University of Oxford coronavirus vaccine trial aims to have 500 people in testing by mid-May & Preliminary Study Claims To Have Discovered The First Significant Mutation In The SARS-CoV-2 Pathogen @ & A look back at medical advances in 2019 and the role played by animal research @ ´´What animals are used in coronavirus research? In the search for vaccines and treatments for Covid-19 animals can play an essential role in both basic research and testing. Various animal species are currently being bred and used as suitable models for predicting what effects a vaccine or treatment for Covid-19 may have on the human body.´´ @ COVID-19 vaccine protects monkeys from new coronavirus, Chinese biotech reports – By Jon Cohen – Apr. 23, 2020, 1:05 PM @ Scientists find genes can determine if you are at higher risk for fatal COVID-19 – John Anderer April 20, 2020 @ Very Important Images about Antiviral Drugs ´´From my experience, antiviral drugs work better early in illness vc later. Same probably true of convalescent plasma. This fig kind of show this, giving it early to inhibit viral replication vc late during host inflammatory response. So clinical trials need to control for this´´ Prof Peter Hotez MD PhD @PeterHotez Vaccine Scientist-Pediatrician-Author, Prof Dean @BCM_TropMed @TexasChildrens , Univ Prof @Baylor , Hagler Inst Advanced Study @TAMU , Founding Editor @PLOSNTDs @ Os bilionários que salvam o mundo com vacinas -> YouTube Video @ Links about ´´my´´ Dissertation, ´´my´´ Monograph and Animal Models for Human Diseases like Cardiovascular Diseases @ OTHER VERY IMPORTANT INFORMATION OF THE WORLD LIKE WEBSITES, LINKS, TEXTS AND IMAGES

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  • – > Mestrado – Dissertation – Tabelas, Figuras e Gráficos – Tables, Figures and Graphics´´My´´ Dissertation @ #Innovation #energy #life #health #Countries #Time #Researches #Reference #Graphics #Ages #Age #Mice #People #Person #Mouse #Genetics #PersonalizedMedicine #Diagnosis #Prognosis #Treatment #Disease #UnknownDiseases #Future #VeryEfficientDrugs #VeryEfficientVaccines #VeryEfficientTherapeuticalSubstances #Tests #Laboratories #Investments #Details #HumanLongevity #DNA #Cell #Memory #Physiology #Nanomedicine #Nanotechnology #Biochemistry #NewMedicalDevices #GeneticEngineering #Internet #History #Science #World

Pathol Res Pract. 2012 Jul 15;208(7):377-81. doi: 10.1016/j.prp.2012.04.006. Epub 2012 Jun 8.

The influence of physical activity in the progression of experimental lung cancer in mice

Renato Batista Paceli 1Rodrigo Nunes CalCarlos Henrique Ferreira dos SantosJosé Antonio CordeiroCassiano Merussi NeivaKazuo Kawano NagaminePatrícia Maluf Cury


Impact_Fator-wise_Top100Science_Journals

GRUPO_AF1GROUP AFA1 – Aerobic Physical Activity – Atividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 1GROUP AFAN1 – Anaerobic Physical ActivityAtividade Física Anaeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO_AF2GROUP AFA2 – Aerobic Physical ActivityAtividade Física Aeróbia – ´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

GRUPO AFAN 2GROUP AFAN 2 – Anaerobic Physical ActivityAtividade Física Anaeróbia´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

Slides – mestrado´´My´´ Dissertation – Faculty of Medicine of Sao Jose do Rio Preto

CARCINÓGENO DMBA EM MODELOS EXPERIMENTAIS

DMBA CARCINOGEN IN EXPERIMENTAL MODELS

Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo´´My´´ Dissertation Faculty of Medicine of Sao Jose do Rio Preto

https://pubmed.ncbi.nlm.nih.gov/22683274/

Abstract

Lung cancer is one of the most incident neoplasms in the world, representing the main cause of mortality for cancer. Many epidemiologic studies have suggested that physical activity may reduce the risk of lung cancer, other works evaluate the effectiveness of the use of the physical activity in the suppression, remission and reduction of the recurrence of tumors. The aim of this study was to evaluate the effects of aerobic and anaerobic physical activity in the development and the progression of lung cancer. Lung tumors were induced with a dose of 3mg of urethane/kg, in 67 male Balb – C type mice, divided in three groups: group 1_24 mice treated with urethane and without physical activity; group 2_25 mice with urethane and subjected to aerobic swimming free exercise; group 3_18 mice with urethane, subjected to anaerobic swimming exercise with gradual loading 5-20% of body weight. All the animals were sacrificed after 20 weeks, and lung lesions were analyzed. The median number of lesions (nodules and hyperplasia) was 3.0 for group 1, 2.0 for group 2 and 1.5-3 (p=0.052). When comparing only the presence or absence of lesion, there was a decrease in the number of lesions in group 3 as compared with group 1 (p=0.03) but not in relation to group 2. There were no metastases or other changes in other organs. The anaerobic physical activity, but not aerobic, diminishes the incidence of experimental lung tumors.

