Novavax to Develop COVID-19 Vaccine with Initial $4M Budget from CEPI @ Engineered Virus Might be Able to Block Coronavirus Infections, Mouse Study Shows @ Coronavirus: Can Diet Help? @ Liu, X., & Wang, X.-J. (2020). Potential inhibitors for 2019-nCoV coronavirus M protease from clinically approved medicines. BioRxiv, 2020.01.29.924100. &@ Harvard geneticist George Church has been assembling a list of genetic mutations that could give people longer lives and superhuman powers. @ Do not underestimate the power of human intelligence – Não subestime o poder da inteligência humana @ It’s World Rat Day In The Year Of The Rat: Gratitude For Rats’ Role In Biomedical Advances @ The woman who discovered the first coronavirus @ Can the Coronavirus Be Cured by Stem Cells? @ Significância estatística / Statistical significance @ Não houve diferença estatística significativa. E agora? & There was no statistically significant difference. And now? @ How to Write & Publish a Successful Research Paper (PART 1) – YouTube Video @ Drug compound used to overcome chemotherapy resistance in mice & CRISPR DX, CRISPR TOOLBOX, GENOME EDITING – Discoveries from the field of metagenomics & Human-Centered Artificial Intelligence Stanford University – Treating COVID-19: How Researchers Are Using AI to Scale Care, Find Cures, and Crowdsource Solutions – By Sachin Waikar April 6, 2020 – Experts offer insights on combating the coronavirus during Stanford HAI’s COVID-19 and AI Conference. & The Artificial Intelligence Debate: Is It Time for AI Regulation? @ Links about ´´my´´ dissertation, my monograph and animal models for human diseases like cardiovascular diseases @& VERY IMPORTANT LINKS, WEBSITES, IMAGES AND TEXTS OF THE WORLD


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  • – > Mestrado – Dissertation – Tabelas, Figuras e Gráficos – Tables, Figures and Graphics – ´´My´´ Dissertation @ #Innovation #energy #life #health #Countries #Time #Researches #Reference #Graphics #Ages #Age #Mice #People #Person #Mouse #Genetics #PersonalizedMedicine #Diagnosis #Prognosis #Treatment #Disease #UnknownDiseases #Future #VeryEfficientDrugs #VeryEfficientVaccines #VeryEfficientTherapeuticalSubstances #Tests #Laboratories #Investments #Details #HumanLongevity #DNA #Cell #Memory #Physiology #Nanomedicine #Nanotechnology #Biochemistry #NewMedicalDevices #GeneticEngineering #Internet #History #Science #World

Pathol Res Pract. 2012 Jul 15;208(7):377-81. doi: 10.1016/j.prp.2012.04.006. Epub 2012 Jun 8.

The influence of physical activity in the progression of experimental lung cancer in mice

Renato Batista Paceli 1Rodrigo Nunes CalCarlos Henrique Ferreira dos SantosJosé Antonio CordeiroCassiano Merussi NeivaKazuo Kawano NagaminePatrícia Maluf Cury


Impact_Fator-wise_Top100Science_Journals

GRUPO_AF1 – GROUP AFA1 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 1 – GROUP AFAN1 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO_AF2 – GROUP AFA2 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 2 – GROUP AFAN 2 – Anaerobic Physical Activity – Atividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

Slides – mestrado – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

CARCINÓGENO DMBA EM MODELOS EXPERIMENTAIS

DMBA CARCINOGEN IN EXPERIMENTAL MODELS

Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

https://pubmed.ncbi.nlm.nih.gov/22683274/

Abstract

Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.

´´We propose to change the default P-value threshold for statistical significance from 0.05 to 0.005 for claims of new discoveries.´´ https://www.nature.com/articles/s41562-017-0189-z Published:  Daniel J. Benjamin, James O. Berger, […]Valen E. Johnson Nature Human Behaviour volume 2, pages6–10 (2018)

Um mundo além de p < 0,05 « Sandra Merlo – Fonoaudiologia da Fluência

´´My´´ Monograph – ´´Minha´´ Monografia – Induction of benznidazole resistance in human Trypanosoma cruzi isolates – Indução de resistência ao benzonidazol em isolados humanos de Trypanosoma cruzi – UFTM – Federal University of Triangulo Mineiro – Uberaba 

Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo

Weird neutrino behavior could explain longstanding antimatter mystery @ CRISPR–Cas9 could allow ‘universal’ retinal cells for treating blindness – Researchers have found a way to enhance the production of retinal cells from ESCs, and also a method to allow them to remain undetected by the immune system. @ ‘We have a whole globe to protect’: Pandemic vaccine research speeds up @ CDC to launch clinical reporting app for COVID-19 in May @ SpaceX to launch NASA astronauts in historic mission – First privately owned and operated rocket to launch American astronauts – By James LeggateFOXBusiness @ Scientists in China have discovered more than 30 mutations of the new coronavirus, which they say may partly explain why it has been more deadly in certain parts of the world. @ FDA approves computer chip for humans – Devices could help doctors with stored medical information &amp; Rapid development of an inactivated vaccine for SARS-CoV-2 @ Coronavirus: Scientists in China find 33 mutations of virus in warning to vaccine developers – Researchers say vaccine developers need to consider the impact of these “accumulating mutations… to avoid potential pitfalls” – David Mercer, news reporter David Mercer – News reporter @DavidMercerSky – Wednesday 22 April 2020 06:08, UK &amp; Africa joins the race to trace COVID-19 with genomics @ Hundreds of People Volunteer to Be Infected with Coronavirus – Support grows for a controversial ‘human challenge’ vaccine study—but no trial is yet planned – By Ewen Callaway, Nature magazine on April 22, 2020 @ Virus Researchers Cast Doubt On Theory Of Coronavirus Lab Accident April 23, 20207:08 AM ET @ APRIL 21, 2020 More deaths, no benefit from malaria drug in VA virus study (Update) by Marilynn Marchione @ MIT community weighs in to address the coronavirus pandemic @ 04/25/2020 WBUR On Point: The Need For Innovation, Especially In A Crisis – The coronavirus pandemic has jump-started America’s innovation engine as companies, institutions and entrepreneurs step up to the challenge.

* Link about my monograph: Induction of benzonidazole resistance in human isolates of Trypanosoma cruzi: https://science1984.wordpress.com/2018/07/15/my-monography-chagas-disease-research-in-laboratory-2/

 

-Link about animal model diseases like cardiovascular diseases: https://science1984.wordpress.com/2020/04/29/33426/

 

– Links related with my dissertation: https://science1984.wordpress.com/2019/11/28/links-of-my-dissertation-the-influence-of-physical-activity-in-the-progression-of-experimental-lung-cancer-in-mice-and-monograph-induction-of-benzonidazole-resistance-in-human-isolates-of-trypanoso/

https://science1984.wordpress.com/2019/11/29/about-my-dissertation-the-influence-of-physical-activity-in-the-progression-of-experimental-lung-cancer-in-mice-pathol-res-pract-2012-jul-152087377-81-doi-10-1016-j-prp-2012-04-006-epub-20/

https://science1984.wordpress.com/2018/07/15/i-did-very-important-detailed-and-innovative-graphics-about-variations-of-all-mice-weigths-during-all-exerimental-time-my-dissertation-they-can-be-an-excelent-reference-for-future-researches-like-2/

https://science1984.wordpress.com/2019/03/08/it-is-fundamental-professors-students-researchers-and-other-people-worldwide-know-about-my-dissertation-because-the-research-was-very-innovative-and-important-in-the-world-these-data-like-graphics/

 

https://www.npr.org/sections/goatsandsoda/2020/04/23/841729646/virus-researchers-cast-doubt-on-theory-of-coronavirus-lab-accident?fbclid=IwAR0_CxQvklCK9Mrv9Ya54-SMyH2F23pOa3szI7xAsauvh_CzNfDzGohEXCw

https://medicalxpress.com/news/2020-04-deaths-benefit-malaria-drug-va.html?fbclid=IwAR0Ii7p7Cab7iA4349ll-RwUuo1bCevLRmcaKzh7q8Tpf34piA-6gpFPl0c

WBUR On Point: The Need For Innovation, Especially In A Crisis

https://www.techrepublic.com/article/mit-community-weighs-in-to-address-the-pandemic/

https://news.sky.com/story/coronavirus-has-mutated-into-more-than-30-strains-say-scientists-in-china-11976380?fbclid=IwAR3uxcaqFqQPBKpmYHuXp4e_CmZzdZyfLlH8M2keo92fthLzE-UhRhRbn-0

https://www.scientificamerican.com/article/hundreds-of-people-volunteer-to-be-infected-with-coronavirus/?utm_medium=social&utm_content=organic&utm_source=facebook&utm_campaign=SciAm_&sf233084850=1&fbclid=IwAR36q6rYjdu5VwdOJie5FiBopgk30yLejL3bxZdDglYDk6FJJ6op_1Wd5Os

