-February. He is a member of the community of Saint Raphael Academy in Pawtucket. [source]
    1 in illinois [source]
    1 in California (third in Santa Clara County) [source]
  • 1 new case in Mexico: first in Chiapas, a student who had traveled to Italy[source]
  •  1st case in the Dominican Republic, a 62-year old Italian citizen who entered the country on February 22nd. [source]

Mar. 1 News ↑ ]

OCEANIA
  •  1st death in Australia: a 78-year-old man in Perth who was among the 164 Australians flown out of Japan after being quarantined aboard the Diamond Princess cruise ship. His wife also tested positive to the virus and is currently in a stable condition in isolation at a Perth hospital.29 cases in Australia of which: [source]9 in Queensland
    6 in New South Wales
    9 in Victoria
    3 in South Australia
    2 in Western Australia15 have recovered
    10 are associated with the Diamond princess cruise ship
    9 are receiving medical treatment at home
    1 deathIncoming travel from Iran to Australia is banned starting Sunday. Appropriate level of travel advisory to Italy is being considered. But “it’s not possible to further isolate Australia,” said Chief Medical Officer Brendan Murphy, adding that the focus should be on detection and containment instead. [source]

Mar. 1 News ↑ ]

ASIA
  • 4 new cases and 2 new discharges iSingapore[source]
  •  1 new death in Thailand
  • 4 new cases in Malaysia: nurse among infected. [source]
  • 26 new cases and 1 new death in Japan: a man in his 70s in the Kushiro district in Hokkaido [source] [source]
  • 1 new case and 3 new discharges in Taiwan
  • 586 new cases, and 3 new deaths in South Korea. [source] [source] [source] [source]
  • 573 new cases35 new deaths (of which 34 in Hubei) and 2,623 new discharges occurred in China on Feb. 29, as reported by the National Health Commission (NHC) of China. [source]

Mar. 1 News ↑ ]

Timeline:

  • On February 3, two new cases were reported in Germany, one is the children of a family already infected with the virus.
  • On February 2, doctors in Thailand said they discovered medical treatment that cured a patient of coronavirus ‘in 48 Hours’
  • On February 2, a death in the Philippines marked the first death occurring outside of China. It was a 44-year-old Chinese man from Wuhan who was admitted to the hospital on Jan. 25 with fever, cough, and sore throat, developed severe pneumonia but in the last few days “was stable and showed signs of improvement; however, the condition of the patient deteriorated within his last 24 hours resulting in his demise.” reported the Philippine Department of Health.
  • On February 2, China shut down another major city as it closed roads and restricted the movement of residents in Wenzhou, a city with a population of 9 million that is located 800 km away from Wuhan, in Hubei province. The Zhejiang province, where Wenzhou is located, has the highest number of confirmed cases outside the Hubei province.
  • On February 1, the 8th case in the United States was reported (a male in his 20s, in Boston, MA).
  • On January 31, the first 2 novel coronavirus cases in the UK, [18] the first 2 cases in Russia, [20] and the first case in Sweden and in Spain were reported. Canada reported its 4th case.
  • On Jan. 31, the United States
    • declared Coronavirus a Public Health Emergency
    • issued 14 days quarantine rules for US citizens entering the US from China (mandatory if entering from the Hubei province).
    • issued an order to deny entry to foreigners who have traveled to China within the past two weeks.
  • On January 30, the novel coronavirus total case count surpassed that for SARS (which affected 8,096 people worldwide).
  • On January 30, the World Health Organization declared the coronavirus outbreak a Global Public Health Emergency.
  • On January 30 CDC confirmed the first US case of human to human transmission[17].
  • Germany, Japan, Vietnam and the United States have reported cases in patients who didn’t personally visit China, but contracted the virus from someone else who had visited Wuhan, China[15]. These cases of human to human transmission are the most worrisome, according to the WHO[16].
  • Wuhan (the city where the virus originated) is the largest city in Central China, with a population of over 11 million people. The city, on January 23, shut down transport links. Following Wuhan lock down, the city of Huanggang was also placed in quarantine, and the city of Ezhou closed its train stations. This means than 18 million people have been placed in isolation. The World Health Organization (WHO) said cutting off a city as large as Wuhan is “unprecedented in public health history.”[12and praised China for its incredible commitment to isolate the virus and minimize the spread to other countries.

How dangerous is the virus?

There are three parameters to understand in order to assess the magnitude of the risk posed by this novel coronavirus:

How contagious is the Wuhan Coronavirus? (Ro)

The attack rate or transmissibility (how rapidly the disease spreads) of a virus is indicated by its reproductive number (Ro, pronounced R-nought or r-zero), which represents the average number of people to which a single infected person will transmit the virus.