Data – Time – Database – Websites – Information – Respect – E-mails – Archives – Research – Reading – Probability – Innovations – Messages – Message @ Energy – Improvement – Probabilities – Intelligence – Technologies – Countries – Mind – Goals – Longevity – Science – Analysis – Work – Country – City – Money – Price – Cities – Life Experiences – Thinking – Communications – Cities – People – Friendship – Knowledgment – Friendships – Acts – Person – Health – Diseases – Lives – Time – Life – Write – Communication – Links – Humans – DNA – Link – Genetics – Thinking – RNA – Mice – Mouse – Speak – Type – Thoughts – Paper – Articles – Researches – Journal – Nature – Detail – Visibility – Journals – Magazines – References – Utility – Age – Efficiency – Reflections – Articles – Laboratory – Papers – Content – Issue – Subject – Phrases – Click – Affirmation – Imagination – Name – Issues – Thoughts – Details – Investigations – Intentions – Graphics – Science Events – Subjects – Blogs – Internet Society – Statistics – Interpretation – Reality – Society – Laboratories – Phrase – Affirmations – Questions – Virtuality – Investments – Graphics – Personal Opinions – Scientific Discoveries – Videos – Photos – Scientific Discovery – Opinion – Projects – Graphic -Economy – Money – Price – Impact – Context – Images – Ideas – History – Words – World @

Coronavirus clue? Most cases aboard U.S. aircraft carrier are symptom-free @ Trumpists Believe Bill Gates Is Using Coronavirus to Implant Brain Chips @ April 16 COVID-19 Update from Kent Scientific – Additional Questions? Our product specialists are here to help with additional information on our products, grant proposals, orders and more. Call 888-572-8887 – Link About Kent Scientific @ Animal Researches & Time & Countries @ History & Where Do New Genes Come From? @ Working in isolation to find a cure for COVID-19 – Li Hua is seeking drugs that can treat people infected with the coronavirus. @ Coronavirus: Scientists in China find 33 mutations of virus in warning to vaccine developers – Researchers say vaccine developers need to consider the impact of these “accumulating mutations… to avoid potential pitfalls” @ Como a imunologia pode contribuir pra o controle da COVID-19 – YouTube Video & A look back at medical advances in 2019 and the role played by animal research @ ´´What animals are used in coronavirus research? In the search for vaccines and treatments for Covid-19 animals can play an essential role in both basic research and testing. Various animal species are currently being bred and used as suitable models for predicting what effects a vaccine or treatment for Covid-19 may have on the human body.´´ @ COVID-19 vaccine protects monkeys from new coronavirus, Chinese biotech reports – By Jon Cohen – Apr. 23, 2020, 1:05 PM @ Scientists find genes can determine if you are at higher risk for fatal COVID-19 – John Anderer April 20, 2020

Coronavirus: Scientists in China find 33 mutations of virus in warning to vaccine developers – Researchers say vaccine developers need to consider the impact of these “accumulating mutations… to avoid potential pitfalls” @ Como a imunologia pode contribuir pra o controle da COVID-19 – YouTube Video

 

* Link about my monograph: Induction of benzonidazole resistance in human isolates of Trypanosoma cruzi: https://science1984.wordpress.com/2018/07/15/my-monography-chagas-disease-research-in-laboratory-2/

 

-Link about animal model diseases like cardiovascular diseases: https://science1984.wordpress.com/2020/04/29/33426/

 

– Links related with my dissertation: https://science1984.wordpress.com/2019/11/28/links-of-my-dissertation-the-influence-of-physical-activity-in-the-progression-of-experimental-lung-cancer-in-mice-and-monograph-induction-of-benzonidazole-resistance-in-human-isolates-of-trypanoso/

https://science1984.wordpress.com/2019/11/29/about-my-dissertation-the-influence-of-physical-activity-in-the-progression-of-experimental-lung-cancer-in-mice-pathol-res-pract-2012-jul-152087377-81-doi-10-1016-j-prp-2012-04-006-epub-20/

https://science1984.wordpress.com/2018/07/15/i-did-very-important-detailed-and-innovative-graphics-about-variations-of-all-mice-weigths-during-all-exerimental-time-my-dissertation-they-can-be-an-excelent-reference-for-future-researches-like-2/

https://science1984.wordpress.com/2019/03/08/it-is-fundamental-professors-students-researchers-and-other-people-worldwide-know-about-my-dissertation-because-the-research-was-very-innovative-and-important-in-the-world-these-data-like-graphics/