https://theconversation.com/africa-joins-the-race-to-trace-covid-19-with-genomics-136427?fbclid=IwAR1Rt6Zhm73S27rykJrv0As7B1aQQ9yScv4Dmk4RqlIMRsomY2DkORxeyUE

https://www.biorxiv.org/content/10.1101/2020.04.17.046375v1?fbclid=IwAR1cvHqdnmsudUvwOGaAepfBRCeSor6tVd9O26T8RSgT7lYUL_Csp9Wmb4w

http://www.nbcnews.com/id/6237364/ns/health-health_care/t/fda-approves-computer-chip-humans?fbclid=IwAR26mjB3FsDoMnvGLO-wuDpTqUG69A0eFELo1qlqtcB9ZHDnkqM5zeWi9aw#.XqHUT8ij_IU

https://news.sky.com/story/coronavirus-has-mutated-into-more-than-30-strains-say-scientists-in-china-11976380?fbclid=IwAR3uxcaqFqQPBKpmYHuXp4e_CmZzdZyfLlH8M2keo92fthLzE-UhRhRbn-0

https://www.regmednet.com/users/346348-ebony-torrington/posts/64980-crispr-cas9-allows-universal-retinal-cells-for-treating-blindness?utm_source=Adestra&utm_medium=email&utm_term=&utm_content=READ%20MORE%20%E2%96%BA

http://www.google.com http://www.yahoo.com http://www.gmail.com http://www.forbes.com http://www.harvard.edu http://www.princeton.edu http://www.mit.edu http://www.stanford.edu http://www.ucla.edu http://www.nobelprize.org http://www.nasa.gov

https://www.foxbusiness.com/technology/spacex-launch-nasa-astronauts-historic-mission?fbclid=IwAR2Th3cBmC0uFKg_Fim6PQ_ddCZ22g6kGbUflOHcl-ceExWMHej4zt5PJkM

https://www.healthcaredive.com/news/cdc-to-launch-clinical-reporting-app-for-covid-19-in-may/576129/?hss_channel=fbp-508209262538427&fbclid=IwAR0xNlKXkvuHcbXEGuyMG24iTqcuskKGkyhHN8hNoLoGtPctBvJe5DPYIAA

https://www.cbc.ca/news/health/covid-vaccine-trials-accelerate-1.5533797?utm_content=126715614&utm_medium=social&utm_source=facebook&hss_channel=fbp-508209262538427&fbclid=IwAR1Jy33Ng9MccfjNIOqHCHtgU6hiN62j9b5PKfC9utV3GvvdfJMfNQfxB4Y

https://hai.stanford.edu/news/treating-covid-19-how-researchers-are-using-ai-scale-care-find-cures-and-crowdsource-solutions?sf120898296=1&fbclid=IwAR3p2G6RKBdp0q_jZVd2Lf_QwnDdrFO_MuFqAlTxa1qEqrjOlv4vvF1W3rE

https://www.space.com/antimatter-mystery-weird-neutrino-experiment.html?fbclid=IwAR0v3CdR-_iImPx16kOKYdwV3l8StwxbU0TvM2OUIeP0qUEUfuN83X3QfRA

The Artificial Intelligence Debate: Is It Time for AI Regulation?

https://mammoth.bio/2020/04/13/discoveries-from-the-field-of-metagenomics/?fbclid=IwAR175dqwphXoP4KcuB_owh3zcqKRMmIfT2RA6gLLVbkgkufPb_hDuYLwxKs

Drug compound used to overcome chemotherapy resistance in mice

Não houve diferença estatística significativa. E agora?

https://www.forbes.com/sites/tarahaelle/2020/04/04/its-world-rat-day-in-the-year-of-the-rat-gratitude-for-rats-role-in-biomedical-advances/?fbclid=IwAR2jyhWDPyDkgxTmsI1o9FiFkFf3MoidPb1S1qZjC4lC0SQr-VhGg38bAtk#49e0f9747e12

https://en.wikipedia.org/wiki/Statistical_significance

https://pt.wikipedia.org/wiki/Signific%C3%A2ncia_estat%C3%ADstica?fbclid=IwAR3sWwe-z3EqEqCbs108mqXvSqlaHHhXjSA5QuJ_NtejrcRLkOIUN47Ibd0

https://teletype.in/@theinsightpartners/koDDKqdCY?fbclid=IwAR2mLs5QbHrpbsoMskpHqOQCs36zwsiBN9z0QAcX8hJSnKt-0vBiGYMaMGU

https://www.bbc.com/news/uk-scotland-52278716?fbclid=IwAR33vgzy_8BblqUFBXzZlyBcB5wk6SO8HPXpaHpfWcHqJCalKSODkCqJQjE