WHO’s estimated (on Jan. 23) Ro to be between 1.4 and 2.5. [13]

Other studies have estimated a Ro between 3.6 and 4.0, and between 2.24 to 3.58. [23].

Preliminary studies had estimated Ro to be between 1.5 and 3.5. [5][6][7]

An outbreak with a reproductive number of below 1 will gradually disappear.

For comparison, the Ro for the common flu is 1.3 and for SARS it was 2.0.

Fatality Rate (case fatality ratio or CFR) of the Wuhan Coronavirus

See full details: Wuhan Coronavirus Fatality Rate

The novel coronavirus’ case fatality rate has been estimated at around 2%, in the WHO press conference held on January 29, 2020 [16] . However, it noted that, without knowing how many were infected, it was too early to be able to put a percentage on the mortality rate figure.

A prior estimate [9] had put that number at 3%.

Fatality rate can change as a virus can mutate, according to epidemiologists.

For comparison, the case fatality rate for SARS was 10%, and for MERS 34%.

Incubation Period (how long it takes for symptoms to appear)

See full details: COVID-19 Coronavirus Incubation Period

Symptoms of the novel coronavirus (2019-nCoV) may appear in as few as 2 days or as long as 14 (estimated ranges vary from 2-10 days, 2-14 days, and 10-14 days, see details), during which the virus is contagious but the patient does not display any symptom (asymptomatic transmission).

Age and conditions of Coronavirus cases

 See latest findings: Age, Sex, Demographics of COVID-19 Cases and Deaths

According to China’s National Health Commission (NHC), about 80% of those who died were over the age of 60 and 75% of them had pre-existing health conditions such as cardiovascular diseases and diabetes.[24]

According to the WHO Situation Report no. 7 issued on Jan. 27:

  • The median age of cases detected outside of China is 45 years, ranging from 2 to 74 years.
  • 71% of cases were male.

A study of 138 hospitalized patients with NCIP found that the median age was 56 years (interquartile range, 42-68; range, 22-92 years) and 75 (54.3%) were men.[25]

The WHO, in its Myth busters FAQs, addresses the question: “Does the new coronavirus affect older people, or are younger people also susceptible?” by answering that:

  • People of all ages can be infected by the new coronavirus (2019-nCoV).
  • Older people, and people with pre-existing medical conditions (such as asthma, diabetes, heart disease) appear to be more vulnerable to becoming severely ill with the virus.

Patient who died in the Philippines was a 44-year old male

The patient who died in the Philippines on February 2, in what was the first death occurring outside of China, was a 44-year-old Chinese man from Wuhan who was admitted on Jan. 25 after experiencing fever, cough, and sore throat, before developing severe pneumonia. In the last few days, “the patient was stable and showed signs of improvement, however, the condition of the patient deteriorated within his last 24 hours resulting in his demise.” according to the Philippine Department of Health.

Serious Cases of 30 year old patients in France

As of Jan. 29, according to French authorities, the conditions of the two earliest Paris cases had worsened and the patients were being treated in intensive care, according to French authorities. The patients have been described as a young couple aged 30 and 31 years old, both Chinese citizens from Wuhan who were asymptomatic when they arrived in Paris on January 18 [19].

Age and Sex of the first deaths as reported by the China National Health Commission (NHC)

The NHC reported the details of the first 17 deaths up to 24 pm on January 22, 2020. The deaths included 13 males and 4 females. The median age of the deaths was 75 (range 48-89) years.[21]

WHO Risk Assessment: Global Emergency

See full details: WHO coronavirus updates

On January 30, the World Health Organization declared the coronavirus outbreak a Global Public Health Emergency.

For more information from the WHO regarding novel coronavirus: WHO page on Novel Coronavirus (2019-nCoV)

Comparisons:

  • Every year an estimated 290,000 to 650,000 people die in the world due to complications from seasonal influenza (flu) viruses. This figure corresponds to 795 to 1,781 deaths per day due to the seasonal flu.
  • SARS (November 2002 to July 2003): was a coronavirus that originated from Beijing, China, spread to 29 countries, and resulted in 8,096 people infected with 774 deaths (fatality rate of 9.6%). Considering that SARS ended up infecting 5,237 people in mainland China, Wuhan Coronavirus surpassed SARS on January 29, 2020, when Chinese officials confirmed 5,974 cases of the novel coronavirus (2019-nCoV). One day later, on January 30, 2020 the novel coronavirus cases surpassed even the 8,096 cases worldwide which were the final SARS count in 2003.
  • MERS (in 2012) killed 858 people out of the 2,494 infected (fatality rate of 34.4%).

