DMBA CARCINOGEN IN EXPERIMENTAL MODELS

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´´The world people need to have very efficient researches and projects resulting in very innovative drugs, vaccines, therapeutical substances, medical devices and other technologies according to the age, the genetics and medical records of the person. So, the treatment, diagnosis and prognosis will be very efficient and better, of course´´. Rodrigo Nunes Cal

https://science1984.wordpress.com/2021/08/14/do-the-downloads-of-very-important-detailed-and-innovative-data-of-the-world-about-my-dissertation-like-the-graphics-i-did-about-the-variations-of-weights-of-all-mice-control/

Mestrado – Dissertation – Tabelas, Figuras e Gráficos – Tables, Figures and Graphics

Impact_Fator-wise_Top100Science_Journals

GRUPO_AF1

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GRUPO AFAN 1

GRUPO AFAN 2

Slides – mestrado

CARCINÓGENO DMBA EM MODELOS EXPERIMENTAIS

Avaliação da influência da atividade física aeróbia e anaeróbia na progressão do câncer de pulmão experimental – Summary – Resumo

Mestrado – Dissertation – Tabelas, Figuras e Gráficos – Tables, Figures and Graphics

Redefine Statistical Significance

´´We propose to change the default P-value threshold for statistical significance from 0.05 to 0.005 for claims of new discoveries.´´ https://www.nature.com/articles/s41562-017-0189-z Published: 01 September 2017 Daniel J. Benjamin, James O. Berger, […]Valen E. Johnson Nature Human Behaviour volume 2, pages6–10 (2018)

Um mundo além de p < 0,05 « Sandra Merlo – Fonoaudiologia da Fluência

American Statistical Association – https://www.amstat.org/

https://www.amstat.org/ASA/about/home.aspx?hkey=6a706b5c-e60b-496b-b0c6-195c953ffdbc

Positive Feedbacks by Facebook and Twitter about this Blog, like the very important, innovative and detailed graphics I did about variations of all mice weights (Control and Study Groups) of different ages during all experimental time of ´´my´´ dissertation. Note: I have received positive feedbacks about this Blog by LinkedIn, E-mails and Instagram too. @ Internet invitations I received by direct messages to participate in very important science events worldwide in less than 1 year because I participated of great researches in Brazil and other informations @ Links & The next step in nanotechnology | George Tulevski & Animated Nanomedicine movie @ Nanotechnology Animation & Powering Nanorobots & The World’s Smallest Robots: Rise of the Nanomachines & Building Medical Robots, Bacteria sized: Bradley Nelson at TEDxZurich @ Mind-controlled Machines: Jose del R. Millan at TEDxZurich & The present and future of brain-computer interfaces: Avi Goldberg at TEDxAsheville & Future of human/computer interface: Paul McAvinney at TEDxGreenville 2014 @ Bio-interfaced nanoengineering: human-machine interfaces | Hong Yeo | TEDxVCU @ Very important images, websites, social networks and links – https://science1984.wordpress.com/2019/03/17/feedbacks-on-facebook-related-to-researches-i-participated-in-brazil-for-example-the-graphics-i-did-about-variations-of-all-mice-weights-control-and-study-groups-of-different-ages-during-all-exper/

Positive feedback of people about my dissertation, blog and YouTube channel by Messenger (Facebook). Feedback positivo de pessoas sobre minha dissertação, blog e canal do YouTube pelo Facebook (Messenger) Year / Ano: 2018 – positive-feedback-of-people-about-my-dissertation-blog-and-youtube-channel-by-facebook-messenger-ano-year-2018

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http://www.unicamp.br http://www.twitter.com/CalZole http://www.cornell.edu http://www.uftm.edu.br/

https://www.indispensablesoma.info/who-is-marios-kyriazis​

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My Facebook Page: http://www.facebook.com/scientificblog

https://www.facebook.com/marios.kyriazis/

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Biogerentology.2017 Aug;18(4):711-715. doi: 10.1007/s10522-017-9680-1. Epub 2017 Feb 9.