https://futurism.com/the-byte/harvard-list-genes-superhuman?fbclid=IwAR1B7I84HAP1BqeJwkT3cdT5DIgIJ90NxDX4aBEKnBcokE9uGj4Gj8nnfJM

https://statnano.com/news/67561/Novavax-to-Develop-COVID-19-Vaccine-with-Initial-4M-Budget-from-CEPI?fbclid=IwAR0NpS9Jxa0OjU2wsNPT0Vy2fPfQFf_03N8XAPX2TvR-H_XvB1CWq-Obo0k

https://michaellustgarten.com/2020/04/11/sars-cov-2-can-diet-help-in-the-fight/?fbclid=IwAR1M5xM0Fr6n7mvZdkSaorIxDejCUCWcV7VhWVFuBdx-dvnPPPZ28UIRSYc

https://www.asm.org/Press-Releases/2020/Engineered-Virus-Might-be-Able-to-Block-Coronaviru?fbclid=IwAR3DlKchlYG-CeHoVyt8vInoui909JuQVqPGpfJYEc6GRs37EiPAdEx0M60

Liu, X., & Wang, X.-J. (2020). Potential inhibitors for 2019-nCoV coronavirus M protease from clinically approved medicines. BioRxiv, 2020.01.29.924100. https://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1007236

Flav_R03USDA Database for the Flavonoid Content of Selected Foods 

Sem título868456846545686856857573583357358358358757555675757754674574575486585684865854688788888888888888888888Sem título86578686VACCINE

 

 

 

Novavax to Develop COVID-19 Vaccine with Initial $4M Budget from CEPI

2020-04-10

(5)

starstarstarstarstar
Novavax to Develop COVID-19 Vaccine with Initial $4M Budget from CEPI

The Coalition for Epidemic Preparedness Innovations (CEPI), a foundation that finances independent research projects for developing vaccines against emerging infectious diseases, awarded $4 million to Novavax, Inc. – a USA-based clinical-stage vaccine company that develops novel products for preventing a broad spectrum of infectious diseases – to accelerate the development of a COVID-19 vaccine based on its proprietary recombinant protein nanoparticle technology platform to be soon delivered to the Phase 1 clinical trial.

Novavax, Inc., a late-stage biotechnology company developing next-generation vaccines for serious infectious diseases, today announced that the Coalition for Epidemic Preparedness Innovations (CEPI) awarded an initial funding of $4 million to support Novavax’ efforts to develop a COVID-19 vaccine. CEPI and Novavax are having ongoing discussions on additional funding from CEPI to address Novavax’ costs through Phase 1.“This first stage of funding from CEPI is critical to enable ongoing development of our COVID-19 vaccine candidates,” said Stanley C. Erck, President and Chief Executive Officer of Novavax. “We commend CEPI for its role as a vital partner to bridge the funding gap for innovative biotech companies like Novavax, which have robust vaccine technology platforms. Novavax is working tirelessly to create a vaccine against this growing epidemic.”

 

Novavax has produced and is currently assessing multiple recombinant nanoparticle vaccine candidates in animal models prior to advancing to clinical trials. Initiation of Phase1 clinical testing is expected in late spring of 2020. Novavax’ COVID-19 vaccine candidates were created with its proprietary recombinant protein nanoparticle technology platform to generate antigens derived from the coronavirus spike (S) protein. Novavax also expects to utilize its proprietary Matrix-M™ adjuvant with its COVID-19 vaccine candidates to enhance immune responses.

“The current crisis shows that we cannot prevent all infectious diseases from emerging. But we can and must double down on developing vaccines,” said Richard Hatchett, Chief Executive Officer of CEPI. “CEPI has moved quickly and urgently to coordinate with global health authorities and vaccine-development partners. CEPI is pleased to be partnering with Novavax to rapidly develop a potential vaccine candidate against the global threat posed by COVID-19.”

Novavax recently entered into an agreement with Emergent BioSolutions, Inc. (Emergent) to provide contract development and manufacturing services, supplying Novavax with vaccine product for preclinical testing and for use in its Phase 1 clinical trial. In addition, this arrangement offers the potential to leverage Emergent’s rapid deployment capabilities and expertise that provide Novavax scalability and capacity to produce vaccine product for future stockpiling. Emergent will utilize its two Baltimore, MD facilities to manufacture drug substance at its Bayview facility, designated by the U.S. Health and Human Services (HHS) as a Center for Innovation in Advanced Development and Manufacturing (CIADM), and drug product at its Camden facility.

 

Read the original article on GlobeNewswire.

 

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