 

 

https://www.theladders.com/career-advice/scientists-find-that-genes-can-determine-if-you-are-at-higher-risk-for-fatal-covid-19?fbclid=IwAR2gLvsbcrGiyf7EM4-t-Cg_O5y_lkXLgKyU50LYaxte790IU6KYFIylXIs

VACCINE-VACCINES447VACCINES3333VACCINES7457VACCINES5436456VACCINES6454357

785559797979767976

https://www.eara.eu/post/a-look-back-at-medical-advances-in-2019-and-the-role-played-by-animal-research?fbclid=IwAR32gcXh68G1LrP-pOvc7jB9ix_YxqtbckRPGkB-PfTF0nLUPM_lSX7NCHg

https://www.linkedin.com/company/european-animal-research-association/

https://www.facebook.com/The.EARA/

https://www.sciencemag.org/news/2020/04/covid-19-vaccine-protects-monkeys-new-coronavirus-chinese-biotech-reports?fbclid=IwAR1XFDEdVOVUYQtXCWr1nlEHRqcGRmcAKnDkVXoK6Uy5VRMGXJRSvegBUhg#

https://www.eara.eu/post/what-animals-are-used-in-coronavirus-research

https://news.sky.com/story/coronavirus-has-mutated-into-more-than-30-strains-say-scientists-in-china-11976380?fbclid=IwAR3uxcaqFqQPBKpmYHuXp4e_CmZzdZyfLlH8M2keo92fthLzE-UhRhRbn-0

https://www.quantamagazine.org/where-do-new-genes-come-from-20200409/?fbclid=IwAR2JDfQ-j1DcmJ-Gt1P2GuddUmYq4Or5QI1wZSGKv6zxMnXmQWRkZxLtItE

https://www.kentscientific.com/

https://www.nature.com/articles/d41586-020-01026-z?fbclid=IwAR1-9gqAkseIOWqGTULxK97tOTiflXnAPpGIcJe8Pu6Ft9PacoRg6-xr4BQ

https://www.kentscientific.com/news/april-16-covid-19-update-from-kent-scientific/?utm_source=facebook&utm_medium=social&utm_campaign=4-17_covid&fbclid=IwAR1m1kWEDjb_G7rhVwjjlkAEt72cwjTFNIC0LgJ_q35zklTOIZw8S4uu3Rk

https://www.kentscientific.com/about/

https://www.msn.com/en-ca/news/newspolitics/trumpists-believe-bill-gates-is-using-coronavirus-to-implant-brain-chips/ar-BB12IZnS?ocid=sf2

https://www.reuters.com/article/us-health-coronavirus-usa-military-sympt-idUSKCN21Y2GB?fbclid=IwAR0MGNjRuuZaN3tmWDurSa9kO59KIdmxNQhu4nzbaqPWC_GtFqKfVIzQuV4

https://www.theguardian.com/world/2020/apr/17/world-biggest-drug-trial-covid-19-uk?fbclid=IwAR3YJJmhpbyQ0bM1ZsOCo_L2wR5CJHUHoej1l1dgyGEHetbzdNDPAf-qM4A

https://www.iflscience.com/health-and-medicine/preliminary-study-claims-to-have-discovered-the-first-significant-mutation-in-the-sars-cov-2-pathogen/?fbclid=IwAR1Zo0ovzq4XuW86dP2SE2T_ApAOK-KLIA7cCdYpAzzTGEuvVyU-FGnXM-o

https://finance.yahoo.com/news/university-oxford-coronavirus-vaccine-trial-132144256.html?utm_content=126717147&utm_medium=social&utm_source=facebook&hss_channel=fbp-508209262538427&fbclid=IwAR0a7v_zhAx0CUOYPl6LOBbCjJD2Fpl1y8Hx5VKnrwYZ1caPraxWbpXYWcQ

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U.S. markets closed

University of Oxford coronavirus vaccine trial aims to have 500 people in testing by mid-May

Darrell Etherington
TechCrunch
Chinese pathogen called Coronavirus or Covid-19, as a type of flu. Outbreak of coronavirus, which leads to death. Concept of a pandemic that infects the lungs, i.e. atypical pneumonia. 3D illustration

One of the largest COVID-19 vaccine trials currently underway will have over 500 volunteers actively testing its solution by the middle of next month. Researchers at the University of Oxford have already secured that number of participants, including a representative sample of people between the ages of 18 to 55, for a large-scale randomized clinical early and mid-stage trial of its potential vaccine, which uses a harmless, modified virus to trigger an immune response that is also effective against the novel coronavirus.

