DMBA CARCINOGEN IN EXPERIMENTAL MODELS

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´´The world people need to have very efficient researches and projects resulting in very innovative drugs, vaccines, therapeutical substances, medical devices and other technologies according to the age, the genetics and medical records of the person. So, the treatment, disgnosis and prognosis will be very efficient and better, of course´´. Rodrigo Nunes Cal

https://science1984.wordpress.com/2021/08/14/do-the-downloads-of-very-important-detailed-and-innovative-data-of-the-world-about-my-dissertation-like-the-graphics-i-did-about-the-variations-of-weights-of-all-mice-control/

Mestrado – Dissertation – Tabelas, Figuras e Gráficos – Tables, Figures and Graphics

Impact_Fator-wise_Top100Science_Journals

GRUPO_AF1

GRUPO_AF2

GRUPO AFAN 1

GRUPO AFAN 2

Slides – mestrado

CARCINÓGENO DMBA EM MODELOS EXPERIMENTAIS

Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – ResumoMestrado – Dissertation – Tabelas, Figuras e Gráficos – Tables, Figures and GraphicsBaixarRedefine Statistical SignificanceBaixar

´´We propose to change the default P-value threshold for statistical significance from 0.05 to 0.005 for claims of new discoveries.´´ https://www.nature.com/articles/s41562-017-0189-z Published: 01 September 2017 Daniel J. Benjamin, James O. Berger, […]Valen E. Johnson Nature Human Behaviour volume 2, pages6–10 (2018)

Um mundo além de p < 0,05 « Sandra Merlo – Fonoaudiologia da Fluência

• I DID VERY INTERESTING, INNOVATIVE, IMPORTANT AND DETAILED GRAPHICS ABOUT VARIATIONS OF ALL MICE WEIGHTS OF DIFFERENT AGES DURING ALL EXPERIMENTAL TIME OF ´´MY´´ DISSERTATION. THEY´RE AVAILABLE IN THIS BLOG AND ARE VERY IMPORTANT TO THE SCIENTIFIC COMMUNITY!! THE DIFFUSION OF RELEVANT KNOWLEDGE IS ALWAYS ESSENTIAL FOR A COUNTRY PROGRESS. NEW SCIENTIFIC DISCOVERIES NEED TO EMERGE URGENTLY !! BELOW YOU CAN DO DOWNLOAD OF THESE GRAPHICS AND OTHER DOCUMENTS RELATED TO SCIENCE, TECHNOLOGY AND INNOVATION. SO, SHARE THESE GRAPHICS AND OTHER DOCUMENTS TO OTHER PEOPLE KNOW ABOUT IT AND PERHAPS USE THEM AS AN EXCELLENT REFERENCE IN THE SCIENTIFIC RESEARCHES. @ PERSON – PEOPLE – ANALYSIS – TIME – DATA – GRAPHICS – RESEARCHES – VISION – READING – SPEAKING – LISTENIG – INFORMATION – KNOWLEDGE – INTENTIONS – INNOVATIONS – CHANGES – DATA INTERPRETATIONS – NEW INNOVATIONS – INTERNET – BOOKS – GRAPHICS INTERPRETATIONS – GRAPHICS COMPARISONS – INFLUENCES – TIME – SUBSTANCES – DRUGS – VACCINES – NEW MEDICAL DEVICES – WORLD HISTORY – NEW TECHNOLOGIES – HUMAN ENERGY – WORK – NEW SCIENTIFIC DISCOVERIES – SCIENCE – GRAPHICS ANALYSIS – AGES – AGE – GENETICS – PHYSIOLOGY – MIND – MOLECULAR BIOLOGY – STATISTICS – BIOSTATISTICS – HUMAN LONGEVITY

Mestrado – ´´My´´ Dissertation – Tabelas, Figuras e Gráficos – Tables, Figures and Graphics