Novel Coronavirus Worldometer Sections:

More info

Sources

  1. Novel Coronavirus (2019-nCoV) situation reports – World Health Organization (WHO)
  2. 2019 Novel Coronavirus (2019-nCoV) in the U.S. -. U.S. Centers for Disease Control and Prevention (CDC)
  3. Outbreak Notification – National Health Commission (NHC) of the People’s Republic of China
  4. Novel coronavirus (2019-nCoV) – Australian Government Department of Health
  5. Novel coronavirus 2019-nCoV: early estimation of epidemiological parameters and epidemic prediction – Jonathan M. Read et al, Jan. 23,2020.
  6. Early Transmissibility Assessment of a Novel Coronavirus in Wuhan, China – Maimuna Majumder and Kenneth D. Mandl, Harvard University – Computational Health Informatics Program – Posted: 24 Jan 2020 Last revised: 27 Jan 2020
  7. Report 3: Transmissibility of 2019-nCoV – 25 January 2020 – Imperial College London‌
  8. Case fatality risk of influenza A(H1N1pdm09): a systematic review – Epidemiology. Nov. 24, 2013
  9. A novel coronavirus outbreak of global health concern – Chen Want et al. The Lancet. January 24, 2020
  10. Symptoms of Novel Coronavirus (2019-nCoV) – CDC
  11. China’s National Health Commission news conference on coronavirus – Al Jazeera. January 26, 2020
  12. Wuhan lockdown ‘unprecedented’, shows commitment to contain virus: WHO representative in China – Reuters. January 23, 2020
  13. Statement on the meeting of the International Health Regulations (2005) Emergency Committee regarding the outbreak of novel coronavirus (2019-nCoV) – WHO, January 23, 2020
  14. International Health Regulations Emergency Committee on novel coronavirus in China – WHO, January 30, 2020
  15. Human-to-human transmission of Wuhan virus outside of China, confirmed in Germany, Japan and Vietnam – The Online Citizen, Jan. 29, 2020
  16. Who: “Live from Geneva on the new #coronavirus outbreak”
  17. CDC Confirms Person-to-Person Spread of New Coronavirus in the United States – CDC Press Release, Jan. 30, 2020
  18. CMO confirms cases of coronavirus in England – CMO, UK, Jan. 31, 2020
  19. Coronavirus in France: what you need to know – The Local France, Jan. 31, 2020
  20. First two persons infected with coronavirus identified in Russia – Tass, Jan. 31, 2020
  21. Updated understanding of the outbreak of 2019 novel coronavirus (2019nCoV) in Wuhan, China – Journal of Medical Virology, Jan. 29, 2020
  22. Estimating the effective reproduction number of the 2019-nCoV in China – Zhidong Cao et al., Jan. 29, 2020
  23. Preliminary estimation of the basic reproduction number of novel coronavirus (2019-nCoV) in China, from 2019 to 2020: A data-driven analysis in the early phase of the outbreak – Jan. 30, 2020
  24. Coronavirus: Window of opportunity to act, World Health Organization says – BBC, Feb,\. 4, 2020
  25. Clinical Characteristics of 138 Hospitalized Patients With 2019 Novel Coronavirus–Infected Pneumonia in Wuhan, China – Wang et. al, JAMA, Feb. 7, 2020
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In creating a coronavirus vaccine, researchers prepare for future

In creating a coronavirus vaccine, researchers prepare for future

Transmission electron micrograph of SARS-CoV-2 virus particles. Credit: NIAID

As the number of novel coronavirus infections rises daily across the globe, strategies for developing a safe and effective vaccine are rapidly moving forward.

In response to this public health crisis, researchers in the Precision Vaccines Program (PVP) at Boston Children’s Hospital are on the front lines of developing a vaccine specially targeted toward older populations—those who are at greatest risk of developing coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome-2 coronavirus (SARS-CoV-2).

According to the World Health Organization, older people and people with preexisting medical conditions appear to be more vulnerable to becoming severely ill with COVID-19.

“Elderly individuals have a different  than healthy middle-aged adults and often do not respond as robustly to immunization, so a one-size vaccine does not fit all,” said Ofer Levy, professor of pediatrics at Harvard Medical School and director of the PVP.

Focusing on adjuvants

The current antigen used for  is the coronavirus spike protein, so named because it sits atop the spike of a coronavirus particle. This is the part of the virus that the immune system “remembers.”

Vaccine-induced antibodies, made by the immune system against the spike protein, can prevent infection.

PVP’s strategy is to combine the coronavirus spike protein with adjuvants: small molecules added to a vaccine to boost the recipient’s immune response.

“Overall, we are hoping that a precision adjuvant approach will assist the various ongoing vaccine efforts across the globe,” said Levy. “Adjuvants can be crucial for getting a stronger, longer-lasting, broader immune response, especially among those with weakened immunity, like the elderly.”