The trial will divide a total of 510 participant sent five groups, with one group receiving a follow-up, booster shot of the vaccine after the original does. The technology behind the vaccine has already been used in developing about 10 different other treatments, but will require an approach that includes setting up different test groups in different countries to ensure representative results, since infection rates are varying greatly place to place with prevention measures in place, study lead Sarah Gilbert told Bloomberg.

The team behind the vaccine is also still seeking additional funding to help scale manufacturing, since it aims to begin producing it in volume following the six month period this human trial phase will span. The goal is to have mass production up and running by this fall, under the assumption that the trial proves the potential vaccine effective, with a final stage trial of 5,000 people and the potential to begin providing some doses for use by frontline healthcare workers by as early as September.

The Oxford trial is one of just a handful that have progressed to the human testing phase, but more are coming online all the time. Existing clinical human trials from Moderna and Inovio are underway in the U.S., and those have also expressed the potential for earlier access for emergency use prior to broad rollout following the initial clinical results.

Even if there is some availability by fall of some of these vaccine candidates (and that assumes they even prove effective), that doesn’t mean they’ll be broadly available: That will still require further testing, and scaling manufacturing, as well as working out distribution and administration – all processes that will add months of work. Already, however, the unprecedented nature of the COVID-19 pandemic has resulted in new efficiencies in the development process, and more could follow in these extraordinary times.

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ADVERTISMENT

Preliminary Study Claims To Have Discovered The First Significant Mutation In The SARS-CoV-2 Pathogen

POLINA TOMTOSOVA/SHUTTERSTOCK

ADVERTISMENT

Rachael Funnell

16 APR 2020, 18:16

A preliminary study reports that a significant mutation in the SARS-CoV-2 pathogen may have been detected for the first time. Authors of the study, published on the website bioRxiv and not yet peer-reviewed, posit that if the mutations continue to occur, it could impact efforts to find a vaccine, but they told Newsweek they think this is unlikely due to the genome’s relatively stable nature compared to the SARS coronavirus.

The study looked at the genetic makeup of 106 samples of the Covid-19 pathogen from a database compiling information taken from infections across the globe. They then compared the information on the Covid-19 coronavirus with 39 genome sequences of the SARS coronavirus. SARS causes severe acute respiratory syndrome, which saw an outbreak in 2002.

Their investigations revealed that, despite having had a smaller impact on humanity, SARS actually contained higher genetic diversity with a greater rate of mutation compared to the Covid-19 pathogen, which was found to have a comparatively stable genome. The “first significant” mutation they did encounter was from a sample collected in India on January 27, 2020, which showed an alteration to the genome that appeared to make the pathogen less able to bind to a receptor on human cells called ACE2.

“A relatively stable genome of SARS-CoV-2 is a good indication for the epidemic control, as less mutation raises the hope of the rapid development of [a valid] vaccine and antiviral drugs,” wrote the authors.

The seasonal influenza (flu) has long been a headache for epidemiologists as a high mutation rate means that vaccinations become invalid from one flu season to the next (though there is promise that a universal vaccine may now be on the cards). Vaccines help the body to fight off serious illness by training our immune systems to recognize the pathogen once it enters our bodies. If the pathogen has mutated too significantly since the vaccine was developed, our immune cells won’t be able to recognize it and we’ll experience a more significant bout of illness.

If the SARS-CoV-2 genome is indeed stable, as the researchers believe their investigations indicate, then the mutation doesn’t necessarily spell bad news for vaccination efforts. A promising finding from the study was that the spike protein, which is a key feature that enables it to attack human cells, had stayed the same after the mutation.

The study has not yet undergone peer review, a vigorous process that establishes the methodology and results of the study are accurate. While this kind of publishing can help spur discussions, it also means concrete conclusions must be suspended until the research is validated.

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6 Comments

  1. Wow, fantastic blog layout! How long have you been blogging for? you make blogging look easy. The overall look of your website is great, as well as the content!

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