Impact_Fator-wise_Top100Science_Journals

GRUPO_AF1 – ´´my´´ dissertation

GRUPO_AF2 – ´´my´´ dissertation

GRUPO AFAN 1 – ´´my´´ dissertation

GRUPO AFAN 2 – ´´my´´ dissertation

Slides – mestrado – ´´my´´ dissertation

CARCINÓGENO DMBA EM MODELOS EXPERIMENTAIS

Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo – ´´my´´ dissertation

Positive Feedbacks by Facebook and Twitter about this Blog, like the very important, innovative and detailed graphics I did about variations of all mice weights (Control and Study Groups) of different ages during all experimental time of ´´my´´ dissertation. Note: I have received positive feedbacks about this Blog by LinkedIn, E-mails and Instagram too. @ Internet invitations I received by direct messages to participate in very important science events worldwide in less than 1 year because I participated of great researches in Brazil and other informations @ Links & The next step in nanotechnology | George Tulevski & Animated Nanomedicine movie @ Nanotechnology Animation & Powering Nanorobots & The World’s Smallest Robots: Rise of the Nanomachines & Building Medical Robots, Bacteria sized: Bradley Nelson at TEDxZurich @ Mind-controlled Machines: Jose del R. Millan at TEDxZurich & The present and future of brain-computer interfaces: Avi Goldberg at TEDxAsheville & Future of human/computer interface: Paul McAvinney at TEDxGreenville 2014 @ Bio-interfaced nanoengineering: human-machine interfaces | Hong Yeo | TEDxVCU @ Very important images, websites, social networks and links – https://science1984.wordpress.com/2019/03/17/feedbacks-on-facebook-related-to-researches-i-participated-in-brazil-for-example-the-graphics-i-did-about-variations-of-all-mice-weights-control-and-study-groups-of-different-ages-during-all-exper/

CARCINÓGENO DMBA EM MODELOS EXPERIMENTAIS

monografia – ´´my´´ monograph

Feedback positivo de pessoas sobre minha dissertação pelo Messenger – Facebook. Positive feedback of people about my dissertation, blog and YouTube channel by Facebook – Messenger. Ano – Year: 2018

My suggestion of a very important Project…

rodrigonunescal_dissertation

Apostila – Pubmed

LISTA DE NOMES – PEOPLE´S NAMES – E-MAIL LIST – LISTA DE E-MAILS

A Psicossomática Psicanalítica

O Homem como Sujeito da Realidade da Saúde – Redação

ÁCIDO HIALURONICO

As credenciais da ciência (1)

Aula_Resultados – Results

Frases que digitei – Phrases I typed

Nanomedicina – Texto que escrevi. Nanomedicine – Text I typed(1)

Nanomedicine123(2)57

Genes e Epilepsia

MÉTODOS DE DOSAGEM DO ÁCIDO HIALURÔNICO

microbiologia-famerp – Copia

Impact_Fator-wise_Top100Sciene_Journals

Positive feedback of people about my dissertation, blog and YouTube channel by Messenger (Facebook). Feedback positivo de pessoas sobre minha dissertação, blog e canal do YouTube pelo Facebook (Messenger) Year / Ano: 2018 – positive-feedback-of-people-about-my-dissertation-blog-and-youtube-channel-by-facebook-messenger-ano-year-2018

https://www.nih.gov/

https://www.alphaknockout.com/

https://www.fda.gov/ U.S. Food and Drug Administration

DNA and human cell research

Labmonk

Facts and Statistics About Animal Testing

´´Each year, more than 100 million animals—including mice, rats, frogs, dogs, cats, rabbits, hamsters, guinea pigs, monkeys, fish, and birds—are killed in U.S. laboratories for biology lessons, medical training, curiosity-driven experimentation, and chemical, drug, food, and cosmetics testing. Before their deaths, some are forced to inhale toxic fumes, others are immobilized in restraint devices for hours, some have holes drilled into their skulls, and others have their skin burned off or their spinal cords crushed. In addition to the torment of the actual experiments, animals in laboratories are deprived of everything that is natural and important to them—they are confined to barren cages, socially isolated, and psychologically traumatized. The thinking, feeling animals who are used in experiments are treated like nothing more than disposable laboratory equipment.´´ https://www.peta.org/issues/animals-used-for-experimentation/animals-used-experimentation-factsheets/animal-experiments-overview/

https://en.wikipedia.org/wiki/Animal_testing#:~:text=The%20earliest%20references%20to%20animal,the%20%22father%20of%20vivisection%22.