The team’s approach is unusual in the range and novelty of adjuvants they will screen, said Levy.

In addition to a collection of known vaccine adjuvants, the team will test new adjuvants it has discovered in the PVP’s National Institutes of Health-funded Adjuvant Discovery Program.

“These adjuvants were discovered by screening against ,” said Levy. “This species-specific approach represents an example of precision vaccinology.”

Age-specific

The PVP plans on testing a variety of adjuvants and adjuvant combinations in human white blood cells sourced from older people. Researchers will then study the adjuvant-induced immune responses.

“Our screen, comparing individual and combination adjuvants with and without the coronavirus antigen, will identify an adjuvant combination that most effectively induces an optimal immune response in the elderly,” Levy said. These screens will start immediately and continue over the next six to eight weeks.

“We’re hoping to have a clear signal within the next few months which adjuvanted vaccine to go forward with in clinical testing,” he added.

Typically, adjuvant-based vaccine research does not consider species or age in the discovery and early development phases.

“Our use of age-specific human in vitro systems to de-risk and accelerate an adjuvanted vaccine tailored to the elderly is novel,” said Levy. “In this way, we are bringing precision medicine to vaccinology.”

Adjuvants could also be a cost-saving strategy, the authors said, because the antigen is typically the most expensive part of a vaccine.

“If we want to be able to provide billions of vaccine doses, adjuvants can be the answer as they enhance the immune system so much less antigen is needed to get a protective immune response,” said Levy.

Testing in mice

The group is also studying coronavirus immune responses in a living animal model.

The first mice have already been inoculated with a similar coronavirus spike protein derived from the SARS-2003 coronavirus with or without a lead adjuvant combination to get an early read on measuring an antibody response.

Several leading laboratories are providing essential input to the PVP in efforts to develop an effective, targeted coronavirus vaccine that works well for older individuals:

  • Barney Graham, deputy director of the Vaccine Research Center at the National Institute of Allergy and Infectious Diseases (NIAID), provided the coronavirus spike protein to the PVP a few weeks ago.
  • Florian Krammer at the Icahn School of Medicine at Mount Sinai provided SARS-CoV-2 virus from the current strain.
  • Peter Hotez and Maria Bottazzi at Baylor University contributed antigen from the 2003 SARS outbreak.
  • Lindsey Baden, director of clinical research at Brigham and Women’s Hospital, provided blood samples from elderly patients.

Envisioning a seasonal coronavirus vaccine

Looking ahead, the PVP is looking to create a vaccine platform and systematic program that would facilitate vaccine development in any future coronavirus outbreaks.

“Dr. Anthony Fauci, director of the NIAID, has warned of the potential of SARS-CoV-2 to become a seasonal virus like flu,” said David Dowling, instructor in pediatrics at HMS and a member of the PVP. “If so, the biomedical community may need to consider developing a multivalent yearly seasonal vaccine effective against multiple coronaviruses.”

As ongoing international surveillance identifies circulating coronavirus strains, the PVP envisions collaborating with other laboratories to obtain corresponding viral spike proteins and modeling responses of the elderly to different adjuvant/antigen combinations to determine which is most effective.

Three COVID-19 vaccine concepts

Levy and Dowling estimate that more than 24 COVID-19 vaccine candidates are in development globally. These vaccines fall into three general types:

  • RNA-based vaccines. The first COVID-19 vaccines in development have used SARS-CoV-2 RNA. “This approach is innovative and attractive, but even if proven effective it may be difficult to create hundreds of millions of doses, and each dose may be relatively expensive as it may require a fair amount of RNA,” said Dowling. “While there is less experience with human testing for this approach, it is possible that adjuvants may help enhance the immune response when such vaccines are administered to older populations and may reduce the amount of RNA needed in each vaccine.”
  • DNA-based technology. Like RNA-based vaccines, this promising approach uses the genetic material of the virus to produce a vaccine. “You can make more vaccine doses with DNA than with RNA, but it is unclear whether the production could be rapidly scaled to meet the massive international demand,” said Dowling. “And, to our knowledge, these nucleic acid vaccines have not yet been tested in elderly patients either.”
  • Building on earlier coronavirus vaccines. This is the approach PVP is taking: learning from earlier vaccines from prior coronavirus outbreaks and making them more effective. “If you add an  chosen specifically for optimal activity in an older population, not only does it work better in that group, but it may dramatically reduce the cost per  dose by reducing the amount of antigen required,” said Dowling.

Explore further

When will there be a coronavirus vaccine? 5 questions answered


Provided by Harvard University

This story is published courtesy of the Harvard Gazette, Harvard University’s official newspaper. For additional university news, visit Harvard.edu.

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