Biological ageing and clinical consequences of modern technology

Marios Kyriazis ¹

https://pubmed.ncbi.nlm.nih.gov/28185019/

Who are the top 10 pharmaceutical companies in the world? (2020)
11/08/2020 Hannah Burke

https://www.proclinical.com/blogs/2020-8/the-top-10-pharmaceutical-companies-in-the-world-2020

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Ty Haqqi

September 13, 2020

https://finance.yahoo.com/news/10-biggest-pharmaceutical-companies-world-184321012.html

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Pharm Exec’s Top 50 Companies 2020

July 9, 2020Michael Christel

Pharmaceutical Executive, Pharmaceutical Executive-06-01-2020, Volume 40, Issue 6

https://www.pharmexec.com/view/pharm-execs-top-50-companies-2020

https://www.pharmaceutical-technology.com/features/top-ten-pharma-companies-in-2020/

google-site-verification=ZCx0AbfQWbzm-iXvCsaBE21zojBkOqDC-XbLhIL9rU8

https://www.pharmaceutical-technology.com/features/top-ten-pharma-companies-in-2020/

https://en.wikipedia.org/wiki/Disease https://en.wikipedia.org/wiki/Physiology

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https://en.wikipedia.org/wiki/Central_dogma_of_molecular_biology#Biological_sequence_information

https://en.wikipedia.org/wiki/Evolution https://en.wikipedia.org/wiki/Gene

https://en.wikipedia.org/wiki/Biology https://en.wikipedia.org/wiki/Life

https://en.wikipedia.org/wiki/Cell_(biology) https://en.wikipedia.org/wiki/Energy

https://en.wikipedia.org/wiki/RNA https://en.wikipedia.org/wiki/Genome

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https://en.wikipedia.org/wiki/Biotechnology https://en.wikipedia.org/wiki/Genomics

https://en.wikipedia.org/wiki/Genetics https://en.wikipedia.org/wiki/Genetic_variation

https://en.wikipedia.org/wiki/Mutation https://en.wikipedia.org/wiki/Viral_replication

https://en.wikipedia.org/wiki/Mobile_genetic_elements https://en.wikipedia.org/wiki/Genetic_recombination

https://en.wikipedia.org/wiki/ https://en.wikipedia.org/wiki/Apoptosis

https://en.wikipedia.org/wiki/Necrosis https://en.wikipedia.org/wiki/Cell_damage

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https://en.wikipedia.org/wiki/Robust_statistics#resistant_statistic

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https://en.wikipedia.org/wiki/Organ_(anatomy) https://en.wikipedia.org/wiki/Unicellular_organism

Phases of clinical research: https://en.wikipedia.org/wiki/Phases_of_clinical_research

´´The phases of clinical research are the stages in which scientists conduct experiments with a health intervention to obtain sufficient evidence for a process considered effective as a medical treatment.^[1] For drug development, the clinical phases start with testing for safety in a few human subjects, then expand to many study participants (potentially tens of thousands) to determine if the treatment is effective.^[1] Clinical research is conducted on drug candidates, vaccine candidates, new medical devices, and new diagnostic assays.´´

´´Clinical trials testing potential medical products are commonly classified into four phases. The drug development process will normally proceed through all four phases over many years.^[1] If the drug successfully passes through Phases I, II, and III, it will usually be approved by the national regulatory authority for use in the general population.^[1] Phase IV trials are ‘post-marketing’ or ‘surveillance’ studies conducted to monitor safety over several years.^[1]´´

´´Before clinical trials are undertaken for a candidate drug, vaccine, medical device, or diagnostic assay, the product candidate is tested extensively in preclinical studies.^[1] Such studies involve in vitro (test tube or cell culture) and in vivo (animal model) experiments using wide-ranging doses of the study agent to obtain preliminary efficacy, toxicity and pharmacokinetic information. Such tests assist the developer to decide whether a drug candidate has scientific merit for further development as an investigational new drug.^[1]´´

https://en.wikipedia.org/wiki/Model_organism

´´Genomic data is used to make close comparisons between species and determine relatedness. As humans, we share about 99% of our genome with chimpanzees^[57][58] (98.7% with bonobos)^[59] and over 90% with the mouse.^[56] With so much of the genome conserved across species, it is relatively impressive that the differences between humans and mice can be accounted for in approximately six thousand genes (of ~30,000 total). Scientists have been able to take advantage of these similarities in generating experimental and predictive models of human disease.´´