https://en.wikipedia.org/wiki/Animal_testing#:~:text=The%20earliest%20references%20to%20animal,the%20%22father%20of%20vivisection%22. ´´The earliest references to animal testing are found in the writings of the Greeks in the 2nd and 4th centuries BC. Aristotle and Erasistratus were among the first to perform experiments on living animals.[22] Galen, a 2nd-century Roman physician, dissected pigs and goats; he is known as the “father of vivisection”.[23] Avenzoar, a 12th-century Arabic physician in Moorish Spain also practiced dissection; he introduced animal testing as an experimental method of testing surgical procedures before applying them to human patients.[24][25]´´

https://www.genscript.com/

https://www.jax.org/jax-mice-and-services/find-and-order-jax-mice

https://www.sciencemag.org/news/2020/03/it-s-heartbreaking-labs-are-euthanizing-thousands-mice-response-coronavirus-pandemic

https://www.understandinganimalresearch.org.uk/animals/a-z-animals/mouse/

´´Mice are the most commonly used vertebrate animals in medical research. This trend looks likely to continue now that both mouse and human genomes have been mapped (80% of human genes are exactly the same as those found in mice, and at least a further 10% are very similar) allowing human genetic disorders and diseases to be studied with greater accuracy.´´

´´Often, the only way of determining the function of a human gene is to insert it into, or remove it from, the mouse genome. Many thousands of mouse strains now exist, some frozen as embryos. Eventually, such techniques could lead to new methods of preventing, treating or even curing genetic diseases and other diseases with a genetic component.´´

´´Around 87% of all genetically modified animals used in research in the UK are mice [UK 2019 figures].´´ https://www.understandinganimalresearch.org.uk/animals/a-z-animals/mouse/

´´More than 111 million mice and rats are used annually in U.S. biomedical research, according to a new study. That represents more than 99% of all lab animals.´´ https://www.sciencemag.org/news/2021/01/how-many-mice-and-rats-are-used-us-labs-controversial-study-says-more-100-million

https://www.reading.ac.uk/research/research-environment/animal-research.aspx

https://www.cyagen.com/us/en/service/humanized-knockin-mice.html?gclid=Cj0KCQjw–GFBhDeARIsACH_kdZ7-6N58Jl4pXEX8_NZMoTa4RENMY1WffWdpKGg9k7Gc9UmucnMTdcaAuNOEALw_wcB

https://www.cyagen.com/

Tel: 877-459-3975 or +1 408-969-0306 (Int’l) (8am-6pm Pacific Time)

Email: animal-service@cyagen.com (Animal Model Services)
animal-bank@cyagen.com (Cyagen Catalog Models)
cell-service@cyagen.com (Cell Products and Services)

https://en.wikipedia.org/wiki/Humanized_mouse

https://en.wikipedia.org/wiki/Humanized_mouse ´´Um camundongo humanizado é um camundongo que carrega genes, células, tecidos e / ou órgãos humanos em funcionamento. Camundongos humanizados são comumente usados ​​como modelos de pequenos animais em pesquisas biológicas e médicas para a terapêutica humana.´´

´´A humanized mouse is a mouse carrying functioning human genes, cells, tissues, and/or organs. Humanized mice are commonly used as small animal models in biological and medical research for human therapeutics.´´ https://en.wikipedia.org/wiki/Humanized_mouse

https://www.creative-biolabs.com/drug-discovery/therapeutics/humanized-mouse-models.htm?gclid=Cj0KCQjw–GFBhDeARIsACH_kdZAdFRE2h6OZ2dq7mcDroJ1JJZv-WK7J2lRtuSRVvMvEo5Bc3fVHr4aAjeeEALw_wcB

http://www.gempharmatech.com/en/market/mouse/39.html?gclid=Cj0KCQjw–GFBhDeARIsACH_kdbctRjY5EihlQESe0WeYToKdEuFofo610S0APG10WlG0kPX2AqaDP0aAq85EALw_wcB

https://www.kentscientific.com/

https://animalab.eu/partners/kent-scientific

https://www.fishersci.com/shop/products/mouse-surgical-kit/13005204

https://www.tigm.org/services/?gclid=Cj0KCQjw–GFBhDeARIsACH_kda2lTeIGaJO07yPD5I9vBkgGZChzRhRkWSnzDgXY8HtpLJ2hhohjRYaAiJTEALw_wcB

https://www.tigm.org/repository/ The World´s Largest Collection of C57 ES Cells and Mice

https://www.tigm.org/services/?gclid=Cj0KCQjw–GFBhDeARIsACH_kda2lTeIGaJO07yPD5I9vBkgGZChzRhRkWSnzDgXY8HtpLJ2hhohjRYaAiJTEALw_wcB

https://www.tigm.org/publications/

https://www.genome.gov/about-genomics/fact-sheets/Knockout-Mice-Fact-Sheet

• Open Access
• Published: 06 June 2017

One-step generation of complete gene knockout mice and monkeys by CRISPR/Cas9-mediated gene editing with multiple sgRNAs

• Erwei Zuo, 
• Yi-Jun Cai, 
• […]
• Hui Yang 

Cell Research volume 27, pages933–945 (2017)Cite this article

https://www.nature.com/articles/cr201781

doi: 10.1007/s13238-012-2932-6

• Junbing Wu^1,2 , 
• Shengyi Peng^1,2 , 
• Rong Wu^1,2 , 
• Yumin Hao^1,2 , 
• Guangju Ji¹ , 
• Zengqiang Yuan^1 , 

• 1 State Key Laboratory of Brain and Cognitive Sciences, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China;
• 2 College of Life Sciences, Graduate School of Chinese Academy of Sciences, Beijing 100049, China

http://www.protein-cell.org/en/article/doi/10.1007/s13238-012-2932-6?

https://www.eara.eu/?lang=pt European Animal Research Association

https://www.jax.org/about-us/where-we-work/china

´´In December, 2020, we announced the establishment of a joint venture company headquartered in Beijing, China. The newly constructed facility will increase accessibility and provide researchers in China with a more economical, convenient and immediate supply of JAX® Mice.´´https://www.jax.org/about-us/where-we-work/china

https://www.arca.fiocruz.br/handle/icict/42203

https://science1984.wordpress.com/2019/11/29/alphaknockout-gene-targeting-expert-system-is-made-possible-by-utilizing-the-computing-power-of-milkyway-2-of-national-super-computer-center-in-guangzhou-the-super-machine-rated-by-top500-ranking-a/

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Genotyping services

Proteomic-Based Cell Map Offers Ultra-Detailed Look at Cellular Organization

The Mighty Mouse: The Impact of Rodents on Advances in Biomedical Research

Mo Med. 2013 May-Jun; 110(3): 207–211.PMCID: PMC3987984NIHMSID: NIHMS570066PMID: 23829104

Elizabeth C. Bryda, PhD

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3987984/

https://www.thermofisher.com/br/en/home/life-science/cloning/gene-synthesis/geneart-gene-synthesis.html?ef_id=Cj0KCQjw–GFBhDeARIsACH_kdZjJmG4us6MSB7t6Fd-GD4U3pOu19FIhXOyt_9HptiCGKx9_cSBwJoaAuwKEALw_wcB:G:s&s_kwcid=AL!3652!3!430064204149!e!!g!!genscript&cid=bid_mol_gse_r01_co_cp1358_pjt0000_bid00000_0se_gaw_nt_con_con&gclid=Cj0KCQjw–GFBhDeARIsACH_kdZjJmG4us6MSB7t6Fd-GD4U3pOu19FIhXOyt_9HptiCGKx9_cSBwJoaAuwKEALw_wcB

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