The Drug Development Process – https://www.fda.gov/patients/learn-about-drug-and-device-approvals/drug-development-process

Step 1: Discovery and Development: https://www.fda.gov/patients/drug-development-process/step-1-discovery-and-development

Step 2: Preclinical Research: https://www.fda.gov/patients/drug-development-process/step-2-preclinical-research

Step 3: Clinical Research: https://www.fda.gov/patients/drug-development-process/step-3-clinical-research

Step 4: FDA Drug Review: https://www.fda.gov/patients/drug-development-process/step-4-fda-drug-review

Step 5: FDA Post-Market Drug Safety Monitoring: https://www.fda.gov/patients/drug-development-process/step-5-fda-post-market-drug-safety-monitoring

Drug development – https://www.sciencedirect.com/topics/nursing-and-health-professions/drug-development#:~:text=Drug%20development%20is%20the%20process,commercial%20launch%20of%20the%20drug.

Drug development: https://en.wikipedia.org/wiki/Drug_development

Drug Discovery and Development Process

https://www.nebiolab.com/drug-discovery-and-development-process/

Exploring the Drug Development Process – ARTICLE   Mar 13, 2020 | By Laura Elizabeth Lansdowne, Senior Science Writer, Technology Networks – https://www.technologynetworks.com/drug-discovery/articles/exploring-the-drug-development-process-331894

Drug Development Research – https://onlinelibrary.wiley.com/journal/10982299

Drug development

Drug development describes the process of developing a new drug that effectively targets a specific weakness in a cell. This process involves specific pre-clinical development and testing, followed by trials in humans to determine the efficacy of the drug.

https://www.nature.com/subjects/drug-development

Phases of New Drug Development

• https://www.investopedia.com/articles/investing/072913/8-stages-new-drug-development.asp

The Importance of Clinical Trials in Drug Development – Avicenna J Med Biotechnol. 2016 Oct-Dec; 8(4): 151. Shahin Akhondzadeh, Ph.D., FBPharmacolS, Editor in Chief

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5124250/

Stages of Drug Development: https://pacificbiolabs.com/stages-of-drug-development

https://drug-dev.com/

Centers for Disease Control and Prevention – https://www.cdc.gov/

Vaccines & Immunizations

• Vaccine Testing and the Approval Process: https://www.cdc.gov/vaccines/basics/test-approve.html

Development of New Vaccines

Vaccine Product Approval Process

Tracking Side Effects Once a Vaccine is Administered

Related Topics and Sources

Related Topics and Sources: https://www.cdc.gov/vaccines/vac-gen/default.htm

For Specific Groups of People: https://www.cdc.gov/vaccines/spec-grps.html

Price Lists and Vaccine Codes: https://www.cdc.gov/vaccines/imz-managers/lists-codes.html

Vaccine Safety: https://www.cdc.gov/vaccinesafety/index.html

Guidelines and Publications: https://www.cdc.gov/vaccines/imz-managers/guides-pubs/index.html

https://www.cdc.gov/vaccines/imz-managers/contacts/index.html

https://www.cdc.gov/vaccines/vaxview/index.html

https://www.cdc.gov/vaccines/imz-managers/laws/index.html

https://www.cdc.gov/vaccines/imz-managers/program-components/index.html

https://www.cdc.gov/vaccines/imz-managers/awardee-imz-websites.html

https://www.cdc.gov/vaccines/pregnancy/index.html

https://www.cdc.gov/vaccines/parents/index.html

https://www.cdc.gov/vaccines/adults/index.html

https://www.cdc.gov/vaccines/hcp/index.html

https://www.cdc.gov/vaccines/covid-19/index.html

https://www.cdc.gov/vaccines/imz-managers/index.html

Vaccines and Preventable Diseases: https://www.cdc.gov/vaccines/vpd/index.html

News and Media Resources

https://www.cdc.gov/vaccines/news/index.html

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